Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy
Open accessAbstract
The microbiome of the female reproductive tract has implications for women's reproductive health. We examined the vaginal microbiome in two cohorts of women who experienced normal term births: a cross-sectionally sampled cohort of 613 pregnant and 1,969 non-pregnant women, focusing on 300 pregnant and 300 non-pregnant women of African, Hispanic or European ancestry case-matched for race, gestational age and household income; and a longitudinally sampled cohort of 90 pregnant women of African or non-African ancestry. In these women, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis. The shifts occurred early in pregnancy, followed predictable patterns, were associated with simplification of the metabolic capacity of the microbiome and were significant only in women of African or Hispanic ancestry. Both genomic and environmental factors are likely contributors to these trends, with socioeconomic status as a likely environmental influence.
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In MOMS-PI, women who began pregnancy with a vaginal microbiome of greater ecological complexity generally converged towards a more homogeneous Lactobacillus-dominated microbiome by the second trimester.
“Women who often began pregnancy with a vaginal microbiome of greater ecological complexity generally converged towards a more homogeneous Lactobacillus-dominated microbiome by the second trimester58.”
From The Integrative Human Microbiome Project (2019) · cites this paper as [58]
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An Insight into Vaginal Microbiome Techniques
Sharma, M., Chopra, C., Mehta, M., Sharma, V., Mallubhotla, S., Sistla, S., Sistla, J. C., & Bhushan, I. (2021) · Life · doi:10.3390/life11111229 · Cited by 20 · see citing works
- Authors
- Serrano, M. G., Parikh, H. I., Brooks, J. P., Edwards, D. J., Arodz, T. J., Edupuganti, L., Huang, B., Girerd, P. H., Bokhari, Y. A., Bradley, S. P., Brooks, J. L., Dickinson, M. R., Drake, J. I., Duckworth, R. A., Fong, S. S., Glascock, A. L., Jean, S., Jimenez, N. R., Khoury, J., Koparde, V. N., Lara, A. M., Lee, V., Matveyev, A. V., Milton, S. H., Mistry, S. D., Rozycki, S. K., Sheth, N. U., Smirnova, E., Vivadelli, S. C., Wijesooriya, N. R., Xu, J., Xu, P., Chaffin, D. O., Sexton, A. L., Gravett, M. G., Rubens, C. E., Hendricks-Muñoz, K. D., Jefferson, K. K., Strauss, J. F., Fettweis, J. M., & Buck, G. A.
- Affiliations
- Virginia Commonwealth University (US)
- Global Alliance to Prevent Prematurity and Stillbirth (US)
- University of Washington (US)
- Corresponding author
- Buck, Gregory A.
- ORCID
- Serrano, Myrna G.
- Parikh, Hardik I.
- Brooks, J. Paul
- Edwards, David J.
- Arodz, Tom J.
- Edupuganti, Laahirie
- Bokhari, Yahya A.
- Brooks, Jamie L.
- Drake, Jennifer I.
- Fong, Stephen S.
- Glascock, Abigail L.
- Jimenez, Nicole R.
- Rozycki, Sarah K.
- Smirnova, Ekaterina
- Xu, Ping
- Gravett, Michael G.
- Jefferson, Kimberly K.
- Strauss, Jerome F.
- Fettweis, Jennifer M.
- Buck, Gregory A.
- Venue
- Nature Medicine
- Published
- 2019-05-29
- Volume
- 25
- Issue
- 6
- Pages
- 1001-1011
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC6746180
- OpenAlex
- W2947787281
- Cited by
- 300
- References
- 70
- Citations by year
- 2026: 28 · 2025: 31 · 2024: 40 · 2023: 58 · 2022: 46 · 2021: 52 · 2020: 33 · 2019: 12
- FWCI
- 26.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R25GM090084)
- National Institute of Allergy and Infectious Diseases (UH2AI083263, UH3AI083263)
- National Institute of Dental and Craniofacial Research (U54DE023786)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD080784, R01HD092415, R21HD092965)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- vaginal microbiota, pregnancy, racial and ethnic diversity, Lactobacillus, vaginal dysbiosis, African ancestry, Hispanic origin, socioeconomic status, reproductive tract microbiome, term birth
- MeSH terms
- Host Microbial Interactions, Adult, Black or African American, Cross-Sectional Studies, Female, Hispanic or Latino, Humans, Pregnancy, Social Class, Vagina, Cohort Studies, White People, Biodiversity, Microbiota
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