Environmentally induced epigenetic transgenerational inheritance of phenotype and disease
Open accessAbstract
Environmental epigenetics has an important role in regulating phenotype formation or disease etiology. The ability of environmental factors and exposures early in life to alter somatic cell epigenomes and subsequent development is a critical factor in how environment affects biology. Environmental epigenetics provides a molecular mechanism to explain long term effects of environment on the development of altered phenotypes and "emergent" properties, which the "genetic determinism" paradigm cannot. When environmental factors permanently alter the germ line epigenome, then epigenetic transgenerational inheritance of these environmentally altered phenotypes and diseases can occur. This environmental epigenetic transgenerational inheritance of phenotype and disease is reviewed with a systems biology perspective.
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Offspring effects may be mediated, in part, by epigenetic changes in parental germ cells resulting from acquired parental stress exposures throughout life.
“Offspring effects may be mediated, in part, by epigenetic changes in parental germ cells resulting from acquired parental stress exposures throughout life 3,[168][169][170]”
From Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms (2018) · cites this paper as [169]
Section 2 (page unavailable) says environmental exposures can alter the germ-line epigenome and affect subsequent generations. Section 3 identifies stress as a factor that can influence phenotypes transgenerationally. But the paper places germ-line epigenetic alteration in a narrow developmental window, rather than supporting the claim that parental exposures throughout life produce those changes. (LLM, conf=0.87)
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Byun, J., Peterson, C. M., Backonja, U., Taylor, R. N., Stanford, J. B., Allen-Brady, K. L., Smith, K. R., Louis, G. M. B., & Schliep, K. C. (2020) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2020.01.002 · Cited by 27 · see citing works
- Authors
- Guerrero-Bosagna, C., & Skinner, M. K.
- Affiliations
- Washington State University (US)
- ORCID
- Skinner, Michael K.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 354
- Issue
- 1-2
- Pages
- 3-8
- ISSN
- 0303-7207 (ISSN-L)
- PMC
- PMC3312615
- OpenAlex
- W2097945707
- Cited by
- 222
- References
- 99
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 21 · 2023: 14 · 2022: 9 · 2021: 6 · 2020: 19 · 2019: 8 · 2018: 13 · 2017: 19 · 2016: 14 · 2015: 21 · 2014: 24 · 2013: 23 · 2012: 18
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Environmental Health Sciences (R01ES012974)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- environmental epigenetics, transgenerational epigenetic inheritance, early life exposure, etiology, genetic determinism, systems biology
- MeSH terms
- Animals, Cell Division, Disease, Environment, Environmental Exposure, Environmental Pollutants, Humans, Phenotype, Reproduction, Germ-Line Mutation, Epigenesis, Genetic, Systems Biology, Endocrine Disruptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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