Neuroactive steroids and stress axis regulation: Pregnancy and beyond

Epigenetic programming by maternal behavior

Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works

Neuroactive steroids

Paul, S. M., & Purdy, R. H. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.6.1347506 · Cited by 1,413 · see citing works

Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis

Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322 · see citing works

Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states

Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274 · see citing works

Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy

Mueller, B. R., & Bale, T. L. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1424-08.2008 · Cited by 988 · see citing works

The stress system in the human brain in depression and neurodegeneration

Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984 · see citing works

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

Purdy, R. H., Morrow, A. L., Moore, P. H., & Paul, S. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.10.4553 · Cited by 951 · see citing works

Prenatal Stress Induces High Anxiety and Postnatal Handling Induces Low Anxiety in Adult Offspring: Correlation with Stress-Induced Corticosterone Secretion

Vallée, M., Mayo, W., Dellu-Hagedorn, F., Moal, M. L., Simon, H., & Maccari, S. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02626.1997 · Cited by 772 · see citing works

Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress

Maccari, S., Piazza, P., Kabbaj, M., Barbazanges, A., Simon, H., & Moal, M. L. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00110.1995 · Cited by 574 · see citing works

Prenatal stress and the programming of the HPA axis

Glover, V., O’Connor, T. G., & O’Donnell, K. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.008 · Cited by 567 · see citing works

Prenatal Stress Increases the Hypothalamo‐Pituitary‐Adrenal Axis Response in Young and Adult Rats

Henry, C., Kabbaj, M., Simon, H., Moal, M. L., & Maccari, S. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00591.x · Cited by 528 · see citing works

Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta

O’Donnell, K. J., O’Connor, T. G., & Glover, V. A. S. (2009) · Developmental Neuroscience · doi:10.1159/000216539 · Cited by 509 · see citing works

Glucocorticoid excess and the developmental origins of disease: Two decades of testing the hypothesis – 2012 Curt Richter Award Winner

Reynolds, R. M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.08.012 · Cited by 497 · see citing works

Distribution of estrogen receptor β immunoreactivity in the rat central nervous system

Shughrue, P. J., & Merchenthaler, I. J. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1054 · Cited by 490 · see citing works

A Quantitative Analysis of the Roles of Dosage, Sequence, and Duration of Estradiol and Progesterone Exposure in the Regulation of Maternal Behavior in the Rat *

Bridges, R. S. (1984) · Endocrinology · doi:10.1210/endo-114-3-930 · Cited by 464 · see citing works

Effects of Antidepressant Treatment on Neuroactive Steroids in Major Depression

Romeo, E., Ströhle, A., Spalletta, G., di Michele, F., Hermann, B., Holsboer, F., Pasini, A., & Rupprecht, R. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.7.910 · Cited by 463 · see citing works

Antenatal maternal anxiety is related to HPA-axis dysregulation and self-reported depressive symptoms in adolescence: a prospective study on the fetal origins of depressed mood

Van den Bergh, B. R. H., Van Calster, B., Smits, T., Van Huffel, S., & Lagae, L. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301450 · Cited by 434 · see citing works

Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.

Concas, A., Mostallino, M. C., Porcu, P., Follesa, P., Barbaccia, M., Trabucchi, M., Purdy, R., Grisenti, P., & Biggio, G. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.22.13284 · Cited by 432 · see citing works

Hypothalamic–pituitary–adrenal axis dysregulation in depressed children and adolescents: A meta-analysis

Lopez-Duran, N. L., Kovacs, M., & George, C. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.016 · Cited by 425 · see citing works

Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat

Weinstock, M., Matlina, E., Keshet, G. I., Rosen, H., & McEwen, B. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91049-k · Cited by 410 · see citing works

The expectant brain: adapting for motherhood

Brunton, P. J., & Russell, J. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2280 · Cited by 407 · see citing works

Physiological stress reactivity in human pregnancy—a review

de Weerth, C., & Buitelaar, J. K. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.005 · Cited by 399 · see citing works

Prenatal Stress and Its Effects on the Fetus and the Child: Possible Underlying Biological Mechanisms

Glover, V. A. S. (2014) · Advances in neurobiology · doi:10.1007/978-1-4939-1372-5_13 · Cited by 398 · see citing works

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis

Agís‐Balboa, R. C., Pinna, G., Zhubi, A., Maloku, E., Veldić, M., Costa, E., & Guidotti, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606544103 · Cited by 384 · see citing works

Neurosteroids: Expression of Steroidogenic Enzymes and Regulation of Steroid Biosynthesis in the Central Nervous System

Mensah‐Nyagan, A. G., do Rego, J. L., Beaujean, D., Luu-The, V., Pelletier, G., & Vaudry, H. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01395-4 · Cited by 379 · see citing works

Child maltreatment and HPA axis dysregulation: relationship to major depressive disorder and post traumatic stress disorder in females

Shea, A., Walsh, C., MacMillan, H., & Steiner, M. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.07.001 · Cited by 378 · see citing works

Neurosteroids: Biosynthesis of Pregnenolone and Progesterone in Primary Cultures of Rat Glial Cells*

Jung‐Testas, I., Hu, Z. Y., BAULIEUf, E. E., & ROBEL, A. P. (1989) · Endocrinology · doi:10.1210/endo-125-4-2083 · Cited by 366 · see citing works

Attenuated neuroendocrine responses to emotional and physical stressors in pregnant rats involve adenohypophysial changes

Neumann, I. D., Johnstone, H. A., Hatzinger, M., Liebsch, G., Shipston, M. J., Russell, J. A., Landgraf, R., & Douglas, A. J. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.289br.x · Cited by 365 · see citing works

The Consequences of Early‐Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations

Maccari, S., Krugers, H. J., Morley‐Fletcher, S., Moshe Szyf, A., & Brunton, P. J. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12175 · Cited by 347 · see citing works

Prenatal Restraint Stress Generates Two Distinct Behavioral and Neurochemical Profiles in Male and Female Rats

Zuena, A. R., Mairesse, J., Casolini, P., Cinque, C., Alemà, G., Morley‐Fletcher, S., Chiodi, V., Spagnoli, L. G., Gradini, R., Catalani, A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002170 · Cited by 339 · see citing works

Social Isolation‐Induced Decreases in Both the Abundance of Neuroactive Steroids and GABAA Receptor Function in Rat Brain

Serra, M., Pisu, M. G., Littera, M., Papi, G., Sanna, E., Tuveri, F., Usala, L., Purdy, R. H., & Biggio, G. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750732.x · Cited by 315 · see citing works

The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

Patchev, V. K., Shoaib, M., Holsboer, F., & Almeida, O. F. X. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90330-1 · Cited by 306 · see citing works

Adaptive Responses of the Maternal Hypothalamic‐Pituitary‐Adrenal Axis during Pregnancy and Lactation

Brunton, P. J., Russell, J. A., & Douglas, A. J. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01735.x · Cited by 298 · see citing works

Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia

Koenig, J. I., Elmer, G. I., Shepard, P. D., Lee, P. R., Mayo, C. L., Joy, B., Hercher, E., & Brady, D. L. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.030 · Cited by 297 · see citing works

Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency

Morrow, A. L., Suzdak, P. D., & Paul, S. M. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90094-x · Cited by 296 · see citing works

Effects of prenatal stress on vulnerability to stress in prepubertal and adult rats

Fride, E., Dan, Y., Feldon, J., Halevy, G., & Weinstock, M. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90172-1 · Cited by 295 · see citing works

Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates

Ferrari, E., Cravello, L., Muzzoni, B., Casarotti, D., Paltro, M., Sb, S., Fioravanti, M., Cuzzoni, G., Pontiggia, B., & Magri, F. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1440319 · Cited by 288 · see citing works

The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus

Patchev, V (1996) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00096-6 · Cited by 283 · see citing works

Human Cytosolic 3α-Hydroxysteroid Dehydrogenases of the Aldo-keto Reductase Superfamily Display Significant 3β-Hydroxysteroid Dehydrogenase Activity

Steckelbroeck, S., Jin, Y., Gopishetty, S., Oyesanmi, B., & Penning, T. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313308200 · Cited by 270 · see citing works

Prenatal Social Stress in the Rat Programmes Neuroendocrine and Behavioural Responses to Stress in the Adult Offspring: Sex‐Specific Effects

Brunton, P. J., & Russell, J. A. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01969.x · Cited by 264 · see citing works

Brain 5α-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation

Dong, E., Matsumoto, K., Uzunova, V., Sugaya, I., Takahata, H., Nomura, H., Watanabe, H., Costa, E., & Guidotti, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051628598 · Cited by 261 · see citing works

Prenatal stress increase anxiety related behavior and alters cerebral lateralization of dopamine activity

Fride, E., & Weinstock, M. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90561-9 · Cited by 255 · see citing works

Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA_AReceptors

Sarkar, J., Wakefield, S., MacKenzie, G., Moss, S. J., & Maguire, J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2560-11.2011 · Cited by 254 · see citing works

HPA axis responsiveness to stress: implications for healthy aging

Aguilera, G. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.023 · Cited by 250 · see citing works

The Androgen 5α-Dihydrotestosterone and Its Metabolite 5α-Androstan-3β, 17β-Diol Inhibit the Hypothalamo–Pituitary–Adrenal Response to Stress by Acting through Estrogen Receptor β-Expressing Neurons in the Hypothalamus

Lund, T. D., Hinds, L. R., & Handa, R. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3777-05.2006 · Cited by 236 · see citing works

Effect of comorbid anxiety disorders on the Hypothalamic-Pituitary-Adrenal axis response to a social stressor in major depression

Young, E. A., Abelson, J. L., & Cameron, O. G. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.017 · Cited by 228 · see citing works

Aromatization and 5α-Reduction of Androgens in Discrete Hypothalamic and Limbic Regions of the Male and Female Rat1

SELMANOFF, M. K., BRODKIN, L. D., Weiner, R. I., & Siiteri, P. K. (1977) · Endocrinology · doi:10.1210/endo-101-3-841 · Cited by 226 · see citing works

Short periods of prenatal stress affect growth, behaviour and hypothalamo–pituitary–adrenal axis activity in male guinea pig offspring

Kapoor, A., & Matthews, S. G. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.090191 · Cited by 206 · see citing works

The corticotrophin releasing hormone test in late pregnancy: lack of adrenocorticotrophin and cortisol response

SCHULTE, H. M., WEISNER, D., & ALLOLIO, B. (1990) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1990.tb00470.x · Cited by 199 · see citing works

Brain and behavior interface: Stress and the developing brain

Gunnar, M. R., & Cheatham, C. L. (2003) · Infant Mental Health Journal · doi:10.1002/imhj.10052 · Cited by 188 · see citing works

Allopregnanolone regulates neurogenesis and depressive/anxiety-like behaviour in a social isolation rodent model of chronic stress

Evans, J., Sun, Y., McGregor, A., & Connor, B. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.012 · Cited by 184 · see citing works

Neurosteroids: Endogenous allosteric modulators of GABAA receptors

Lambert, J. J., Cooper, M. A., Simmons, R. D. J., Weir, C. J., & Belelli, D. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.08.009 · Cited by 180 · see citing works

The Testosterone-Derived Neurosteroid Androstanediol Is a Positive Allosteric Modulator of GABAA Receptors

Reddy, D. S., & Jian, K. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.169854 · Cited by 180 · see citing works

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice

Agís‐Balboa, R. C., Pinna, G., Pibiri, F., Kadriu, B., Costa, E., & Guidotti, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709419104 · Cited by 175 · see citing works

Serum allopregnanolone in women with postpartum “blues”

Nappi, R. (2001) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(00)01112-1 · Cited by 166 · see citing works

Social isolation stress-induced aggression in mice: A model to study the pharmacology of neurosteroidogenesis

Matsumoto, K., Pinna, G., Puia, G., Guidotti, A., & Costa, E. (2005) · Stress · doi:10.1080/10253890500159022 · Cited by 162 · see citing works

Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response

Gunn, B. G., Cunningham, L., Cooper, M. A., Corteen, N. L., Seifi, M., Swinny, J. D., Lambert, J. J., & Belelli, D. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1337-13.2013 · Cited by 151 · see citing works

GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response

Gunn, B. G., Cunningham, L., Mitchell, S. G., Swinny, J. D., Lambert, J. J., & Belelli, D. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.06.001 · Cited by 149 · see citing works

Neurosteroids in the context of stress: implications for depressive disorders

Girdler, S. S., & Klatzkin, R. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.05.006 · Cited by 148 · see citing works

Differential localization of the 5 alpha-reductase and the 3 alpha- hydroxysteroid dehydrogenase in neuronal and glial cultures

Melcangi, R. C., Celotti, F., Castano, P., & Martini, L. (1993) · Endocrinology · doi:10.1210/endo.132.3.8440186 · Cited by 148 · see citing works

Irreversible Androgenic Programming at Birth of Microsomal and Soluble Rat Liver Enzymes Active on 4-Androstene-3,17-dione and 5α-Androstane-3α,17β-diol

Gustafsson, J.-Α., & Stenbeŕg, Å. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42988-8 · Cited by 142 · see citing works

Maternal Antenatal Anxiety and Amniotic Fluid Cortisol and Testosterone: Possible Implications for Foetal Programming

Sarkar, P., Bergman, K., O’Connor, T. G., & Glover, V. A. S. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01659.x · Cited by 138 · see citing works

Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic‐pituitary‐adrenal function

Bertram, C. E., Khan, O., Ohri, S. K., Phillips, D. I., Matthews, S. G., & Hanson, M. A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.147967 · Cited by 135 · see citing works

Region-specific reduction in stress-induced c- fos mRNA expression during pregnancy and lactation

Costa, A. P. C., Wood, S. A., Ingram, C. D., & Lightman, S. L. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00962-6 · Cited by 135 · see citing works

Neuroendocrine Responses to Stress in Mice: Hyporesponsiveness in Pregnancy and Parturition

Douglas, A. J., Brunton, P. J., Bosch, O. J., Russell, J. A., & Neumann, I. D. (2003) · Endocrinology · doi:10.1210/en.2003-0461 · Cited by 134 · see citing works

Prenatal stress impairs maternal behavior in a conflict situation and reduces hippocampal benzodiazepine receptors

Fride, E., Dan, Y., Gavish, M., & Weinstock, M. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90306-6 · Cited by 129 · see citing works

Central opioid inhibition of neuroendocrine stress responses in pregnancy in the rat is induced by the neurosteroid allopregnanolone

Brunton, P. J., McKay, A. J., Ochędalski, T., Piastowska, A., Rębas, E., Lachowicz, A., & Russell, J. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0708-09.2009 · Cited by 126 · see citing works

Administration of ACTH to restrained, pregnant sows alters their pigs' hypothalamic-pituitary-adrenal (HPA) axis.

Haussmann, M. F., Carroll, J. A., Weesner, G. D., Daniels, M. J., Matteri, R. L., & Lay, D. C., Jr. (2000) · Journal of Animal Science · doi:10.2527/2000.7892399x · Cited by 120 · see citing works

Endogenous Opioids and Attenuated Hypothalamic-Pituitary-Adrenal Axis Responses to Immune Challenge in Pregnant Rats

Brunton, P. J., Meddle, S., Ma, S., Ochędalski, T., Douglas, A. J., & Russell, J. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0866-05.2005 · Cited by 120 · see citing works

Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events.

Patchev, V., Montkowski, A., Rouskova, D., Korányi, L., Holsboer, F., & Almeida, O. F. X. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119261 · Cited by 120 · see citing works

Regulation of the hypothalamic-pituitary-adrenal axis in the neonatal rat: The role of maternal behavior

Levine, S. D. (2002) · Neurotoxicity Research · doi:10.1080/10298420290030569 · Cited by 118 · see citing works

Purification and properties of 3 alpha-hydroxysteroid dehydrogenase from rat brain cytosol. Inhibition by nonsteroidal anti-inflammatory drugs and progestins.

Penning, T. M., Sharp, R. B., & Krieger, N. R. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)95730-3 · Cited by 112 · see citing works

Progesterone 5-α-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes

Melcangi, R. C., Celotti, F., & Martini, L. (1994) · Brain Research · doi:10.1016/0006-8993(94)91731-0 · Cited by 107 · see citing works

Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system

Kraulis, I., Foldes, G., TRAIKOV, H., Dubrovsky, B. O., & Birmingham, M. K. (1975) · Brain Research · doi:10.1016/0006-8993(75)90942-7 · Cited by 106 · see citing works

Transient Expression of the 5α-Reductase Type 2 Isozyme in the Rat Brain in Late Fetal and Early Postnatal Life¹

Poletti, A., Negri-Cesi, P., Rabuffetti, M., Colciago, A., Celotti, F., & Martini, L. (1998) · Endocrinology · doi:10.1210/endo.139.4.5866 · Cited by 106 · see citing works

Anxiety-Like Behavior of Prenatally Stressed Rats Is Associated with a Selective Reduction of Glutamate Release in the Ventral Hippocampus

Marrocco, J., Mairesse, J., Ngomba, R. T., Silletti, V., Camp, G. V., Bouwalerh, H., Summa, M., Pittaluga, A., Nicoletti, F., Maccari, S., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1040-12.2012 · Cited by 104 · see citing works

The role of endogenous opioids in neurohypophysial and hypothalamo-pituitary-adrenal axis hormone secretory responses to stress in pregnant rats

Douglas, A., Johnstone, H., Wigger, A., Landgraf, R., Russell, J., & Neumann, I. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1580285 · Cited by 102 · see citing works

Pseudo‐symmetry of C19‐steroids, alternative binding orientations and multispecificity in human estrogenic 17β‐hydroxysteroid dehydrogenase

Gangloff, A., Shi, R., Nahoum, V., & Lin, S. (2002) · The FASEB Journal · doi:10.1096/fj.02-0397fje · Cited by 96 · see citing works

The developmental impact of prenatal stress, prenatal dexamethasone and postnatal social stress on physiology, behaviour and neuroanatomy of primate offspring: studies in rhesus macaque and common marmoset

Pryce, C. R., Aubert, Y., Maier, C., Pearce, P. C., & Fuchs, E. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1989-2 · Cited by 94 · see citing works

Estrogen Receptor (ER)β Isoforms Rather Than ERα Regulate Corticotropin-Releasing Hormone Promoter Activity through an Alternate Pathway

Miller, W. J. S., Suzuki, S., Miller, L. K., Handa, R. J., & Uht, R. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5540-03.2004 · Cited by 93 · see citing works

5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann’s area 9 (BA9) of depressed patients

Agís-Balboa, R. C., Guidotti, A., & Pinna, G. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3567-5 · Cited by 92 · see citing works

Chernobyl exposure as stressor during pregnancy and hormone levels in adolescent offspring

Huizink, A. C., Bartels, M., Rose, R. J., Pulkkinen, L., Eriksson, C. J. P., & Kaprio, J. A. (2008) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2007.060350 · Cited by 90 · see citing works

Single and combined effects of prenatal immune activation and peripubertal stress on parvalbumin and reelin expression in the hippocampal formation

Giovanoli, S., Weber, L., & Meyer, U. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.005 · Cited by 81 · see citing works

Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic–pituitary–adrenal axis and induces anxiety-like behavior in adult male rat offspring

Fan, J., Chen, X.-Q., Jin, H., & Du, J.-Z. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.02.009 · Cited by 79 · see citing works

Prenatal stress and early adoption effects on benzodiazepine receptors and anxiogenic behavior in the adult rat brain

Barros, V. G., Rodríguez, P., Martijena, I. D., Pérez, A. A., Molina, V. A., & Antonelli, M. C. (2006) · Synapse · doi:10.1002/syn.20336 · Cited by 79 · see citing works

GABAergic control of neuropeptide gene expression in parvocellular neurons of the hypothalamic paraventricular nucleus

Bali, B., & Kovács, K. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02877.x · Cited by 79 · see citing works

Changes in 5α-Pregnane Steroids and Neurosteroidogenic Enzyme Expression in the Perinatal Sheep

Nguyen, P. N., Billiards, S. S., Walker, D. W., & Hirst, J. J. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000064905.64688.10 · Cited by 78 · see citing works

5a-Pregnane-3a,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam

Owens, M. J., Ritchie, J. C., & Nemeroff, C. B. (1992) · Brain Research · doi:10.1016/0006-8993(92)90788-b · Cited by 77 · see citing works

Gender differences in the regulation of 3 alpha-hydroxysteroid dehydrogenase in rat brain and sensitivity to neurosteroid-mediated stress protection.

Mitev, Y., Darwish, M., Wolf, S., Holsboer, F., Almeida, O. F. X., & Patchev, V. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00287-2 · Cited by 76 · see citing works

Selective loss of parvalbumin-positive GABAergic interneurons in the cerebral cortex of maternally stressed Gad1-heterozygous mouse offspring

Uchida, T., Furukawa, T., Iwata, S., Yanagawa, Y., & Fukuda, A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.13 · Cited by 73 · see citing works

Transgenerational effects of prenatal synthetic glucocorticoids on hypothalamic-pituitary-adrenal function

Iqbal, M., Moisiadis, V. G., Kostaki, A., & Matthews, S. G. (2012) · Endocrinology · doi:10.1210/en.2012-1054 · Cited by 72 · see citing works

Reduced Activity of the Noradrenergic System in the Paraventricular Nucleus at the End of Pregnancy: Implications for Stress Hyporesponsiveness

Douglas, A. J., Meddle, S., Toschi, N., Bosch, O. J., & Neumann, I. D. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01272.x · Cited by 69 · see citing works

Testosterone 5α-reductase activity in the rat brain is highly concentrated in white matter structures and in purified myelin sheaths of axons

Melcangi, R. C., Celotti, F., Ballabio, M., Poletti, A., Castano, P., & Martini, L. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90051-9 · Cited by 68 · see citing works

Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion

Nguyen, P. N., Yan, E. B., Castillo-Meléndez, M., Walker, D. W., & Hirst, J. J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.069336 · Cited by 67 · see citing works

Immune stress in late pregnant rats decreases length of gestation and fecundity, and alters later cognitive and affective behaviour of surviving pre-adolescent offspring

Paris, J. J., Brunton, P. J., Russell, J. A., & Frye, C. A. (2011) · Stress · doi:10.3109/10253890.2011.628719 · Cited by 60 · see citing works

Reduced Hypothalamic Vasopressin Secretion Underlies Attenuated Adrenocorticotropin Stress Responses in Pregnant Rats

Ma, S., Shipston, M. J., Morilak, D. A., & Russell, J. A. (2005) · Endocrinology · doi:10.1210/en.2004-1368 · Cited by 60 · see citing works

Sex-specific effects of prenatal stress on glucose homoeostasis and peripheral metabolism in rats.

Brunton, P., Sullivan, K., Kerrigan, D., Russell, J., Seckl, J., & Drake, A. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0540 · Cited by 59 · see citing works

Nonneuronal Localization for Steroid Converting Enzyme: 3α‐Hydroxysteroid Oxidoreductase in Olfactory Tubercle of Rat Brain

Krieger, N. R., & Scott, R. G. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07269.x · Cited by 56 · see citing works

Central 5-alpha reduction of testosterone is required for testosterone's inhibition of the hypothalamo-pituitary–adrenal axis response to restraint stress in adult male rats

Handa, R. J., Kudwa, A. E., Donner, N. C., McGivern, R. F., & Brown, R. (2013) · Brain Research · doi:10.1016/j.brainres.2013.07.021 · Cited by 52 · see citing works

Gestational Hypoxia Induces Sex-Differential Methylation of Crhr1 Linked to Anxiety-like Behavior

Wang, X., Meng, F.-S., Liu, Z.-Y., Fan, J.-M., Hao, K., Chen, X.-Q., & Du, J.-Z. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8444-4 · Cited by 52 · see citing works

Sex‐Steroid Induction of Endogenous Opioid Inhibition on Oxytocin Secretory Responses to Stress

Douglas, Johnstone, Brunton, P. J., & Russell (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00460.x · Cited by 50 · see citing works

The Effect of Betamethasone Treatment on Neuroactive Steroid Synthesis in a Foetal Guinea Pig Model of Growth Restriction

McKendry, A. A., Palliser, H. K., Yates, D. M., Walker, D. W., & Hirst, J. J. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01949.x · Cited by 49 · see citing works

Juvenile offspring of rats exposed to restraint stress in late gestation have impaired cognitive performance and dysregulated progestogen formation

Paris, J. J., & Frye, C. A. (2010) · Stress · doi:10.3109/10253890.2010.512375 · Cited by 48 · see citing works

5α-Reduced Neurosteroids Sex-Dependently Reverse Central Prenatal Programming of Neuroendocrine Stress Responses in Rats

Brunton, P. J., Donadio, M. V. F., Yao, S. T., Greenwood, M., Seckl, J. R., Murphy, D., & Russell, J. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5104-13.2015 · Cited by 48 · see citing works

METABOLISM OF [14C]TESTOSTERONE BY HUMAN FOETAL AND ADULT BRAIN TISSUE

Jenkins, J. S., & Hall, C. (1977) · Journal of Endocrinology · doi:10.1677/joe.0.0740425 · Cited by 41 · see citing works

Two neuroactive steroids in midpregnancy as measured in maternal and fetal sera and in amniotic fluid

Bičı́ková, M., Klak, J., Hill, M., Žižka, Z., Hampl, R., & Calda, P. (2002) · Steroids · doi:10.1016/s0039-128x(01)00196-9 · Cited by 41 · see citing works

Changes in Neuroactive Steroid Concentrations After Preterm Delivery in the Guinea Pig

Kelleher, M. A., Hirst, J. J., & Palliser, H. K. (2013) · Reproductive Sciences · doi:10.1177/1933719113485295 · Cited by 39 · see citing works

The neurosteroid allopregnanolone modulates oxytocin expression in the hypothalamic paraventricular nucleus

Blyth, B. J., Hauger, R. L., Purdy, R. H., & Amico, J. A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.3.r684 · Cited by 39 · see citing works

Serum Allopregnanolone in Women With Postpartum “Blues”

Nappi, R. E., Petraglia, F., Luisi, S. V., et al. (2001) · Obstetrics and Gynecology · doi:10.1097/00006250-200101000-00016 · Cited by 35 · see citing works

Adrenal steroidogenesis following prenatal dexamethasone exposure in the spiny mouse

Quinn, T. A., Ratnayake, U., Castillo-Melendez, M., Moritz, K. M., Dickinson, H., & Walker, D. W. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0514 · Cited by 34 · see citing works

Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo‐keto reductase

Fry, J. P., Li, K. Y., Devall, A., Cockcroft, S., Honour, J. W., & Lovick, T. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12891 · Cited by 31 · see citing works

Effects of swim stress on mRNA and protein levels of steroid 5α-reductase isozymes in prefrontal cortex of adult male rats

Sánchez, P., Torres, J. M., Gavete, P., & Ortega, E. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.07.019 · Cited by 31 · see citing works

Gestational Exposure to Variable Stressors Produces Decrements in Cognitive and Neural Development of Juvenile Male and Female Rats

Frye, C. A., & Paris, J. J. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611796117649 · Cited by 29 · see citing works

Distribution and ovarian control of progestin-metabolizing enzymes in various rat hypothalamic regions

Bertics, S. J., Bertics, P. J., Clarke, J. L., & Karavolas, H. J. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90096-3 · Cited by 27 · see citing works

Gestational or acute restraint in adulthood reduces levels of 5α-reduced testosterone metabolites in the hippocampus and produces behavioral inhibition of adult male rats

Walf, A. A., & Frye, C. A. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00040 · Cited by 26 · see citing works

No effect of experimental noise exposure on human pregnancy.

Hartikainen-Sorri, A. L., Kirkinen, P. P., Sorri, M., Anttonen, H., & Tuimala, R. J. (1991) · PubMed · Cited by 26 · see citing works

Studies on Neurosteroids XXVI. Fluoxetine-Evoked Changes in Rat Brain and Serum Levels of Neuroactive Androgen, 5.ALPHA.-Androstane-3.ALPHA.,17.BETA.-diol

Higashi, T., Nagura, Y., Shimada, K., & Toyo’oka, T. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1636 · Cited by 25 · see citing works

Ethanol Attenuates Spatial Memory Deficits and Increases mGlu1a Receptor Expression in the Hippocampus of Rats Exposed to Prenatal Stress

Waes, V. V., Enache, M., Zuena, A. R., Mairesse, J., Nicoletti, F., Vinner, É., Lhermitte, M., Maccari, S., & Darnaudéry, M. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00964.x · Cited by 23 · see citing works

Effects of Prenatal Stress on the Activity of an Enzyme Involved in Neurosteroid Synthesis During the “Critical Period” of Sexual Differentiation of the Brain in Male Rats

Ordyan, N. E., & Пивина, С. Г. (2005) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-005-0148-4 · Cited by 22 · see citing works

Effects of neurosteroids on the human corticotropin-releasing hormone gene

Budziszewska, B., Zając, A., Basta‐Kaim, A., Leśkiewicz, M., Steczkowska, M., Lasoń, W., & Kaciński, M. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70365-0 · Cited by 21 · see citing works

Allopregnanolone in the brain and blood after disruption of the hypothalamic-pituitary-adrenal axis in fetal sheep

Nguyen, P., Young, I. R., Walker, D., & Hirst, J. J. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1820081 · Cited by 19 · see citing works

Effects of Sulpiride on Prolactin and mRNA Levels of Steroid 5α-reductase Isozymes in Adult Rat Brain

Sánchez, P., Torres, J. M., Vílchez, P., del Moral, R. G., & Ortega, E. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9512-9 · Cited by 16 · see citing works

The effects of betamethasone on allopregnanolone concentrations and brain development in preterm fetal sheep

Yawno, T., Mortale, M., Sutherland, A. E., Jenkin, G., Wallace, E. M., Walker, D. W., & Miller, S. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.031 · Cited by 13 · see citing works

Expression levels of mRNA for neurosteroidogenic enzymes 17β-HSD, 5α-reductase, 3α-HSD and cytochrome P450 aromatase in the fetal wild type and SF-1 knockout mouse brain

Španić, T., Fabjan, T., & Majdič, G. (2014) · Endocrine Research · doi:10.3109/07435800.2014.933974 · Cited by 11 · see citing works

Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development

Frieder, A., Fersh, M., Hainline, R., & Deligiannidis, K. M. (2019) · CNS Drugs · doi:10.1007/s40263-019-00605-7 · Cited by 156 · see citing works

Fine particulate matter constituents and stress hormones in the hypothalamus–pituitary–adrenal axis

Niu, Y., Chen, R., Xia, Y., Cai, J., Ying, Z., Lin, Z., Liu, C., Chen, C., Peng, L., Zhao, Z., et al. (2018) · Environment International · doi:10.1016/j.envint.2018.06.027 · Cited by 147 · see citing works

Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression

Maguire, J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00083 · Cited by 113 · see citing works

Higher Circulating Cortisol in the Follicular vs. Luteal Phase of the Menstrual Cycle: A Meta-Analysis

Hamidovic, A., Karapetyan, K., Serdarevic, F., Choi, S. H., Eisenlohr-Moul, T., & Pinna, G. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00311 · Cited by 99 · see citing works

Sex, stress and steroids

Sze, Y., & Brunton, P. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14615 · Cited by 85 · see citing works

The levonorgestrel-releasing intrauterine device potentiates stress reactivity

Aleknavičiūtė, J., Tulen, J. H. M., de Rijke, Y. B., Bouwkamp, C. G., van der Kroeg, M., Timmermans, M., Wester, V. L., Bergink, V., Hoogendijk, W. J. G., Tiemeier, H. W., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.02.025 · Cited by 70 · see citing works

Placental CRH as a Signal of Pregnancy Adversity and Impact on Fetal Neurodevelopment

Kassotaki, I., Valsamakis, G., Mastorakos, G. P., & Grammatopoulos, D. K. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.714214 · Cited by 62 · see citing works

Allopregnanolone levels and depressive symptoms during pregnancy in relation to single nucleotide polymorphisms in the allopregnanolone synthesis pathway

Hellgren, C., Comasco, E., Skalkidou, A., & Poromaa, I. S. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.06.008 · Cited by 55 · see citing works

Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex

Portero-Tresserra, M., Gracia-Rubio, I., Cantacorps, L., Pozo, O. J., Gómez-Gómez, A., Pastor, A., López-Arnau, R., de la Torre, R., & Valverde, O. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.02.003 · Cited by 55 · see citing works

Regulation of the corticosteroid signalling system in rainbow trout HPI axis during confinement stress

Kiilerich, P., Servili, A., Péron, S., Valotaire, C., Goardon, L., Leguen, I., & Prunet, P. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.08.013 · Cited by 52 · see citing works

Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice

Morrison, K. E., Epperson, C. N., Sammel, M. D., Ewing, G., Podcasy, J., Hantsoo, L. V., Kim, D. R., & Bale, T. L. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.027 · Cited by 54 · see citing works

Untargeted Metabolomics Screen of Mid‐pregnancy Maternal Serum and Autism in Offspring

Ritz, B. R., Yan, Q. J., Uppal, K., Liew, Z., Cui, X., Ling, C., Inoue, K., von Ehrenstein, O., Walker, D. I., & Jones, D. P. (2020) · Autism Research · doi:10.1002/aur.2311 · Cited by 39 · see citing works

Prenatal drug exposure and neurodevelopmental programming of glucocorticoid signalling

Franks, A. L., Berry, K. J., & DeFranco, D. B. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12786 · Cited by 39 · see citing works

Association of levonorgestrel intrauterine devices with stress reactivity, mental health, quality of life and sexual functioning: A systematic review

Bürger, Z., Bucher, A. M., Comasco, E., Henes, M., Hübner, S., Kogler, L., & Derntl, B. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100943 · Cited by 38 · see citing works

Age, sex and storage time influence hair cortisol levels in a wild mammal population

Azevedo, A., Bailey, L., Bandeira, V., Dehnhard, M., Fonseca, C., de Sousa, L., & Jewgenow, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221124 · Cited by 33 · see citing works

Corticotropin-Releasing Hormone As the Homeostatic Rheostat of Feto-Maternal Symbiosis and Developmental Programming In Utero and Neonatal Life

Alcántara‐Alonso, V., Panetta, P., de Gortari, P., & Grammatopoulos, D. K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00161 · Cited by 35 · see citing works

Review of psychological stress on oocyte and early embryonic development in female mice

Zhai, Q., Wang, J., Tian, Y., Liu, X., & Song, Z. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00657-1 · Cited by 34 · see citing works

Prenatal betamethasone exposure and psychopathology risk in extremely low birth weight survivors in the third and fourth decades of life

Savoy, C. D., Ferro, M. A., Schmidt, L. A., Saigal, S., & Lieshout, R. J. V. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.021 · Cited by 33 · see citing works

Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: a liquid chromatography-tandem mass spectrometry analysis.

Deligiannidis, K. M., Kroll-Desrosiers, A. R., Tan, Y., Dubuke, M. L., & Shaffer, S. A. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104827 · Cited by 31 · see citing works

Enduring Neurobiological Consequences of Early-Life Stress: Insights from Rodent Behavioral Paradigms

Speranza, L., Filiz, K. D., Lippiello, P., Ferraro, M. G., Pascarella, S., Miniaci, M. C., & Volpicelli, F. (2024) · Biomedicines · doi:10.3390/biomedicines12091978 · Cited by 34 · see citing works

Progesterone, 5a-dihydropogesterone and allopregnanolone's effects on seizures: A review of animal and clinical studies

Wu, Y. V., & Burnham, W. M. (2018) · Seizure · doi:10.1016/j.seizure.2018.10.012 · Cited by 27 · see citing works

Fifty Years of Advances in Neuroendocrinology

Russell, J. A. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818812014 · Cited by 26 · see citing works

How is prenatal stress transmitted from the mother to the fetus?

Sze, Y., & Brunton, P. J. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.246073 · Cited by 29 · see citing works

Allopregnanolone reduces neuroendocrine response to acute stressful stimuli in sheep

Misztal, T., Młotkowska, P., Marciniak, E., & Misztal, A. (2020) · Journal of Endocrinology · doi:10.1530/joe-19-0376 · Cited by 22 · see citing works

Early life stress and metabolism

Malik, S., & Spencer, S. J. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.01.016 · Cited by 21 · see citing works

Effects of prenatal stress on neuroactive steroid responses to acute stress in adult male and female rats

Sze, Y., & Brunton, P. J. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12916 · Cited by 18 · see citing works

Endocrine disrupting chemicals (EDCs) and placental function: Impact on fetal brain development

Marinello, W. P., & Patisaul, H. B. (2021) · Advances in pharmacology · doi:10.1016/bs.apha.2021.04.003 · Cited by 16 · see citing works

Neurosteroids and early-life programming: An updated perspective

Sze, Y., & Brunton, P. J. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100367 · Cited by 11 · see citing works

The complement system in human pregnancy and preeclampsia

Kumar, V., & Stewart, J. H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1617140 · Cited by 9 · see citing works

Prediction of gestational age using urinary metabolites in term and preterm pregnancies

Contrepois, K., Chen, S., Ghaemi, M. S., Wong, R. J., Jehan, F., Sazawal, S., Baqui, A. H., Stringer, J. S. A., Rahman, A. M., Nisar, M. I., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11866-6 · Cited by 9 · see citing works

Brain intracrinology of allopregnanolone during pregnancy and hormonal contraception

Pluchino, N., Ansaldi, Y., & Genazzani, A. R. (2019) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0032 · Cited by 9 · see citing works

Cortisol Regulation among Women Who Experience Suicidal Ideation during Pregnancy

El-Refaay, S. M. M., & Weiss, S. J. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100642 · Cited by 10 · see citing works

CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone

Martins, A. G. G. D. M., Allegretta, G., Unteregger, G., Haupenthal, J., Eberhard, J., Hoffmann, M., van der Zee, J. A., Junker, K., Stöckle, M., Müller, R., et al. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.09.006 · Cited by 8 · see citing works

Post-partum depression: From clinical understanding to preclinical assessments

Moreira, L. K. D. S., Moreira, C. V. L., Custódio, C. H. X., Dias, M. L. P., Rosa, D. A., Neto, M. L. F., Colombari, E., Costa, É. A., Fajemiroye, J. O., & Pedrino, G. R. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1173635 · Cited by 8 · see citing works

Fibromyalgia in Pregnancy: Neuro-Endocrine Fluctuations Provide Insight into Pathophysiology and Neuromodulation Treatment

Mucci, V., Demori, I., Browne, C. J., Deblieck, C., & Burlando, B. (2023) · Biomedicines · doi:10.3390/biomedicines11020615 · Cited by 7 · see citing works

The Effect of Allopregnanolone on Enzymatic Activity of the DNA Base Excision Repair Pathway in the Sheep Hippocampus and Amygdala under Natural and Stressful Conditions

Misztal, T., Kowalczyk, P., Młotkowska, P., & Marciniak, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207762 · Cited by 5 · see citing works

Cortisol awakening response in pregnant women with depressive disorders: a potential marker of recovery status from pregnancy to postpartum

Broeks, C. W., Bais, B., Van, R., Bijma, H. H., van Rossum, E. F. C., Hoogendijk, W. J. G., den Berg, M. P. L., & Kamperman, A. M. (2025) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2025.100297 · Cited by 4 · see citing works

Brexanolone and current methods of treating postpartum and perinatal depression

Oracz, A. J., Modzelewski, S., Iłendo, K., & Sokół, A. (2023) · Pharmacotherapy in Psychiatry and Neurology · doi:10.5114/fpn.2023.127424 · Cited by 4 · see citing works

Prenatal corticosteroid use and offspring neurological outcomes

Yan, Y., Wang, J., & Lei, X. (2025) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2025.107564 · Cited by 3 · see citing works

Effects of Stress and Allopregnanolone on the Expression of Neurotrophins and TrkB Receptor in the Sheep Hippocampus

Misztal, T., Młotkowska, P., Marciniak, E., Barszcz, M., Osuch, B., Gajewska, A., & Misztal, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136190 · Cited by 3 · see citing works

Neuropeptide Y and amygdala circuitry: Modulation of stress-related behavior

Urban, J. H. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-815134-1.00007-6 · Cited by 3 · see citing works

Management of Postpartum Anxiety and Depression: A Narrative Review

Whei, S. J., Deva, S., Vijayakumar, V., Khan, S. S., Awad, S. A., Asfeen, U. Z., Maniar, R. H., & Shrestha, B. (2025) · Mental Health Science · doi:10.1002/mhs2.70012 · Cited by 3 · see citing works

Involvement of neurosteroids in the control of prolactin secretion in sheep under basal, stressful and pregnancy conditions

Marciniak, E., Młotkowska, P., ROSZKOWICZ-OSTROWSKA, K. I., Ciska, E., & Misztal, T. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.08.013 · Cited by 2 · see citing works

Características de los corticoides particulados y no particulados. Condicionantes para su uso en el tratamiento del dolor crónico

Orduña-Valls, J. M., Nebreda-Clavo, C. L., López, P., Torres-Rodríguez, D. L., Quintans-Rodríguez, M., & Álvarez, J. (2016) · Revista Española de Anestesiología y Reanimación · doi:10.1016/j.redar.2016.01.005 · Cited by 1 · see citing works

Judith M. Stern

Lonstein, J. S. (2022) · Springer eBooks · doi:10.1007/978-3-031-12970-4_41

Association between gut virome and prenatal stress-induced changes in behavior and immune responses in male offspring

Chen, J., Xiao, C., Cao, M., Hu, Y., Yan, Y., Tong, J., Cheng, C., & Huang, J. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106532

Effects of different micro- and nanoplastic polymers on steroidogenesis in a feto-placental in vitro model

van Boxel, J., Nijmeijer, S. M., Cenijn, P. H., Heinzelmann, M. T., Dusza, H. M., Mandemaker, L. D. B., Meirer, F., Lamoree, M. H., & van Duursen, M. B. M. (2026) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2026.112871

Chain-length-selective inhibition of human and rat steroid 5α-reductase type 1 by alkyltrimethylammonium chloride disinfectants: kinetic, surface plasmon resonance, computational, and network toxicology analyses with implications for neurosteroidogenesis

Chen, J., Chen, J., Chen, Y., Xia, J., Fang, H., Zhang, P., Ge, R.-S., & Wang, Y. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112273

329. Median eminence mediated cortisone effect and cold stress on pituitary histology

LEELA, N. S. (1978) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(78)91029-4

333. Adrenocortical function in hypophysectomized dogs with parotid gland transplants in direct contact with the basal hypothalamus

Álvarez-Buylla, R., & Tsutsumi, V. (1978) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(78)91033-6

Allopregnanolone and suppressed hypothalamo–pituitary–adrenal axis stress responses in late pregnancy in the rat

Brunton, P. J., & Russell, J. A. (2010) · Stress · doi:10.3109/10253890.2010.482628 · Cited by 55 · see citing works

5α-Reduced Neurosteroids Sex-Dependently Reverse Central Prenatal Programming of Neuroendocrine Stress Responses in Rats

Brunton, P. J., Donadio, M. V. F., Yao, S. T., Greenwood, M., Seckl, J. R., Murphy, D., & Russell, J. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5104-13.2015 · Cited by 48 · see citing works

Resetting the Dynamic Range of Hypothalamic‐Pituitary‐Adrenal Axis Stress Responses Through Pregnancy

Brunton, P. J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02067.x · Cited by 43 · see citing works