Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents

Holt, Erica M.; Steffen, Lyn M.; Moran, Antoinette; Basu, Samar; Steinberger, Julia; Ross, Julie A.; Hong, Ching-Ping; Sinaiko, Alan R.

doi:10.1016/j.jada.2008.11.036

Cited by 499Nutritional Studies and DietPhytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative Stress

Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents

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Holt, Erica M., Steffen, Lyn M., Moran, Antoinette, Basu, Samar, Steinberger, Julia, Ross, Julie A., Hong, Ching-Ping, Sinaiko, Alan R.·2009·Journal of the American Dietetic Association

DOI 10.1016/j.jada.2008.11.036PMC PMC2676354

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Abstract

Background Fruits and vegetables, foods rich in flavonoids and antioxidants, have been associated with lower risk of stroke, coronary heart disease, and markers of inflammation and oxidative stress in adults. Markers of inflammation and oxidative stress are predictors of coronary heart disease risk; however, it is unknown whether these markers are related to dietary flavonoid and antioxidant intake in youth.Objective To determine whether greater intakes of fruit and vegetables, antioxidants, folate, and total flavonoids were inversely associated with markers of inflammation and oxidative stress in 285 adolescent boys and girls aged 13 to 17 years.Design In this cross-sectional study conducted between February 1996 and January 2000, diet was assessed by a 127-item food frequency questionnaire. Height and weight measurements were obtained and a fasting blood sample drawn. Spearman partial correlation analyses evaluated the relation of intakes of fruit and vegetables, antioxidants, folate, and flavonoids with markers of inflammation (C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and 15-keto-dihydro-PGF(2alpha) metabolite and oxidative stress (urinary 8-iso prostaglandin F(2alpha), an F(2)-isoprostane), adjusting for age, sex, race, Tanner stage, energy intake, and body mass index.Results Urinary F(2)-isoprostane was inversely correlated with intakes of total fruit and vegetables, vitamin C, beta carotene, and flavonoids. Serum C-reactive protein was significantly inversely associated with intakes of fruit (r=-0.19; P=0.004), vitamin C (r=-0.13, P=0.03), and folate (r=-0.18; P=0.004). Serum interleukin-6 was inversely associated with intakes of legumes, vegetables, beta carotene, and vitamin C. Serum tumor necrosis factor-alpha was inversely associated with beta carotene (r=-0.14, P=0.02) and luteolin (r=-0.15, P=0.02).Conclusion Study results show that the beneficial effects of fruit and vegetable intake on markers of inflammation and oxidative stress are already present by early adolescence and provide support for the Dietary Guidelines for Americans "to consume five or more servings per day" of fruits and vegetables to promote beneficial cardiovascular health.

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Consumption of fruits and vegetables has been correlated with decreased risks of cardiovascular disease.
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Bennet, A. M., Alarcón-Riquelme, M. E., Wiman, B., Fairé, U. D., & Prokunina‐Olsson, L. (2006) · Human Immunology · doi:10.1016/j.humimm.2006.05.005 · Cited by 17 · see citing works
Dietary Guidelines for Children: U.S. Recommendations
Kleinman, R. E., Finberg, L., Klish, W. J., & Lauer, R. N. (1996) · Journal of Nutrition · doi:10.1093/jn/126.suppl_4.1028s · Cited by 16 · see citing works
Influence of the DASH diet and other low-fat, high-carbohydrate diets on blood pressure
Delichatsios, H. K., & Welty, F. K. (2005) · Current Atherosclerosis Reports · doi:10.1007/s11883-005-0061-x · Cited by 15 · see citing works
Cardiovascular risk, the metabolic syndrome and the hypertriglyceridaemic waist.
Underwood, P. (2004) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000137237.97341.fd · Cited by 10 · see citing works

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[17]Food and Nutrition Board Institute of Medicine Dietary Reference Intakes (DRI) for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline: A Report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients National Academy Press Washington, D.C.

Sorted by citations

Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
“In one study, no association with CRP was observed((288)), while in a second study, an inverse association was seen in men but not in women((327)).”
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Quach, A., Levine, M. E., Tanaka, T., Lu, A. T., Chen, B. H., Ferrucci, L., Ritz, B., Bandinelli, S., Neuhouser, M. L., Beasley, J. M., et al. (2017) · Aging · doi:10.18632/aging.101168 · Cited by 801 · see citing works
“The association between fruit and vegetables with aging of the blood immune system may be partially mediated by antiinflammatory [83, 84] and cardiometabolic effects, however it is interesting to note that the explanatory power of mean carotenoid levels remained even after including the other explanatory factors into…”
Basic biochemical mechanisms behind the health benefits of polyphenols
Fraga, C. G., Galleano, M., Verstraeten, S. V., & Oteiza, P. I. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.006 · Cited by 748 · see citing works
Diet and Inflammation
Galland, L. (2010) · Nutrition in Clinical Practice · doi:10.1177/0884533610385703 · Cited by 686 · see citing works
Fruits, vegetables, and health: A comprehensive narrative, umbrella review of the science and recommendations for enhanced public policy to improve intake
Wallace, T. C., Bailey, R. L., Blumberg, J. B., Burton-Freeman, B., Chen, C.-Y. O., Crowe-White, K. M., Drewnowski, A., Hooshmand, S., Johnson, E., Lewis, R., et al. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1632258 · Cited by 638 · see citing works
“A study of adolescent boys found that a diet high in F&V was associated with lower levels with markers of inflammation (Holt et al. 2009).”
Background
COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation
Zabetakis, I., Lordan, R., Norton, C., & Τσούπρας, Α. (2020) · Nutrients · doi:10.3390/nu12051466 · Cited by 535 · see citing works
“Fruit and vegetable intakes have been investigated for potential benefits in association with respiratory [139] and inflammatory [140] conditions due to their nutrient profile consisting of antioxidants, vitamins, minerals, and phytochemicals that include phenolic compounds that can exert antioxidant, anti-inflammator…”
Background
Berries: emerging impact on cardiovascular health
Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462 · see citing works
Fruit polyphenols, immunity and inflammation
González-Gallego, J., García-Mediavilla, M. V., Sánchez-Campos, S., & Tuñón, M. J. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003910 · Cited by 387 · see citing works
“In Caco-2 cells, procyanidins inhibit NF-kB translocation and TNF-a-induced IkB phosphorylation and degradation(49).”
BackgroundInfluential
Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth
Balagopal, P., de Ferranti, S. D., Cook, S., Daniels, S. R., Gidding, S. S., Hayman, L. L., McCrindle, B. W., Mietus‐Snyder, M., & Steinberger, J. (2011) · Circulation · doi:10.1161/cir.0b013e31821c7c64 · Cited by 353 · see citing works
Nutrition and Cardiovascular Health
Casas, R. M., Castro‐Barquero, S., Estruch, R., & Sacanella, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123988 · Cited by 344 · see citing works
Strawberry As a Functional Food: An Evidence-Based Review
Basu, A., Nguyen, A., Betts, N. M., & Lyons, T. J. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.608174 · Cited by 312 · see citing works
“…AND CANCER Nutritional epidemiology provides convincing evidence on the cardio-protective effects of frequent consumption of fruits and vegetables high in fiber, micronutrients, and several phytochemicals (Liu et al., 2000; Joshipura et al., 2001; Bazzano et al., 2002; Holt et al., 2009).”
Background
Stability and biological activity of wild blueberry (Vaccinium angustifolium) polyphenols during simulated in vitro gastrointestinal digestion
Correa-Betanzo, J., Allen‐Vercoe, E., McDonald, J. A. K., Schroeter, K., Corredig, M., & Paliyath, G. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.05.135 · Cited by 311 · see citing works
“Results from several studies across the world show an inverse correlation between fruit and vegetable consumption, and the expression of inflammation markers in blood, such as CRP (C-Reactive protein), IL6 (interleukin 6) and TNF a (Holt et al., 2009).”
Background
UV-B-Induced Secondary Plant Metabolites - Potential Benefits for Plant and Human Health
Schreiner, M., Mewis, I., Huyskens-Keil, S., Jansen, M. A. K., Zrenner, R. M., Winkler, J. B., O’Brien, N. M., & Krumbein, A. (2012) · Critical Reviews in Plant Sciences · doi:10.1080/07352689.2012.664979 · Cited by 284 · see citing works
“Additionally, studies show that various phenolic compounds can act as scavengers of free radicals such as ROS which are overproduced under oxidative stress conditions (e.g. Holt et al., 2009).”
Background
Role of Diet in Chronic Obstructive Pulmonary Disease Prevention and Treatment
Scoditti, E., Massaro, M., Garbarino, S., & Toraldo, D. M. (2019) · Nutrients · doi:10.3390/nu11061357 · Cited by 287 · see citing works
“Plausible mechanisms underlying fruit and vegetable protective effects include their antioxidant and anti-inflammatory activities, as suggested by the epidemiologic association observed between fruit and vegetable consumption and lower markers of oxidative stress and inflammation, and higher levels of antioxidant mark…”
Background
Fruits and Vegetables Consumption and Risk of Stroke: A Meta-Analysis of Prospective Cohort Studies
Hu, D., Huang, J., Wang, Y., Zhang, D., & Qu, Y. (2014) · Stroke · doi:10.1161/strokeaha.114.004836 · Cited by 258 · see citing works
“index, waist circumference, total cholesterol and low-density lipoprotein-cholesterol,(34) inflammation, and oxidative stress, were also found.(35,36) Higher fruits and vegetables consump-”
Background
Effects of fruit and vegetable consumption on inflammatory biomarkers and immune cell populations: a systematic literature review and meta-analysis.
Hosseini, B., Berthon, B. S., Saedisomeolia, A., Starkey, M. R., Collison, A., Wark, P. A. B., & Wood, L. G. (2018) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy082 · Cited by 252 · see citing works
“FRUIT AND VEGETABLE INTAKE AND IMMUNE RESPONSES 139 TABLE 1 (Continued) First author (year) Q12 Q23 Q34 Q45 Q56 Q67 Q78 Q89 Q910 Q1011 QA Holt (2009) (20) Y Y Y Y N Y Y Y Y Y Pos Hermsdorff (2010) (74) Y Y Y Y N Y Y Y Y Y Pos Lopez-Garcia (2004) (75) Y N Y Y N Y Y Y Y Y Neu Root (2012) (76) Y Y Y Y N Y Y Y Y Y Pos Wan…”
Quercetin and the mitochondria: A mechanistic view
de Oliveira, M. R., Nabavi, S. M., Braidy, N., Setzer, W. N., Ahmed, T., & Nabavi, S. F. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.12.014 · Cited by 252 · see citing works
Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context
Ruiz-Núñez, B., Pruimboom, L., Dijck-Brouwer, D. A. J., & Muskiet, F. A. J. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.02.009 · Cited by 246 · see citing works
“, hydrogen peroxide, hypochlorite anion, superoxide anion and hydroxyl radical), with substantial evidence upholding the contention that: a diet rich in natural antioxidants supports health [104,246], is associated with lower oxidative stress and inflammation [77,103,140], and is therefore associated with lower risk o…”
Background
Don't tell me what I should do, but what others do: The influence of descriptive and injunctive peer norms on fruit consumption in adolescents
Stok, F. M., de Ridder, D. T. D., de Vet, E., & de Wit, J. B. F. (2013) · British Journal of Health Psychology · doi:10.1111/bjhp.12030 · Cited by 239 · see citing works
“This is worrisome given that adequate fruit consumption is considered highly beneficial to various important health issues such as weight management and the prevention of cardiovascular diseases (Alinia, Hels, & Tetens, 2009; Holt et al., 2009).”
Background
Plant secondary metabolites and gut health: the case for phenolic acids
Russell, W. R., & Duthie, G. G. (2011) · Proceedings of The Nutrition Society · doi:10.1017/s0029665111000152 · Cited by 198 · see citing works
“Although some observational studies((63,64)) suggest inverse associations between the consumption of phenolic-rich diets and inflammatory markers, in general, the impact of dietary phenolic acids on gut health in human subjects has not yet been assessed in adequately powered and controlled dietary intervention trials.”
Background
Adverse Childhood Experiences, Outcomes, and Interventions
Gilgoff, R., Singh, L. B., Koita, K., Gentile, B., & Marques, S. S. (2020) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2019.12.001 · Cited by 168 · see citing works
“various ways with varying specificity, making research into their impact on physiology and health complicated.(59,60,62,63,67,68,70,71) A frequently used definition of mindfulness by Kabat-Zinn identifies core components, including nonjudgmental,”
Background
Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-κB independent of NRF2-mediated mechanism
Lee, S. G., Kim, B., Yang, Y., Pham, T. X., Park, Y., Manatou, J., Koo, S. I., Chun, O. K., & Lee, J. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.12.001 · Cited by 160 · see citing works
“High consumption of fruits and vegetables was inversely associated with plasma proinflammatory biomarkers in humans, which is attributed to high polyphenols present in fruits and vegetables [19–21].”
Background
Strategies for Achieving Healthy Vascular Aging
Nowak, K. L., Rossman, M. J., Chonchol, M., & Seals, D. R. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10439 · Cited by 152 · see citing works
“ents and phytochemicals, as well as via reductions in oxidative stress, inflammation, and insulin resistance.(188,189)”
The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases
Kurowska, A., Ziemichód, W., Herbet, M., & Piątkowska‐Chmiel, I. (2023) · Nutrients · doi:10.3390/nu15061436 · Cited by 159 · see citing works
“Various narrative reviews and cross-sectional studies indicate that consuming a diet abundant in fruits and vegetables is associated with reduced concentrations of inflammatory markers and oxidative stress (such as urinary 8-iso PG F2α, an F2-isoprostane) [50,51].”
BackgroundInfluential
Association of vegetarian diet with inflammatory biomarkers: a systematic review and meta-analysis of observational studies
Haghighatdoost, F., Bellissimo, N., Totosy de Zepetnek, J. O., & Rouhani, M. H. (2017) · Public Health Nutrition · doi:10.1017/s1368980017001768 · Cited by 153 · see citing works
“Several studies reported indirect associations between fruit intake and inflammatory markers((38,45,46)); however, one study reported that hs-CRP levels depend on the type of fruit consumed((38)).”
Background
The Dietary Approaches to Stop Hypertension (DASH) Diet Affects Inflammation in Childhood Metabolic Syndrome: A Randomized Cross-Over Clinical Trial
Saneei, P., Hashemipour, M., Kelishadi, R., & Esmaillzadeh, A. (2014) · Annals of Nutrition and Metabolism · doi:10.1159/000358341 · Cited by 149 · see citing works
Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men
Kałuża, J., Larsson, S. C., Orsini, N., Lindén, A., & Wolk, A. (2017) · Thorax · doi:10.1136/thoraxjnl-2015-207851 · Cited by 147 · see citing works
Biomedical effects of grape products
Vislocky, L. M., & Fernández, M. L. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00335.x · Cited by 146 · see citing works
Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study
Hermsdorff, H. H. M., Zulet, M. Á., Puchau, B., & Martínez, J. A. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-42 · Cited by 141 · see citing works
“These results are consistent with some earlier cross-sectional studies carried out on children and adolescents [38,39] as well as middle-age adults [7,40].”
BackgroundResult
Diet and risk of inflammatory bowel disease
Andersen, V. C., Olsen, A., Carbonnel, F., Tjønneland, A. M., & Vogel, U. B. (2011) · Digestive and Liver Disease · doi:10.1016/j.dld.2011.10.001 · Cited by 140 · see citing works
“Intake of fruit and vegetable has been found to be inversely correlated to markers of inflammation (C-reactive protein, Interleukin-6, Tumour necrosis factor) [70].”
Background
Effects of DASH Diet on Lipid Profiles and Biomarkers of Oxidative Stress in Overweight and Obese Women with Polycystic Ovary Syndrome: A Randomized Clinical Trial
Asemi, Z., Samimi, M., Tabassi, Z., Shakeri, H., Sabihi, S.-S., & Esmaillzadeh, A. (2014) · Nutrition · doi:10.1016/j.nut.2014.03.008 · Cited by 136 · see citing works
Identification and characterization of phenolic antioxidant compounds from brown Irish seaweed Himanthalia elongata using LC-DAD–ESI-MS/MS
Rajauria, G., Foley, B., & Abu‐Ghannam, N. (2016) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2016.02.005 · Cited by 133 · see citing works
Associations of Dietary Intake on Biological Markers of Inflammation in Children and Adolescents: A Systematic Review
Bujtor, M., Turner, A. I., Torres, S. J., Esteban‐Gonzalo, L., Pariante, C. M., & Borsini, A. (2021) · Nutrients · doi:10.3390/nu13020356 · Cited by 136 · see citing works
“In particular, three studies found an association between vegetable and fruit intake and lower levels of CRP [63–65], and IL-6 and TNF-α [66], both in healthy males and females, as well as in males and females with obesity [69].”
BackgroundInfluential
The effects of dietary flavonoids on the regulation of redox inflammatory networks
Izzi, V. (2012) · Frontiers in bioscience · doi:10.2741/4061 · Cited by 133 · see citing works
Fruit and vegetable consumption and risk of type 2 diabetes mellitus: A dose-response meta-analysis of prospective cohort studies
Wu, Y., Zhang, D., Jiang, X., & Jiang, W. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.10.004 · Cited by 128 · see citing works
“In addition, FV consumption confers beneficial effects on markers of inflammation and oxidative stress [5].”
Background
Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: modulation of inflammation and oxidative stress
Badawi, A. F. (2011) · Biologics · doi:10.2147/btt.s14417 · Cited by 124 · see citing works
“134 Another cross-sectional study of adolescents aged 13–17 found inverse associations between intake of fruit, vegetables, legumes, and vitamin C and urinary F 2 -isoprostane, CRP, and IL-6.”
Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents
Rondanelli, M., Faliva, M. A., Miccono, A., Naso, M., Nichetti, M., Riva, A., Guerriero, F., Gregori, M. D., Peroni, G., & Perna, S. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422417000270 · Cited by 124 · see citing works
“Holt et al.((32)) investigated this association in adolescents, confirming the results obtained for adults: the consumption of fruit and vegetables was inversely correlated with markers of inflammation (CRP, IL-6, TNF-α and 15-keto-dihydro-PGF2α metabolite) and oxidative stress (urinary 8-iso PG F2α, an F2-isoprostane…”
Result
Antioxidants and Sports Performance
Clemente‐Suárez, V. J., Bustamante-Sánchez, Á., Mielgo‐Ayuso, J., Martínez‐Guardado, I., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2023) · Nutrients · doi:10.3390/nu15102371 · Cited by 128 · see citing works
Phenolic compounds, carotenoids, and antioxidant capacities of a thermo-tolerant Scenedesmus sp. (Chlorophyta) extracted with different solvents
Bulut, O., Akın, D., Sönmez, Ç., Öktem, A., Yücel, M., & Öktem, H. A. (2019) · Journal of Applied Phycology · doi:10.1007/s10811-018-1726-5 · Cited by 112 · see citing works
Hippuric Acid in 24-Hour Urine Collections Is a Potential Biomarker for Fruit and Vegetable Consumption in Healthy Children and Adolescents,
Krupp, D., Doberstein, N., Shi, L., & Remer, T. (2012) · Journal of Nutrition · doi:10.3945/jn.112.159319 · Cited by 106 · see citing works
“Even in adolescents, a higher FV consumption has been related to lower markers of inflammation and oxidative stress (5).”
Background
Polyphenol-rich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells
Amatori, S., Mazzoni, L., Álvarez-Suárez, J. M., Giampieri, F., Gasparrini, M., Forbes-Hernández, T. Y., Afrin, S., Provenzano, A. E., Persico, G., Mezzetti, B., et al. (2016) · Scientific Reports · doi:10.1038/srep30917 · Cited by 105 · see citing works
Dietary Behaviors in Psoriasis: Patient-Reported Outcomes from a U.S. National Survey
Afifi, L., Danesh, M. J., Lee, K. M., Beroukhim, K., Farahnik, B., Ahn, R. S., Yan, D., Singh, R., Nakamura, M., Koo, J. Y. M., et al. (2017) · Dermatology and Therapy · doi:10.1007/s13555-017-0183-4 · Cited by 102 · see citing works
Cocoa flavanols: effects on vascular nitric oxide and blood pressure
Fraga, C. G., Litterio, M. C., Prince, P. D., Calabró, V., Piotrkowski, B., & Galleano, M. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-010fr · Cited by 101 · see citing works
Mitigation of Inflammation with Foods
Wu, X., & Schauss, A. G. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3007008 · Cited by 103 · see citing works
Aronia melanocarpa (chokeberry) polyphenol–rich extract improves antioxidant function and reduces total plasma cholesterol in apolipoprotein E knockout mice
Kim, B., Ku, C. S., Pham, T. X., Park, Y., Martin, D., Xie, L., Taheri, R., Lee, J., & Bolling, B. W. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.03.001 · Cited by 100 · see citing works
“Increased flavonoid consumption is also inversely correlatedwith urinary F(2)-isoprostanes, a biomarker for lipid oxidation [3].”
Background
Editorial: Regulation of Inflammation in Chronic Disease
Zhong, J., & Shi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00737 · Cited by 99 · see citing works
Vitamin C and fibre consumption from fruits and vegetables improves oxidative stress markers in healthy young adults
Hermsdorff, H. H. M., Barbosa, K. B. F., Volp, A. C. P., Puchau, B., Bressan, J., Zulet, M. Á., & Martínez, J. A. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004235 · Cited by 97 · see citing works
“Vitamin C was also strongly associated with FV intake((49,55,56)), suggesting the role of this vitamin in the antioxidant and anti-inflammatory effect of FV.”
Background
Flavan‐3‐ols, anthocyanins, and inflammation
Mena, P. R., Domínguez‐Perles, R., Gironés‐Vilaplana, A., Baenas, N., García‐Viguera, C., & Villaño, D. (2014) · IUBMB Life · doi:10.1002/iub.1332 · Cited by 96 · see citing works
Greater variety in fruit and vegetable intake is associated with lower inflammation in Puerto Rican adults
Bhupathiraju, S. N., & Tucker, K. L. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29913 · Cited by 94 · see citing works
Inflammation and oxidative stress are lower in physically fit and active adults
Shanely, R. A., Nieman, D. C., Henson, D. A., Jin, F., Knab, A. M., & Sha, W. (2011) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2011.01373.x · Cited by 93 · see citing works
“Systemic inflammation and oxidative stress are at lower levels in groups with higher fruit and vegetable intake and lower body mass index (BMI; Esmaillzadeh et al., 2006; Vincent & Taylor, 2006; Selvin et al., 2007; Holt et al., 2009).”
Background
Association between Dietary Inflammatory Index, Dietary Patterns, Plant-Based Dietary Index and the Risk of Obesity
Wang, Y. B., Shivappa, N., Hébert, J. R., Page, A. J., Gill, T. K., & Melaku, Y. A. (2021) · Nutrients · doi:10.3390/nu13051536 · Cited by 93 · see citing works
“On the other hand, intake of fruits and vegetables lowers oxidative stress and subsequently, inflammation [50,51].”
Background
Plant-Based Nutrition: Exploring Health Benefits for Atherosclerosis, Chronic Diseases, and Metabolic Syndrome—A Comprehensive Review
Peña-Jorquera, H., Cid-Jofré, V., Landaeta-Díaz, L., Petermann-Rocha, F., Martorell, M., Zbinden-Foncea, H., Ferrari, G., Jorquera-Aguilera, C., & Cristi-Montero, C. (2023) · Nutrients · doi:10.3390/nu15143244 · Cited by 103 · see citing works
“In this line, it has been hypothesized that fiber, different nutrients, bioactive components, and plant-sourced foods, such as fruits and/or vegetables, can exert their benefits on blood pressure due to the improvement in baroreflex sensitivity [290], endothelialdependent vasodilatation related to high-flavonoid intak…”
Background
A comprehensive review on phytochemistry, bioactivity and medicinal value of bioactive compounds of pomegranate (Punica granatum)
Ranjha, M. M. A. N., Shafique, B., Wang, L., Irfan, S., Safdar, M. N., Murtaza, M. A., Nadeem, M., Mahmood, S., Mueen‐ud‐Din, G., & Nadeem, H. R. (2021) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-021-00566-7 · Cited by 95 · see citing works
Combined Fruit and Vegetable Intake Is Correlated with Improved Inflammatory and Oxidant Status from a Cross-Sectional Study in a Community Setting
Root, M. M., McGinn, M. C., Nieman, D. C., Henson, D. A., Heinz, S. A., Shanely, R. A., Knab, A. M., & Jin, F. (2012) · Nutrients · doi:10.3390/nu4010029 · Cited by 89 · see citing works
“Enzyme-linked immunosorbant assays (R&D Systems, Inc. Minneapolis, MN, USA) were used to measure total plasma concentrations of interleukin-6 (IL-6, high sensitivity), interleukin-10 (IL-10, high sensitivity), granulocyte colony stimulating factor (GCSF, high sensitivity), monocyte chemoattractant protein-1 (MCP-1), a…”
BackgroundInfluential
Long-term orange juice consumption is associated with low LDL-cholesterol and apolipoprotein B in normal and moderately hypercholesterolemic subjects
Aptekmann, N. P., & Cesar, T. B. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-119 · Cited by 88 · see citing works
“Consumption of fruits and vegetables is associated with a lower risk of coronary artery disease and this effect is attributed mainly to the functional and antioxidant actions of vitamins and phytochemicals, such as phenolic compounds and flavonoids [1-5].”
Background
Molecular Mechanisms and Pathways as Targets for Cancer Prevention and Progression with Dietary Compounds
Nosrati, N., Bakovic, M., & Paliyath, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102050 · Cited by 88 · see citing works
“They suppress tumor necrosis factor α (TNF-α) induced COX-2 expression followed by down-regulation of activator protein-1 (Ap-1) and NF-κB [67,68].”
BackgroundInfluential
Major metabolite of F2-isoprostane in urine may be a more sensitive biomarker of oxidative stress than isoprostane itself
Dorjgochoo, T., Gao, Y.-T., Chow, W., Shu, X., Yang, G., Cai, Q., Rothman, N., Cai, H., Li, H., Deng, X., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.034918 · Cited by 87 · see citing works
“Antioxidant constituents, such as tocopherols, vitamin C, and polyphenols have been hypothesized to inhibit oxidative stress (3, 14, 15).”
BackgroundInfluential
Adherence to the Mediterranean diet is associated with reduced risk of incident chronic kidney diseases among Tehranian adults
Asghari, G., Farhadnejad, H., Mirmiran, P., Dizavi, A., Yuzbashian, E., & Azizi, F. (2016) · Hypertension Research · doi:10.1038/hr.2016.98 · Cited by 86 · see citing works
Effects of In Vitro Gastrointestinal Digestion on the Antioxidant Capacity and Anthocyanin Content of Cornelian Cherry Fruit Extract
David, L., Danciu, V., Moldovan, B. E., & Filip, G. A. (2019) · Antioxidants · doi:10.3390/antiox8050114 · Cited by 86 · see citing works
“A diet rich in anthocyanins results in downregulating disease markers, improves the antioxidant function, and protects cells against the deleterious effects of oxidative stress [27].”
Background
Polysaccharides as wall materials in spray-dried microencapsulation of bioactive compounds: Physicochemical properties and characterization
Halahlah, A., Piironen, V. I., Mikkonen, K. S., & Ho, T. M. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2038080 · Cited by 92 · see citing works
Epicatechin attenuates atherosclerosis and exerts anti-inflammatory effects on diet-induced human-CRP and NFκB in vivo
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Self-Report of Fruit and Vegetable Intake that Meets the 5 A Day Recommendation Is Associated with Reduced Levels of Oxidative Stress Biomarkers and Increased Levels of Antioxidant Defense in Premenopausal Women
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Authors: Holt, E. M., Steffen, L. M., Moran, A., Basu, S., Steinberger, J., Ross, J. A., Hong, C.-P., & Sinaiko, A. R.
Affiliations: University of Minnesota (US)
Uppsala University (SE)
Corresponding author: Steffen, Lyn M.
ORCID: Steffen, Lyn M.
Moran, Antoinette
Steinberger, Julia
Sinaiko, Alan R.
Venue: Journal of the American Dietetic Association
Publisher: Elsevier BV
Published: 2009-03
Volume: 109
Issue: 3
Pages: 414-421
ISSN: 0002-8223 (ISSN-L)
DOI: 10.1016/j.jada.2008.11.036
PMC: PMC2676354
OpenAlex: W2051281636
Cited by: 496
References: 80
Citations by year: 2026: 10 · 2025: 21 · 2024: 45 · 2023: 25 · 2022: 35 · 2021: 35 · 2020: 30 · 2019: 24 · 2018: 29 · 2017: 33 · 2016: 28 · 2015: 33 · 2014: 34 · 2013: 35 · 2012: 30
FWCI: 26.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the American Dietetic Association (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL052851, HL-52851)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: fruit and vegetable intake, dietary flavonoids, antioxidants, folic acid, inflammatory markers, oxidative stress, C-reactive protein, interleukin-6, TNF-α, vitamin C, beta-carotene, adolescents, cardiovascular disease prevention, dietary guidelines, Fabaceae, luteolin, dietary habits, body mass index, sex differences
MeSH terms: Adolescent, Antioxidants, C-Reactive Protein, Cardiovascular Diseases, Cross-Sectional Studies, Diet, Diet Surveys, Female, Flavonoids, Folic Acid, Fruit, Humans, Inflammation, Male, Surveys and Questionnaires, Tumor Necrosis Factor-alpha, Vegetables, Dinoprost, Biomarkers, Interleukin-6, Body Mass Index, Oxidative Stress, Statistics, Nonparametric, F2-Isoprostanes

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Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents

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