Cited by 52Attention Deficit Hyperactivity DisorderSubstance Abuse Treatment and OutcomesOpioid Use Disorder Treatment

Predictors of treatment response in adolescents with comorbid substance use disorder and attention-deficit/hyperactivity disorder

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Tamm, Leanne, Trello-Rishel, Kathlene, Riggs, Paula, Nakonezny, Paul A., Acosta, Michelle, Bailey, Genie, Winhusen, Theresa·2013·Journal of Substance Abuse Treatment

Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) frequently co-occurs with substance use disorder (SUD) and is associated with poor substance-use treatment outcomes. A trial evaluating osmotic-release oral system methylphenidate (OROS-MPH) for adolescents with ADHD and SUD, concurrently receiving behavioral therapy, revealed inconsistent medication effects on ADHD or SUD. Clinical care for this population would be advanced by knowledge of treatment outcome predictors. Data from the randomized placebo-controlled trial (n = 299) were analyzed. Significant treatment predictors included: 1) Substance use severity, associated with poorer ADHD and SUD outcomes, 2) ADHD severity, associated with better ADHD and SUD outcomes, 3) comorbid conduct disorder, associated with poorer ADHD outcomes, and 4) court-mandated status, associated with better SUD outcomes but poorer treatment completion. An interaction effect showed that OROS-MPH improved SUD outcomes in adolescents with comorbid conduct disorder compared to placebo. While severe SUD may require more intensive psychosocial treatment, OROS-MPH may improve substance treatment outcomes in adolescents with co-morbid attention and conduct problems.

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  1. Crowley TJ Mikulich SK MacDonald M Young SE Zerbe GO Substance-dependent, conduct-disordered adolescent males: severity of diagnosis predicts 2-year outcome Drug and alcohol dependence 1998 49 3 225 237 9571387
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Authors
Tamm, L., Trello-Rishel, K., Riggs, P., Nakonezny, P. A., Acosta, M., Bailey, G., & Winhusen, T.
Affiliations
  • Cincinnati Children's Hospital Medical Center (US)
  • The University of Texas Southwestern Medical Center (US)
  • University of Colorado Anschutz (US)
  • National Development and Research Institutes (US)
  • Brown University (US)
  • University of Cincinnati (US)
Corresponding author
Tamm, Leanne
Venue
Journal of Substance Abuse Treatment
Publisher
Elsevier BV
Published
2013-02
Volume
44
Issue
2
Pages
224-230
ISSN
0740-5472 (ISSN-L)
OpenAlex
W2126570875
Cited by
52
References
65
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 2
FWCI
3.43
Type
journal article
Language
en
Open access
Locations
  • Journal of Substance Abuse Treatment (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (U10DA013035, K24DA022412, U10DA013732, U10DA013716, U10DA020024, U10 DA012732, UG1DA020024, K12DA000357)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
Keywords
attention deficit hyperactivity disorder, substance use disorders, comorbidities, adolescents, treatment outcome predictors, conduct disorder, substance use severity, ADHD symptom severity, court-ordered treatment, treatment completion, behavior therapy
MeSH terms
Administration, Oral, Adolescent, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Behavior Therapy, Female, Humans, Male, Methylphenidate, Osmosis, Severity of Illness Index, Drug Delivery Systems, Treatment Outcome, Diagnosis, Dual (Psychiatry), Conduct Disorder, Substance-Related Disorders, Mandatory Programs

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