Menopause and the vaginal microbiome

Vaginal microbiome of reproductive-age women

Ravel, J., Gajer, P., Abdo, Z., Schneider, G. M., Koenig, S. S. K., McCulle, S. L., Karlebach, S., Gorle, R., Russell, J., Tacket, C. O., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002611107 · Cited by 4,254

Temporal Dynamics of the Human Vaginal Microbiota

Gajer, P., Brotman, R. M., Bai, G., Sakamoto, J., Schütte, U. M. E., Zhong, X., Koenig, S. S. K., Fu, L., Ma, Z. (., Zhou, X., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003605 · Cited by 1,558

Association between Bacterial Vaginosis and Preterm Delivery of a Low-Birth-Weight Infant

Hillier, S. L., Nugent, R. P., Eschenbach, D. A., Krohn, M. A., Gibbs, R. S., Martin, D. H., Cotch, M. F., Edelman, R., Pastorek, J. G., Rao, A. V., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199512283332604 · Cited by 1,492

A Controlled Trial of Intravaginal Estriol in Postmenopausal Women with Recurrent Urinary Tract Infections

Raz, R., & Stamm, W. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199309093291102 · Cited by 928

Vaginal Lactobacilli, Microbial Flora, and Risk of Human Immunodeficiency Virus Type 1 and Sexually Transmitted Disease Acquisition

Martin, H. L., Richardson, B. A., Nyange, P. M., Lavreys, L., Hillier, S. L., Chohan, B., Mandaliya, K., Ndinya‐Achola, J. O., Bwayo, J., & Kreiss, J. (1999) · The Journal of Infectious Diseases · doi:10.1086/315127 · Cited by 891

Vaginal Microbiome: Rethinking Health and Disease

Ma, B., Forney, L. J., & Ravel, J. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150157 · Cited by 729

Diagnosis and clinical manifestations of bacterial vaginosis

Eschenbach, D. A., Hillier, S., Critchlow, C., Stevens, C., DeRouen, T., & Holmes, K. K. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90078-6 · Cited by 549

Vaginal pH and Microbicidal Lactic Acid When Lactobacilli Dominate the Microbiota

O’Hanlon, D. E., Moench, T. R., & Cone, R. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080074 · Cited by 547

Emerging Role of Lactobacilli in the Control and Maintenance of the Vaginal Bacterial Microflora

redondo-Lopez, V., Cook, R. L., & Sobel, J. D. (1990) · Clinical Infectious Diseases · doi:10.1093/clinids/12.5.856 · Cited by 545

Temporal Variability of Human Vaginal Bacteria and Relationship with Bacterial Vaginosis

Srinivasan, S., Liu, C., Mitchell, C. M., Fiedler, T. L., Thomas, K. K., Agnew, K. J., Marrazzo, J. M., & Fredricks, D. N. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010197 · Cited by 465

Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations

Bodai, B. I., & Tuso, P. (2015) · The Permanente Journal · doi:10.7812/tpp/14-241 · Cited by 397

Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy

Brotman, R. M., Shardell, M. D., Gajer, P., Fadrosh, D., Chang, K., Silver, M. I., Viscidi, R. P., Burke, A. E., Ravel, J., & Gravitt, P. E. (2014) · Menopause · doi:10.1097/gme.0b013e3182a4690b · Cited by 391

Lifetime changes in the vulva and vagina

Farage, M., & Maibach, H. (2006) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-005-0079-x · Cited by 325

Bacteria in the Vaginal Microbiome Alter the Innate Immune Response and Barrier Properties of the Human Vaginal Epithelia in a Species-Specific Manner

Doerflinger, S. Y., Throop, A. L., & Herbst-Kralovetz, M. M. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu004 · Cited by 315

Quantitative Bacteriology of the Vaginal Flora

Bartlett, J. G., Onderdonk, A. B., Drude, E., Goldstein, C., Anderka, M., Alpert, S., & McCormack, W. M. (1977) · Journal of Infectious Diseases · doi:10.1093/infdis/136.2.271 · Cited by 302

Commonly Used Types of Postmenopausal Estrogen for Treatment of Hot Flashes: Scientific Review

Nelson, H. D. (2004) · JAMA · doi:10.1001/jama.291.13.1610 · Cited by 296

Vulvovaginal atrophy is strongly associated with female sexual dysfunction among sexually active postmenopausal women

Levine, K. B., Williams, R. E., & Hartmann, K. E. (2008) · Menopause · doi:10.1097/gme.0b013e31815a5168 · Cited by 296

Influence of the Normal Menstrual Cycle on Vaginal Tissue, Discharge, and Microflora

Eschenbach, D. A., Thwin, S. S., Patton, D. L., Hooton, T. M., Stapleton, A. E., Agnew, K., Winter, C., Meier, A., & Stamm, W. E. (2000) · Clinical Infectious Diseases · doi:10.1086/313818 · Cited by 288

Understanding vaginal microbiome complexity from an ecological perspective

Hickey, R. J., Zhou, X., Pierson, J. D., Ravel, J., & Forney, L. J. (2012) · Translational Research · doi:10.1016/j.trsl.2012.02.008 · Cited by 269

Free Glycogen in Vaginal Fluids Is Associated with Lactobacillus Colonization and Low Vaginal pH

Mirmonsef, P., Hotton, A., Gilbert, D. Z., Burgad, D., LANDAY, A. L., Weber, K. M., Cohen, M. H., Ravel, J., & Spear, G. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102467 · Cited by 249

The Microbiota of the Vagina and Its Influence on Women’s Health and Disease

Martin, D. H. (2011) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31823ea228 · Cited by 244

Antimicrobial peptides in the female reproductive tract: a critical component of the mucosal immune barrier with physiological and clinical implications

Aime, V. L., Winkle, S. M., & Herbst‐Kralovetz, M. M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu065 · Cited by 219

Prevalence of Bacterial Vaginosis and Vaginal Flora Changes in Peri- and Postmenopausal Women

Cauci, S., Driussi, S., Santo, D. D., Penacchioni, P., Iannicelli, T., Lanzafame, P., Seta, F. D., Quadrifoglio, F., Aloysio, D. D., & Guaschino, S. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.6.2147-2152.2002 · Cited by 210

Improved Understanding of the Bacterial Vaginal Microbiota of Women before and after Probiotic Instillation

Burton, J. P., Cadieux, P. A., & Reid, G. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.1.97-101.2003 · Cited by 205

Vaginal Microbiome and Epithelial Gene Array in Post-Menopausal Women with Moderate to Severe Dryness

Hummelen, R., Macklaim, J. M., Bisanz, J. E., Hammond, J.-A., McMillan, A., Vongsa, R., Koenig, D., Gloor, G. B., & Reid, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026602 · Cited by 190

Probiotics for the treatment of bacterial vaginosis

Senok, A. C., Verstraelen, H., Temmerman, M., & Botta, G. A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006289.pub2 · Cited by 189

Evaluation of the Bacterial Vaginal Flora of 20 Postmenopausal Women by Direct (Nugent Score) and Molecular (Polymerase Chain Reaction and Denaturing Gradient Gel Electrophoresis) Techniques

Burton, J. P., & Reid, G. (2002) · The Journal of Infectious Diseases · doi:10.1086/345761 · Cited by 176

Vaginal Microflora in Postmenopausal Women Who Have Not Received Estrogen Replacement Therapy

Hillier, S. L., & Lau, R. J. (1997) · Clinical Infectious Diseases · doi:10.1086/516221 · Cited by 169

The vaginal and gastrointestinal microbiomes in gynecologic cancers: A review of applications in etiology, symptoms and treatment

Chase, D. M., Goulder, A., Zenhausern, F., Monk, B. J., & Herbst‐Kralovetz, M. M. (2015) · Gynecologic Oncology · doi:10.1016/j.ygyno.2015.04.036 · Cited by 149

Comparison of methods for diagnosing bacterial vaginosis among pregnant women

Krohn, M. A., Hillier, S. L., & Eschenbach, D. A. (1989) · Journal of Clinical Microbiology · doi:10.1128/jcm.27.6.1266-1271.1989 · Cited by 143

Vaginal microbial diversity among postmenopausal women with and without hormone replacement therapy

Heinemann, C., & Reid, G. (2005) · Canadian Journal of Microbiology · doi:10.1139/w05-070 · Cited by 142

Prevalence and Determinants of Vaginal Flora Alterations in Postmenopausal Women

Pabich, W. L., Fihn, S. D., Stamm, W. E., Scholes, D., Boyko, E. J., & Gupta, K. (2003) · The Journal of Infectious Diseases · doi:10.1086/378203 · Cited by 141

Practical Aspects in the Management of Vaginal Atrophy and Sexual Dysfunction in Perimenopausal and Postmenopausal Women

Goldstein, I., & Alexander, J. L. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00131.x · Cited by 131

Ultra-low-dose estriol and Lactobacillus acidophilus vaginal tablets (Gynoflor®) for vaginal atrophy in postmenopausal breast cancer patients on aromatase inhibitors: pharmacokinetic, safety, and efficacy phase I clinical study

Donders, G. G. G., Neven, P., Mögele, M., Lintermans, A., Bellen, G., Prasauskas, V., Grob, P., Ortmann, O., & Buchholz, S. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-2930-x · Cited by 127

Association of breast cancer and its therapy with menopause-related symptoms

Crandall, C. J., Petersen, L., Ganz, P. A., & Greendale, G. A. (2004) · Menopause The Journal of The North American Menopause Society · doi:10.1097/01.gme.0000117061.40493.ab · Cited by 125

Randomized, double-blind, placebo-controlled study of oral lactobacilli to improve the vaginal flora of postmenopausal women

Petričević, L., Unger, F. M., Viernstein, H., & Kiss, H. (2008) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2008.06.003 · Cited by 121

Detection of Atopobium vaginae in Postmenopausal Women by Cultivation-Independent Methods Warrants Further Investigation

Burton, J. P., Devillard, E., Cadieux, P. A., Hammond, J.-A., & Reid, G. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.4.1829-1831.2004 · Cited by 89

Qualitative and semiquantitative analysis of Lactobacillus species in the vaginas of healthy fertile and postmenopausal Chinese women

Zhang, R., Daroczy, K., Xiao, B., Li, Y., Chen, R., & Liao, Q. (2012) · Journal of Medical Microbiology · doi:10.1099/jmm.0.038687-0 · Cited by 84

Estrogen effects on the vaginal pH, flora and cytology in late postmenopause after a long period without hormone therapy.

Galhardo, C. L., Soares, J. M., Simões, R. S., Haidar, M. A., de Lima, G. R., & Baracat, E. C. E. (2006) · PubMed · Cited by 79

Novel insight into the vaginal microflora in postmenopausal women under hormone replacement therapy as analyzed by PCR-denaturing gradient gel electrophoresis

Devillard, E., Burton, J. P., Hammond, J.-A., Lam, D., & Reid, G. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2004.02.001 · Cited by 69

Vaginal symptoms in postmenopausal women: self-reported severity, natural history, and risk factors

Huang, A. J., Moore, E. E., Boyko, E. J., Scholes, D., Lin, F., Vittinghoff, E., & Fihn, S. D. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181acb9ed · Cited by 68

Ultra-low-dose estriol and lactobacilli in the local treatment of postmenopausal vaginal atrophy

Jaisamrarn, U., Triratanachat, S., Chaikittisilpa, S., Grob, P., Prasauskas, V., & Taechakraichana, N. (2013) · Climacteric · doi:10.3109/13697137.2013.769097 · Cited by 68

Clinical diagnosis of bacterial vaginosis

Simoes, J. A., Discacciati, M. G., Brolazo, E. M., Portugal, P. M., Dini, D. V., & Dantas, M. C. M. (2006) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2006.04.013 · Cited by 63

The Lactobacillus flora in vagina and rectum of fertile and postmenopausal healthy Swedish women

Gustafsson, R. J., Ahrné, S., Jeppsson, B. W., Benoni, C., Olsson, C., Stjernquist, M., & Ohlsson, B. (2011) · BMC Women s Health · doi:10.1186/1472-6874-11-17 · Cited by 59

Vaginal flora and pelvic inflammatory disease

Faro, S., Martens, M. G., Maccato, M. L., Hammill, H., & Pearlman, M. D. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90344-i · Cited by 50

Vaginal estriol–lactobacilli combination and quality of life in endocrine-treated breast cancer

Buchholz, S., Mögele, M., Lintermans, A., et al. (2014) · Climacteric · doi:10.3109/13697137.2014.991301 · Cited by 46

A Persistent(ly) Enigmatic Ecological Mystery: Bacterial Vaginosis

Marrazzo, J. M. (2006) · The Journal of Infectious Diseases · doi:10.1086/503783 · Cited by 42

Vaginal Flora in Postmenopausal Women: The Effect of Estrogen Replacement

Ginkel, P. D., Soper, D. E., Bump, R. C., & Dalton, H. P. (1993) · Infectious Diseases in Obstetrics and Gynecology · doi:10.1155/s1064744993000225 · Cited by 41

Effect of bacterial vaginosis, Lactobacillus and Premarin estrogen replacement therapy on vaginal gene expression changes

Dahn, A., Saunders, S., Hammond, J.-A., Carter, D., Kirjavainen, P. V., Anukam, K. C., & Reid, G. (2008) · Microbes and Infection · doi:10.1016/j.micinf.2008.02.007 · Cited by 30

Differences in the vaginal lactobacilli of postmenopausal women and influence of rectal lactobacilli

Petričević, L., Domig, K. J., Nierscher, F. J., Sandhofer, M. J., Krondorfer, I., Kneifel, W., & Kiss, H. (2012) · Climacteric · doi:10.3109/13697137.2012.725788 · Cited by 25

Sexually transmitted infections in the older woman

Drew, O., & Sherrard, J. (2008) · Menopause international · doi:10.1258/mi.2008.008020 · Cited by 24

Bacterial vaginosis in climacteric and menopausal women

TAYLOR‐ROBINSON, D., McCaffrey, M. P., Pitkin, J., & Lamont, R. (2002) · International Journal of STD & AIDS · doi:10.1258/09564620260079581 · Cited by 24

The Vaginal Microenvironment: The Physiologic Role of Lactobacilli

Amabebe, E., & Anumba, D. O. C. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00181 · Cited by 785

Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy

Serrano, M. G., Parikh, H. I., Brooks, J. P., Edwards, D. J., Arodz, T. J., Edupuganti, L., Huang, B., Girerd, P. H., Bokhari, Y. A., Bradley, S. P., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0465-8 · Cited by 300

Vaginal Microbiome and Its Relationship to Behavior, Sexual Health, and Sexually Transmitted Diseases

Lewis, F. M. T., Bernstein, K. T., & Aral, S. O. (2017) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000001932 · Cited by 248

You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan

Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200

Compositional and functional features of the female premenopausal and postmenopausal gut microbiota

Zhao, H., Chen, J., Li, X., Sun, Q., Qin, P., & Wang, Q. (2019) · FEBS Letters · doi:10.1002/1873-3468.13527 · Cited by 138