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Cited by 303Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchTraumatic Brain Injury and Neurovascular Disturbances

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Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

Liu, W., Tang, Y., Feng, J.·2011·Life Sciences
DOI 10.1016/j.lfs.2011.05.011
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Abstract

Microglia and astrocytes in the central nervous system are now recognized as active participants in various pathological conditions such as trauma, stroke, or chronic neurodegenerative disorders. Their activation is closely related with the development and severity of diseases. Interestingly, activation of microglia and astrocytes occurs with a spatially and temporarily distinct pattern. The present review explores the cross talk in the process of their activation. Microglia, activated earlier than astrocytes, promote astrocytic activation. On the other hand, activated astrocytes not only facilitate activation of distant microglia, but also inhibit microglial activities. Molecules contributing to their intercommunication include interleukin-1 (IL-1), adenosine triphosphate (ATP), and transforming growth factor beta (TGF-β). A better understanding about the cross talk between activation of microglia and astrocytes would be helpful to elucidate the role of glial cells in pathological conditions, which could accelerate the development of treatment for various diseases.

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Metadata

Authors
Liu, W., Tang, Y., & Feng, J.
Affiliations
  • Guangzhou University of Chinese Medicine (CN)
  • Sun Yat-sen University (CN)
Corresponding author
  • Liu, W.
  • Tang, Y.
ORCID
Tang, Y.
Venue
Life Sciences
Publisher
Elsevier BV
Published
2011-08
Volume
89
Issue
5-6
Pages
141-146
ISSN
0024-3205 (ISSN-L)
DOI
10.1016/j.lfs.2011.05.011
OpenAlex
W2036224773
Cited by
303
References
84
Citations by year
2026: 11 · 2025: 21 · 2024: 15 · 2023: 11 · 2022: 18 · 2021: 20 · 2020: 35 · 2019: 20 · 2018: 20 · 2017: 24 · 2016: 29 · 2015: 20 · 2014: 15 · 2013: 22 · 2012: 18
FWCI
1.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
Guangzhou University of Chinese Medicine
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
microglia, astrocytes, microglial activation, astrocyte activation, central nervous system pathology, neuroinflammation, stroke, traumatic brain injury, neurodegenerative diseases, interleukin-1, adenosine triphosphate, TGF-beta, glial communication
MeSH terms
Animals, Astrocytes, Cell Communication, Central Nervous System Diseases, Humans, Macrophage Activation, Microglia, Calcium Signaling, Receptor Cross-Talk

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