The DOI matches its Crossref record; 114 of the 117 references it cites were found in a registry or an index.
Mechanism of intranasal drug delivery directly to the brain
Abstract
Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging populations, which greatly contributes to increasing healthcare costs. The development of neuroprotective drugs has so far proven exceptionally difficult due to the blood-brain barrier. One novel approach to address this challenge is to administer drugs intranasally to noninvasively bypass the blood-brain barrier. The intranasal route can thus transport drugs directly to the brain from the nasal cavity along the olfactory and trigeminal nerves. The purpose of this review is to describe the details of this mechanism to better direct future research. The intranasal route is composed of two pathways, one being intracellular while the other being extracellular. The intracellular pathway begins with endocytosis by olfactory sensory cells, followed by axonal transport to their synaptic clefts in the olfactory bulb where the drug is exocytosed. This transynaptic process is repeated by olfactory neurons, thereby distributing the drug to other brain regions. In the extracellular mechanism, drugs are transported directly into the cerebral spinal fluid by first passing through the paracellular space across the nasal epithelium, then through the perineural space to the subarachnoid space of the brain. With a growing body of evidence and trials in both rodent and human models, this is an exciting area for research as therapeutics come to market.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The intra-neuronal transport of neuropeptides from the nasal cavity to the olfactory bulb takes several hours, 29 which makes it more likely that IN administered peptides are primarily transported along extra-neuronal routes (ie, through intercellular clefts of the olfactory epithelium).”
From Intranasal insulin (2021) · cites this paper as [33]
Citations
Cites
The blood-brain barrier: Bottleneck in brain drug development
Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798
Alzheimer disease in the United States (2010–2050) estimated using the 2010 census
Hebert, L. E., Weuve, J., Scherr, P. A., & Evans, D. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31828726f5 · Cited by 2,642
FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE
Reese, T. S., & Karnovsky, M. J. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.1.207 · Cited by 2,629
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
Lai, S. K., Wang, Y.-Y., & Hanes, J. S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.11.002 · Cited by 1,863
Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
Craft, S. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.233 · Cited by 1,253
Handbook of Olfaction and Gustation
Doty, R. L. (2003) · CRC Press eBooks · doi:10.1201/9780203911457 · Cited by 1,228
Intranasal delivery of biologics to the central nervous system
Lochhead, J. J., & Thorne, R. G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.002 · Cited by 1,214
Thorne, R. G., Pronk, G. J., Padmanabhan, V., & Frey, W. H. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.029 · Cited by 958
Flagged first, then by citations
3 of the 117 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Schwalbe, 1869, Die arachnoidalraum, ein lymphraum und sein zusammenhang mit den perichorioidalraum, Zentralbl. Med. Wiss., 7, 465
- Kim, 2009, Gene knockout in the olfactory bulb, amygdala, and hypothalamus by intranasal siRNA administration, Kor. J. Anat., 42, 285
Cited by
Sorted by citations
Evaluation of intranasal delivery route of drug administration for brain targeting
Erdő, F., Bors, L. A., Farkas, D., Bajza, Á., & Gizurarson, S. S. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.009 · Cited by 773
Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Chougule, M. B., Shoyele, S. A., & Alexander, A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.011 · Cited by 630
Intranasal drug delivery: opportunities and toxicologic challenges during drug development
Keller, L.-A., Merkel, O. M., & Popp, A. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00891-5 · Cited by 636
Evolution of drug delivery systems: From 1950 to 2020 and beyond
Park, H., Otte, A., & Park, K. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.12.030 · Cited by 507
Gänger, S., & Schindowski, K. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030116 · Cited by 447
Bernardo-Castro, S., Sousa, J. A., Brás, A., Cecília, C., Rodrigues, B., Almendra, L., Machado, C., Santo, G., da Silva, F. A. D. A., Ferreira, L., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.594672 · Cited by 395
Costa, C. P., Moreira, J. N., Lobo, J. M. S., & Silva, A. C. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.02.012 · Cited by 317
Stimuli-responsive In situ gelling system for nose-to-brain drug delivery
Agrawal, M., Saraf, S., Saraf, S., Dubey, S. K., Puri, A., Gupta, U. D., Kesharwani, P., Ravichandiran, V., Kumar, P., Naidu, V. G. M., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.044 · Cited by 304
Agrawal, M., Saraf, S., Saraf, S., Dubey, S. K., Puri, A., Patel, R. J., Ajazuddin, M., Ravichandiran, V., Murty, U. S., & Alexander, A. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.02.020 · Cited by 239
Xiong, B., Wang, Y., Chen, Y., Xing, S., Liao, Q., Chen, Y., Li, Q., Li, W., & Sun, H. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00910 · Cited by 232
Chatterjee, B., Gorain, B., Mohananaidu, K., Sengupta, P., Mandal, U. K., & Choudhury, H. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.05.032 · Cited by 223
Mathiesen, S. N., Lock, J. L., Schoderboeck, L., Abraham, W. C., & Hughes, S. M. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.10.011 · Cited by 219
Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier
Lee, D., & Minko, T. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122049 · Cited by 227
Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis
Costa, C. P., Moreira, J. N., Amaral, M. H., Lobo, J. M. S., & Silva, A. C. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.049 · Cited by 216
Microplastics in the Olfactory Bulb of the Human Brain
Amato‐Lourenço, L. F., Dantas, K. C., Júnior, G. R., Paes, V. R., Ando, R. A., Freitas, R. O., da Costa, O. M. M. M., Rabelo, R. S., Bispo, K. C. S., Carvalho-Oliveira, R., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.40018 · Cited by 228
Chen, L.-L., Fan, Y.-G., Zhao, L.-X., Zhang, Q., & Wang, Z.-Y. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106301 · Cited by 200
Evaluation of Recent Intranasal Drug Delivery Systems to the Central Nervous System
Crowe, T. P., & Hsu, W. H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030629 · Cited by 208
Self-citationMitusova, K. A., Peltek, O. O., Karpov, T. E., Muslimov, A. R., Zyuzin, M. V., & Timin, A. S. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01610-7 · Cited by 193
Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders
Islam, S. U., Shehzad, A., Ahmed, M. B., & Lee, Y. S. (2020) · Molecules · doi:10.3390/molecules25081929 · Cited by 193
Intranasal Insulin for Alzheimer’s Disease
Hallschmid, M. (2021) · CNS Drugs · doi:10.1007/s40263-020-00781-x · Cited by 188
Fung, T. K. H., Lau, B. W.-M., Ngai, S. P. C., & Tsang, H. W. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094844 · Cited by 173
Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders
Bahadur, S., Pardhi, D. M., Rautio, J., Rosenholm, J. M., & Pathak, K. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121230 · Cited by 178
Koo, J., Lim, C., & Oh, K. T. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s439181 · Cited by 174
Liposomal Formulations for Nose-to-Brain Delivery: Recent Advances and Future Perspectives
Hong, S.-S., Oh, K. T., Choi, H., & Lim, S. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11100540 · Cited by 167
Recent expansions of novel strategies towards the drug targeting into the brain
Alexander, A., Agrawal, M., Uddin, A. N. M. S., Siddique, S., Shehata, A. M., Shaker, M. A., Rahman, S. A. U., Abdul, M. I. M., & Shaker, M. A. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s210876 · Cited by 165
Long, Y., Yang, Q., Xiang, Y., Zhang, Y., Wan, J., Liu, S., Li, N., & Peng, W. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104795 · Cited by 151
Farr, A. C., & Xiong, M. P. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00474 · Cited by 154
Kashyap, K., & Shukla, R. (2019) · Current Drug Delivery · doi:10.2174/1567201816666191029122740 · Cited by 147
Cubosomes as an emerging platform for drug delivery: a review of the state of the art
Abourehab, M. A. S., Ansari, M. J., Singh, A., Hassan, A., Abdelgawad, M. A., Shrivastav, P., Abualsoud, B. M., Amaral, L. S., & Pramanik, S. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb00031h · Cited by 143
Awad, R., Avital, A., & Sosnik, A. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.07.003 · Cited by 150
Nanostructured lipid carriers: a promising drug carrier for targeting brain tumours
Garg, J., Pathania, K., Sah, S. P., & Pawar, S. V. (2022) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-022-00414-8 · Cited by 149
Polymeric Nanoparticles for Nasal Drug Delivery to the Brain: Relevance to Alzheimer's Disease
Rabiee, N., Ahmadi, S., Afshari, R., Khalaji, S., Rabiee, M., Bagherzadeh, M., Fatahi, Y., Dinarvand, R., Tahriri, M., Tayebi, L., et al. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000076 · Cited by 144
Quader, S., Kataoka, K., & Cabral, H. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114115 · Cited by 146
Harnessing Exosomes for the Development of Brain Drug Delivery Systems
Zheng, M., Huang, M., Ma, X., Chen, H., & Gao, X. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00085 · Cited by 136
Epilepsy Disease and Nose-to-Brain Delivery of Polymeric Nanoparticles: An Overview
Musumeci, T., Bonaccorso, A., & Puglisi, G. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030118 · Cited by 137
Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases
Renaud, J., & Martinoli, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081883 · Cited by 124
Bruinsmann, F. A., Vaz, G. R., Alves, A. D. C. S., Aguirre, T. A. S., Pohlmann, A. R., Guterres, S. S., & Sonvico, F. (2019) · Molecules · doi:10.3390/molecules24234312 · Cited by 123
Advances in intranasal vaccine delivery: A promising non-invasive route of immunization
Kehagia, E., Papakyriakopoulou, P., & Valsami, G. N. (2023) · Vaccine · doi:10.1016/j.vaccine.2023.05.011 · Cited by 121
Research progress in brain-targeted nasal drug delivery
Huang, Q., Chen, X., Yu, S., Gong, G., & Shu, H. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1341295 · Cited by 136
Hallschmid, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12934 · Cited by 113
Cheng, G., Liu, Y., Ma, R., Cheng, G., Guan, Y., Chen, X., Wu, Z., & Chen, T. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00847-z · Cited by 113
Recent progress in nanocarriers for direct nose to brain drug delivery
Emad, N. A., Ahmed, B., Alhalmi, A., Alzobaidi, N., & Al-Kubati, S. S. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102642 · Cited by 114
Akel, H., Ismail, R., & Csóka, I. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.12.014 · Cited by 113
Blázquez, E., Hurtado-Carneiro, V., Ayuso, Y. L. B., Velázquez, E., García‐García, L., Gómez-Oliver, F., Ruiz‐Albusac, J. M., Ávila, J., & Pozo, M. A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.873301 · Cited by 110
Kanazawa, T., Taki, H., & Okada, H. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.05.001 · Cited by 107
Microemulsion-Based Media in Nose-to-Brain Drug Delivery
Froelich, A., Osmałek, T. Z., Jadach, B., Puri, V., & Michniak‐Kohn, B. B. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13020201 · Cited by 110
Chitosan-Based Nanocarriers for Nose to Brain Delivery
Aderibigbe, B. A., & Naki, T. (2019) · Applied Sciences · doi:10.3390/app9112219 · Cited by 105
Chung, S. S., Peters, J. M., Detyniecki, K., Tatum, W. O., Rabinowicz, A. L., & Carrazana, E. J. (2022) · Epilepsy & Behavior Reports · doi:10.1016/j.ebr.2022.100581 · Cited by 117
Hydrogels in Burn Wound Management—A Review
Surowiecka, A., Strużyna, J., Winiarska, A., & Korzeniowski, T. (2022) · Gels · doi:10.3390/gels8020122 · Cited by 116
Formulation Strategies to Improve Nose-to-Brain Delivery of Donepezil
Espinoza, L. C., Silva-Abreu, M., Clares, B., Rodríguez-Lagunas, M. J., Halbaut, L., Cañas, M.-A., & Calpena, A. C. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020064 · Cited by 99
Yin, T., Liu, Y., Ji, W., Zhuang, J., Chen, X., Gong, B., Chu, J., Liang, W., Gao, J., & Yin, Y. (2023) · Theranostics · doi:10.7150/thno.81860 · Cited by 107
Gene therapy for CNS disorders: modalities, delivery and translational challenges
Gao, J., Gunasekar, S., Xia, Z. J., Shalin, K., Jiang, C., Chen, H., Lee, D., Lee, S., Pisal, N. D., Luo, J. N., et al. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00829-7 · Cited by 100
Azambuja, J. H., Schuh, R. S., Michels, L. R., Gelsleichter, N. E., Beckenkamp, L. R., Iser, I. C., Lenz, G. S., de Oliveira, F. H., Venturin, G. T., Greggio, S., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01730-6 · Cited by 96
Non-Invasive Strategies for Nose-to-Brain Drug Delivery.
Ja, T., Quispe, R. C., Khan, F. A., & Новак (2020) · PubMed · Cited by 114
The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventions
Hunsberger, H. C., Pinky, P. D., Smith, W., Suppiramaniam, V., & Reed, M. N. (2019) · Neuronal Signaling · doi:10.1042/ns20180203 · Cited by 94
Ladel, S., Schlossbauer, P., Flamm, J., Luksch, H., Mizaikoff, B., & Schindowski, K. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11080367 · Cited by 96
Dodd, G. T., Xirouchaki, C. E., Eramo, M. J., Mitchell, C. A., Andrews, Z. B., Henry, B. A., Cowley, M. A., & Tiganis, T. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.019 · Cited by 95
Transcellular brain drug delivery: A review on recent advancements
Azarmi, M., Maleki, H., Nikkam, N., & Malekinejad, H. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119582 · Cited by 96
Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins
Gabold, B., Adams, F., Brameyer, S., Jung, K., Ried, C. L., Merdan, T., & Merkel, O. M. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01245-z · Cited by 93
Application of quercetin in neurological disorders: from nutrition to nanomedicine
Jajin, E. A., Esmaeili, A., Rahgozar, S., & Noorbakhshnia, M. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0080 · Cited by 94
Intranasal drug delivery for treatment of Alzheimer’s disease
Fonseca, L., Lopes, J. A., Vieira, J., Viegas, C., Oliveira, C. S., Hartmann, R. P., & Fonte, P. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00940-7 · Cited by 93
Lim, S. H., Yee, G. T., & Khang, D. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s450853 · Cited by 99
Wu, H., Zhou, Y., Wang, Y., Tong, L., Wang, F., Song, S., Xu, L., Liu, B., Yan, H., & Sun, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.717192 · Cited by 90
Sabir, F., Ismail, R., & Csóka, I. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.10.005 · Cited by 91
Advances in drug delivery technology for the treatment of glioblastoma multiforme
Cha, G. D., Kang, T., Baik, S., Kim, D., Choi, S., Hyeon, T., & Kim, D.-H. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.002 · Cited by 96
Mignani, S. M., Shi, X., Karpus, A. O., & Majoral, J. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112905 · Cited by 93
Lam, J. K. W., Cheung, C. K. C., Chow, M. Y. T., Harrop, E. J., Lapwood, S., Barclay, S. I. G., & Wong, I. C. K. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.10.018 · Cited by 95
Endothelin signalling mediates experience-dependent myelination in the CNS
Swire, M., Kotelevtsev, Y. V., Webb, D. J., Lyons, D. A., & ffrench‐Constant, C. (2019) · eLife · doi:10.7554/elife.49493 · Cited by 88
Zheng, Y., Wang, Y., Xia, M., Gao, Y., Zhang, L., Song, Y., & Zhang, C. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01029-x · Cited by 92
Intranasal Perillyl Alcohol for Glioma Therapy: Molecular Mechanisms and Clinical Development
Chen, T. C., da Fonseca, C. O., & Schönthal, A. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123905 · Cited by 90
Organ-specific toxicity of magnetic iron oxide-based nanoparticles
Chrishtop, V. V., Mironov, V. A., Prilepskii, A. Y., Nikonorova, V. G., & Vinogradov, V. V. (2021) · Nanotoxicology · doi:10.1080/17435390.2020.1842934 · Cited by 86
Taweel, M. M. E., Aboul-Einien, M. H., Kassem, M. A., & ElKasabgy, N. A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111828 · Cited by 86
Borneol: a Promising Monoterpenoid in Enhancing Drug Delivery Across Various Physiological Barriers
Kulkarni, M., Sawant, N. D., Kolapkar, A., Huprikar, A., & Desai, N. D. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-021-01999-8 · Cited by 86
Levodopa-loaded nanoparticles for the treatment of Parkinson's disease
van Vliet, E. F., Knol, M. J., Schiffelers, R. M., Caiazzo, M., & Fens, M. H. A. M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.06.026 · Cited by 85
Facciolà, A., Visalli, G., La Maestra, S., Ceccarelli, M., D’Aleo, F., Nunnari, G., Pellicanò, G. F., & Di Pietro, A. (2019) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.11.006 · Cited by 84
Zhang, D., Lu, Z., Man, J., Cui, K., Fu, X., Yu, L., Gao, Y., Liao, L., Xiao, Q., Guo, R., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105760 · Cited by 84
Adnet, T., Groo, A., Picard, C., Davis, A., Corvaisier, S., Since, M., Bounoure, F., Rochais, C., Pluart, L. L., Dallemagne, P., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030251 · Cited by 88
Witika, B. A., Poka, M., Demana, P. H., Matafwali, S. K., Melamane, S., Khamanga, S. M., & Makoni, P. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040836 · Cited by 85
Nair, A. B., Chaudhary, S. A., Shah, H., Jacob, S., Mewada, V., Shinu, P., Al‐Dhubiab, B. E., Sreeharsha, N., Venugopala, K. N., Attimarad, M., et al. (2022) · Gels · doi:10.3390/gels8060342 · Cited by 81
Kumbhar, S. A., Kokare, C., Shrivastava, B., Gorain, B., & Choudhury, H. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119499 · Cited by 80
Meng, Q., Meng, H., Pan, Y., Liu, J., Li, J., Qi, Y., & Huang, Y. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb02015c · Cited by 80
Polysaccharides-based nanocarriers enhance the anti-inflammatory effect of curcumin
Luo, W. H., Bai, L., Zhang, J., Li, Z., Liu, Y., Tang, X., Xia, P., Xu, M., Shi, A., Liu, X., et al. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120718 · Cited by 79
The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases
Qiu, Y., Huang, S., Peng, L., Yang, L., Zhang, G., Liu, T., Yan, F., & Peng, X. (2025) · MedComm · doi:10.1002/mco2.70213 · Cited by 90
Alexander, A., & Saraf, S. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.241458 · Cited by 77
Cho, Y., Seo, E. U., Hwang, K. S., Kim, H., Choi, J. H., & Kim, H. N. (2024) · Nano Convergence · doi:10.1186/s40580-024-00448-z · Cited by 80
Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer’s disease
Taliyan, R., Kakoty, V., Sarathlal, K. C., Kharavtekar, S. S., Karennanavar, C. R., Choudhary, Y. K., Singhvi, G., Riadi, Y., Dubey, S. K., & Kesharwani, P. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.044 · Cited by 79
Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders
Boyuklieva, R., & Pilicheva, B. (2022) · Biomedicines · doi:10.3390/biomedicines10071706 · Cited by 77
Yu-Taeger, L., Stricker-Shaver, J., Arnold, K., Bambynek-Dziuk, P., Novati, A., Singer, E., Lourhmati, A., Fabian, C., Magg, J. C. D., Rieß, O., et al. (2019) · Cells · doi:10.3390/cells8060595 · Cited by 76
Nanotechnologies for intranasal drug delivery: an update of literature
Lombardo, R., Musumeci, T., Carbone, C., & Pignatello, R. (2021) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2021.1950186 · Cited by 75
Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury
Meneses, G., Cárdenas, G., Espinosa, A., Rassy, D., Pérez‐Osorio, I. N., Bárcena, B., Fleury, A., Besedovsky, H. O., Fragoso, G., & Sciutto, E. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13985 · Cited by 74
Nose-to-brain delivery of levetiracetam after intranasal administration to mice
Gonçalves, J., Bicker, J., Gouveia, F., Liberal, J. M. T., Oliveira, R. C., Alves, G., Falcão, A. C., & Fortuna, A. C. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.04.047 · Cited by 72
Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain
Zha, S., Wong, K., & All, A. H. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202102610 · Cited by 72
Briguglio, M., Bona, A. R., Porta, M., Dell’Osso, B. M., Pregliasco, F. E., & Banfi, G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00671 · Cited by 70
Montegiove, N., Calzoni, E., Emiliani, C., & Cesaretti, A. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb13030125 · Cited by 70
Patharapankal, E. J., Ajiboye, A. L., Mattern, C., & Trivedi, V. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010066 · Cited by 75
Li, X., Li, S., Ma, C., Li, T., & Yang, L. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2064564 · Cited by 68
RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
Hao, R., Sun, B., Yang, L., Ma, C., & Li, S. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1760960 · Cited by 68
Nanotechnology to improve the Alzheimer’s disease therapy with natural compounds
Ramalho, M. J., Andrade, S., Loureiro, J. A., & do Carmo Pereira, M. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-019-00694-3 · Cited by 75
Spray dried powders for nasal delivery: Process and formulation considerations
Henriques, P., Fortuna, A. C., & Doktorovová, S. (2022) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2022.05.002 · Cited by 66
Advancements in drug delivery methods for the treatment of brain disease
Partridge, B. R., Eardley, A., Morales, B. E., Campelo, S. N., Lorenzo, M. F., Mehta, J. N., Kani, Y., Mora, J. K. G., Campbell, E.-O. Y., Arena, C. B., et al. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.1039745 · Cited by 67
Metadata
- Authors
- Crowe, T. P., Greenlee, M. H. W., Kanthasamy, A. G., & Hsu, W. H.
- Affiliations
- Iowa State University (US)
- Corresponding author
- Hsu, Walter H.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 195
- Pages
- 44-52
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2776146933
- Cited by
- 721
- References
- 117
- Citations by year
- 2026: 97 · 2025: 123 · 2024: 100 · 2023: 92 · 2022: 91 · 2021: 82 · 2020: 72 · 2019: 49 · 2018: 15
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Surgery › Head and Neck Surgical Oncology
- Keywords
- intranasal drug delivery, blood-brain barrier bypass, olfactory pathway, trigeminal pathway, olfactory sensory neurons, axonal transport, olfactory bulb, paracellular transport, perineural space, subarachnoid space, cerebrospinal fluid, neuroprotective agents, neurological disorders
- MeSH terms
- Administration, Intranasal, Animals, Blood-Brain Barrier, Brain, Humans, Nasal Cavity, Nervous System Diseases, Drug Delivery Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
