Cited by 156Endometriosis Research and TreatmentEstrogen and related hormone effectsEndometrial and Cervical Cancer Treatments

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Estrogen metabolism and action in endometriosis

Rižner, Tea Lanišnik·2009·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2009.03.022

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Abstract

Endometriosis is a complex estrogen-dependent disease that is defined as the presence of endometrial glands and stroma outside the uterine cavity. The etiology of endometriosis is multifactorial and includes complex interactions of genetic, immunological, hormonal and environmental factors. Many theories have been proposed, but no single theory can explain all aspects of endometriosis, suggesting that endometriosis is a heterogeneous disease. This review presents the current theories on the pathogenesis of endometriosis, followed by an overview on estrogen metabolism in normal endometrium and diseased endometrium of endometriosis patients. The potential role of aberrant expression of individual estrogen-metabolizing enzymes is discussed, and a model mechanism for increased formation of estradiol is presented separately for different types of endometriosis. The disturbed expression of estrogen receptors in endometriosis is detailed, and the estrogen biosynthetic enzymes and receptors are discussed as novel therapeutic targets for the treatment of endometriosis.

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Authors: Rižner, T. L.
Affiliations: University of Ljubljana (SI)
Corresponding author: Rižner, Tea Lanišnik
ORCID: Rižner, Tea Lanišnik
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2009-08
Volume: 307
Issue: 1-2
Pages: 8-18
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2009.03.022
OpenAlex: W2163825655
Semantic Scholar: c603753d7a96016b2da52a05cc0370ed18a55340
Cited by: 153
References: 120
Citations by year: 2026: 5 · 2025: 10 · 2024: 13 · 2023: 8 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 10 · 2018: 9 · 2017: 9 · 2016: 13 · 2015: 9 · 2014: 9 · 2013: 8 · 2012: 11
FWCI: 1.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords: endometriosis, estrogen metabolism, estradiol synthesis, estrogen receptor, endometrium, endometriosis pathogenesis, therapeutic target
MeSH terms: Endometriosis, Endometrium, Estrogens, Female, Humans, Receptors, Estrogen

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Estrogen metabolism and action in endometriosis

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