Early adverse experience and substance addiction: Dopamine, oxytocin, and glucocorticoid pathways

Kim, Sohye; Kwok, Stephanie; Mayes, Linda C.; Potenza, Marc N.; Rutherford, Helena J. V.; Strathearn, Lane

doi:10.1111/nyas.13140

Cited by 85Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorChild Abuse and Trauma

Early adverse experience and substance addiction: Dopamine, oxytocin, and glucocorticoid pathways

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Kim, Sohye, Kwok, Stephanie, Mayes, Linda C., Potenza, Marc N., Rutherford, Helena J. V., Strathearn, Lane·2017·Annals of the New York Academy of Sciences

DOI 10.1111/nyas.13140PMC PMC5303188

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Abstract

Substance addiction may follow a chronic, relapsing course and critically undermine the physical and psychological well-being of the affected individual and the social units of which the individual is a member. Despite the public health burden associated with substance addiction, treatment options remain suboptimal, with relapses often seen. The present review synthesizes growing insights from animal and human research to shed light upon developmental and neurobiological pathways that may increase susceptibility to addiction. We examine the dopamine system, the oxytocin system, and the glucocorticoid system, as they are particularly relevant to substance addiction. Our aim is to delineate how early adverse experience may induce long-lasting alterations in each of these systems at molecular, neuroendocrine, and behavioral levels and ultimately lead to heightened vulnerability to substance addiction. We further discuss how substance addiction in adulthood may increase the risk of suboptimal caregiving for the next generation, perpetuating the intergenerational cycle of early adverse experiences and addiction.

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In rodent studies, early life adversity (ELA) induces alterations in DA neuronal activity and synaptic function, impacting reward-directed behavior and partially accounting for individual variation along the mesolimbic DA projection.
“In rodent studies, early life adversity (ELA) has been shown to induce alterations in DA neuronal activity and synaptic function [15], impacting reward-directed behavior and partially accounting for individual variation along the mesolimbic DA projection [16].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [15]

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Authors: Kim, S., Kwok, S., Mayes, L. C., Potenza, M. N., Rutherford, H. J. V., & Strathearn, L.
Affiliations: Baylor College of Medicine (US)
Yale University (US)
University of Iowa (US)
Corresponding author: Strathearn, Lane
ORCID: Kim, Sohye
Potenza, Marc N.
Rutherford, Helena J. V.
Strathearn, Lane
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2016-08-10
Volume: 1394
Issue: 1
Pages: 74-91
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/nyas.13140
PMC: PMC5303188
OpenAlex: W2514444724
Cited by: 85
References: 210
Citations by year: 2026: 6 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 11 · 2021: 14 · 2020: 9 · 2019: 10 · 2018: 6 · 2017: 10 · 2016: 1
FWCI: 1.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01 DA02446, R01 DA06025, R01 DA026437)
National Institute of Child Health and Human Development (R01 HD065819, R03 HD080998)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: substance addiction, childhood adversity, dopaminergic system, oxytocinergic system, glucocorticoid system, addiction vulnerability, neuroendocrine pathways, developmental programming, intergenerational transmission, caregiving, relapse, neurobiology of addiction
MeSH terms: Animals, Dopamine, Glucocorticoids, Humans, Oxytocin, Signal Transduction, Substance-Related Disorders

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Early adverse experience and substance addiction: Dopamine, oxytocin, and glucocorticoid pathways

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