Cited by 150Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorHypothalamic control of reproductive hormones

Serotonin and the regulation of mammalian energy balance

Open access
Donovan, Michael H., Tecott, Laurence H.·2013·Frontiers in Neuroscience

Abstract

Maintenance of energy balance requires regulation of the amount and timing of food intake. Decades of experiments utilizing pharmacological and later genetic manipulations have demonstrated the importance of serotonin signaling in this regulation. Much progress has been made in recent years in understanding how central nervous system (CNS) serotonin systems acting through a diverse array of serotonin receptors impact feeding behavior and metabolism. Particular attention has been paid to mechanisms through which serotonin impacts energy balance pathways within the hypothalamus. How upstream factors relevant to energy balance regulate the release of hypothalamic serotonin is less clear, but work addressing this issue is underway. Generally, investigation into the central serotonergic regulation of energy balance has had a predominantly "hypothalamocentric" focus, yet non-hypothalamic structures that have been implicated in energy balance regulation also receive serotonergic innervation and express multiple subtypes of serotonin receptors. Moreover, there is a growing appreciation of the diverse mechanisms through which peripheral serotonin impacts energy balance regulation. Clearly, the serotonergic regulation of energy balance is a field characterized by both rapid advances and by an extensive and diverse set of central and peripheral mechanisms yet to be delineated.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fnins.2013.00036

Cites

248 of 248 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Variations in intestinal 5-HT production are unlikely to have a direct effect on the brain because 5-HT cannot cross the BBB.

    “Variations in intestinal 5-HT production are unlikely to have a direct effect on the brain because 5-HT cannot cross the BBB (Donovan and Tecott, 2013).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Donovan and Tecott, 2013

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Erspamer V. (1966). Handbook of Experimental Pharmacology: 5-Hydroxytryptamine and Related Indolealkylamines, Vol. 19. New York, NY: Springer-Verlag

Cited by

Sorted by citations

Authors
Donovan, M. H., & Tecott, L. H.
Affiliations
University of California, San Francisco (US)
Corresponding author
Tecott, Laurence H.
Venue
Frontiers in Neuroscience
Published
2013
Volume
7
Pages
36-36
ISSN
1662-453X (ISSN-L)
OpenAlex
W2112809623
Cited by
150
References
248
Citations by year
2026: 6 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 10 · 2021: 22 · 2020: 16 · 2019: 14 · 2018: 14 · 2017: 10 · 2016: 12 · 2015: 11 · 2014: 6 · 2013: 3
FWCI
5.76
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
serotonin, energy balance, feeding behavior, serotonin receptors, hypothalamus, central serotonergic system, peripheral serotonin, food intake regulation, metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review