Symptom Prevalence in Lung and Colorectal Cancer Patients
Open accessAbstract
Context Relatively few data are available about symptoms among cancer patients.Objectives To describe the prevalence and severity of symptoms among a large, representative cohort of newly diagnosed cancer patients.Methods We collected survey data about symptoms (pain, fatigue, depression, nausea/vomiting, cough, dyspnea, and diarrhea) from 5422 patients with incident lung and colorectal cancer from the diverse, nationally representative Cancer Care Outcomes Research and Surveillance Consortium cohort. We described the prevalence of any symptoms and moderate/severe symptoms approximately four to six months after diagnosis. We used logistic regression to identify patient and clinical characteristics associated with symptoms, and calculated adjusted proportions of patients with symptoms.Results In total, 5067 (93.5%) patients reported at least one symptom in the four weeks before their survey, with 51% reporting at least one moderate/severe symptom. Lung cancer patients reported more symptoms than colorectal cancer patients. Patients who received treatment or had more comorbidities were more likely to report symptoms. For example, after adjustment, patients who received chemotherapy during the six weeks before the survey were more likely than others to report at least one symptom (97.3% vs. 90.8%, P<0.001), and at least one moderate/severe symptom (56.8% vs. 46.2%, P<0.001). After adjustment, early- vs. late-stage patients did not differ in reports of at least one symptom (93.6% vs. 93.4%, P=0.853) and differed only slightly in reports of at least one moderate/severe symptom (53.3% vs. 49.6%, P=0.009).Conclusion Most recently diagnosed lung and colorectal cancer patients have cancer-related symptoms regardless of stage, and more than half have at least one moderate/severe symptom.
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Many advanced cancer patients have symptoms that interfere with functioning.
“Many advanced cancer patients have symptoms that interfere with functioning.1–3”
From Symptom experiences in advanced cancer: Relationships to acceptance and commitment therapy constructs (2021) · cites this paper as [3]
The Results (Patient Factors Associated with Symptom Prevalence; page not provided) report that 49.6% of late-stage lung and colorectal cancer patients had at least one moderate or severe symptom, supporting the claim that many advanced cancer patients have symptoms. The paper measures symptom severity, not whether those symptoms interfere with functioning, so that part is not established by this source. (LLM, conf=0.84)
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- Authors
- Walling, A. M., Weeks, J. C., Kahn, K. L., Tisnado, D., Keating, N. L., Dy, S. M., Arora, N. K., Mack, J. W., Pantoja, P. M., & Malin, J. L.
- Affiliations
- RAND Corporation (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- Brigham and Women's Hospital (US)
- Johns Hopkins University (US)
- National Cancer Institute (US)
- VA Greater Los Angeles Healthcare System (US)
- Corresponding author
- Walling, Anne M.
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 49
- Issue
- 2
- Pages
- 192-202
- ISSN
- 0885-3924 (ISSN-L)
- PMC
- PMC4277493
- OpenAlex
- W2059521335
- Cited by
- 110
- References
- 54
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 13 · 2021: 14 · 2020: 11 · 2019: 9 · 2018: 10 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 3
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- American Cancer Society (119663-RSG-10-176-01-PCSM)
- National Cancer Institute (U01 CA093344)
- Harvard Medical School and Northern California Cancer Center (U01 CA093324)
- Dana-Farber Cancer Institute and Cancer Research Network (U01 CA093332)
- RAND Corporation
- University of California (U01 CA093348)
- University of Alabama (U01 CA093329)
- University of Iowa (U01 CA093339)
- University of North Carolina (U01 CA093326)
- Durham VA Medical Center (U01 CDA093344 (MOU), HARQ 03-438MO-03)
- National Institutes of Health (R011CA164021-01A1)
- NIH
- National Center for Advancing Translational Sciences
- UCLA CTSI (UL1TR000123)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Financial Impacts of Cancer
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- cancer symptoms, symptom prevalence, lung cancer, colorectal cancer, newly diagnosed cancer, chemotherapy, comorbidities, tumor stage, symptom severity, cancer care outcomes
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Humans, Lung Neoplasms, Male, Middle Aged, Surveys and Questionnaires, Severity of Illness Index, United States, Colorectal Neoplasms, Cohort Studies, Comorbidity, Prevalence, Multivariate Analysis, Logistic Models, Disease Progression, Young Adult
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