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Cited by 88Child and Adolescent Psychosocial and Emotional DevelopmentMental Health Treatment and AccessTreatment of Major Depression

Childhood onset major depressive disorder: course of illness and psychiatric comorbidity in a community sample

Korczak, Daphne J., Goldstein, Benjamin I.·2009·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2009.01.061
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Abstract

Objective To examine the effect of childhood-onset major depressive disorder (MDD) on course of illness and psychiatric comorbidity, as compared with adolescent- and adult-onset MDD, in a large nonclinical sample.Study design This study included 6778 civilian noninstitutionalized participants in the National Epidemiologic Survey on Alcohol and Related Conditions with nonpsychotic, non-substance-induced MDD. Subjects were divided into 3 groups on the basis of age at first episode of MDD: childhood-onset (CHLD; onset < or =12 yrs, n = 372), adolescent-onset (ADOL; onset 13 to 17 years, n = 854), and adult-onset (ADLT; onset > or =18 years, n = 5552).Results Compared with subjects with ADLT, CHLD MDD was associated with a greater number of MDD episodes, longer episode duration, increased suicidality, and increased need for hospitalization for MDD compared with adult-onset illness. Subjects with CHLD had a higher rate of psychiatric comorbidity and were more likely to have a parental history of MDD. Among subjects treated for MDD, latency from MDD onset to treatment was greater among subjects with CHLD compared with subjects with ADLT. Data for subjects with ADOL was intermediate to those of subjects with CHLD and ADLT.Conclusions This epidemiologic study confirms and extends clinical findings of childhood-onset MDD as a more familial form of illness associated with increased comorbidity, suicidality, and treatment use.

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Authors
Korczak, D. J., & Goldstein, B. I.
Affiliations
  • University of Toronto (CA)
  • University of Pittsburgh (US)
Corresponding author
Korczak, Daphne J.
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2009-07
Volume
155
Issue
1
Pages
118-123
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2009.01.061
OpenAlex
W1971604762
Cited by
88
References
39
Citations by year
2026: 3 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 2
FWCI
3.54
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
adolescent-onset depression, clinical course, psychiatric comorbidity, suicidality, hospitalization, treatment delay, age of onset, NESARC
MeSH terms
Adolescent, Adult, Anxiety Disorders, Child, Commitment of Mentally Ill, Commitment of Persons with Psychiatric Disorders, Depressive Disorder, Major, Major Depressive Disorder, Emergency Service, Hospital, Female, Humans, Interviews as Topic, Male, Middle Aged, Parents, Personality Disorders, Sampling Studies, Suicide, Attempted, United States, Comorbidity, Age of Onset, Dysthymic Disorder, Substance-Related Disorders

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