Cited by 19Stress Responses and CortisolSchizophrenia research and treatmentMental Health and Psychiatry

Associations between diurnal cortisol patterns and lifestyle factors, psychotic symptoms, and neurological deficits: A longitudinal study on patients with chronic schizophrenia

Ho, Rainbow T.H., Fong, Ted C.T., Wan, Adrian H.Y., Au-Yeung, Friendly S.W., Chen, Eric Y.H., Spiegel, David·2016·Journal of Psychiatric Research

Abstract

The present study examined the relationships between diurnal cortisol patterns and perceived stress, lifestyle factors, psychotic symptoms, neurological deficits, and daily functioning in patients with chronic schizophrenia. The participants were 149 Chinese patients with chronic schizophrenia, who provided salivary cortisol measures upon waking, before lunchtime, and before bedtime at baseline (Time 1). Self-report measures on perceived stress and lifestyle factors such as body-mass index and daily exercise span were recorded at Time 1. Diagnostic assessments on psychotic symptoms, neurological deficits, and daily functioning were made at Time 1 and Time 2 (3 months later). Latent growth modeling and path modeling analysis were performed to investigate the diurnal cortisol patterns and the relationships with the study variables, respectively. Greater perceived stress and body-mass index and less physical activity were significantly linked to reduced cortisol decline. Reduced cortisol decline at Time 1 significantly predicted greater psychotic (positive and negative) symptoms and more severe neurological deficits in motor coordination and sequencing of complex motor acts at Time 2. The present results contribute to a better understanding of the diurnal cortisol patterns among chronic schizophrenia patients and the associations with lifestyle factors, psychotic symptoms, and neurological deficits. The findings lend support to the neural diathesis-stress model and suggest that hypothalamic-pituitary-adrenal axis may potentially mediate the effects of lifestyle factors on psychotic symptoms and neurological deficits.

Integrity signals

Registry

Crossref · 10.1016/j.jpsychires.2016.06.014

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Altered regulation of the HPA axis in schizophrenia is predictive of more severe psychotic and motor symptoms.

    “Furthermore, altered regulation of the HPA axis in SZ is predictive of more severe psychotic and motor symptoms159,160.”

    From Circadian rhythm disruption and mental health (2020) · cites this paper as [159]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Ho, R. T. H., Fong, T. C. T., Wan, A. H. Y., Au-Yeung, F. S. W., Chen, E. Y. H., & Spiegel, D.
Affiliations
  • University of Hong Kong (HK)
  • Hong Kong Sheng Kung Hui Welfare Council Limited (HK)
  • Stanford Medicine (US)
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2016-10
Volume
81
Pages
16-22
ISSN
0022-3956 (ISSN-L)
OpenAlex
W2437127101
Cited by
19
References
46
Citations by year
2025: 3 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2018: 2
FWCI
0.43
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders
  • General Research Fund of Shanghai Normal University (GRF/HKU 744912)
  • Research Grants Council, University Grants Committee (GRF/HKU 744912)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
chronic schizophrenia, perceived stress, lifestyle factors, body mass index, physical activity, psychotic symptoms, neurological deficit, motor coordination, daily functioning, hypothalamic-pituitary-adrenal axis, salivary cortisol
MeSH terms
Adult, Chronic Disease, Circadian Rhythm, Female, Hong Kong, Humans, Hydrocortisone, Life Style, Longitudinal Studies, Male, Middle Aged, Nervous System Diseases, Predictive Value of Tests, Saliva, Schizophrenia, Schizophrenic Psychology, Area Under Curve, Self Report

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review