Oral resveratrol supplementation improves metabolic syndrome features in obese patients submitted to a lifestyle-changing program
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Aims The aim of the present study was to evaluate the oral resveratrol effects associated with diet and physical training changes on anthropometric and biochemical parameters.Main methods 25 individuals aged from 30 to 60 years old; with Body Mass Index (BMI) ≥ 30 kg/m 2 were included in the study. Following the primary evaluation (anthropometric and clinical), the patients were randomly divided into 2 groups: (1) Placebo: Physical activity program + Diet + Placebo; (2) Resveratrol: Physical activity program + Diet + Resveratrol (RVS) (250 mg/day) for three months. Anthropometric and biochemical parameters were evaluated at baseline and after the treatment period.Key findings The main findings showed that the resveratrol supplementation improved total cholesterol (TC), High-density Lipoprotein cholesterol (HDL-c), Very-low density Lipoprotein cholesterol (VLDL-c), urea, creatinine and albumin serum levels.Significance These findings indicate that this polyphenol may be an option to potentiate the beneficial effects induced by dietary and physical activity programs in the Metabolic Syndrome (MetS) treatment.
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Resveratrol administration appears to improve the metabolic profile in obese and/or insulin-resistant patients.
“Administration of resveratrol appears to improve the metabolic profile in obese and/or insulin-resistant patients.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [4]
In Batista-Jorge et al.'s study, only the resveratrol group showed an increase in HDL and a significant decrease of VLDL, total cholesterol, urea, creatinine, and albumin.
“After 3 months, BMI and waist circumference were significantly lower in both groups, however, only the resveratrol group showed an increase in HDL and a significant decrease of very-low-density lipoprotein (VLDL), total cholesterol, urea, creatinine, and albumin [4].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [4]
In Batista-Jorge et al.'s study, after 3 months, BMI and waist circumference were significantly lower in both placebo and resveratrol groups (all patients followed physical activity and diet).
“After 3 months, BMI and waist circumference were significantly lower in both groups, however, only the resveratrol group showed an increase in HDL and a significant decrease of very-low-density lipoprotein (VLDL), total cholesterol, urea, creatinine, and albumin [4].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [4]
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- Authors
- Batista-Jorge, G. C., Barcala-Jorge, A. S., Silveira, M. F., Lelis, D. F., Andrade, J. M. O., de Paula, A. M. B., Guimarães, A. L. S., & Santos, S. H. S.
- Affiliations
- Universidade Estadual de Montes Claros (BR)
- Universidade Federal de Minas Gerais (BR)
- Corresponding author
- Santos, S.H.S.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 256
- Pages
- 117962
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W3035729075
- Cited by
- 55
- References
- 59
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 6 · 2023: 12 · 2022: 11 · 2021: 6 · 2020: 3
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 303 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- resveratrol, metabolic syndrome, obesity, lifestyle intervention, physical activity, dietary intervention, cholesterol, HDL cholesterol, VLDL cholesterol, serum albumin, creatinine, urea, polyphenols, dietary supplementation
- MeSH terms
- Resveratrol, Administration, Oral, Adult, Energy Metabolism, Female, Humans, Life Style, Lipids, Male, Middle Aged, Obesity, Placebos, Dietary Supplements, Metabolic Syndrome
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