Effects of different stimulation parameters on the antidepressant-like response of medial prefrontal cortex deep brain stimulation in rats
Abstract
Subcallosal cingulate gyrus (SCG) deep brain stimulation (DBS) is currently being investigated as a treatment for major depression. Despite the encouraging findings of the initial clinical series, several questions remain unanswered, including the most effective stimulation parameters (i.e., current intensity and frequency) and whether unilateral stimulation is also beneficial. We have recently found that some of the effects of SCG DBS could be modeled by stimulating the ventromedial prefrontal cortex (vmPFC) of rats undergoing the forced swim test (FST). Here we investigate whether changes in a number of DBS parameters, including electrode placement, influence outcome in this paradigm. Overall, we found that the antidepressant-like effects of DBS varied as a function of stimulation settings and target. The strongest response was observed with a current intensity of 200 microA, followed by 100 microA, and 300 microA. In contrast, 400 microA produced no effect. Using 200 microA, a frequency of 130 Hz was more effective than 20 Hz. An intriguing finding was that left unilateral stimulation was as effective as bilateral DBS. When different targets within the vmPFC were considered, a significant antidepressant-like response was observed after PL DBS, whereas IL stimulation was associated with a non-significant reduction in immobility scores. In summary, vmPFC DBS at high frequency and moderate intensity led to a maximal response in the FST.
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The sweet spot is in the high-frequency range of 100-150 Hz, which is also supported by animal studies.
“the sweet spot is in the high-frequency range (100-150 Hz) [103], which is also supported by animal studies [104,105].”
From Deep brain stimulation for depression. (2022) · cites this paper as [104]
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Self-citation
- Authors
- Hamani, C., Diwan, M., Isabella, S., Lozano, A. M., & Nobrega, J. N.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Hamani, Clement
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 44
- Issue
- 11
- Pages
- 683-687
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2043220571
- Cited by
- 145
- References
- 51
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 11 · 2017: 9 · 2016: 11 · 2015: 15 · 2014: 13 · 2013: 8 · 2012: 14
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- deep brain stimulation, antidepressant-like effects, medial prefrontal cortex, major depressive disorder, stimulation parameters, current intensity, stimulation frequency, electrode placement, ventromedial prefrontal cortex, dorsal prefrontal cortex, forced swim test, immobility
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Biophysics, Major Depressive Disorder, Electric Stimulation, Functional Laterality, Male, Swimming, Rats, Sprague-Dawley, Prefrontal Cortex, Deep Brain Stimulation, Rats, Biophysical Phenomena
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