Adaptive Responses of the Maternal Hypothalamic‐Pituitary‐Adrenal Axis during Pregnancy and Lactation

Brunton, P. J.; Russell, J. A.; Douglas, A. J.

doi:10.1111/j.1365-2826.2008.01735.x

Cited by 298Stress Responses and CortisolNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

Adaptive Responses of the Maternal Hypothalamic‐Pituitary‐Adrenal Axis during Pregnancy and Lactation

Open access

Brunton, P. J., Russell, J. A., Douglas, A. J.·2008·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2008.01735.x

Open this paper in CoChat — free account Open PDF

Abstract

Over the past 40 years, it has been recognised that the maternal hypothalamic‐pituitary‐adrenal (HPA) axis undergoes adaptations through pregnancy and lactation that might contribute to avoidance of adverse effects of stress on the mother and offspring. The extent of the global adaptations in the HPA axis has been revealed and the underlying mechanisms investigated within the last 20 years. Both basal, including the circadian rhythm, and stress‐induced adrenocorticotrophic hormone and glucocorticoid secretory patterns are altered. Throughout most of pregnancy, and in lactation, these changes predominantly reflect reduced drive by the corticotropin‐releasing factor (CRF) neurones in the parvocellular paraventricular nucleus (pPVN). An accompanying profound attenuation of HPA axis responses to a wide variety of psychological and physical stressors emerges after mid‐pregnancy and persists until the end of lactation. Central to this suppression of stress responsiveness is reduced activation of the pPVN CRF neurones. This is consequent on the reduced effectiveness of the stimulation of brainstem afferents to these CRF neurones (for physical stressors) and of altered processing by limbic structures (for emotional stressors). The mechanism of reduced CRF neurone responses to physical stressors in pregnancy is the suppression of noradrenaline release in the PVN by an up‐regulated endogenous opioid mechanism, which is induced by neuroactive steroid produced from progesterone. By contrast, in lactation suckling the young provides a neural stimulus that dampens the HPA axis circadian rhythm and reduces stress responses. Reduced noradrenergic input activity is involved in reduced stress responses in lactation, although central prolactin action also appears important. Such adaptations limit the adverse effects of excess glucocorticoid exposure on the foetus(es) and facilitate appropriate metabolic and immune responses.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/j.1365-2826.2008.01735.x

Cites

155 of 155 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

EO contributes to maternal euphoria and the inhibition of stress-related HPA reactivity to protect the foetus in the late-gestation and lactation phases.
“Additionally, EO contributes to maternal euphoria and the inhibition of stress-related HPA reactivity to protect the foetus in the late-gestation (65) and lactation phases (65).”
From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [65]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Limbic system mechanisms of stress regulation: Hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Ostrander, M. M., Mueller, N. K., & Figueiredo, H. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.006 · Cited by 1,322 · see citing works
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059 · see citing works
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965 · see citing works
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works
Prenatal stress, glucocorticoids and the programming of the brain
Welberg, L. A. M., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2001.00601.x · Cited by 928 · see citing works
Prenatal Stress, Glucocorticoids and the Programming of the Brain
Welberg, L., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00601.x · Cited by 922 · see citing works
A placental clock controlling the length of human pregnancy
McLean, M. P., Bisits, A. M., Davies, J., Woods, R., Lowry, P., & Smith, R. (1995) · Nature Medicine · doi:10.1038/nm0595-460 · Cited by 907 · see citing works
Regulation of ACTH Secretion: Variations on a Theme of B
DALLMAN, M. F., AKANA, S. F., CASCIO, C. S., DARLINGTON, D. N., JACOBSON, L., & LEVIN, N. (1987) · Proceedings of the 1986 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571143-2.50010-1 · Cited by 655 · see citing works
Maternal and Fetal Hypothalamic‐Pituitary‐Adrenal Axes During Pregnancy and Postpartum
MASTORAKOS, G., & ILIAS, I. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1290.016 · Cited by 621 · see citing works
Glucocorticoids, metabolism and metabolic diseases
Vegiopoulos, A., & Herzig, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.015 · Cited by 535 · see citing works
Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
Bosch, O. J., Meddle, S. L., Beiderbeck, D. I., Douglas, A. J., & Neumann, I. D. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1342-05.2005 · Cited by 439 · see citing works
Self-citation
Role of brain allopregnanolone in the plasticity of γ-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery
Concas, A., Mostallino, M. C., Porcu, P., Follesa, P., Barbaccia, M. L., Trabucchi, M., Purdy, R. H., Grisenti, P., & Biggio, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13284 · Cited by 422 · see citing works
Oxytocin Attenuates Stress-Induced c-<i>fos</i>mRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity
Windle, R. J., Kershaw, Y. M., Shanks, N., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-03.2004 · Cited by 408 · see citing works
The expectant brain: adapting for motherhood
Brunton, P. J., & Russell, J. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2280 · Cited by 407 · see citing works
Self-citation
Brain oxytocin: differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats
Neumann, I. D., Torner, L., & Wigger, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00433-9 · Cited by 402 · see citing works
Physiological stress reactivity in human pregnancy—a review
de Weerth, C., & Buitelaar, J. K. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.10.005 · Cited by 399 · see citing works
Corticosteroid hormones in the central stress response: Quick-and-slow
de Kloet, E. R., Karst, H., & Joëls, M. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.002 · Cited by 391 · see citing works
Effects of suckling on hypothalamic-pituitary-adrenal axis responses to psychosocial stress in postpartum lactating women
Heinrichs, M., Meinlschmidt, G., Neumann, I., Wagner, S., Kirschbaum, C., Ehlert, U., & Hellhammer, D. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7919 · Cited by 386 · see citing works
Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women
Altemus, M. M., Deuster, P. A., Galliven, E., Carter, C. S., & Gold, P. W. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.10.7559880 · Cited by 383 · see citing works
Maternal plasma adrenocorticotropin and cortisol relationships throughout human pregnancy
Carr, B. R., Parker, C. R., Madden, J. D., MacDonald, P. C., & Porter, J. C. (1981) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(81)90318-5 · Cited by 370 · see citing works
Attenuated neuroendocrine responses to emotional and physical stressors in pregnant rats involve adenohypophysial changes
Neumann, I. D., Johnstone, H. A., Hatzinger, M., Liebsch, G., Shipston, M. J., Russell, J. A., Landgraf, R., & Douglas, A. J. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.289br.x · Cited by 365 · see citing works
Self-citation
Peptide Signaling in Human Placenta and Membranes: Autocrine, Paracrine, and Endocrine Mechanisms*
Petraglia, F., Florio, P., Nappi, C., & GENAZZANI, A. R. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-156 · Cited by 350 · see citing works
Oxytocin and vasopressin release within the supraoptic and paraventricular nuclei of pregnant, parturient and lactating rats: A microdialysis study
Neumann, I., Russell, J. A., & Landgraf, R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90285-n · Cited by 337 · see citing works
Self-citation
Cortisol levels and very early pregnancy loss in humans
Nepomnaschy, P. A., Welch, K. B., McConnell, D. S., Low, B. S., Strassmann, B. I., & England, B. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511183103 · Cited by 335 · see citing works
Vasopressin, oxytocin, dynorphin, enkephalin and corticotrophin‐releasing factor mRNA stimulation in the rat.
Lightman, S. L., & Young, W. S. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016858 · Cited by 324 · see citing works
Stress and salivary cortisol during pregnancy
Obel, C., Hedegaard, M. S., Henriksen, T. B., Secher, N. J., Olsen, J., & Levine, S. D. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.11.006 · Cited by 291 · see citing works
Role of GABA and Glutamate Circuitry in Hypothalamo‐Pituitary‐Adrenocortical Stress Integration
HERMAN, J. P., MUELLER, N. K., & FIGUEIREDO, H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.004 · Cited by 282 · see citing works
Anxiolytic and Anti-Stress Effects of Brain Prolactin: Improved Efficacy of Antisense Targeting of the Prolactin Receptor by Molecular Modeling
Torner, L., Toschi, N., Pohlinger, A., Landgraf, R., & Neumann, I. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03207.2001 · Cited by 266 · see citing works
Endocrine and Behavioural Responses to Noise Stress:Comparison of Virgin and Lactating Female Ratsduring Non‐Disrupted Maternal Activity
Windle, R. J., Wood, S. A., Shanks, N. M., Perks, P., Condé, G. L., Costa, A. P. C., Ingram, C. D., & Lightman, S. L. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00587.x · Cited by 226 · see citing works
Increased hypothalamic expression of prolactin in lactation: involvement in behavioural and neuroendocrine stress responses
Torner, L., Toschi, N., Nava, G., Clapp, C., & Neumann, I. D. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01965.x · Cited by 221 · see citing works
Pituitary-Adrenal Responsiveness during Lactation in Rats
Stern, J. M., Goldman, L., & Levine, S. (2008) · Neuroendocrinology · doi:10.1159/000122167 · Cited by 214 · see citing works
MOLECULAR MECHANISMS OF GLUCOCORTICOIDS IN THE CONTROL OF INFLAMMATION AND LYMPHOCYTE APOPTOSIS
Tuckermann, J. P., Kleiman, A., McPherson, K., & Reichardt, H. M. (2004) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360590888983 · Cited by 203 · see citing works
Pregnant women become insensitive to cold stress
Kammerer, M. H., Adams, D., von Castelberg, B., & Glover, V. A. S. (2002) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-2-8 · Cited by 201 · see citing works
Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: Focus on vasopressin and glyoxalase-I
Landgraf, R., Kessler, M. S., Bunck, M., Murgatroyd, C., Spengler, D., Zimbelmann, M., Nußbaumer, M., Czibere, L., Turck, C. W., Singewald, N., et al. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.003 · Cited by 199 · see citing works
The corticotrophin releasing hormone test in late pregnancy: lack of adrenocorticotrophin and cortisol response
SCHULTE, H. M., WEISNER, D., & ALLOLIO, B. (1990) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1990.tb00470.x · Cited by 199 · see citing works
Glucocorticoids, chronic stress, and obesity
Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., et al. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53004-3 · Cited by 198 · see citing works
Atlas of the neurons that express mRNA for the long form of the prolactin receptor in the forebrain of the female rat
Bakowska, J. C., & Morrell, J. I. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970922)386:2 · Cited by 198 · see citing works
The effect of environment on behaviour, plasma cortisol and prolactin in parturient sows
Lawrence, A. B., Petherick, J. C., McLean, K. A., Deans, L. A., Chirnside, J., Gaughan, A., Clutton, E. R., & Terlouw, C. E. M. (1994) · Applied Animal Behaviour Science · doi:10.1016/0168-1591(94)90165-1 · Cited by 195 · see citing works
Responses to laboratory psychosocial stress in postpartum women
Altemus, M., Redwine, L. S., Leong, Y.-M., Frye, C. A., Porges, S. W., & Sue Carter, C. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200109000-00015 · Cited by 187 · see citing works
Lactation Inhibits Stress-Mediated Secretion of Corticosterone and Oxytocin and Hypothalamic Accumulation of Corticotropin-Releasing Factor and Enkephalin Messenger Ribonucleic Acids
Lightman, S. L., & Young, W. S. (1989) · Endocrinology · doi:10.1210/endo-124-5-2358 · Cited by 184 · see citing works
Stress and reproductive failure: past notions, present insights and future directions
Nakamura, K., Sheps, S. B., & Arck, P. (2008) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-008-9206-5 · Cited by 175 · see citing works
Estrogen potentiates adrenocortical responses to stress in female rats
Figueiredo, H. F., Ulrich‐Lai, Y. M., Choi, D. C., & Herman, J. P. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00102.2006 · Cited by 174 · see citing works
Chapter 8 Peripartum plasticity within the hypothalamo-pituitary-adrenal axis
Lightman, S. L., Windle, R. J., Wood, S. A., Kershaw, Y. M., Shanks, N. M., & Ingram, C. D. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33009-1 · Cited by 171 · see citing works
Central Oxytocin Administration Reduces Stress-Induced Corticosterone Release and Anxiety Behavior in Rats<sup>1</sup>
Windle, R. J., Shanks, N., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/en.138.7.2829 · Cited by 170 · see citing works
The hypothalamic-pituitary-adrenal axis in rat pregnancy and lactation: circadian variation and interrelationship of plasma adrenocorticotropin and corticosterone.
Atkinson, H. C., & Waddell, B. J. (1995) · Endocrinology · doi:10.1210/endo.136.2.7835284 · Cited by 167 · see citing works
Suckling is a persistent stimulus to the adrenocortical system of the rat
Walker, C. D., Lightman, S. L., Steele, M. K., & Dallman, M. F. (1992) · Endocrinology · doi:10.1210/endo.130.1.1309321 · Cited by 162 · see citing works
Expression and Regulation of Proopiomelanocortin-Like Gene in the Ovary and Placenta: Comparison with the Testis*
Chen, C. C., CHANG, C.-C., Krieger, D. T., & Bardin, C. W. (1986) · Endocrinology · doi:10.1210/endo-118-6-2382 · Cited by 161 · see citing works
Inhibitory effect of oxytocin on corticotrope function in humans: are vasopressin and oxytocin ying–yang neurohormones?
Legros, J.-J. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00018-x · Cited by 159 · see citing works
The Brain Prolactin System: Involvement in Stress Response Adaptations in Lactation
Torner, L., & Neumann, I. D. (2002) · Stress · doi:10.1080/1025389021000048638 · Cited by 159 · see citing works
Dissociation Between Behavioral and Hormonal Responses to the Forced Swim Stress in Lactating Rats
Walker, C., Trottier, G., Rochford, J. M., & Lavallée, D. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00799.x · Cited by 159 · see citing works
Maternal defence as an emotional stressor in female rats: correlation of neuroendocrine and behavioural parameters and involvement of brain oxytocin
Neumann, I. D., Toschi, N., Ohl, F., Torner, L., & Krömer, S. A. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01460.x · Cited by 158 · see citing works
Attenuation of Hypothalamic‐Pituitary‐Adrenal Axis Stress Responses in Late Pregnancy: Changes in Feedforward and Feedback Mechanisms
Johnstone, H. A., Wigger, A., Douglas, A. J., Neumann, I. D., Landgraf, R., Seckl, J. R., & Russell, J. A. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00525.x · Cited by 156 · see citing works
Self-citation
Lactation and Stress: Protective Effects of Breast-feeding in Humans
Heinrichs, M., Neumann, I. D., & Ehlert, U. (2002) · Stress · doi:10.1080/1025389021000010530 · Cited by 156 · see citing works
Prenatal stress increases HPA axis activity and impairs maternal care in lactating female offspring: Implications for postpartum mood disorder
Bosch, O. J., Müsch, W., Bredewold, R., Slattery, D. A., & Neumann, I. D. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.12.012 · Cited by 155 · see citing works
Relationship between Plasma Profiles of Oxytocin and Adrenocorticotropic Hormone during Suckling or Breast Stimulation in Women
Chiodera, P., Salvarani, C., Bacchi-Modena, A., Spallanzani, R., Cigarini, C., Alboni, A., Gardini, E., & Coiro, V. (2008) · Hormone Research · doi:10.1159/000181886 · Cited by 154 · see citing works
Suckling-Induced Attenuation of Plasma Cortisol Concentrations in Postpartum Lactating Women
Amico, J. A., Johnston, J. M., & Vagnucci, A. H. (1994) · Endocrine Research · doi:10.3109/07435809409035858 · Cited by 142 · see citing works
The rat prolactin gene is expressed in brain tissue: detection of normal and alternatively spliced prolactin messenger RNA
Emanuele, N., Jurgens, J. K., Halloran, M. M., Tentler, J. J., Lawrence, A. M., & Kelley, M. R. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.1.1738369 · Cited by 138 · see citing works
Region-specific reduction in stress-induced c- fos mRNA expression during pregnancy and lactation
Costa, A. P. C., Wood, S. A., Ingram, C. D., & Lightman, S. L. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00962-6 · Cited by 135 · see citing works
Neuroendocrine Responses to Stress in Mice: Hyporesponsiveness in Pregnancy and Parturition
Douglas, A. J., Brunton, P. J., Bosch, O. J., Russell, J. A., & Neumann, I. D. (2003) · Endocrinology · doi:10.1210/en.2003-0461 · Cited by 134 · see citing works
Self-citation
Interaction between oestrogen and oxytocin on hypothalamic-pituitary-adrenal axis activity
Ochedalski, T., Subburaju, S., Wynn, P. C., & Aguilera, G. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01525.x · Cited by 133 · see citing works
Prolactin-Releasing Peptide as a Novel Stress Mediator in the Central Nervous System
Maruyama, M., Matsumoto, H., Fujiwara, K., Noguchi, J., Kitada, C., Fujino, M., & Inoue, K. (2001) · Endocrinology · doi:10.1210/endo.142.5.8118 · Cited by 124 · see citing works
Endogenous Opioids and Attenuated Hypothalamic-Pituitary-Adrenal Axis Responses to Immune Challenge in Pregnant Rats
Brunton, P. J., Meddle, S., Ma, S., Ochędalski, T., Douglas, A. J., & Russell, J. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0866-05.2005 · Cited by 120 · see citing works
Self-citation
The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response
Joachim, R., Zenclussen, A. C., Polgár, B., Douglas, A. J., Fest, S., Knackstedt, M., Klapp, B. F., & Arck, P. (2003) · Steroids · doi:10.1016/j.steroids.2003.08.010 · Cited by 120 · see citing works
Self-citation
Effects of psycho-social stress during pregnancy on neuroendocrine and behavioural parameters in lactation depend on the genetically determined stress vulnerability
Neumann, I. D., Krömer, S. A., & Bosch, O. J. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.03.008 · Cited by 115 · see citing works
Chronic intracerebral prolactin attenuates neuronal stress circuitries in virgin rats
Donner, N. C., Bredewold, R., Maloumby, R., & Neumann, I. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05416.x · Cited by 114 · see citing works
Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress
Tilbrook, A. J., & Clarke, I. J. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.06.002 · Cited by 113 · see citing works
Pups Presence Eliminates the Stress Hyporesponsiveness of Early Lactating Females to a Psychological Stress Representing a Threat to the Pups
Deschamps, S., Woodside, B. C., & Walker, C. D. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01022.x · Cited by 111 · see citing works
Differential expression of the two forms of prolactin receptor mRNA within microdissected hypothalamic nuclei of the rat
Pi, X., & Grattan, D. R. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00109-0 · Cited by 109 · see citing works
Corticotropin-Releasing Hormone and Arginine Vasopressin Gene Transcription in the Hypothalamic Paraventricular Nucleus of Unstressed Rats: Daily Rhythms and Their Interactions with Corticosterone
Watts, A. G., Tanimura, S. M., & Sanchez‐Watts, G. (2003) · Endocrinology · doi:10.1210/en.2003-0394 · Cited by 109 · see citing works
Role of Corticotropin-Releasing Factor Receptors Type 1 and 2 in Modulating the Rat Adrenocorticotropin Response to Stressors
RIVIER, C. L., Grigoriadis, D. E., & Rivier, J. (2003) · Endocrinology · doi:10.1210/en.2002-0117 · Cited by 108 · see citing works
The role of endogenous opioids in neurohypophysial and hypothalamo-pituitary-adrenal axis hormone secretory responses to stress in pregnant rats
Douglas, A., Johnstone, H., Wigger, A., Landgraf, R., Russell, J., & Neumann, I. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1580285 · Cited by 102 · see citing works
Self-citation
Isolation and Characterization of a Corticotropin-Releasing Hormone-Like Peptide From Human Placenta
Sasaki, A., Tempst, P., Liotta, A. S., Margioris, A. N., Hood, L., Kent, S. B. H., Sato, S., Shinkawa, O., YOSHINAGA, K., & Krieger, D. T. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-4-768 · Cited by 100 · see citing works
Peptide signaling in human placenta and membranes: autocrine, paracrine, and endocrine mechanisms
Petraglia, F. (1996) · Endocrine Reviews · doi:10.1210/er.17.2.156 · Cited by 100 · see citing works
In vivo release and gene upregulation of brain prolactin in response to physiological stimuli
Torner, L., Maloumby, R., Nava, G., Aranda, J., Clapp, C., & Neumann, I. D. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03264.x · Cited by 99 · see citing works
Chapter 7 Hypothalamic and limbic expression of CRF and vasopressin during lactation: implications for the control of ACTH secretion and stress hyporesponsiveness
Walker, C., Toufexis, D. J., & Burlet, A. J. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33008-x · Cited by 98 · see citing works
The Hypothalamic‐Pituitary‐Adrenal Axis Response to Endotoxin is Attenuated During Lactation
Shanks, Windle, Perks, Wood, Ingram, I., & Lightman, S. L. (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00400.x · Cited by 97 · see citing works
Stress‐Triggered Abortion: Inhibition of Protective Suppression and Promotion of Tumor Necrosis Factor‐α (TNF‐α) Release as a Mechanism Triggering Resorptions in Mice
Arck, P., Merali, F. S., Manuel, J., Chaouat, G., & Clark, D. A. (1995) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1995.tb01141.x · Cited by 97 · see citing works
Increased Prolactin Receptor Immunoreactivity in the Hypothalamus of Lactating Rats
Pi, P., & Grattan, D. R. (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00386.x · Cited by 96 · see citing works
Gonadal Steroid Modulation of Stress-Induced Hypothalamo-Pituitary-Adrenal Activity and Anxiety Behavior: Role of Central Oxytocin
Windle, R. J., Gamble, L. E., Kershaw, Y. M., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2006) · Endocrinology · doi:10.1210/en.2005-1079 · Cited by 90 · see citing works
Quantitation of prolactin receptor mRNA in the maternal rat brain during pregnancy and lactation
Augustine, R. A., Kokay, I. C., Andrews, Z. B., Ladyman, S. R., & Grattan, D. R. (2003) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0310221 · Cited by 89 · see citing works
Endogenous opioid actions and effects of environmental disturbance on parturition and oxytocin secretion in rats
Leng, G., Mansfield, S., Bicknell, R. J., Blackburn, R. E., Brown, D., Chapman, C., Dyer, R. G., Hollingsworth, S., Shibuki, K., Yates, J. O., et al. (1988) · Reproduction · doi:10.1530/jrf.0.0840345 · Cited by 88 · see citing works
Hypothalamic and amygdaloid corticotropin-releasing hormone (CRH) and CRH receptor-1 mRNA expression in the stress-hyporesponsive late pregnant and early lactating rat
Costa, A. P. C., Ma, X., Ingram, C. D., Lightman, S. L., & Aguilera, G. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00137-1 · Cited by 87 · see citing works
Reduced Noradrenergic Tone to the Hypothalamic Paraventricular Nucleus Contributes to the Stress Hyporesponsiveness of Lactation
Toufexis, D. J., Thrivikraman, Plotsky, P. M., Morilak, D. A., Huang, N., & Walker, C. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00223.x · Cited by 84 · see citing works
Oxytocin and prolactin suppress cortisol responses to acute stress in both lactating and non-lactating sheep
Cook, C. J. (1997) · Journal of Dairy Research · doi:10.1017/s0022029997002240 · Cited by 84 · see citing works
Measuring stress responses in postpartum mothers: Perspectives from studies in human and animal populations
Tu, M. T., LUPIEN, S. J., & Walker, C. (2005) · Stress · doi:10.1080/10253890500103806 · Cited by 82 · see citing works
Lactation as a model for naturally reversible hypercorticalism plasticity in the mechanisms governing hypothalamo-pituitary- adrenocortical activity in rats.
Fischer, D., Patchev, V. K., Hellbach, S., Hassan, A. H., & Almeida, O. F. X. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118153 · Cited by 80 · see citing works
GABAergic control of neuropeptide gene expression in parvocellular neurons of the hypothalamic paraventricular nucleus
Bali, B., & Kovács, K. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02877.x · Cited by 79 · see citing works
EFFECTS OF ACUTE AND CHRONIC STRESS ON PLASMA CORTICOSTERONE LEVELS IN THE PREGNANT AND NON-PREGNANT MOUSE
BARLOW, S. M., Morrison, P. J., & Sullivan, F. (1975) · Journal of Endocrinology · doi:10.1677/joe.0.0660093 · Cited by 76 · see citing works
Prolactin‐Releasing Peptide is Expressed in Afferents to the Endocrine Hypothalamus, but not in Neurosecretory Neurones
Morales, T., Hinuma, S., & Sawchenko, P. E. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00428.x · Cited by 75 · see citing works
The Role of Glucocorticoids in Secretory Activation and Milk Secretion, a Historical Perspective
Casey, T., & Plaut, K. I. (2007) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-007-9055-3 · Cited by 74 · see citing works
The importance of oxytocin mechanisms in the control of mouse parturition
Douglas, A. J., Leng, G., & Russell, J. A. (2002) · Reproduction · doi:10.1530/rep.0.1230543 · Cited by 73 · see citing works
Self-citation
Noradrenergic facilitation of the adrenocorticotropin response to stress is absent during lactation in the rat
Toufexis, D. J., & Walker, C. (1996) · Brain Research · doi:10.1016/0006-8993(96)00627-0 · Cited by 71 · see citing works
Negative regulation of corticotropin releasing factor expression and limitation of stress response
Aguilera, G., Kiss, A., Liu, Y., & Kamitakahara, A. K. (2007) · Stress · doi:10.1080/10253890701391192 · Cited by 71 · see citing works
Diurnal salivary cortisol levels in postpartum mothers as a function of infant feeding choice and parity
Tu, M. T., LUPIEN, S. J., & Walker, C. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.03.006 · Cited by 70 · see citing works
Reduced Activity of the Noradrenergic System in the Paraventricular Nucleus at the End of Pregnancy: Implications for Stress Hyporesponsiveness
Douglas, A. J., Meddle, S., Toschi, N., Bosch, O. J., & Neumann, I. D. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01272.x · Cited by 69 · see citing works
Self-citation
Lactation suppresses adrenal corticosteroid activity and aggressiveness in rats: Erratum.
Thoman, E. B., Conner, R. L., & Levine, S. (1970) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0020527 · Cited by 68 · see citing works
Hypothalamic‐Pituitary‐Adrenal Responses to Centrally Administered Orexin‐A are Suppressed in Pregnant Rats
Brunton, P. J., & Russell, J. A. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01045.x · Cited by 68 · see citing works
Self-citation
Placental Corticotrophin‐Releasing Hormone and its Receptors in Human Pregnancy and Labour: Still a Scientific Enigma
Grammatopoulos, D. K. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01660.x · Cited by 67 · see citing works
Reduced Response of the Hypothalamo-Pituitary-Adrenal Axis toα 1-Agonist Stimulation during Lactation*
Windle, R. J., Brady, M. M., Kunanandam, T., Costa, A. P. C., Wilson, B. C., Harbuz, M. S., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/endo.138.9.5405 · Cited by 67 · see citing works
Lactation suppresses adrenal corticosteroid activity and aggressiveness in rats.
Thoman, E. B., Conner, R. L., & Levine, S. (1970) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0028710 · Cited by 66 · see citing works
Altered Pituitary Sensitivity to Corticotropin‐Releasing Factor and Arginine Vasopressin Participates in the Stress Hyporesponsiveness of Lactation in the Rat
Toufexis, Tesolin, Huang, & Walker (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00381.x · Cited by 65 · see citing works
Pituitary-adrenal activity in the postpartum rat in the absence of suckling stimulation
STERN, J. (1972) · Hormones and Behavior · doi:10.1016/0018-506x(72)90037-2 · Cited by 65 · see citing works
Multiparity Reveals the Blunting Effect of Breastfeeding on Physiological Reactivity to Psychological Stress
Tu, M. T., LUPIEN, S. J., & Walker, C. D. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01441.x · Cited by 64 · see citing works
OVARIAN AND ADRENAL STEROIDS DURING PREGNANCY AND THE OESTROUS CYCLE IN THE RAT
Ogle, T. F., & Kitay, J. I. (1977) · Journal of Endocrinology · doi:10.1677/joe.0.0740089 · Cited by 63 · see citing works
Absolute requirement of glucocorticoid for expression of the casein gene in the presence of prolactin.
Ganguly, R., Ganguly, N., Mehta, N. M., & Banerjee, M. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.10.6003 · Cited by 63 · see citing works
THE ROLE OF PROLACTIN IN THE DEPRESSED OR 'BUFFERED' ADRENOCORTICOSTEROID RESPONSE OF THE RAT
SCHLEIN, P. A., ZARROW, M. X., & Denenberg, V. H. (1974) · Journal of Endocrinology · doi:10.1677/joe.0.0620093 · Cited by 63 · see citing works
Attenuated hypothalamo‐pituitary‐adrenal axis responses to immune challenge during pregnancy: the neurosteroid–opioid connection
Brunton, P., & Russell, J. (2008) · Journal of Physiology · doi:10.1113/jphysiol.2007.146233 · Cited by 62 · see citing works
Self-citation
Psychological stressors as a model of maternal adversity: Diurnal modulation of corticosterone responses and changes in maternal behavior
Léonhardt, M., Matthews, S. G., Meaney, M. J., & Walker, C. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.08.008 · Cited by 60 · see citing works
Reduced Hypothalamic Vasopressin Secretion Underlies Attenuated Adrenocorticotropin Stress Responses in Pregnant Rats
Ma, S., Shipston, M. J., Morilak, D. A., & Russell, J. A. (2005) · Endocrinology · doi:10.1210/en.2004-1368 · Cited by 60 · see citing works
Self-citation
Stress-induced disruption of parturition in the rat may be mediated by endogenous opioids
Leng, G., Mansfield, S., Bicknell, R. J., Brown, D., Chapman, C., Hollingsworth, S., Ingram, C. D., Marsh, M., Yates, J. O., & Dyer, R. G. (1987) · Journal of Endocrinology · doi:10.1677/joe.0.1140247 · Cited by 58 · see citing works
Immunoreactive corticotropin-releasing factor and corticotropin during pregnancy, labor and puerperium
Laatikainen, T. K., Virtanen, T., Räisänen, I., & Salminen, K. R. (1987) · Neuropeptides · doi:10.1016/s0143-4179(87)90101-6 · Cited by 58 · see citing works
Nonresponsiveness of the Rat Hypothalamo-Pituitary-Adrenocortical Axis to Parturition-Related Events: Inhibitory Action of Endogenous Opioids
Wigger, A., Lörscher, P., Oehler, I., Keck, M. E., Naruo, T., & Neumann, I. D. (1999) · Endocrinology · doi:10.1210/endo.140.6.6784 · Cited by 58 · see citing works
The effect of environment on plasma cortisol and β-endorphin in the parturient pig and the involvement of endogenous opioids
Jarvis, S., Lawrence, A. B., McLean, K. A., Chirnside, J., Deans, L. A., & Calvert, S. (1998) · Animal Reproduction Science · doi:10.1016/s0378-4320(98)00090-6 · Cited by 56 · see citing works
Patterns of salivary cortisol secretion in pregnancy and implications for assessment protocols
Harville, E. W., Savitz, D. A., Dole, N., Herring, A. H., Thorp, J. M., & Light, K. C. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.07.005 · Cited by 55 · see citing works
Region-specific immediate-early gene expression following the administration of corticotropin-releasing hormone in virgin and lactating rats
Costa, A. P. C., Kampa, R. J., Windle, R. J., Ingram, C. D., & Lightman, S. L. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00764-6 · Cited by 53 · see citing works
Comparison of Plasma Corticosterone and Prolactin Levels in Cycling and Lactating Rats
Stern, J. M., & Voogt, J. L. (2008) · Neuroendocrinology · doi:10.1159/000122235 · Cited by 52 · see citing works
Brainstem prolactin-releasing peptide neurons are sensitive to stress and lactation
Morales, T., & Sawchenko, P. E. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00522-0 · Cited by 50 · see citing works
Sex‐Steroid Induction of Endogenous Opioid Inhibition on Oxytocin Secretory Responses to Stress
Douglas, Johnstone, Brunton, P. J., & Russell (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00460.x · Cited by 50 · see citing works
Self-citation
“Reproductive” Corticotropin‐Releasing Hormone
Vitoratos, N., Papatheodorou, D. C., Kalantaridou, S., & Mastorakos, G. P. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1365.029 · Cited by 49 · see citing works
Corticosterone is required for the prolactin receptor gene expression in the late pregnant mouse mammary gland
MIZOGUCHI, Y., Yamaguchi, H., Aoki, F., Enami, J., & Sakai, S. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)00134-2 · Cited by 49 · see citing works
Relation of the Ovary to Adrenal Corticosterone Production and Adrenal Enzyme Activity in the Rat
Kitay, J. I., Coyne, M. D., Newsom, W. T., & NELSON, R. (1965) · Endocrinology · doi:10.1210/endo-77-5-902 · Cited by 47 · see citing works
Production rate, metabolic clearance rate and uterine extraction of corticosterone during rat pregnancy
Waddell, B. J., & Atkinson, H. C. (1994) · Journal of Endocrinology · doi:10.1677/joe.0.1430183 · Cited by 45 · see citing works
Neuroendocrine Stress But Not Feeding Responses to Centrally Administered Neuropeptide Y Are Suppressed in Pregnant Rats
Brunton, P. J., Bales, J., & Russell, J. A. (2006) · Endocrinology · doi:10.1210/en.2006-0048 · Cited by 44 · see citing works
Self-citation
Insulin, dexamethasone and their interactions in the control of glucose metabolism in adipose tissue from lactating and nonlactating sheep
Vernon, R. G., & Taylor, E. (1988) · Biochemical Journal · doi:10.1042/bj2560509 · Cited by 43 · see citing works
No Stress Response of the Hypothalamo-Pituitary-Adrenal Axis in Parturient Rats: Lack of Involvement of Brain Oxytocin
Neumann, I. D., Bosch, O. J., Toschi, N., Torner, L., & Douglas, A. J. (2003) · Endocrinology · doi:10.1210/en.2003-0037 · Cited by 43 · see citing works
Self-citation
Attenuated Stress Response to Acute Lipopolysaccharide Challenge and Ethanol Administration in Vasopressin V1b Receptor Knockout Mice
Lolait, S. J., Stewart, L. Q., Roper, J. A., Harrison, G., Jessop, D., Young, W. S., & O’Carroll, A. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01560.x · Cited by 43 · see citing works
Regulation of the hypothalamic–pituitary–adrenal axis in birth
Brooks, A. N., & Challis, J. R. G. (1988) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y88-182 · Cited by 41 · see citing works
The relationship between hormones and human parturition
Chaim, W., & Mazor, M. (1998) · Archives of Gynecology and Obstetrics · doi:10.1007/s004040050226 · Cited by 41 · see citing works
Increased Colocalization of Corticotropin-Releasing Factor and Arginine Vasopressin in Paraventricular Neurones of the Hypothalamus in Lactating Rats: Evidence from Immunotargeted Lesions and Immunohistochemistry
Walker, C. D., Tilders, F. J. H., & Burlet, A. J. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00589.x · Cited by 40 · see citing works
Prolactin-releasing peptide is a potent mediator of stress responses in the brain through the hypothalamic paraventricular nucleus
Mera, T., Fujihara, H., Kawasaki, M., Hashimoto, H., Saito, T., Shibata, M., Saito, J., Oka, T., Tsuji, S., Onaka, T., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.023 · Cited by 39 · see citing works
The neurosteroid allopregnanolone modulates oxytocin expression in the hypothalamic paraventricular nucleus
Blyth, B. J., Hauger, R. L., Purdy, R. H., & Amico, J. A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.3.r684 · Cited by 39 · see citing works
Plasma immunoreactive beta-endorphin, ACTH and cortisol concentrations in mothers and their neonates immediately after delivery — their relationship to the duration of labor
Bacigalupo, G., Langner, K., Schmidt, S., & Saling, E. (1987) · Journal of Perinatal Medicine · doi:10.1515/jpme.1987.15.1.45 · Cited by 37 · see citing works
Activation of the Hypothalamo-Pituitary-Adrenal Axis by Isolation and Restraint Stress during Lactation in Ewes: Effect of the Presence of the Lamb and Suckling
Tilbrook, A. J., Turner, A. I., Ibbott, M. D., & Clarke, I. J. (2006) · Endocrinology · doi:10.1210/en.2005-1632 · Cited by 37 · see citing works
Corticotrophin-releasing hormone and ACTH levels in maternal and fetal blood during spontaneous and oxytocin-induced labour
Ochędalski, T., Żylińska, K., LAUDAŃSKI, T., & Lachowicz, A. (2001) · European Journal of Endocrinology · doi:10.1530/eje.0.1440117 · Cited by 37 · see citing works
Pituitary–Adrenal Responsiveness of Rat Mothers to Noxious Stimuli and Stimuli Produced by Pups
Smotherman, W. P., Wiener, S. G., Mendoza, S. P., & Levine, S. (1976) · Novartis Foundation symposium · doi:10.1002/9780470720271.ch2 · Cited by 35 · see citing works
Pregnancy and social stress in female rats: Influences on blood leukocytes and corticosterone concentrations
Stefanski, V., Raabe, C., & Schulte, M. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.01.011 · Cited by 33 · see citing works
Chronic repeated restraint stress increases prolactin‐releasing peptide/tyrosine‐hydroxylase ratio with gender‐related differences in the rat brain
Tóth, Z., Zelena, D., Mergl, Z., Kirilly, E., Várnai, P., Mezey, É., Makara, G. B., & Palkovits, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05069.x · Cited by 31 · see citing works
Lactation decreases mRNA levels of opioid peptides in the arcuate nucleus of the rat
Kim, E.-M., Kotz, C. M., Welch, C. C., Grace, M. K., Billington, C. J., & LEVINE, A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00722-1 · Cited by 29 · see citing works
Adrenal Function and Serum Protein Concentrations in a Kindred with Decreased Corticosteroid-Binding Globulin (CBG) Concentration
Lohrenz, F. N., Seal, U. S., & DOE, R. P. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-7-966 · Cited by 28 · see citing works
Responses to the 35% CO2 challenge in postpartum women
Kaye, J. M., SOOTHILL, P. W., Hunt, M. A., & Lightman, S. L. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02133.x · Cited by 28 · see citing works
Involvement of Histamine in Suckling-Induced Release of Oxytocin, Prolactin and Adrenocorticotropin in Lactating Rats
Schagen, F. H. E., Knigge, U., Kjær, A., Larsen, P. J., & Warberg, J. (2008) · Neuroendocrinology · doi:10.1159/000127084 · Cited by 28 · see citing works
Inhibitory effect of pregnancy on stress-induced immunosuppression through corticotropin releasing hormone (CRH) and dopaminergic systems
Nakamura, H., Seto, T., Nagase, H., Yoshida, M., Dan, S., & Ogino, K. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00232-9 · Cited by 24 · see citing works
Plasma levels of β-endorphin and ACTH during labor and immediate puerperium
Fajardo, M. C., Florido, J., Villaverde, C., Oltras, C. M., Ramírez, A. R. G., & González-Gómez, F. (1994) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(94)90062-0 · Cited by 23 · see citing works
Maternal plasma vasopressin, oxytocin and cortisol concentrations following foetal ejection in the pig
Gilbert, C. L., Lawrence, A. B., Forsling, M. L., Goode, J. A., McGrath, T. J., McLean, K. A., & Petherick, J. C. (1996) · Animal Reproduction Science · doi:10.1016/0378-4320(96)01497-2 · Cited by 21 · see citing works
The Effects of Litter Size on Plasma Corticosterone and Prolactin Response to Ether Stress in the Lactating Rat
Myers, M. M., Denenberg, V. H., Thoman, E. B., Holloway, W. R., & Bowerman, D. R. (2008) · Neuroendocrinology · doi:10.1159/000122425 · Cited by 20 · see citing works
Restricting maternal space during parturition in the pig. Effects on oxytocin, vasopressin and cortisol secretion following vagino-cervical stimulation and administration of naloxone
Gilbert, C. L., Boulton, M. I., Forsling, M. L., Goode, J. A., & McGrath, T. J. (1997) · Animal Reproduction Science · doi:10.1016/s0378-4320(96)01596-5 · Cited by 19 · see citing works
PERIPHERAL CONCENTRATIONS OF PROGESTERONE, CORTISOL, ALDOSTERONE, SODIUM AND POTASSIUM IN THE PLASMA OF THE TADMIT EWE DURING PREGNANCY AND PARTURITION
BOULFEKHAR, L., & Brudieux, R. (1980) · Journal of Endocrinology · doi:10.1677/joe.0.0840025 · Cited by 16 · see citing works
Local and systemic control of myometrial contractile activity during labour in the sheep
Lye, S. J., & Freitag, C. (1990) · Reproduction · doi:10.1530/jrf.0.0900483 · Cited by 15 · see citing works
Social stress induces hypothalamo‐pituitary‐adrenal axis responses in lactating rats bred for high trait anxiety
Douglas, A. J., Meddle, S., Krömer, S. A., Müsch, W., Bosch, O. J., & Neumann, I. D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05380.x · Cited by 15 · see citing works
Self-citation
Altered Plasma Corticosterone Responses during Lactation in Mice of Two Inbred Strains
Hennessy, M. B., Coyle, S., & Levine, S. (2008) · Neuroendocrinology · doi:10.1159/000123105 · Cited by 12 · see citing works
Feeding upon awakening in breastfeeding and bottlefeeding mothers does not affect the awakening cortisol response
Tu, M. T., Walker, C., & LUPIEN, S. J. (2005) · Stress · doi:10.1080/10715760500306737 · Cited by 6 · see citing works
Increased Colocalization of Corticotropin‐Releasing Factor and Arginine Vasopressin in Paraventricular Neurones of the Hypothalamus in Lactating Rats: Evidence from Immunotargeted Lesions and Immunohistochemistry
Walker, C. D., Tilders, F. J. H., & Burlet, A. J. (2001) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2001.00589.x · Cited by 6 · see citing works
Hypothalamo-pituitary-adrenal responses to social defeat are reduced in pregnant rats
Brunton, P. J., Meddle, S., Krömer, S. A., Neumann, I., & Russell, J. A. (2003) · The Journal of Physiology · Cited by 4 · see citing works
Self-citation
[Lactation and sensitivity to corticotropicaxis to stress].
Lescoat, G., & Maniey, J. (1976) · PubMed · Cited by 3 · see citing works
Proceedings: Plasma corticosterone levels during pregnancy in the mouse.
Sm, B., Pj, M., & Sullivan, F. (1973) · PubMed · Cited by 2 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

Brunton PJ, Ma S, Shipston MJ, Wigger A, Neumann ID, Douglas AJ, Russell JA. Central mechanisms underlying reduced ACTH stress responses in pregnant rats: attenuated acute gene activation in the parvocellular paraventricular nucleus (pPVN). Eur J Neurosci 2000; 12: 184.
Kaye J, Soothill P, Hunt M, Lightman S. Responses to the 35% CO 2 chal- lenge in postpartum women. Clin Endocrinol (Oxf) 2004; 61: 582-588. 126

Sorted by citations

Measures of physiological stress: a transparent or opaque window into the status, management and conservation of species?
Dantzer, B., Fletcher, Q. E., Boonstra, R., & Sheriff, M. J. (2014) · Conservation Physiology · doi:10.1093/conphys/cou023 · Cited by 444 · see citing works
The Consequences of Early‐Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations
Maccari, S., Krugers, H. J., Morley‐Fletcher, S., Moshe Szyf, A., & Brunton, P. J. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12175 · Cited by 347 · see citing works
Self-citation
Perinatal maternal depression and cortisol function in pregnancy and the postpartum period: a systematic literature review
Seth, S., Lewis, A. J., & Galbally, M. (2016) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-016-0915-y · Cited by 274 · see citing works
Prenatal Social Stress in the Rat Programmes Neuroendocrine and Behavioural Responses to Stress in the Adult Offspring: Sex‐Specific Effects
Brunton, P. J., & Russell, J. A. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01969.x · Cited by 264 · see citing works
Self-citation
Maternal Psychological Distress and Lactation and Breastfeeding Outcomes: a Narrative Review
Nagel, E., Howland, M. A., Pando, C., Stang, J. L., Mason, S. M., Fields, D. A., & Demerath, E. W. (2021) · Clinical Therapeutics · doi:10.1016/j.clinthera.2021.11.007 · Cited by 247 · see citing works
Effects of maternal exposure to social stress during pregnancy: consequences for mother and offspring
Brunton, P. J. (2013) · Reproduction · doi:10.1530/rep-13-0258 · Cited by 219 · see citing works
Self-citation
Oxytocin signaling in the lateral septum prevents social fear during lactation
Menon, R., Grund, T., Zoicas, I., Althammer, F., Fiedler, D., Biermeier, V., Bosch, O. J., Hiraoka, Y., Nishimori, K., Eliava, M., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.044 · Cited by 211 · see citing works
Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam
Brummelte, S., & Galea, L. A. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.07.012 · Cited by 211 · see citing works
Stress in early pregnancy: maternal neuro-endocrine-immune responses and effects
Parker, V. J., & Douglas, A. J. (2010) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2009.10.011 · Cited by 184 · see citing works
Self-citation
Changes in anxiety and cognition due to reproductive experience: A review of data from rodent and human mothers
Macbeth, A. H., & Luine, V. N. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.011 · Cited by 169 · see citing works
Prenatal maternal stress exposure and immune function in the offspring
Veru, F., Laplante, D. P., Luheshi, G. N., & King, S. (2014) · Stress · doi:10.3109/10253890.2013.876404 · Cited by 159 · see citing works
Stress: Influence of sex, reproductive status and gender
Rincón‐Cortés, M., Herman, J. P., LUPIEN, S. J., Maguire, J. L., & Shansky, R. M. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100155 · Cited by 152 · see citing works
The HPA Axis During the Perinatal Period: Implications for Perinatal Depression
Dickens, M. J., & Pawluski, J. L. (2018) · Endocrinology · doi:10.1210/en.2018-00677 · Cited by 148 · see citing works
Evolutionary functions of early social modulation of hypothalamic-pituitary-adrenal axis development in humans
Flinn, M. V., Nepomnaschy, P. A., Muehlenbein, M. P., & Ponzi, D. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.01.005 · Cited by 139 · see citing works
Failed Lactation and Perinatal Depression: Common Problems with Shared Neuroendocrine Mechanisms?
Stuebe, A. M., Grewen, K., Pedersen, C. A., Propper, C. B., & Meltzer-Brody, S. E. (2011) · Journal of Women s Health · doi:10.1089/jwh.2011.3083 · Cited by 137 · see citing works
Cortisol and DHEA-S levels in pregnant women with severe anxiety
Leff, P., Flores‐Ramos, M., Carrasco, A. E. Á., Martínez, M. L., Takashima, M. F. S., Coronel, F., Farfán-Labonne, B. E., Dosal, J. A. Z., Chávez-Peón, P. B., Morales, S. G., et al. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02788-6 · Cited by 137 · see citing works
Endocrine induced changes in brain function during pregnancy
Brunton, P. J., & Russell, J. A. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.062 · Cited by 134 · see citing works
Self-citation
Allopregnanolone in postpartum depression: Role in pathophysiology and treatment
Meltzer-Brody, S. E., & Kanes, S. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100212 · Cited by 133 · see citing works
Glucocorticosteroid concentrations in feces and hair of captive caribou and reindeer following adrenocorticotropic hormone challenge
Ashley, N. T., Barboza, P. S., Macbeth, B. J., Janz, D. M., Cattet, M., Booth, R. K., & Wasser, S. K. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.03.029 · Cited by 129 · see citing works
Social capital and physiological stress levels in free-ranging adult female rhesus macaques
Brent, L. J. N., Semple, S., Dubuc, C., Heistermann, M., & MacLarnon, A. M. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.09.022 · Cited by 129 · see citing works
Central opioid inhibition of neuroendocrine stress responses in pregnancy in the rat is induced by the neurosteroid allopregnanolone
Brunton, P. J., McKay, A. J., Ochędalski, T., Piastowska, A., Rębas, E., Lachowicz, A., & Russell, J. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0708-09.2009 · Cited by 126 · see citing works
Self-citation
Neuroendocrine Regulation of Lactation and Milk Production
Crowley, W. R. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140029 · Cited by 124 · see citing works
From here to paternity: Neural correlates of the onset of paternal behavior in California mice (Peromyscus californicus)
A, T. R. D. J., Miyetani Chauke, A., Harris, B. N., & Wendy Saltzman, A. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.05.001 · Cited by 123 · see citing works
Allopregnanolone in the brain: Protecting pregnancy and birth outcomes
Brunton, P. J., Russell, J. A., & Hirst, J. J. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.08.005 · Cited by 122 · see citing works
Self-citation
Exposure to Chronic Pregnancy Stress Reverses Peripartum-Associated Adaptations: Implications for Postpartum Anxiety and Mood Disorders
Hillerer, K. M., Reber, S. O., Neumann, I. D., & Slattery, D. A. (2011) · Endocrinology · doi:10.1210/en.2011-1091 · Cited by 122 · see citing works
The maternal brain: an organ with peripartal plasticity
Hillerer, K. M., Jacobs, V. R., Fischer, T., & Aigner, L. (2014) · Neural Plasticity · doi:10.1155/2014/574159 · Cited by 120 · see citing works
Functional Significance of Hormonal Changes in Mammalian Fathers
Saltzman, W., & Ziegler, T. E. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12176 · Cited by 114 · see citing works
Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice.
Melón, L. C., Hooper, A., Yang, X., Moss, S. J., & Maguire, J. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.12.003 · Cited by 106 · see citing works
Neuroendocrinology of Parental Response to Baby‐Cry
Swain, J. E., Kim, P., & Ho, S. S. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02212.x · Cited by 106 · see citing works
Maternal corticosterone effects on hypothalamus–pituitary–adrenal axis regulation and behavior of the offspring in rodents
Catalani, A., Alemà, G., Cinque, C., Zuena, A. R., & Casolini, P. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.017 · Cited by 106 · see citing works
Long-term effects of early life stress exposure: Role of epigenetic mechanisms
Silberman, D. M., Acosta, G. B., & Zubilete, M. A. Z. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2015.12.033 · Cited by 104 · see citing works
Modeling prenatal opioid exposure in animals: Current findings and future directions
Byrnes, E. M., & Vassoler, F. M. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.09.001 · Cited by 103 · see citing works
Psychosocial stress and cortisol stress reactivity predict breast milk composition
Ziomkiewicz, A., Babiszewska-Aksamit, M., Apanasewicz, A., Piosek, M., Wychowaniec, P., Cierniak, A., Barbarska, O., Szołtysik, M., Danel, D. P., & Wichary, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-90980-3 · Cited by 101 · see citing works
Stress Responsiveness of the Hypothalamic–Pituitary–Adrenal Axis: Age-Related Features of the Vasopressinergic Regulation
Goncharova, N. D. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00026 · Cited by 99 · see citing works
Hippocampal Plasticity during the Peripartum Period: Influence of Sex Steroids, Stress and Ageing
Galea, L. A. M., Leuner, B., & Slattery, D. A. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12177 · Cited by 98 · see citing works
Less can be more: Fine tuning the maternal brain
Pawluski, J. L., Hoekzema, E., Leuner, B., & Lonstein, J. S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.045 · Cited by 91 · see citing works
Sex, hormones, and genotype interact to influence psychiatric disease, treatment, and behavioral research
Gobinath, A. R., Choleris, E., & Galea, L. A. M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23872 · Cited by 87 · see citing works
Neuroendocrine control of maternal stress responses and fetal programming by stress in pregnancy
Brunton, P. J., & Russell, J. A. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.023 · Cited by 87 · see citing works
Self-citation
Sex, stress and steroids
Sze, Y., & Brunton, P. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14615 · Cited by 85 · see citing works
Self-citation
G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei – serpentine gateways to neuroendocrine homeostasis
Hazell, G. G. J., Hindmarch, C. C. T., Pope, G. R., Roper, J. A., Lightman, S. L., Murphy, D., O’Carroll, A., & Lolait, S. J. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.002 · Cited by 85 · see citing works
From stress to postpartum mood and anxiety disorders: How chronic peripartum stress can impair maternal adaptations
Hillerer, K. M., Neumann, I. D., & Slattery, D. A. (2012) · Neuroendocrinology · doi:10.1159/000330445 · Cited by 82 · see citing works
Early maternal separation: Neurobehavioral consequences in mother rats
Aguggia, J. P., Suárez, M. M., & Rivarola, M. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.03.040 · Cited by 80 · see citing works
Neuroendocrinology of childbirth and mother–child attachment: The basis of an etiopathogenic model of perinatal neurobiological disorders
Fernández, I. O., Gabriel, M. Á. M., Gil-Sánchez, A., García‐Segura, L. M., & Arévalo, M. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.007 · Cited by 78 · see citing works
Magnocellular Neurons and Posterior Pituitary Function
Brown, C. H. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150053 · Cited by 77 · see citing works
Developmental responses to early‐life adversity: Evolutionary and mechanistic perspectives
Lu, A., Petrullo, L. A., Carrera, S. C., Feder, J. A., Schneider‐Crease, I. A., & Snyder‐Mackler, N. (2019) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.21791 · Cited by 75 · see citing works
DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm
Cao-Lei, L., Veru, F., Elgbeili, G., Szyf, M., Laplante, D. P., & King, S. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0219-0 · Cited by 75 · see citing works
How stress can influence brain adaptations to motherhood
Kim, P. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100875 · Cited by 73 · see citing works
Prenatal maternal stress predicts reductions in CD4+ lymphocytes, increases in innate-derived cytokines, and a Th2 shift in adolescents: Project Ice Storm
Veru, F., Dancause, K. N., Laplante, D. P., King, S., & Luheshi, G. N. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.03.016 · Cited by 73 · see citing works
Neuroanatomical and neurochemical basis of parenting: Dynamic coordination of motivational, affective and cognitive processes
Pereira, M., & Ferreira, A. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.005 · Cited by 68 · see citing works
Long-lasting effects of prenatal stress on HPA axis and inflammation: A systematic review and multilevel meta-analysis in rodent studies
Creutzberg, K. C., Sanson, A., Viola, T. W., Marchisella, F., Begni, V., Grassi‐Oliveira, R., & Riva, M. A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.032 · Cited by 65 · see citing works
Gestational and postpartum corticosterone exposure to the dam affects behavioral and endocrine outcome of the offspring in a sexually-dimorphic manner
Brummelte, S., Lieblich, S. E., & Galea, L. A. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.017 · Cited by 65 · see citing works
The Emotional and Hormonal Pathways of Labour and Birth: Integrating Mind, Body and Behaviour.
Dixon, L., Skinner, J. L., III, & Foureur, M. J. (2013) · New Zealand College of Midwives · doi:10.12784/nzcomjnl48.2013.3.15-23 · Cited by 64 · see citing works
Effectiveness of different corticosterone administration methods to elevate corticosterone serum levels, induce depressive-like behavior, and affect neurogenesis levels in female rats
Kott, J., Mooney‐Leber, S. M., Shoubah, F. A., & Brummelte, S. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.006 · Cited by 64 · see citing works
Using animal models to study post‐partum psychiatric disorders
Perani, C. V., & Slattery, D. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12640 · Cited by 62 · see citing works
Epigenomics and genotype-phenotype association analyses reveal conserved genetic architecture of complex traits in cattle and human
Liu, S., Yu, Y., Zhang, S., Cole, J. B., Tenesa, A., Wang, T., McDaneld, T. G., Ma, L., Liu, G. E., & Fang, L. (2020) · BMC Biology · doi:10.1186/s12915-020-00792-6 · Cited by 60 · see citing works
Brain and Behavioral Modifications That Accompany the Onset of Motherhood
Lambert, K. G., & Kinsley, C. H. (2012) · Parenting · doi:10.1080/15295192.2012.638868 · Cited by 58 · see citing works
Postpartum Depression: Etiology, Treatment, and Consequences for Maternal Care
Dimcea, D. A., Petca, R., Dumitrașcu, M. C., Şandru, F., Mehedințu, C., & Petca, A. T. (2024) · Diagnostics · doi:10.3390/diagnostics14090865 · Cited by 57 · see citing works
The neuroendocrine basis of lactation-induced suppression of GnRH: Role of kisspeptin and leptin
Smith, M. S., True, C. A., & Grove, K. L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.038 · Cited by 57 · see citing works
The association between maternal cortisol and depression during pregnancy, a systematic review
Orta, O. R., Gelaye, B., Bain, P. A., & Williams, M. A. (2017) · Archives of Women s Mental Health · doi:10.1007/s00737-017-0777-y · Cited by 56 · see citing works
Allopregnanolone and suppressed hypothalamo–pituitary–adrenal axis stress responses in late pregnancy in the rat
Brunton, P. J., & Russell, J. A. (2010) · Stress · doi:10.3109/10253890.2010.482628 · Cited by 55 · see citing works
Self-citation
Hormonal systems, human social bonding, and affiliation
Gangestad, S. W., & Grebe, N. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.08.005 · Cited by 55 · see citing works
Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons
Yip, S. H., Romanò, N., Gustafson, P. E., Hodson, D. J., Williams, E. J., Kokay, I. C., Martin, A., Mollard, P., Grattan, D. R., & Bunn, S. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.067 · Cited by 54 · see citing works
On the function of placental corticotropin‐releasing hormone: a role in maternal‐fetal conflicts over blood glucose concentrations
Gangestad, S. W., Caldwell Hooper, A. E., & Eaton, M. A. (2012) · Biological Reviews · doi:10.1111/j.1469-185x.2012.00226.x · Cited by 54 · see citing works
A systematic review investigating if genetic or epigenetic markers are associated with postnatal depression
Elwood, J., Murray, E. K., Bell, A. F., Sinclair, M., Kernohan, G. W., & Stockdale, J. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.059 · Cited by 52 · see citing works
Effects of repeated pup exposure on behavioral, neural, and adrenocortical responses to pups in male California mice (Peromyscus californicus)
Horrell, N. D., Perea-Rodríguez, J. P., Harris, B. N., & Wendy Saltzman, A. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.02.008 · Cited by 51 · see citing works
Lactation‐induced reduction in hippocampal neurogenesis is reversed by repeated stress exposure
Hillerer, K. M., Neumann, I. D., Couillard‐Després, S., Aigner, L., & Slattery, D. A. (2014) · Hippocampus · doi:10.1002/hipo.22258 · Cited by 50 · see citing works
Prenatal Maternal Stress Causes Preterm Birth and Affects Neonatal Adaptive Immunity in Mice
Garcia‐Flores, V., Romero, R. J., Furcron, A.-E., Levenson, D., Galaz, J., Zou, C., Hassan, S. S., Hsu, C., Olson, D. M., Metz, G. A. S., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00254 · Cited by 49 · see citing works
Effects of reproductive status on behavioral and endocrine responses to acute stress in a biparental rodent, the California mouse (Peromyscus californicus)
Miyetani Chauke, A., Malisch, J. L., Robinson, C., A, T. R. D. J., & Wendy Saltzman, A. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.04.002 · Cited by 49 · see citing works
Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology
Barrientos, R. M., Brunton, P. J., Lenz, K. M., Pyter, L. M., & Spencer, S. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.03.010 · Cited by 49 · see citing works
Self-citation
Neuroactive steroids and stress axis regulation: Pregnancy and beyond
Brunton, P. J. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.08.003 · Cited by 48 · see citing works
Self-citation
Selective attention to fearful faces during pregnancy
Roos, A., Löchner, C., Kidd, M., van Honk, J., Vythilingum, B., & Stein, D. J. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.11.012 · Cited by 48 · see citing works
Tissue-Specific Changes in Molecular Clocks During the Transition from Pregnancy to Lactation in Mice1
Casey, T., Crodian, J. S., Erickson, E. C., Kuropatwinski, K. K., Gleiberman, A. S., & Antoch, M. P. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.116137 · Cited by 48 · see citing works
The evolutionary origin and significance of menopause
Pollycove, R., Naftolin, F. N., & Simon, J. A. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181ed957a · Cited by 47 · see citing works
Maternal separation changes maternal care, anxiety-like behaviour and expression of paraventricular oxytocin and corticotrophin-releasing factor immunoreactivity in lactating rats
Baracz, S. J., Everett, N. A., Robinson, K. J., Campbell, G. R., & Cornish, J. L. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12861 · Cited by 46 · see citing works
Antidepressant-like effects of omega-3 fatty acids in postpartum model of depression in rats
Arbabi, L., Baharuldin, M. T. H., Moklas, M. A. M., Fakurazi, S., & Ismaila, M. S. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.036 · Cited by 46 · see citing works
Neuroendocrinology of pregnancy and parturition
Voltolini, C., & Petraglia, F. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00002-2 · Cited by 46 · see citing works
Bridging the Gap between GPCR Activation and Behaviour: Oxytocin and Prolactin Signalling in the Hypothalamus
van den Burg, E. H., & Neumann, I. D. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9452-8 · Cited by 45 · see citing works
Making Sense of Stress: An Evolutionary—Developmental Framework
Giudice, M. D., Ellis, B. J., & Shirtcliff, E. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5605-6_2 · Cited by 44 · see citing works
Adaptive Changes in Basal and Stress-Induced HPA Activity in Lactating and Post-Lactating Female Rats
Windle, R. J., Wood, S. A., Kershaw, Y. M., Lightman, S. L., & Ingram, C. D. (2013) · Endocrinology · doi:10.1210/en.2012-1779 · Cited by 43 · see citing works
Resetting the Dynamic Range of Hypothalamic‐Pituitary‐Adrenal Axis Stress Responses Through Pregnancy
Brunton, P. J. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02067.x · Cited by 43 · see citing works
Self-citation
Brief pup exposure induces Fos expression in the lateral habenula and serotonergic caudal dorsal raphe nucleus of paternally experienced male California mice (Peromyscus californicus)
A, T. R. D. J., Measor, K., Miyetani Chauke, A., Harris, B. N., & Wendy Saltzman, A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.012 · Cited by 43 · see citing works
Of mammals and milk: how maternal stress affects nursing offspring
Stead, S. M., Bădescu, I., & Boonstra, R. (2021) · Mammal Review · doi:10.1111/mam.12267 · Cited by 42 · see citing works
Levels of maternal serum corticotropin-releasing hormone (CRH) at midpregnancy in relation to maternal characteristics
Chen, Y., Holzman, C., Chung, H., Senagore, P. K., Talge, N. M., & Siler-Khodr, T. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.11.007 · Cited by 41 · see citing works
Reduced Cortisol and Metabolic Responses of Thin Ewes to an Acute Cold Challenge in Mid-Pregnancy: Implications for Animal Physiology and Welfare
Verbeek, E., Oliver, M. H., Waas, J. R., McLeay, L. M., Blache, D., & Matthews, L. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037315 · Cited by 39 · see citing works
Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice
Maguire, J. L., & Módy, I. (2015) · Neural Plasticity · doi:10.1155/2016/2762518 · Cited by 38 · see citing works
Luman/CREB3 Recruitment Factor Regulates Glucocorticoid Receptor Activity and Is Essential for Prolactin-Mediated Maternal Instinct
Martyn, A. C., Choleris, E., Gillis, D. J., Armstrong, J. N., Amor, T. R., McCluggage, A. R. R., Turner, P. V., Liang, G., Cai, K., & Lu, R. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.01142-12 · Cited by 38 · see citing works
‘Subordination style’ in pigs? The response of pregnant sows to mixing stress affects their offspring's behaviour and stress reactivity
Ison, S. H., D’Eath, R. B., Robson, S. K., Baxter, E., Ormandy, E., Douglas, A. J., Russell, J. A., Lawrence, A. B., & Jarvis, S. (2010) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2010.02.001 · Cited by 38 · see citing works
Self-citation
Perinatal depression: Heterogeneity of disease and in animal models
Qiu, W., Hodges, T. E., Clark, E. L., Blankers, S. A., & Galea, L. A. M. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100854 · Cited by 37 · see citing works
Effects of opioids on the parental brain in health and disease
Swain, J. E., Ho, S.-H. S., Fox, H. C., Garry, D. J., & Brummelte, S. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100766 · Cited by 37 · see citing works
Circadian clocks and their integration with metabolic and reproductive systems: our current understanding and its application to the management of dairy cows
Casey, T., & Plaut, K. I. (2022) · Journal of Animal Science · doi:10.1093/jas/skac233 · Cited by 36 · see citing works
The effect of energetic and psychosocial stressors on glucocorticoids in mantled howler monkeys (Alouatta palliata)
Espinosa, E. E. G., Negrín, A. R., Chavira, R., Canales‐Espinosa, D., & Dias, P. A. D. (2013) · American Journal of Primatology · doi:10.1002/ajp.22240 · Cited by 36 · see citing works
Modelling female physiology from head to Toe: impact of sex hormones, menstrual cycle, and pregnancy
Abo, S., Smith, D., Stadt, M., & Layton, A. (2022) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2022.111074 · Cited by 35 · see citing works
Food restriction during pregnancy in rabbits: Effects on hormones and metabolites involved in energy homeostasis and metabolic programming
Menchetti, L., Brecchia, G., Canali, C., Cardinali, R., Polisca, A., Zerani, M., & Boiti, C. (2014) · Research in Veterinary Science · doi:10.1016/j.rvsc.2014.11.017 · Cited by 35 · see citing works
Glucocorticoids Disrupt Neuroendocrine and Behavioral Responses during Lactation
Vilela, F. C., & Giusti‐Paiva, A. (2011) · Endocrinology · doi:10.1210/en.2011-1096 · Cited by 35 · see citing works
Glutamate, GABA, and glutamine are synchronously upregulated in the mouse lateral septum during the postpartum period
Zhao, C., & Gammie, S. C. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.023 · Cited by 35 · see citing works
Corticotropin-Releasing Hormone As the Homeostatic Rheostat of Feto-Maternal Symbiosis and Developmental Programming In Utero and Neonatal Life
Alcántara‐Alonso, V., Panetta, P., de Gortari, P., & Grammatopoulos, D. K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00161 · Cited by 35 · see citing works
Age, sex and storage time influence hair cortisol levels in a wild mammal population
Azevedo, A., Bailey, L. D., Bandeira, V., Dehnhard, M., Fonseca, C. M. D., de Sousa, L., & Jewgenow, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221124 · Cited by 34 · see citing works
From Breastfeeding to Support in Mothers’ Feeding Choices: A Key Role in the Prevention of Postpartum Depression?
Dessì, A., Pianese, G., Mureddu, P., Fanos, V., & Bosco, A. (2024) · Nutrients · doi:10.3390/nu16142285 · Cited by 32 · see citing works
Effect of reproductive status on hypothalamic–pituitary–adrenal (HPA) activity and reactivity in male California mice (Peromyscus californicus)
Harris, B. N., & Wendy Saltzman, A. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.016 · Cited by 31 · see citing works
How is prenatal stress transmitted from the mother to the fetus?
Sze, Y., & Brunton, P. J. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.246073 · Cited by 29 · see citing works
Self-citation

Regulation of the Hypothalamo-Pituitary-Adrenal Axis in Pregnancy and Lactation
Brunton, P. J., & Walker, C. (2024) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-51138-7_4 · Cited by 4 · see citing works
Self-citation
Central noradrenergic mechanisms underlying acute stress responses of the Hypothalamo-pituitary-adrenal axis: Adaptations through pregnancy and lactation
Douglas, A. J. (2005) · Stress · doi:10.1080/10253890500044380 · Cited by 68 · see citing works
Self-citation
Chapter 8 Peripartum plasticity within the hypothalamo-pituitary-adrenal axis
Lightman, S. L., Windle, R. J., Wood, S. A., Kershaw, Y. M., Shanks, N. M., & Ingram, C. D. (2001) · Progress in brain research · doi:10.1016/s0079-6123(01)33009-1 · Cited by 171 · see citing works
Reduced Hypothalamo‐pituitary‐adrenal Axis Stress Responses in Late Pregnancy
Russell, J. A., Douglas, A. J., & Brunton, P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.032 · Cited by 55 · see citing works
Self-citation
Attenuated neuroendocrine responses to emotional and physical stressors in pregnant rats involve adenohypophysial changes
Neumann, I. D., Johnstone, H. A., Hatzinger, M., Liebsch, G., Shipston, M. J., Russell, J. A., Landgraf, R., & Douglas, A. J. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.289br.x · Cited by 365 · see citing works
Self-citation

Authors: Brunton, P. J., Russell, J. A., & Douglas, A. J.
Affiliations: University of Edinburgh (GB)
Corresponding author: Russell, J. A.
ORCID: Brunton, P. J.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2008-06
Volume: 20
Issue: 6
Pages: 764-776
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2008.01735.x
OpenAlex: W2125486541
Cited by: 298
References: 155
Citations by year: 2026: 11 · 2025: 11 · 2024: 20 · 2023: 18 · 2022: 15 · 2021: 18 · 2020: 20 · 2019: 21 · 2018: 6 · 2017: 13 · 2016: 21 · 2015: 17 · 2014: 25 · 2013: 13 · 2012: 12
FWCI: 1.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 39 d)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Society for Endocrinology
European Commission
Directorate for Biological Sciences
Medical Research Council
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: pregnancy, lactation, corticotropin-releasing factor, paraventricular nucleus, stress responsiveness, glucocorticoids, ACTH, circadian rhythm, norepinephrine, endogenous opioids, neurosteroids, progesterone, prolactin, suckling
MeSH terms: Analgesics, Opioid, Animals, Animals, Suckling, Arginine Vasopressin, Circadian Rhythm, Corticotropin-Releasing Hormone, Female, Humans, Hypothalamo-Hypophyseal System, Lactation, Pituitary-Adrenal System, Pregnancy, Prolactin, Stress, Psychological

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adaptive Responses of the Maternal Hypothalamic‐Pituitary‐Adrenal Axis during Pregnancy and Lactation

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks