The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: Data from multicenter, prospective, longitudinal clinic practice
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Background Although genetic variants may play a key role in development of treatment-resistant depression (TRD), relevant research is scarce.Methods To examine whether the polymorphisms of BDNF (rs6265) and NTRK2 (rs1387923, rs2769605 and rs1565445) genes confer risk for TRD in major depressive disorder (MDD), a total of 948 MDD patients were recruited in a 12-week, multicenter, prospective longitudinal study.Results Our study showed a significant allelic association between rs1565445 and TRD with an excess of the T allele in the TRD group, compared to non-TRD group (OR = 1.43, 95%CI: 1.16-1.76, p = 0.0008); while patients with genotype C/C and T/C in rs1565445 were less likely to develop TRD than those carrying T/T (OR = 0.52, 95%CI: 0.33-0.82; OR = 0.72, 95%CI: 0.54-0.97, respectively; p = 0.005). Haplotype T-T (rs1565445 and rs1387923) had 1.41-fold increased risk of TRD (p = 0.0014). Furthermore, significant four-locus (rs1387923-rs1565445-rs2769605-rs6265) gene-gene interactions were detected by the Multifactor-dimensionality reduction (MDR) method.Discussion These results suggest that the interactions of BDNF (rs6265) with NTRK2 (rs1387923, rs2769605 and rs1565445) gene polymorphisms likely play an essential role in the development of TRD in Han Chinese MDD patients.
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NTRK2 gene polymorphism has been associated with an increased risk of developing TRD and with a reduction of HAM-D21 score.
“NTRK2 gene polymorphism has been associated with an increased risk of developing Treatment Resistant Depression (TRD) [12], with a reduction of HAM-D21 score [13].”
From The Impact of BDNF, NTRK2, NGFR, CREB1, GSK3B, AKT, MAPK1, MTOR, PTEN, ARC, and SYN1 Genetic Polymorphisms in Antidepressant Treatment Response Phenotypes (2023) · cites this paper as [12]
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“NTRK2 gene polymorphism has been associated with an increased risk of developing Treatment Resistant Depression (TRD) [12], with a reduction of HAM-D21 score [13].”
Background
- Authors
- Li, Z., Zhang, Y., Wang, Z., Chen, J., Fan, J., Guan, Y., Zhang, C., Yuan, C., Hong, W., Wang, Y., Wu, Z., Huang, J., Hu, Y., Cao, L., Yi, Z., Cui, D., Yu, S., & Fang, Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Case Western Reserve University (US)
- Second Military Medical University (CN)
- Corresponding author
- Yu, Shunying
- Fang, Yiru
- ORCID
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 47
- Issue
- 1
- Pages
- 8-14
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC3584686
- OpenAlex
- W2064701697
- Cited by
- 63
- References
- 46
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 10 · 2015: 6 · 2014: 5 · 2013: 5
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5kl2rr024990-05)
- National Center for Research Resources (KL2-RR-024990)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- treatment-resistant depression, major depressive disorder, brain-derived neurotrophic factor, NTRK2, genetic polymorphism, BDNF Val66Met polymorphism, haplotype association, gene-gene interaction, genetic risk, Han Chinese
- MeSH terms
- Adolescent, Adult, Aged, China, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Brain-Derived Neurotrophic Factor, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Receptor, trkB, Depressive Disorder, Treatment-Resistant
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