Automated measurement of hippocampal subfields in PTSD: evidence for smaller dentate gyrus volume
Open accessAbstract
Smaller hippocampal volume has been consistently observed as a biomarker of posttraumatic stress disorder (PTSD). However, less is known about individual volumes of the subfields composing the hippocampus such as the dentate gyrus and cornu ammonis (CA) fields 1-4 in PTSD. The aim of the present study was to examine the hypothesis that volume of the dentate gyrus, a region putatively involved in distinctive encoding of similar events, is smaller in individuals with PTSD versus trauma-exposed controls. Ninety-seven recent war veterans underwent structural imaging on a 3T scanner and were assessed for PTSD using the Clinician-Administered PTSD Scale. The hippocampal subfield automated segmentation program available through FreeSurfer was used to segment the CA4/dentate gyrus, CA1, CA2/3, presubiculum, and subiculum of the hippocampus. Results showed that CA4/dentate gyrus subfield volume was significantly smaller in veterans with PTSD and scaled inversely with PTSD symptom severity. These results support the view that dentate gyrus abnormalities are associated with symptoms of PTSD, although additional evidence is necessary to determine whether these abnormalities underlie fear generalization and other memory alterations in PTSD.
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Increased hippocampal volume may in part be explained by exercise-associated increases in neurogenesis in the dentate gyrus subfield of the hippocampus, which is negatively impacted in PTSD.
“Increased hippocampal volume may in part be explained by exercise associated increases in neurogenesis in the dentate gyrus subfield of the hippocampus (97, 98), which is negatively impacted in PTSD (84).”
From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [84]
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- Authors
- Hayes, J. P., Hayes, S., Miller, D. R., Lafleche, G., Logue, M. W., & Verfaellie, M.
- Affiliations
- Boston University (US)
- Corresponding author
- Hayes, Jasmeet P.
- ORCID
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 95
- Pages
- 247-252
- ISSN
- 0022-3956 (ISSN-L)
- PMC
- PMC6816338
- OpenAlex
- W2751814433
- Cited by
- 81
- References
- 23
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 9 · 2023: 10 · 2022: 16 · 2021: 12 · 2020: 6 · 2019: 13 · 2018: 4 · 2017: 3
- FWCI
- 8.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- VA Rehabilitation Research and Development (1I01RX000216)
- VA Biomedical Laboratory Research and Development (I01BX003477)
- National Center for PTSD
- VA Clinical Science Research and Development Service
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- post-traumatic stress disorder, hippocampal subfields, dentate gyrus, cornu ammonis, hippocampal subfield segmentation, war veterans, trauma exposure, hippocampal volume, fear generalization, PTSD symptom severity
- MeSH terms
- Psychological Trauma, Adult, Combat Disorders, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Stress Disorders, Post-Traumatic, Veterans, Dentate Gyrus, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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