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Corticotropin-releasing hormone, stress and human reproduction: an update

Kalantaridou, S.N., Zoumakis, E., Makrigiannakis, A., Lavasidis, L.G., Vrekoussis, T., Chrousos, G.P.·2010·Journal of Reproductive Immunology
DOI 10.1016/j.jri.2010.02.005
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Abstract

The stress system has suppressive effects on female and male reproductive function. Corticotrophin-releasing hormone (CRH), the principal regulator of stress, has been identified in the female and male reproductive system. Reproductive CRH participates in various reproductive functions that have an inflammatory component, where it serves as an autocrine and paracrine modulator. These include ovarian and endometrial CRH, which may participate in the regulation of steroidogenesis and the inflammatory processes of the ovary (ovulation and luteolysis) and the endometrium (decidualization and blastocyst implantation) and placental CRH, which is secreted mostly during the latter half of pregnancy and is responsible for the onset of labor. It has been suggested that there is a "CRH placental clock" which determines the length of gestation and the timing of parturition and delivery. The potential use of CRH-antagonists is presently under intense investigation. CRH-R1 antagonists have been used in animal studies to elucidate the role of CRH in blastocyst implantation and invasion, early fetal immunotolerance and premature labor. The present review article focuses on the potential roles of CRH on the physiology and pathophysiology of reproduction and highlights its participation in crucial steps of pregnancy, such as implantation, fetal immune tolerance, parturition and fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis.

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Research works printed but not linked: 65

  1. Almeida, 1998, Chronic intermittent immobilization of male rats throughout sexual development: a stress protocol, Exp. Physiol., 83, 701, 10.1113/expphysiol.1998.sp004151 · DOI
  2. Asakura, 1997, Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary, J. Clin. Endocrinol. Metab., 82, 2720, 10.1210/jc.82.8.2720 · DOI
  3. Bamberger, 2006, Corticotropin-releasing hormone modulates human trophoblast invasion through carcinoembryonic antigen-related cell adhesion molecule-1 regulation, Am. J. Pathol., 168, 141, 10.2353/ajpath.2006.050167 · DOI
  4. Barbazanges, 1996, Maternal glucocorticoid secretion mediates long-term effects of prenatal stress, J. Neurosci., 16, 3943, 10.1523/JNEUROSCI.16-12-03943.1996 · DOI
  5. Benedetto, 1994, Corticotropin-releasing hormone increases prostaglandin F2 alpha activity on human myometrium in vitro, Am. J. Obstet. Gynecol., 171, 126, 10.1016/0002-9378(94)90457-X · DOI
  6. Bromberger, 1997, Prospective study of the determinants of age at menopause, Am. J. Epidemiol., 145, 124, 10.1093/oxfordjournals.aje.a009083 · DOI
  7. Calogero, 1996, Effects of corticotropin-releasing hormone on ovarian estrogen production in vitro, Endocrinology, 137, 4161, 10.1210/en.137.10.4161 · DOI
  8. Chen, 1992, Hypoglycemic ‘stress’ and gonadotropin-releasing hormone pulse generator activity in the rhesus monkey: role of the ovary, Neuroendocrinology, 56, 666, 10.1159/000126291 · DOI
  9. Chrousos, 1999, Reproductive placental corticotropin-releasing hormone and its clinical implications, Am. J. Obstet. Gynecol., 180, S249, 10.1016/S0002-9378(99)70710-6 · DOI
  10. Chrousos, 1992, The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis, JAMA, 267, 1244, 10.1001/jama.267.9.1244 · DOI · Paper page
  11. Chrousos, 1998, Interactions between the hypothalamic–pituitary–adrenal axis and the female reproductive system: clinical implications, Ann. Intern. Med., 129, 229, 10.7326/0003-4819-129-3-199808010-00012 · DOI
  12. Clifton, 1995, Corticotropin-releasing hormone-induced vasodilatation in the human fetal-placental circulation: involvement of the nitric oxide-cyclic guanosine 3′,5′-monophosphate-mediated pathway, J. Clin. Endocrinol. Metab., 80, 2888, 10.1210/jc.80.10.2888 · DOI
  13. Di Blasio, 1997, Expression of corticotropin-releasing hormone and its R1 receptor in human endometrial stromal cells, J. Clin. Endocrinol. Metab., 82, 1594, 10.1210/jc.82.5.1594 · DOI
  14. Dufau, 1993, Corticotropin-releasing factor: an antireproductive hormone of the testis, FASEB J., 7, 299, 10.1096/fasebj.7.2.8382638 · DOI
  15. Entringer, 2008, Prenatal psychosocial stress exposure is associated with insulin resistance in young adults, Am. J. Obstet. Gynecol., 199, 10.1016/j.ajog.2008.03.006 · DOI
  16. Fabbri, 1990, Corticotropin-releasing factor is produced by rat Leydig cells and has a major local antireproductive role in the testis, Endocrinology, 127, 1541, 10.1210/endo-127-3-1541 · DOI
  17. Fenster, 1997, Effects of psychological stress on human semen quality, J. Androl., 18, 194, 10.1002/j.1939-4640.1997.tb01900.x · DOI
  18. Ferrari, 1995, Corticotropin releasing factor decidualizes human endometrial stromal cells in vitro. Interaction with progestin, J. Steroid Biochem. Mol. Biol., 54, 251, 10.1016/0960-0760(95)00142-M · DOI
  19. Fowden, 2006, Intrauterine programming of physiological systems: causes and consequences, Physiology (Bethesda), 21, 29, 10.1152/physiol.00050.2005 · DOI
  20. Frank, 1995, Interleukin-1 beta and the endometrium: an inhibitor of stromal cell differentiation and possible autoregulator of decidualization in humans, Biol. Reprod., 52, 184, 10.1095/biolreprod52.1.184 · DOI
  21. Frim, 1988, Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta, J. Clin. Invest., 82, 287, 10.1172/JCI113585 · DOI
  22. Ghizzoni, 1997, Corticotropin-releasing hormone (CRH) inhibits steroid biosynthesis by cultured human granulosa-lutein cells in a CRH and interleukin-1 receptor-mediated fashion, Endocrinology, 138, 4806, 10.1210/en.138.11.4806 · DOI
  23. Goland, 1995, The effect of pre-eclampsia on human placental corticotrophin-releasing hormone content and processing, Placenta, 16, 375, 10.1016/0143-4004(95)90095-0 · DOI
  24. Grammatopoulos, 1999, Role of corticotropin-releasing hormone in onset of labour, Lancet, 354, 1546, 10.1016/S0140-6736(99)03418-2 · DOI
  25. Hillhouse, 2006, The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology, Endocr. Rev., 27, 260, 10.1210/er.2005-0034 · DOI
  26. Hillhouse, 1993, The identification of a human myometrial corticotropin-releasing hormone receptor that increases in affinity during pregnancy, J. Clin. Endocrinol. Metab., 76, 736, 10.1210/jc.76.3.736 · DOI · Paper page
  27. Hu, 2008, Rapid mechanisms of glucocorticoid signaling in the Leydig cell, Steroids, 73, 1018, 10.1016/j.steroids.2007.12.020 · DOI
  28. Jones, 1989, Local stimulation of prostaglandin production by corticotropin-releasing hormone in human fetal membranes and placenta, Biochem. Biophys. Res. Commun., 159, 192, 10.1016/0006-291X(89)92422-4 · DOI
  29. Kalantaridou, 2007, Reproductive corticotropin releasing hormone, implantation, and fetal immunotolerance, Crit. Rev. Clin. Lab. Sci., 44, 461, 10.1080/10408360701548468 · DOI
  30. Karalis, 1996, Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor, Nat. Med., 2, 556, 10.1038/nm0596-556 · DOI
  31. Karteris, 2003, Reduced expression of corticotropin-releasing hormone receptor type-1 alpha in human preeclamptic and growth-restricted placentas, J. Clin. Endocrinol. Metab., 88, 363, 10.1210/jc.2002-020375 · DOI
  32. Karteris, 2005, Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptides, J. Clin. Endocrinol. Metab., 90, 3680, 10.1210/jc.2004-2210 · DOI
  33. Linton, 1993, Corticotropin releasing hormone-binding protein (CRH-BP): plasma levels decrease during the third trimester of normal human pregnancy, J. Clin. Endocrinol. Metab., 76, 260, 10.1210/jc.76.1.260 · DOI
  34. Makrigiannakis, 1995, The corticotropin-releasing hormone (CRH) in normal and tumoral epithelial cells of human endometrium, J. Clin. Endocrinol. Metab., 80, 185, 10.1210/jc.80.1.185 · DOI
  35. Makrigiannakis, 1995, Corticotropin-releasing hormone (CRH) is expressed at the implantation sites of early pregnant rat uterus, Life Sci., 57, 1869, 10.1016/0024-3205(95)02167-H · DOI
  36. Makrigiannakis, 1999, The decidualizing effect of progesterone may involve direct transcriptional activation of corticotrophin-releasing hormone from human endometrial stromal cells, Mol. Hum. Reprod., 5, 789, 10.1093/molehr/5.9.789 · DOI
  37. Makrigiannakis, 2001, Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance, Nat. Immunol., 2, 1018, 10.1038/ni719 · DOI
  38. Makrigiannakis, 2006, Hormonal and cytokine regulation of early implantation, Trends Endocrinol. Metab., 17, 178, 10.1016/j.tem.2006.05.001 · DOI
  39. Makrigiannakis, 2007, Maternal serum corticotropin-releasing hormone and ACTH levels as predictive markers of premature labor, Int. J. Gynaecol. Obstet., 97, 115, 10.1016/j.ijgo.2007.01.007 · DOI
  40. Mastorakos, 1993, Immunoreactive corticotropin-releasing hormone and its binding sites in the rat ovary, J. Clin. Invest., 92, 961, 10.1172/JCI116672 · DOI
  41. Mastorakos, 1996, Presence of immunoreactive corticotropin-releasing hormone in human endometrium, J. Clin. Endocrinol. Metab., 81, 1046, 10.1210/jc.81.3.1046 · DOI
  42. McLean, 1995, A placental clock controlling the length of human pregnancy, Nat. Med., 1, 460, 10.1038/nm0595-460 · DOI
  43. Minas, 2007, Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin, Mol. Hum. Reprod., 13, 663, 10.1093/molehr/gam054 · DOI
  44. Norman, 1993, Effects of corticotropin-releasing hormone on luteinizing hormone, testosterone, and cortisol secretion in intact male rhesus macaques, Biol. Reprod., 49, 148, 10.1095/biolreprod49.1.148 · DOI
  45. O’Donnell, 2009, Prenatal stress and neurodevelopment of the child: focus on the HPA axis and role of the placenta, Dev. Neurosci., 31, 285, 10.1159/000216539 · DOI
  46. Orr, 1994, Acute immobilization stress disrupts testicular steroidogenesis in adult male rats by inhibiting the activities of 17 alpha-hydroxylase and 17,20-lyase without affecting the binding of LH/hCG receptors, J. Androl., 15, 302, 10.1002/j.1939-4640.1994.tb00455.x · DOI
  47. Perkins, 1995, Corticotrophin-releasing hormone and corticotrophin-releasing hormone binding protein in normal and pre-eclamptic human pregnancies, Br. J. Obstet. Gynaecol., 102, 118, 10.1111/j.1471-0528.1995.tb09063.x · DOI
  48. Phillips, 1989, Corticosteroid 11 beta-dehydrogenase in rat testis, Endocrinology, 125, 209, 10.1210/endo-125-1-209 · DOI
  49. Phillips, 2005, Maternal body composition, offspring blood pressure and the hypothalamic–pituitary–adrenal axis, Paediatr. Perinat. Epidemiol., 19, 294, 10.1111/j.1365-3016.2005.00661.x · DOI
  50. Rabin, 1990, Glucocorticoids inhibit estradiol-mediated uterine growth: possible role of the uterine estradiol receptor, Biol. Reprod., 42, 74, 10.1095/biolreprod42.1.74 · DOI
  51. Reynolds, 2007, Stress responsiveness in adult life: influence of mother's diet in late pregnancy, J. Clin. Endocrinol. Metab., 92, 2208, 10.1210/jc.2007-0071 · DOI
  52. Robinson, 1988, Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta, Proc. Natl. Acad. Sci. U.S.A., 85, 5244, 10.1073/pnas.85.14.5244 · DOI · Paper page
  53. Ruiz, 2003, The interrelationship of maternal stress, endocrine factors and inflammation on gestational length, Obstet. Gynecol. Surv., 58, 415, 10.1097/01.OGX.0000071160.26072.DE · DOI
  54. Rusterholz, 2007, Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia, Semin. Immunopathol., 29, 151, 10.1007/s00281-007-0071-6 · DOI
  55. Sakakura, 1975, Inhibition of luteinizing hormone secretion induced by synthetic LRH by long-term treatment with glucocorticoids in human subjects, J. Clin. Endocrinol. Metab., 40, 774, 10.1210/jcem-40-5-774 · DOI · Paper page
  56. Schiessl, 2007, Inflammatory response in preeclampsia, Mol. Aspects Med., 28, 210, 10.1016/j.mam.2007.04.004 · DOI
  57. Sirianni, 2005, Corticotropin-releasing hormone (CRH) and urocortin act through type 1 CRH receptors to stimulate dehydroepiandrosterone sulfate production in human fetal adrenal cells, J. Clin. Endocrinol. Metab., 90, 5393, 10.1210/jc.2005-0680 · DOI
  58. Smals, 1977, Plasma testosterone profiles in Cushing's syndrome, J. Clin. Endocrinol. Metab., 45, 240, 10.1210/jcem-45-2-240 · DOI
  59. Smith, 2007, Parturition, N. Engl. J. Med., 356, 271, 10.1056/NEJMra061360 · DOI
  60. Swamy, 2008, Association of preterm birth with long-term survival, reproduction, and next-generation preterm birth, JAMA, 299, 1429, 10.1001/jama.299.12.1429 · DOI
  61. Yang, 2006, Corticotropin-releasing hormone inhibits progesterone production in cultured human placental trophoblasts, J. Mol. Endocrinol., 37, 533, 10.1677/jme.1.02119 · DOI
  62. Yazawa, 1999, Effect of immobilization stress on testicular germ cell apoptosis in rats, Hum. Reprod., 14, 1806, 10.1093/humrep/14.7.1806 · DOI
  63. Zoumakis, 2000, Corticotrophin-releasing hormone (CRH) interacts with inflammatory prostaglandins and interleukins and affects the decidualization of human endometrial stroma, Mol. Hum. Reprod., 6, 344, 10.1093/molehr/6.4.344 · DOI
  64. Zoumakis, 2001, Cycle and age-related changes in corticotropin-releasing hormone levels in human endometrium and ovaries, Gynecol. Endocrinol., 15, 98, 10.1080/713602800 · DOI
  65. Zoumakis, 2009, CRH-like peptides in human reproduction, Curr. Med. Chem., 16, 4230, 10.2174/092986709789578204 · DOI

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Metadata

Authors
Kalantaridou, S. N., Zoumakis, E., Makrigiannakis, A., Lavasidis, L. G., Vrekoussis, T., & Chrousos, G. P.
Venue
Journal of Reproductive Immunology
Publisher
Elsevier BV
Published
2010-05
Volume
85
Issue
1
Pages
33-39
ISSN
0165-0378
DOI
10.1016/j.jri.2010.02.005
Cited by
136
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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Kalantaridou, S. N., Zoumakis, E., Makrigiannakis, A., Lavasidis, L. G., Vrekoussis, T., & Chrousos, G. P. (2010). Corticotropin-releasing hormone, stress and human reproduction: an update. Journal of Reproductive Immunology. https://doi.org/10.1016/j.jri.2010.02.005