The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Basic biochemical mechanisms behind the health benefits of polyphenols
Open accessAbstract
Polyphenols and consequently many flavonoids have several beneficial actions on human health. However, the actual molecular interactions of polyphenols with biological systems remain mostly speculative. This review addresses the potential mechanisms of action that have been so far identified, as well as the feasibility that they could occur in vivo. Those mechanisms include: i) non specific actions, based on chemical features common to most polyphenols, e.g. the presence of a phenol group to scavenge free radicals; and ii) specific mechanisms; based on particular structural and conformational characteristics of select polyphenols and the biological target, e.g. proteins, or defined membrane domains. A better knowledge about the nature and biological consequences of polyphenol interactions with cell components will certainly contribute to develop nutritional and pharmacological strategies oriented to prevent the onset and/or the consequences of human disease.
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Cited by
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Metadata
- Authors
- Fraga, C. G., Galleano, M., Verstraeten, S. V., & Oteiza, P. I.
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 31
- Issue
- 6
- Pages
- 435-445
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W2080164215
- Cited by
- 737
- References
- 10
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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