One year double blind study of high vs low frequency subcallosal cingulate stimulation for depression
Open accessAbstract
Subcallosal Brodmann's Area 25 (Cg25) Deep Brain Stimulation (DBS) is a new promising therapy for treatment resistant major depressive disorder (TR-MDD). While different DBS stimulating parameters may have an impact on the efficacy and safety of the therapy, there is no data to support a protocol for optimal stimulation parameters for depression. Here we present a prospective multi-center double-blind randomized crossed-over 13-month study that evaluated the effects of High (130 Hz) vs Low (20 Hz) frequency Cg25 stimulation for nine patients with TR-MDD. Four out of nine patients achieved response criteria (≥40% reduction of symptom score) compared to mean baseline values at the end of the study. The mean percent change of MADRS score showed a similar improvement in the high and low frequency stimulation groups after 6 months of stimulation (-15.4 ± 21.1 and -14.7 ± 21.1 respectively). The mean effect at the end of the second period (6 months after cross-over) was higher than the first period (first 6 months of stimulation) in all patients (-23.4 ± 19.9 (n = 6 periods) and -13.0 ± 22 (n = 9 periods) respectively). At the end of the second period, the mean percent change of the MADRS scores improved more in the high than low frequency groups (-31.3 ± 19.3 (n = 4 patients) and -7.7 ± 10.9 (n = 2 patients) respectively). Given the small numbers, detailed statistical analysis is challenging. Nonetheless the results of this study suggest that long term high frequency stimulation might confer the best results. Larger scale, randomized double blind trials are needed in order to evaluate the most effective stimulation parameters.
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Studies of subcallosal cingulate cortex DBS for treatment-resistant depression generally use fixed frequency (130 Hz) and pulse-width (90 μs).
“While in general, studies of SCC DBS for TRD use fixed frequency (130 Hz) and pulse-width (90 μs), three studies were specifically designed to test effects of different stimulation parameters [32][33][34].”
From Deep brain stimulation for depression. (2022) · cites this paper as [32]
Low-frequency stimulation does not seem to be effective.
“Low-frequency stimulation does not seem to be effective [32]”
From Deep brain stimulation for depression. (2022) · cites this paper as [32]
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Deep Brain Stimulation for Treatment-Resistant Depression
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Deep Brain Stimulation Approach in Neurological Diseases
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RetractedDeep brain stimulation for treatment-resistant depression
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- Authors
- Eitan, R., Fontaine, D., Benoît, M., Giordana, C., Darmon, N., Israel, Z., Linesky, E., Arkadir, D., Ben-Naim, S., Iserlles, M., Bergman, H., Hulse, N., Abdelghani, M., McGuffin, P., Farmer, A., DeLea, P., Ashkan, K., & Lerer, B.
- Affiliations
- Brigham and Women's Hospital (US)
- Centre Hospitalier Universitaire de Nice (FR)
- Hebrew University of Jerusalem (IL)
- Hadassah Medical Center (IL)
- King's College Hospital NHS Foundation Trust (GB)
- King's College London (GB)
- Corresponding author
- Eitan, Renana
- ORCID
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 96
- Pages
- 124-134
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2761803381
- Cited by
- 62
- References
- 39
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 12 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 10 · 2019: 5 · 2018: 6
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (acceptedVersion, cc-by-nc-nd)
- Funders
- St Jude Medical LTD
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, subcallosal cingulate, treatment-resistant depression, major depressive disorder, stimulation frequency, high-frequency stimulation, low-frequency stimulation, stimulation parameters
- MeSH terms
- Adult, Major Depressive Disorder, Double-Blind Method, Female, Gyrus Cinguli, Humans, Male, Middle Aged, Time Factors, Treatment Outcome, Cross-Over Studies, Deep Brain Stimulation, Depressive Disorder, Treatment-Resistant
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