Cited by 303Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchTraumatic Brain Injury and Neurovascular Disturbances

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Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

Liu, W., Tang, Y., Feng, J.·2011·Life Sciences

DOI 10.1016/j.lfs.2011.05.011

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Abstract

Microglia and astrocytes in the central nervous system are now recognized as active participants in various pathological conditions such as trauma, stroke, or chronic neurodegenerative disorders. Their activation is closely related with the development and severity of diseases. Interestingly, activation of microglia and astrocytes occurs with a spatially and temporarily distinct pattern. The present review explores the cross talk in the process of their activation. Microglia, activated earlier than astrocytes, promote astrocytic activation. On the other hand, activated astrocytes not only facilitate activation of distant microglia, but also inhibit microglial activities. Molecules contributing to their intercommunication include interleukin-1 (IL-1), adenosine triphosphate (ATP), and transforming growth factor beta (TGF-β). A better understanding about the cross talk between activation of microglia and astrocytes would be helpful to elucidate the role of glial cells in pathological conditions, which could accelerate the development of treatment for various diseases.

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The Evolving Landscape of Neurotoxicity by Unconjugated Bilirubin: Role of Glial Cells and Inflammation
Brites, D. M. T. O. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00088 · Cited by 146
“In contrast, ACM protected microglia from loss of viability by UCB, in line with the property of reactive astrocytes in facilitating activation of distant microglia, while inhibiting microglial activities (Liu et al., 2011a) and preventing overactivation (Renault-Mihara et al.”
BackgroundInfluential
Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms
Helyes, Z., Tékus, V., Szentes, N., Pohóczky, K., Botz, B., Kiss, T., Kemény, Á., Környei, Z., Tóth, K., Lénárt, N., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820168116 · Cited by 122
“Since IL-1– mediated actions are involved in the cross-talk between neurons, microglia, and astrocytes in promoting neuroinflammation (35, 36), we assessed glial IL-1β and IL-1α production in the spinal cord and found that microglial IL-1β production was increased on day 7 in the CRPS IgG-treated group.”
Background
Regulation of brain microglia by female gonadal steroids
Habib, P., & Beyer, C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.02.018 · Cited by 118
Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia
Hernández‐Rabaza, V., Cabrera‐Pastor, A., Taoro‐González, L., González‐Usano, A., Agustí, A., Balzano, T., Llansola, M., & Felipo, V. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0549-z · Cited by 120
“Microglia is activated earlier than astrocytes and promotes activation of astrocytes, which is mediated mainly by IL-1b released from microglia [52].”
Background
Iron uptake in quiescent and inflammation-activated astrocytes: A potentially neuroprotective control of iron burden
Pelizzoni, I., Zacchetti, D., Campanella, A., Grohovaz, F., & Codazzi, F. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.007 · Cited by 112
Neuroprotection by gonadal steroid hormones in acute brain damage requires cooperation with astroglia and microglia
Johann, S., & Beyer, C. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.11.006 · Cited by 115
Posttraumatic Reduction of Edema with Aquaporin-4 RNA Interference Improves Acute and Chronic Functional Recovery
Fukuda, A. M., Adami, A., Pop, V., Bellone, J. A., Coats, J., Hartman, R., Ashwal, S., Obenaus, A., & Badaut, J. (2013) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2013.118 · Cited by 111
White matter involvement in sporadic Creutzfeldt-Jakob disease
Caverzasi, E., Mandelli, M. L., DeArmond, S. J., Hess, C. P., Vitali, P., Papinutto, N., Oehler, A., Miller, B. L., Lobach, I. V., Bastianello, S., et al. (2014) · Brain · doi:10.1093/brain/awu298 · Cited by 54
“Interestingly in animal models, PrP seems to induce microglial activation, and this event precedes reactive astrocytosis and neuronal degeneration (Williams et al., 1997; Marella and Chabry, 2004; Liu et al., 2011).”
Background
CSF1R Inhibition Reduces Microglia Proliferation, Promotes Tissue Preservation and Improves Motor Recovery After Spinal Cord Injury
Gerber, Y. N., Saint-Martin, G., Bringuier, C. M., Bartolami, S., Goze‐Bac, C., Noristani, H. N., & Perrin, F. E. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00368 · Cited by 119
Cortical neuroinflammation contributes to long-term cognitive dysfunctions following adolescent delta-9-tetrahydrocannabinol treatment in female rats
Zamberletti, E., Gabaglio, M., Prini, P., Rubino, T., & Parolaro, D. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.021 · Cited by 114
“However, as activation of microglia and astrocytes occurs with a spatially and temporarily distinct pattern and microglia activation can promote astrocytic activation (Liu et al., 2011), the potential contribution of astrocytes in the effects of adolescent THC warrants further investigations.”
Background
RETRACTED: Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-κB pathway after MCAO in rats
Wu, G., McBride, D. W., & Zhang, J. H. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.11.009 · Cited by 113
“Following brain ischemia, microglia and astrocytes are activated via Toll-like receptors (TLRs) (Liu et al., 2011), leading to up-regulation of nuclear factor kappa B (NF-κB) (Zwagerman et al., 2010).”
BackgroundInfluential
Retracted
Inflammation in Parkinson's Disease
Tüfekçi, K. U., Meuwissen, R. L. J., Genç, Ş., & Genç, K. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-398314-5.00004-0 · Cited by 205
Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments
Rodríguez-Giraldo, M., González-Reyes, R. E., Ramírez-Guerrero, S., Bonilla-Trilleras, C. E., Guardo-Maya, S., & Nava-Mesa, M. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113630 · Cited by 122
Anti-inflammatory Effect of Seeds and Callus of Nigella sativa L. Extracts on Mix Glial Cells with Regard to Their Thymoquinone Content
Alemi, M., Sabouni, F., Sanjarian, F., Haghbeen, K., & Ansari, S. (2012) · AAPS PharmSciTech · doi:10.1208/s12249-012-9899-8 · Cited by 97
Characterization of brain‐derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake
Brenna, S., Altmeppen, H. C., Mohammadi, B., Rissiek, B., Schlink, F., Ludewig, P., Krisp, C., Schlüter, H., Failla, A. V., Schneider, C., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1809065 · Cited by 114
“Since there is close communication between astrocytes and microglia after brain injury, and given that activated astrocytes can in turn contribute to the activation of distant microglia after ischaemia [95], it may be that an elevated release of EVs from astrocytes at 24 h is a factor facilitating the recruitment of r…”
Background
Suppression of Inflammation with Conditional Deletion of the Prostaglandin E 2 EP2 Receptor in Macrophages and Brain Microglia
Johansson, J. U., Pradhan, S., Lokteva, L. A., Woodling, N. S., Ko, N., Brown, H. D., Wang, Q., Loh, C., Cekanaviciute, E., Buckwalter, M., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2203-13.2013 · Cited by 96
Astrocytes Stimulate Microglial Proliferation and M2 Polarization In Vitro through Crosstalk between Astrocytes and Microglia
Kim, S. M., & Son, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168800 · Cited by 101
“Furthermore, the crosstalk between astrocytes and neurons and microglia and neurons has been vigorously studied [18,19], whereas the crosstalk between astrocytes and microglia has been less studied.”
Background
Neuroinflammation, immune system and Alzheimer disease: searching for the missing link
Guerriero, F., Sgarlata, C. S., Francis, M., Maurizi, N., Faragli, A., Perna, S., Rondanelli, M., Rollone, M., & Ricevuti, G. (2016) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0637-z · Cited by 98
Surface chemistry governs cellular tropism of nanoparticles in the brain
Song, E., Gaudin, A., King, A. R., Seo, Y.-E., Suh, H., Deng, Y., Cui, J., Tietjen, G. T., Huttner, A. J., & Saltzman, W. M. (2017) · Nature Communications · doi:10.1038/ncomms15322 · Cited by 101
“The brain environment is complex, with different cell types that are intimately and reciprocally linked to each other, establishing an anatomical and functional neurovascular unit 27 , which ensures correct brain functions 28 .”
Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs
Štrac, D. Š., Pivac, N., Smolders, I. J., Fogel, W. A., Deurwaerdère, P. D., & Giovanni, G. D. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00492 · Cited by 94
Trimethyltin-induced hippocampal neurodegeneration: A mechanism-based review.
Lee, S., Yang, M., Kim, J., Kang, S., Kim, J., Kim, J.-C., Jung, C., Shin, T., Kim, S.-H., & Moon, C. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.07.010 · Cited by 92
Immune dysregulation and autoimmunity in bipolar disorder: Synthesis of the evidence and its clinical application
Rege, S., & Hodgkinson, S. J. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413499077 · Cited by 90
“Cross-talk between microglia and astrocytes has been implicated in several neurological conditions, but the details of this interaction are still unclear (Liu et al., 2011b).”
Background
Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide‐induced microglial and astrocytic neuroinflammation by increasing NAD+
Roboon, J., Hattori, T., Ishii, H., Takarada‐Iemata, M., Nguyen, D. T., Heer, C. D., O’Meally, D., Brenner, C., Yamamoto, Y., Okamoto, H., et al. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15367 · Cited by 94
“…is well documented that sustained inflammatory responses cause the release of harmful mediators such as cytokines and chemokines from activated glial cells, and further affect neuronal cells by triggering neurodegeneration (Jo et al., 2017; Lian et al., 2016; Liu et al., 2011; Norden et al., 2016).”
Background
Delayed decompression exacerbates ischemia-reperfusion injury in cervical compressive myelopathy
Vidal, P. M., Karadimas, S. K., Ulndreaj, A., Laliberté, A. M., Tetreault, L. A., Forner, S., Wang, J., Foltz, W. D., & Fehlings, M. G. (2017) · JCI Insight · doi:10.1172/jci.insight.92512 · Cited by 99
Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury
Menzel, L., Kleber, L., Friedrich, C., Hummel, R., Dangel, L., Winter, J., Schmitz, K., Tegeder, I., & Schäfer, M. K. E. (2016) · Glia · doi:10.1002/glia.23091 · Cited by 95
“Less attention has been paid to the role of PGRN on astrocyte activation, although cross-talk between microglia/macrophages and astrocytes is an abundant feature in neuropathological conditions (Abudara et al., 2015; Liu et al., 2011; Norden et al., 2014).”
Background
Regulation of Hypoxia-Induced Inflammatory Responses and M1-M2 Phenotype Switch of Primary Rat Microglia by Sex Steroids
Habib, P., Slowik, A., Zendedel, A., Johann, S., Dang, J., & Beyer, C. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0137-y · Cited by 96
“…inflammatory action on nerve cells is equally regulated by their competence to detect damaged neurons by transmembrane receptors and their receptiveness for soluble and paracrine-acting mediators arising from neighboring activated astroglia (Liu et al. 2011; Linnartz and Neumann 2013).”
Background
Stress and aging act through common mechanisms to elicit neuroinflammatory priming
Fonken, L. K., Frank, M. G., Gaudet, A. D., & Maier, S. F. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.012 · Cited by 98
Therapeutic potential of mGluR5 targeting in Alzheimer's disease
Kumar, A., Dhull, D. K., & Mishra, P. S. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00215 · Cited by 93
“Moreover, activated microglia can also potentially induce the activation of astrocytes (Liu et al., 2011).”
Background
Differential deregulation of astrocytic calcium signalling by amyloid-β, TNFα, IL-1β and LPS
Ronco, V., Grolla, A. A., Glasnov, T. N., Canonico, P. L., Verkhratsky, A., Genazzani, A. A., & Lim, D. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.02.016 · Cited by 89
Microglia energy metabolism in metabolic disorder
Kalsbeek, M. J. T., Mulder, L., & Yi, C. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.028 · Cited by 93
Microglia–Astrocyte Interaction in Neural Development and Neural Pathogenesis
Sun, M., You, H., Hu, X., Luo, Y., Zhang, Z., Song, Y., An, J., & Lü, H. (2023) · Cells · doi:10.3390/cells12151942 · Cited by 90
“Therefore, there has been a recent surge of interest in the interaction between astrocytes and microglia, including their specific anatomical locations and functions in different scenarios [13,14].”
Background
In vivo Imaging of Glial Activation in Alzheimer's Disease
Edison, P., Donat, C. K., & Sastre, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00625 · Cited by 88
“It is worth noting that astrocytes and microglia communicate with each other and this cross talk is important in promoting glial activation (8, 9).”
Background
Microglial HO‐1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects
Parada, E., Buendía, I., Navarro, E., Avendaño, C., Egea, J., & López, M. G. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500279 · Cited by 87
“Astrocyte/microglia intercellular communication is crucial for the maintenance of many intracellular signals in the CNS [33, 34].”
Background
Rehmannioside A attenuates cognitive deficits in rats with vascular dementia (VD) through suppressing oxidative stress, inflammation and apoptosis
Sun, M., Shen, X., & Yun-zhi, M. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109492 · Cited by 76
Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors
Wang, Y., Ni, J., Zhai, L., Gao, C., Xie, L., Zhao, L., & Yin, X. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.015 · Cited by 75
LPS Preconditioning Attenuates Apoptosis Mechanism by Inhibiting NF-κB and Caspase-3 Activity: TLR4 Pre-activation in the Signaling Pathway of LPS-Induced Neuroprotection
Sangaran, P. G., Ibrahim, Z. A., Chik, Z., Mohamed, Z., & Ahmadiani, A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02227-3 · Cited by 78
Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain
Norden, D. M., Trojanowski, P. J., Walker, F. R., & Godbout, J. P. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.014 · Cited by 73
The psychoneuroimmunology of pregnancy
Sherer, M. L., Posillico, C. K., & Schwarz, J. M. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.006 · Cited by 96
Sex differences in astrocyte and microglia responses immediately following middle cerebral artery occlusion in adult mice
Morrison, H. W., & Filosa, J. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.09.047 · Cited by 85
“…signaling which can result in glutamate excitotoxicity (Nedergaard et al., 2010) or through the release of astrocytederived proteins and small molecular messengers such as ATP, TNFα, and S100β, which further increases neuroinflammation (Agulhon et al., 2012; Liu et al., 2011; Pascual et al., 2012).”
Background
Astrocytes inhibit nitric oxide-dependent Ca2+dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels
Orellana, J. A., Montero, T. D., & Rommy von Bernhardi, M. (2013) · Glia · doi:10.1002/glia.22573 · Cited by 84
“Microglia and astrocytes respond to any injury with a spatial and temporal distinctive pattern of activation in the inflamed CNS, their crosstalk appearing to be critical for neuronal fate (Liu et al., 2011).”
Background
C-Phycocyanin protects against acute tributyltin chloride neurotoxicity by modulating glial cell activity along with its anti-oxidant and anti-inflammatory property: A comparative efficacy evaluation with N-acetyl cysteine in adult rat brain
Mitra, S., Siddiqui, W. A., & Khandelwal, S. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.06.016 · Cited by 67
“Activated astrocytes are known to have inhibitory effect on microglial activity [68, 69].”
Background
Sex steroid hormone-mediated functional regulation of microglia-like BV-2 cells during hypoxia
Habib, P., Dreymueller, D., Ludwig, A., Beyer, C., & Dang, J. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.06.003 · Cited by 67
“In addition, the control of microglia-triggered devastating inflammatory damage to neurons is not only regulated by their capability to directly sense lesioned cells by trans-membrane receptors [43] but comparably by the receptivity for soluble regulatory molecules produced and secreted by activated and lesion-intrins…”
Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system
Bottelbergs, A., Verheijden, S., Van Veldhoven, P. P., Just, W., Devos, R., & Baes, M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-61 · Cited by 66
“Also of note is that astroglial activation lagged behind microglia proliferation, as described before in other neurodegenerative diseases [28].”
Background
An examination of changes in maternal neuroimmune function during pregnancy and the postpartum period
Sherer, M. L., Posillico, C. K., & Schwarz, J. M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.016 · Cited by 76
Neuroinflammation: Microglial Activation During Sepsis
Michels, M., Danielski, L. G., Dal‐Pizzol, F., & Petronilho, F. C. (2014) · Current Neurovascular Research · doi:10.2174/1567202611666140520122744 · Cited by 70
Effects of silver nanoparticles on the interactions of neuron‐ and glia‐like cells: Toxicity, uptake mechanisms, and lysosomal tracking
Hsiao, I.-L., Hsieh, Y.-K., Chuang, C.-Y., Wang, C.-F., & Huang, Y.-J. (2017) · Environmental Toxicology · doi:10.1002/tox.22397 · Cited by 65
“Cell density for the three cocultured system was determined by the ratio of initial seeding cells which should be equal to 10% neuron, 9–18% microglia, and 72–81% astrocytes, and which corresponds to the cell ratio in a human brain.(31,32) To induce inflammation responses prior to NP treatment, bottom chamber cells we…”
Method
Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA
Kuter, K. Z., Olech, Ł., & Głowacka, U. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0529-z · Cited by 73
“On the other hand, activated astrocytes can facilitate activation of distant microglia, as well as inhibit microglial activity [21].”
Background
Modulation of Pain and Itch by Spinal Glia
Tsuda, M. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0129-y · Cited by 74
Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control
de Kloet, A. D., Liu, M., Rodríguez, V., Krause, E. G., & Sumners, C. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00078.2015 · Cited by 64
“Additionally, astrocytes and microglia interact with each other to regulate neuronal function (8, 14, 15, 100, 116).”
Background
Microglia and Astroglia—The Potential Role in Neuroinflammation Induced by Pre- and Neonatal Exposure to Lead (Pb)
Gąssowska-Dobrowolska, M., Chlubek, M., Kolasa, A., Tomasiak, P., Korbecki, J., Skowrońska, K., Tarnowski, M., Masztalewicz, M., & Baranowska‐Bosiacka, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129903 · Cited by 78
“These two primary types of glial cells play a pivotal role in regulating the immune response to pathological processes in the brain [23].”
Background
Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity
Maatouk, L., Yi, C., Sauvage, M.-A. C.-D., Compagnion, A., Hunot, S., Ezan, P., Hirsch, É. C., Koulakoff, A., Pfrieger, F. W., Tronche, F., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0150-3 · Cited by 72
“Thus, for example, in vitro TGF-β secreted from astrocytes was shown to curb microglial production of TNF-α and reactive oxygen species [36] whereas evidence from in vivo PD animal models and in vitro astrocytemicroglia cultures indicates that IL-1β, TNF-α, I-CAM1 or ATP released from astrocytes can enhance microglial…”
Microglia are less pro‐inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus
Vinet, J., Vainchtein, I. D., Spano, C., Giordano, C., Bordini, D., Curia, G., Dominici, M., Boddeke, H. W. G. M., Eggen, B. J. L., & Biagini, G. (2016) · Glia · doi:10.1002/glia.23008 · Cited by 61
“Astrocytes have been shown to produce IL-1b after seizures (De Simoni et al., 2000; Librizzi et al., 2012; Liu et al., 2011).”
Background
Trasmembrane chemokines CX3CL1 and CXCL16 drive interplay between neurons, microglia and astrocytes to counteract pMCAO and excitotoxic neuronal death
Rosito, M., Lauro, C., Chece, G., Porzia, A., Monaco, L., Mainiero, F., Catalano, M., Limatola, C., & Trettel, F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00193 · Cited by 63
“It is now established that both microglia and astrocytes can play dual roles in the CNS having either detrimental or beneficial effects participating and enhancing inflammatory conditions, or limiting neuroinflammation, favoring repair and enhancing neuronal survival (Liu et al., 2011).”
Mesial temporal lobe epilepsy with psychiatric comorbidities: a place for differential neuroinflammatory interplay
Kandratavicius, L., Peixoto-Santos, J. E., Monteiro, M. R., Scandiuzzi, R. C., Carlotti, C. G., Assirati, J. A., Hallak, J. E. C., & Leite, J. P. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0266-z · Cited by 57
“In fact, the crosstalk between activated microglia and reactive astrocytes seems crucial to the maintenance of chronic gliosis [38].”
Background
Chronic Administration of the Methylxanthine Propentofylline Impairs Reinstatement to Cocaine by a GLT-1-Dependent Mechanism
Reissner, K. J., Brown, R. M., Spencer, S. M., Tran, P. K., Thomas, C. A., & Kalivas, P. W. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.223 · Cited by 64
“Beyond sustaining normal nervous system function, in many instances of injury or disease, the activation of both microglia and astrocytes is a fundamentally important process (Liu et al, 2011).”
Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation: IL-6 in Demyelination
Petković, F., Campbell, I. L., Gonzalez, B., & Castellano, B. (2016) · Glia · doi:10.1002/glia.23043 · Cited by 59
“Astrocytes may play an important role in this process as a potent source of various cytokines and chemokines (Liu et al., 2011; Skripueltz et al., 2013).”
Background
Transient Receptor Potential Canonical 3 Inhibitor Pyr3 Improves Outcomes and Attenuates Astrogliosis After Intracerebral Hemorrhage in Mice
Munakata, M., Shirakawa, H., Nagayasu, K., Miyanohara, J., Miyake, T., Nakagawa, T., Katsuki, H., & Kaneko, S. (2013) · Stroke · doi:10.1161/strokeaha.113.679332 · Cited by 72
Behavioral comorbidities of epilepsy and neuroinflammation: Evidence from experimental and clinical studies
Suleymanova, E. M. (2021) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2021.107869 · Cited by 62
Glial smog: Interplay between air pollution and astrocyte-microglia interactions
Gómez‐Budia, M., Konttinen, H., Saveleva, L., Korhonen, P., Jalava, P., Kanninen, K. M., & Malm, T. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104715 · Cited by 60
Neuroimmune and Inflammatory Signals in Complex Disorders of the Central Nervous System
Liberman, A. C., Trías, E., Chagas, L. D. S., Trindade, P., Pereira, M. D. S., Refojo, D., Hedin‐Pereira, C., & Serfaty, C. A. (2018) · NeuroImmunoModulation · doi:10.1159/000494761 · Cited by 62
Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions
Gajardo‐Gómez, R., Labra, V. C., & Orellana, J. A. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00086 · Cited by 62
Activation of microglia and astrocytes in the nucleus tractus solitarius during ventilatory acclimatization to 10% hypoxia in unanesthetized mice
Tadmouri, A., Champagnat, J., & Morin-Surun, M. P. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23336 · Cited by 60
“…neurons, and microglia contribute to normal synaptic plasticity (for review see Ben Achour and Pascual, 2010; Pascual et al., 2012) and could also participate in various pathologies such as neurodegenerative diseases and to brain reactions to ischemia or injury (for review see Liu et al., 2011).”
Background
Early‐life stress increases the survival of midbrain neurons during postnatal development and enhances reward‐related and anxiolytic‐like behaviors in a sex‐dependent fashion
Chocyk, A., Majcher‐Maślanka, I., Przyborowska, A., Maćkowiak, M., & Wędzony, K. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.05.002 · Cited by 45
“Although we found dysregulation of non-neuronal cell functioning, it is worth mentioning that these cells, which are sources of neurotrophins, antioxidants and cytokines, are strongly involved in brain maturation and may affect neural cell survival (Seth and Koul, 2008; Liu et al., 2011).”
Background
Glia, sympathetic activity and cardiovascular disease
Marina, N., Teschemacher, A. G., Kasparov, S., & Gourine, A. V. (2016) · Experimental Physiology · doi:10.1113/ep085713 · Cited by 60
“Indeed, in an animal model of heart failure, the expression of the pro-inflammatory cytokines interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) was found to be significantly increased in at least one brain site that controls sympathetic outflow, namely the hypothalamic paraventricular nucleus (Kang et al. 20…”
BackgroundInfluential
Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine
Gong, Q., Lin, Y., Lu, Z., & Xiao, Z. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.10.019 · Cited by 60
Neuroimmune communication in hypertension and obesity: A new therapeutic angle?
de Kloet, A. D., Krause, E. G., Shi, P. D., Zubcevic, J. A., Raizada, M. K., & Sumners, C. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.02.005 · Cited by 46
“Moreover, astrocytes and microglia interact to regulate one another's function and the function of neurons (Kloss et al., 1997; Bezzi et al., 2001a, 2001b; Belanger et al., 2011; Liu et al., 2011).”
Background
Remodeling Microenvironment for Endogenous Repair through Precise Modulation of Chondroitin Sulfate Proteoglycans Following Spinal Cord Injury
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BackgroundInfluential

Authors: Liu, W., Tang, Y., & Feng, J.
Affiliations: Guangzhou University of Chinese Medicine (CN)
Sun Yat-sen University (CN)
Corresponding author: Liu, W.
Tang, Y.
ORCID: Tang, Y.
Venue: Life Sciences
Publisher: Elsevier BV
Published: 2011-08
Volume: 89
Issue: 5-6
Pages: 141-146
ISSN: 0024-3205 (ISSN-L)
DOI: 10.1016/j.lfs.2011.05.011
OpenAlex: W2036224773
Cited by: 303
References: 84
Citations by year: 2026: 11 · 2025: 21 · 2024: 15 · 2023: 11 · 2022: 18 · 2021: 20 · 2020: 35 · 2019: 20 · 2018: 20 · 2017: 24 · 2016: 29 · 2015: 20 · 2014: 15 · 2013: 22 · 2012: 18
FWCI: 1.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Life Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: Guangzhou University of Chinese Medicine
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: microglia, astrocytes, microglial activation, astrocyte activation, central nervous system pathology, neuroinflammation, stroke, traumatic brain injury, neurodegenerative diseases, interleukin-1, adenosine triphosphate, TGF-beta, glial communication
MeSH terms: Animals, Astrocytes, Cell Communication, Central Nervous System Diseases, Humans, Macrophage Activation, Microglia, Calcium Signaling, Receptor Cross-Talk

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Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

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