Unveiling the interoception impairment in various major depressive disorder stages
Open accessAbstract
Background: The intricate pathophysiological mechanisms of major depressive disorder (MDD) necessitate the development of comprehensive early indicators that reflect the complex interplay of emotional, physical, and cognitive factors. Despite its potential to fulfill these criteria, interoception remains underexplored in MDD. This study aimed to evaluate the potential of interoception in transforming MDD's clinical practices by examining interoception deficits across various MDD stages and analyzing their complex associations with the spectrum of depressive symptoms. Methods: This study included 431 healthy individuals, 206 subclinical depression individuals, and 483 MDD patients. Depressive symptoms and interoception function were assessed using the PHQ‐9 and MAIA‐2, respectively. Results: Interoception dysfunction occurred in the preclinical phase of MDD and further impaired in the clinical stage. Antidepressant therapies showed limited efficacy in improving interoception and might damage some dimensions. Interoceptive dimensions might predict depressive symptoms, primarily enhancing negative thinking patterns. The predictive model based on interoception was built with random split verification and demonstrated good discrimination and predictive performance in identifying MDD. Conclusions: Early alterations in the preclinical stage, multivariate associations with depressive symptoms, and good discrimination and predictive performance highlight the importance of interoception in MDD management, pointing to a paradigm shift in diagnostic and therapeutic approaches.
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Antidepressants demonstrate limited benefits for some components of interoceptive sensitivity while adversely influencing other interoceptive processes.
“Further evidence suggests that antidepressants demonstrate limited benefits for some components of interoceptive sensitivity (e.g., decreased distraction of bodily signals) while adversely influencing other interoceptive processes (e.g., self-regulation and body listening) [18].”
From Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis (2026) · cites this paper as [18]
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Bednarek, L., Harrison, B. J., Davey, C. G., Steward, T., & Jamieson, A. J. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02201-5 · Cited by 1 · see citing works
“Further evidence suggests that antide - pressants demonstrate limited benefits for some components of interoceptive sensitivity (e.g., decreased distraction of bodily signals) while adversely influencing other interocep - tive processes (e.g., self-regulation and body listening) [18].”
- Authors
- Zhou, H., Liu, J., Wu, Y., Huang, Z., Wang, W., Ma, Y., Zhu, H., Zhou, Z., Wang, J., & Jiang, C.
- Affiliations
- Wuxi Fourth People's Hospital (CN)
- Nanjing Medical University (CN)
- Jiangnan University (CN)
- Zhongda Hospital Southeast University (CN)
- Corresponding author
- Zhou, Hongliang
- Venue
- CNS Neuroscience & Therapeutics
- Publisher
- Wiley
- Published
- 2024-08
- Volume
- 30
- Issue
- 8
- Pages
- e14923-e14923
- ISSN
- 1755-5930 (ISSN-L)
- 1755-5949
- PMC
- PMC11330652
- OpenAlex
- W4401673368
- Cited by
- 13
- References
- 80
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 1
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- CNS Neuroscience & Therapeutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- interoception, major depressive disorder, subthreshold depression, depressive symptoms, depression prediction, MAIA-2, PHQ-9
- MeSH terms
- Adult, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Young Adult, Interoception
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