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Cited by 68Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.

Predictors of treatment response to fluvoxamine in obsessive–compulsive disorder: An fMRI study

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Sanematsu, Hirokuni, Nakao, Tomohiro, Yoshiura, Takashi, Nabeyama, Maiko, Togao, Osamu, Tomita, Mayumi, Masuda, Yusuke, Nakatani, Eriko, Nakagawa, Akiko, Kanba, Shigenobu·2010·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2009.08.007
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Abstract

Recent neuroimaging studies suggest that the pathophysiology of obsessive-compulsive disorder (OCD) may involve more widely distributed large-scale brain systems, including the parietal, occipital, and cerebellar areas, rather than the conventional orbitofronto-striatal model. We hypothesized that not only orbitofrontal cortex and caudate nucleus activities but also posterior brain regions might be associated with subsequent treatment response to serotonin reuptake inhibitors in OCD. The participants were 17 patients with OCD. Each patient was required to undergo fluvoxamine pharmacotherapy for 12 weeks. Before treatment, fMRI images of the subjects were obtained in the context of a symptom-provocation paradigm. The percentage changes in total Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) scores, from pre- to post-treatment, served as the index of treatment response. Statistical Parametric Mapping was used to identify brain loci where pre-treatment brain activation significantly correlated with the subsequent treatment response. Fifteen of 17 patients completed the 12-week treatment. During the symptom provocation task, patients showed brain activation in the left superior temporal gyrus (STG), left precuneus, left frontal cortices, right cerebellum, and right frontal cortices. We found that pre-treatment activation in the right cerebellum (Z-score=5.10, x,y,z=22,-84,-18) and the left STG (Z-score=4.95, x,y,z=-62,-22,0) was positively correlated with the improvement in the Y-BOCS score. Our results suggest that pre-treatment activation in the right cerebellum and in the left STG predict subsequent reduction in OCD symptom severity. There is every possibility that fMRI can be used as a tool to predict treatment response.

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  • Other studies have attempted to identify predictors of therapeutic response in OCD patients, but the wide diversity of methodologies and outcomes makes it difficult to identify precise and reproducible markers of resistance.

    “Other studies have attempted to identify predictors of therapeutic response in OCD patients, but the wide diversity of methodologies and outcomes makes it difficult to identify precise and reproducible markers of resistance [47–53].”

    From Error-Related Brain Potentials as Biomarkers of Pathology Severity and Treatment Resistance in Patients With Obsessive-Compulsive Disorder (2026) · cites this paper as [53]

    The Introduction reports that previous studies identified predictors of response to serotonin reuptake inhibitors in OCD. The Discussion (p. 22) attributes discrepancies between its findings and earlier neuroimaging studies to methodological differences and patient variation. It does not establish the broader claim that diverse methods and outcomes prevent identification of precise, reproducible markers of treatment resistance. (LLM, conf=0.82)

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Metadata

Authors
Sanematsu, H., Nakao, T., Yoshiura, T., Nabeyama, M., Togao, O., Tomita, M., Masuda, Y., Nakatani, E., Nakagawa, A., & Kanba, S.
Affiliations
Kyushu University (JP)
Corresponding author
Nakao, Tomohiro
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2010-03
Volume
44
Issue
4
Pages
193-200
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2009.08.007
OpenAlex
W1968498366
Cited by
68
References
64
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 7 · 2018: 4 · 2017: 1 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 8 · 2012: 4
FWCI
3.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion)
  • Kyushu University Institutional Repository (QIR) (Kyushu University) (submittedVersion, other-oa)
Funders
  • Ministry of Health, Labour and Welfare
  • Ministry of Education, Culture, Sports, Science and Technology (14A-1)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
obsessive-compulsive disorder, fluvoxamine, treatment response prediction, cerebellum, superior temporal gyrus, serotonin reuptake inhibitors, brain activation
MeSH terms
Adult, Brain, Brain Mapping, Female, Follow-Up Studies, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Obsessive-Compulsive Disorder, Oxygen, Predictive Value of Tests, Psychiatric Status Rating Scales, Fluvoxamine, Selective Serotonin Reuptake Inhibitors

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