Cited by 42Muscle Physiology and DisordersAdipose Tissue and MetabolismNutrition and Health in Aging

Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy

Singh, Abhishek Kumar, Shree, Sonal, Chattopadhyay, Sourav, Kumar, Sudhir, Gurjar, Anagha, Kushwaha, Sapana, Kumar, Harish, Trivedi, Arun Kumar +4 more·2017·Molecular and Cellular Endocrinology

Abstract

Skeletal muscle atrophy is a debilitating response to several major diseases, muscle disuse and chronic steroid treatment for which currently no therapy is available. Since adiponectin signaling plays key roles in muscle energetics, we assessed if globular adiponectin (gAd) or the small molecule adiponectin mimetic 6-C-β-D-glucopyranosyl-(2S,3S)-(+)-5,7,3',4'-tetrahydroxydihydroflavonol (GTDF) could ameliorate muscle atrophy. Both GTDF and gAd induced C2C12 myoblast differentiation. GTDF and gAd effectively prevented reduction in myotube area and suppressed the expressions of atrophy markers; atrogin-1 and muscle ring finger protein-1 (MuRF1) in models of steroid, cytokine and starvation -induced muscle atrophy. The protective effects of GTDF and gAd were routed through AMPK and AKT activation and thereby stimulation of PPAR gamma coactivator 1α and inhibition of forkhead box O transcription factors. Finally, GTDF and gAd mitigated dexamethasone-induced muscle atrophy in vivo. Together, our results demonstrate that activating adiponectin signaling may be an effective therapeutic strategy against skeletal muscle atrophy.

Integrity signals

Registry

Crossref · 10.1016/j.mce.2016.09.013

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Singh, A. K., Shree, S., Chattopadhyay, S., Kumar, S., Gurjar, A., Kushwaha, S., Kumar, H., Trivedi, A. K., Chattopadhyay, N., Maurya, R., Ramachandran, R., & Sanyal, S.
Affiliations
Central Drug Research Institute (IN)
Corresponding author
Sanyal, Sabyasachi
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2017-01
Volume
439
Pages
273-285
ISSN
0303-7207 (ISSN-L)
OpenAlex
W2519281549
Cited by
42
References
50
Citations by year
2026: 6 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 1
FWCI
1.73
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • CSIR
  • UGC
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
skeletal muscle atrophy, adiponectin receptor agonist, globular adiponectin, AMPK, Akt, PPARγ coactivator-1α, forkhead box O, atrogin-1, MuRF1, dexamethasone-induced atrophy, myogenesis, muscle energetics
MeSH terms
Tripartite Motif Proteins, Adenylate Kinase, Animals, Calcium, Cell Differentiation, Cell Line, Dexamethasone, Female, Glucosides, Lipopolysaccharides, Muscle Proteins, Muscular Atrophy, Tumor Necrosis Factor-alpha, Rats, Sprague-Dawley, Muscle, Skeletal, Phosphatidylinositol 3-Kinases, Protective Agents, Muscle Development, Myoblasts, Ubiquitin-Protein Ligases, Flavonols, Mice, Adiponectin, Receptors, Adiponectin, Small Molecule Libraries

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review