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Cited by 66Posttraumatic Stress Disorder ResearchIndigenous Health, Education, and RightsChild Abuse and Trauma

Lifetime history of traumatic events in an American Indian community sample: heritability and relation to substance dependence, affective disorder, conduct disorder and PTSD

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Ehlers, Cindy L., Gizer, Ian R., Gilder, David A., Yehuda, Rachael·2013·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2012.10.002PMC PMC3530021
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Abstract

American Indians appear to experience a higher rate of traumatic events than what has been reported in general population surveys. American Indians also suffer higher alcohol related death rates than any other ethnic group in the U.S. population. Therefore efforts to delineate factors which may uniquely contribute to increased likelihood of trauma, post traumatic stress disorder (PTSD), and substance use disorders (SUD) over the lifetime in American Indians are important because of the high burden of morbidity and mortality that they pose to American Indian communities. Participants were American Indians recruited from reservations that were assessed with the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA), family history assessment and the stressful-life-events scale. Of the 309 participants, equivalent numbers of men and women (94%) reported experiencing traumas; however, a larger proportion of women received a PTSD diagnosis (38%) than men (29%). Having experienced multiple trauma and sexual abuse were most highly associated with PTSD. Having experienced assaultive trauma and having PTSD symptoms were both found to be moderately heritable (30-50%). Logistic regression revealed that having an anxiety and/or affective disorder and having a substance dependent diagnosis, but not having antisocial personality disorder/conduct disorder, were significantly correlated with having a diagnosis of PTSD. These studies suggest that trauma is highly prevalent in this American Indian community, it is heritable, is associated with PTSD, affective/anxiety disorders and substance dependence. Additionally, trauma, PTSD and substance dependence appear to all co-emerge in early adulthood in this high-risk population.

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Authors
Ehlers, C. L., Gizer, I. R., Gilder, D. A., & Yehuda, R.
Affiliations
  • Scripps Research Institute (US)
  • University of Missouri (US)
  • James J. Peters VA Medical Center (US)
Corresponding author
Ehlers, Cindy L.
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2013-02
Volume
47
Issue
2
Pages
155-161
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2012.10.002
PMC
PMC3530021
OpenAlex
W2153714536
Cited by
66
References
96
Citations by year
2026: 4 · 2025: 3 · 2024: 1 · 2023: 10 · 2022: 5 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 4 · 2014: 3 · 2013: 3
FWCI
3.64
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (R37AA010201, R01AA010201)
  • National Institute on Drug Abuse (DA030976, R01DA030976)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Social Sciences › Health › Indigenous Health, Education, and Rights
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords
traumatic events, heritability, post-traumatic stress disorder, substance dependence, mood disorders, conduct disorder, Native Americans, sexual abuse, alcoholism, family history (medicine), life events, gender differences, early adulthood
MeSH terms
Adolescent, Adult, Female, Humans, Indians, North American, Male, Middle Aged, Psychiatric Status Rating Scales, Residence Characteristics, Stress Disorders, Post-Traumatic, Conduct Disorder, Mood Disorders, Substance-Related Disorders, Young Adult

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