Adiponectin—Consideration for its Role in Skeletal Muscle Health

Krause, Matthew P.; Milne, Kevin J.; Hawke, Thomas J.

doi:10.3390/ijms20071528

Cited by 123Adipokines, Inflammation, and Metabolic DiseasesMuscle Physiology and DisordersAdipose Tissue and Metabolism

Adiponectin—Consideration for its Role in Skeletal Muscle Health

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Krause, Matthew P., Milne, Kevin J., Hawke, Thomas J.·2019·International Journal of Molecular Sciences

DOI 10.3390/ijms20071528PMC PMC6480271

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Abstract

Adiponectin regulates metabolism through blood glucose control and fatty acid oxidation, partly mediated by downstream effects of adiponectin signaling in skeletal muscle. More recently, skeletal muscle has been identified as a source of adiponectin expression, fueling interest in the role of adiponectin as both a circulating adipokine and a locally expressed paracrine/autocrine factor. In addition to being metabolically responsive, skeletal muscle functional capacity, calcium handling, growth and maintenance, regenerative capacity, and susceptibility to chronic inflammation are all strongly influenced by adiponectin stimulation. Furthermore, physical exercise has clear links to adiponectin expression and circulating concentrations in healthy and diseased populations. Greater physical activity is generally related to higher adiponectin expression while lower adiponectin levels are found in inactive obese, pre-diabetic, and diabetic populations. Exercise training typically restores plasma adiponectin and is associated with improved insulin sensitivity. Thus, the role of adiponectin signaling in skeletal muscle has expanded beyond that of a metabolic regulator to include several aspects of skeletal muscle function and maintenance critical to muscle health, many of which are responsive to, and mediated by, physical exercise.

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Effects of acute exercise on ApN parameters are inconsistent, if any.
“Effects of acute exercise on ApN parameters are inconsistent, if any [77,78].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [77]
Circulating ApN was linked to physical activity behavior in large human cross-sectional studies, where greater physical activity was generally associated with higher ApN levels.
“In parallel to imposed bouts of exercise training, circulating ApN was linked to physical activity behavior in large human cross-sectional studies, where greater physical activity was generally associated with higher ApN levels [77,85,86].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [77]

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725 · see citing works
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238 · see citing works
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133 · see citing works
Mechanisms of Diabetic Complications
Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890 · see citing works
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,139 · see citing works
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 1,987 · see citing works
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,762 · see citing works
Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., Retzlaff, B. M., Knopp, R. H., Brunzell, J. D., & Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-003-1074-z · Cited by 1,483 · see citing works
Adiponectin and protection against type 2 diabetes mellitus
Spranger, J., Kroke, A., Möhlig, M., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12255-6 · Cited by 1,120 · see citing works
Calcium Ion in Skeletal Muscle: Its Crucial Role for Muscle Function, Plasticity, and Disease
Berchtold, M. W., Brinkmeier, H., & Müntener, M. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1215 · Cited by 1,007 · see citing works
Adiponectin Levels and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis
Li, S., Shin, H. J., Ding, E. L., & van Dam, R. M. (2009) · JAMA · doi:10.1001/jama.2009.976 · Cited by 991 · see citing works
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms
Shibata, R., Sato, K., Pimentel, D. R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N., & Walsh, K. (2005) · Nature Medicine · doi:10.1038/nm1295 · Cited by 982 · see citing works
Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1
Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., et al. (2010) · Nature · doi:10.1038/nature08991 · Cited by 971 · see citing works
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature · doi:10.1038/nature12656 · Cited by 757 · see citing works
Adiponectin, the past two decades
Wang, Z. V., & Scherer, P. E. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw011 · Cited by 609 · see citing works
Measurement of the High–Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin Resistance and Metabolic Syndrome
Hara, K., Horikoshi, M., Yamauchi, T., Yago, H., Miyazaki, O., Ebinuma, H., Imai, Y., Nagai, R., & Kadowaki, T. (2006) · Diabetes Care · doi:10.2337/dc05-1801 · Cited by 574 · see citing works
Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss
Balducci, S., Zanuso, S., Nicolucci, A., Fernando, F., Cavallo, S., Cardelli, P., Fallucca, S., Alessi, E., Letizia, C., Jimenez, A., et al. (2010) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.04.015 · Cited by 566 · see citing works
Adiponectin and Breast Cancer Risk
Mantzoros, C. S., Petridou, E. T., Dessypris, N., Chavelas, C., Dalamaga, Μ., Alexe, D. M., Papadiamantis, Y., Markopoulos, C. J., Spanos, E., Chrousos, G. P., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031804 · Cited by 532 · see citing works
Circadian clock control of endocrine factors
Gamble, K. L., Berry, R., Frank, S. J., & Young, M. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.78 · Cited by 529 · see citing works
Radioimmunoassay of leptin in human plasma
Ma, Z., Gingerich, R. L., Santiago, J. V., Klein, S., Smith, C. H., & Landt, M. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.6.942 · Cited by 493 · see citing works
Sedentary Lifestyle, Poor Cardiorespiratory Fitness, and the Metabolic Syndrome
Lakka, T. A., Laaksonen, D. E., Lakka, H.-M., NNIKK, N. M., NISKANEN, L. K., Rauramaa, R., & Salonen, J. T. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000079076.74931.9a · Cited by 472 · see citing works
Gender Differences of Adiponectin Levels Develop during the Progression of Puberty and Are Related to Serum Androgen Levels
Böttner, A., Kratzsch, J., Müller, G., Kapellen, T. M., Blüher, S., Keller, E., Blüher, M., & Kieß, W. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0303 · Cited by 454 · see citing works
Post-translational modifications of adiponectin: mechanisms and functional implications
Wang, Y., Lam, K. S. L., Yau, M.-H., & Xu, A. (2008) · Biochemical Journal · doi:10.1042/bj20071492 · Cited by 405 · see citing works
Control of the size of the human muscle mass
Rennie, M. J., Wackerhage, H., Spangenburg, E. E., & Booth, F. W. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.052102.134444 · Cited by 399 · see citing works
Adiponectin receptors: A review of their structure, function and how they work
Yamauchi, T., Iwabu, M., Okada‐Iwabu, M., & Kadowaki, T. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.09.003 · Cited by 355 · see citing works
Decreased Plasma Adiponectin Concentrations Are Closely Related to Hepatic Fat Content and Hepatic Insulin Resistance in Pioglitazone-Treated Type 2 Diabetic Patients
Bajaj, M. S., Suraamornkul, S., Piper, P. K., Hardies, L. J., Glass, L. C., Cersósimo, E., Pratipanawatr, T., Miyazaki, Y., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031315 · Cited by 354 · see citing works
Adiponectin is synthesized and secreted by human and murine cardiomyocytes
Piñeiro, R., Iglesias, M. J., Gallego, R., Raghay, K., Eiras, S., Rubio, J., Diéguez, C., Gualillo, O., González-Juanatey, J. R., & Lago, F. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.098 · Cited by 350 · see citing works
Hydroxylation and Glycosylation of the Four Conserved Lysine Residues in the Collagenous Domain of Adiponectin
Wang, Y., Xu, A., Knight, C. G., Xu, L. Y., & Cooper, G. J. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200601200 · Cited by 342 · see citing works
Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1
Waki, H., Yamauchi, T., Kamon, J., Kita, S., Ito, Y., Hada, Y., Uchida, S., Tsuchida, A., Takekawa, S., & Kadowaki, T. (2005) · Endocrinology · doi:10.1210/en.2004-1096 · Cited by 319 · see citing works
Rhythmic Messenger Ribonucleic Acid Expression of Clock Genes and Adipocytokines in Mouse Visceral Adipose Tissue
Ando, H., Yanagihara, H., Hayashi, Y., Obi, Y., Tsuruoka, S., Takamura, T., Kaneko, S., & Fujimura, A. (2005) · Endocrinology · doi:10.1210/en.2005-0771 · Cited by 312 · see citing works
Correlation Between Adiponectin, Tumor Necrosis Factor-alpha, Insulin Resistance and Atherogenic Dyslipidemia in Non Diabetic Central Obese Males
Ninghayu, C., Wijaya, A., & As’ád, S. (2010) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v2i1.113 · Cited by 305 · see citing works
CTRP family: linking immunity to metabolism
Schäffler, A., & Buechler, C. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.12.003 · Cited by 293 · see citing works
Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: Associations with metabolic parameters and insulin resistance and regulation by physical training
Blüher, M., Bullen, J. W., Lee, J. H., Kralisch, S., Fasshauer, M., Klöting, N., Niebauer, J., Schön, M. R., Williams, C. J., & Mantzoros, C. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2556 · Cited by 293 · see citing works
Effects of Exercise on Adiponectin: A Systematic Review
Simpson, K. A., & Singh, M. A. F. (2008) · Obesity · doi:10.1038/oby.2007.53 · Cited by 260 · see citing works
Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study
Christiansen, T., Paulsen, S. K., Bruun, J. M., Pedersen, S. B., & Richelsen, B. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00574.2009 · Cited by 255 · see citing works
Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: A meta-analysis of randomized controlled trials
Hayashino, Y., Jackson, J. L., Hirata, T., Fukumori, N., Nakamura, F., Fukuhara, S., Tsujii, S., & Ishii, H. (2014) · Metabolism · doi:10.1016/j.metabol.2013.08.018 · Cited by 244 · see citing works
Induction of Adiponectin in Skeletal Muscle by Inflammatory Cytokines: <i>in Vivo</i> and <i>in Vitro</i> Studies
Delaigle, A. M., Jonas, J.-C., Bauche, I. B., Cornu, O., & Brichard, S. M. (2004) · Endocrinology · doi:10.1210/en.2004-0503 · Cited by 241 · see citing works
Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes
Lehr, S., Hartwig, S., Lamers, D., Famulla, S., Müller, S., Hanisch, F., Cuvelier, C. A., Ruige, J. B., Eckardt, K., Ouwens, D. M., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.010504 · Cited by 241 · see citing works
Adiponectin Stimulates Autophagy and Reduces Oxidative Stress to Enhance Insulin Sensitivity During High-Fat Diet Feeding in Mice
Liu, Y., Palanivel, R., Rai, E., Park, M. S., Gabor, T. V., Scheid, M. P., Xu, A., & Sweeney, G. (2014) · Diabetes · doi:10.2337/db14-0267 · Cited by 223 · see citing works
Plasma Adiponectin Complexes Have Distinct Biochemical Characteristics
Schraw, T., Wang, Z. V., Halberg, N., Hawkins, M. A., & Scherer, P. E. (2008) · Endocrinology · doi:10.1210/en.2007-1561 · Cited by 216 · see citing works
The effects of obesity on skeletal muscle contractile function
Tallis, J. A., James, R. S., & Seebacher, F. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.163840 · Cited by 214 · see citing works
Adiponectin Activates AMP-Activated Protein Kinase in Muscle Cells via APPL1/LKB1-Dependent and Phospholipase C/Ca2+/Ca2+/Calmodulin-Dependent Protein Kinase Kinase-Dependent Pathways
Zhou, L., Deepa, S. S., Etzler, J. C., Ryu, J., Mao, X., Fang, Q., Liu, D. D., Torres, J. M., Jia, W., Lechleiter, J. D., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.028357 · Cited by 212 · see citing works
Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms
Krause, M. P., Riddell, M. C., & Hawke, T. J. (2010) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2010.00699.x · Cited by 189 · see citing works
Self-citation
Evidence for the contribution of insulin resistance to the development of cachexia in tumor‐bearing mice
Asp, M., Tian, M., Wendel, A., & Belury, M. (2010) · International Journal of Cancer · doi:10.1002/ijc.24784 · Cited by 176 · see citing works
Serum markers of inflammation and oxidative stress in sarcopenia
Can, B., Kara, O., Kizilarslanoglu, M. C., Arik, G., Aycicek, G. S., Sumer, F., Civelek, R., Demirtas, C., & Ulger, Z. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0626-2 · Cited by 176 · see citing works
Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function
Krause, M. P., Liu, Y., Vu, V., Chan, L., Xu, A., Riddell, M. C., Sweeney, G., & Hawke, T. J. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00030.2008 · Cited by 168 · see citing works
Self-citation
Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor γ
Ding, G., Qin, Q., He, N., Francis, S., Hou, J., Liu, J., Ricks, E., & Yang, Q. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.04.014 · Cited by 150 · see citing works
The metabolism of isoforms of human adiponectin: studies in human subjects and in experimental animals
Peake, P. W., Kriketos, A. D., Campbell, L. V., Shen, Y., & CHARLESWORTH, J. A. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01978 · Cited by 150 · see citing works
Gene Expression Profiles of Nondiabetic and Diabetic Obese Mice Suggest a Role of Hepatic Lipogenic Capacity in Diabetes Susceptibility
Hong, L., Rabaglia, M. E., Stoehr, J. P., Nadler, S. T., Schueler, K. L., Zou, F., Yandell, B. S., & Attie, A. (2003) · Diabetes · doi:10.2337/diabetes.52.3.688 · Cited by 141 · see citing works
Muscle-Specific Adaptations, Impaired Oxidative Capacity and Maintenance of Contractile Function Characterize Diet-Induced Obese Mouse Skeletal Muscle
Shortreed, K. E., Krause, M. P., Huang, J. H., Dhanani, D., Moradi, J., Ceddia, R. B., & Hawke, T. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007293 · Cited by 131 · see citing works
Self-citation
The role of adipokines in skeletal muscle inflammation and insulin sensitivity
Nicholson, T. A., Church, C., Baker, D. J., & Jones, S. W. (2018) · Journal of Inflammation · doi:10.1186/s12950-018-0185-8 · Cited by 128 · see citing works
The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle
Punyadeera, C., Zorenc, A. H. G., Koopman, R., McAinch, A. J., Smit, E., MANDERS, R. J. F., KEIZER, H. A., Cameron‐Smith, D., & van Loon, L. J. C. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01872 · Cited by 111 · see citing works
Sustained Reduction in Plasma Free Fatty Acid Concentration Improves Insulin Action without Altering Plasma Adipocytokine Levels in Subjects with Strong Family History of Type 2 Diabetes
Bajaj, M., Suraamornkul, S., Kashyap, S., Cusi, K., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0224 · Cited by 109 · see citing works
Adiponectin action in skeletal muscle
Liu, Y., & Sweeney, G. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.08.003 · Cited by 107 · see citing works
Benefits of Regular Exercise on Inflammatory and Cardiovascular Risk Markers in Normal Weight, Overweight and Obese Adults
Gondim, O. S., de Camargo, V. T. N., Gutierrez, F. A., Martins, P. F. D. O., Passos, M. E. P., Momesso, C. M., Santos, V. C., Gorjão, R., Pithon‐Curi, T. C., & Cury‐Boaventura, M. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140596 · Cited by 103 · see citing works
Adiponectin promotes muscle regeneration through binding to T-cadherin
Tanaka, Y., Kita, S., Nishizawa, H., Fukuda, S., Fujishima, Y., Obata, Y., Nagao, H., Masuda, S., Nakamura, Y., Shimizu, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37115-3 · Cited by 103 · see citing works
Succination of Thiol Groups in Adipose Tissue Proteins in Diabetes
Frizzell, N., Rajesh, M. P., Jepson, M. J., Nagai, R., Carson, J. A., Thorpe, S. R., & Baynes, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019257 · Cited by 99 · see citing works
Global loss of bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism
Kennaway, D. J., Varcoe, T. J., Voultsios, A., & Boden, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065255 · Cited by 93 · see citing works
Adiponectin—It's all about the modifications
Simpson, F., & Whitehead, J. P. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.12.021 · Cited by 93 · see citing works
Exercise restores muscle stem cell mobilization, regenerative capacity and muscle metabolic alterations via adiponectin/AdipoR1 activation in SAMP10 mice
Inoue, A., Cheng, X. W., Huang, Z., Hu, L., Kikuchi, R., Jiang, H., Piao, L., Sasaki, T., Itakura, K., Wu, H., et al. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12166 · Cited by 89 · see citing works
Acute Anaerobic Exercise Affects the Secretion of Asprosin, Irisin, and Other Cytokines – A Comparison Between Sexes
Więcek, M., Szymura, J., Maciejczyk, M., Kantorowicz, M., & Szyguła, Z. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01782 · Cited by 83 · see citing works
Exercise Training Modifies Ghrelin and Adiponectin Concentrations and Is Related to Inflammation in Older Adults
Markofski, M. M., Carrillo, A. E., Timmerman, K. L., Jennings, K., Coen, P. M., Pence, B. D., & Flynn, M. G. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt132 · Cited by 80 · see citing works
Ronning After the Adiponectin Receptors
Holland, W. L., & Scherer, P. E. (2013) · Science · doi:10.1126/science.1249077 · Cited by 79 · see citing works
Induction of adiponectin in skeletal muscle of type 2 diabetic mice: In vivo and in vitro studies
Delaigle, A. M., Senou, M., Guiot, Y., Many, M. C., & Brichard, S. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0210-y · Cited by 79 · see citing works
Circulating adiponectin levels and risk of type 2 diabetes in the Japanese
Yamamoto, S., Matsushita, Y., Nakagawa, T., Hayashi, T., Noda, M., & Mizoue, T. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2014.27 · Cited by 76 · see citing works
Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats
Guo, Z., Xia, Z., Yuen, V. G., & McNeill, J. H. (2007) · Metabolism · doi:10.1016/j.metabol.2007.05.005 · Cited by 76 · see citing works
Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy
Boursereau, R., Abou-Samra, M., Lecompte, S., Noel, L., & Brichard, S. M. (2018) · BMC Biology · doi:10.1186/s12915-018-0501-z · Cited by 72 · see citing works
Independent and Combined Effects of Physical Activity and Weight Loss on Inflammatory Biomarkers in Overweight and Obese Older Adults
Beavers, K. M., Ambrosius, W. T., Nicklas, B. J., & Rejeski, W. J. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12321 · Cited by 70 · see citing works
Globular adiponectin induces differentiation and fusion of skeletal muscle cells
Fiaschi, T., Cirelli, D., Comito, G., Gelmini, S., Ramponi, G., Serio, M., & Chiarugi, P. (2009) · Cell Research · doi:10.1038/cr.2009.39 · Cited by 70 · see citing works
Acute Exercise Increases Adiponectin Levels in Abdominally Obese Men
Saunders, T. J., Palombella, A. S., McGuire, K. A., Janiszewski, P. M., Després, J., & Ross, R. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/148729 · Cited by 70 · see citing works
High‐fat Diet Followed by Fasting Disrupts Circadian Expression of Adiponectin Signaling Pathway in Muscle and Adipose Tissue
Barnea, M., Madar, Z., & Froy, O. (2009) · Obesity · doi:10.1038/oby.2009.276 · Cited by 67 · see citing works
Adiponectin improves insulin sensitivity via activation of autophagic flux
Ahlstrom, P. F. U., Rai, E., Chakma, S., Cho, H. H., Palanivel, R., & Sweeney, G. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0096 · Cited by 62 · see citing works
Perfect chronic skeletal muscle regeneration in adult spiny mice, Acomys cahirinus
Maden, M., Brant, J. O., Rubiano, A. M., Sandoval, A. G. W., Simmons, C. S., Mitchell, R., Collins‐Hooper, H., Jacobson, J., Omairi, S., & Patel, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-27178-7 · Cited by 62 · see citing works
An approximation to the temporal order in endogenous circadian rhythms of genes implicated in human adipose tissue metabolism
Garaulet, M., Ordovás, J. M., Gómez-Abellán, P., Martínez, J. A., & Madrid, J. A. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22531 · Cited by 61 · see citing works
Succination of proteins in diabetes
Frizzell, N., Lima, M., & Baynes, J. (2010) · Free Radical Research · doi:10.3109/10715762.2010.524643 · Cited by 59 · see citing works
Adiposity, Aerobic Fitness, Muscle Fitness, and Markers of Inflammation in Children
Steene‐Johannessen, J., Kolle, E., Andersen, L. B., & Anderssen, S. A. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318279707a · Cited by 58 · see citing works
New diagnostic index for sarcopenia in patients with cardiovascular diseases
Harada, H., Kai, H., Shibata, R., Niiyama, H., Nishiyama, Y., Murohara, T., Yoshida, N., Katoh, A., & Ikeda, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178123 · Cited by 58 · see citing works
Association of adiponectin with peripheral muscle status in elderly patients with heart failure
Loncar, G., Nedeljković, B. B., von Haehling, S., Düngen, H., Prodanović, N., Lainščak, M., Arandjelovic, A., Dimković, S., Radojicic, Z. A., & POPOVIC, V. M. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.09.011 · Cited by 55 · see citing works
Involvement of adiponectin in the pathogenesis of dystrophinopathy
Abou-Samra, M., Lecompte, S., Schakman, O., Noel, L., Many, M. C., Gailly, P., & Brichard, S. M. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0051-9 · Cited by 55 · see citing works
Adolescent Sex Differences in Adiponectin Are Conditional on Pubertal Development and Adiposity
Woo, J. G., Dolan, L. M., Daniels, S. R., Goodman, E., & Martin, L. J. (2005) · Obesity Research · doi:10.1038/oby.2005.260 · Cited by 49 · see citing works
Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats.
Yang, B.-C., Chen, L.-H., Qian, Y., Triantafillou, J., McNulty, J. A., Carrick, K., Clifton, L. G., Han, B., Geske, R., Strum, J., et al. (2006) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2005.12.172 · Cited by 49 · see citing works
Sialic Acid Modification of Adiponectin Is Not Required for Multimerization or Secretion but Determines Half-Life in Circulation
Richards, A. A., Colgrave, M. L., Zhang, J., Webster, J. A., Simpson, F., Preston, E., Wilks, D. L., Hoehn, K. L., Stephenson, M., Macdonald, G. A., et al. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0133 · Cited by 48 · see citing works
Differential metabolic effects of constant moderate versus high intensity interval training in high-fat fed mice: possible role of muscle adiponectin
Martínez-Huenchullán, S., Maharjan, B. R., Williams, P. F., Tam, C. S., McLennan, S. V., & Twigg, S. M. (2018) · Physiological Reports · doi:10.14814/phy2.13599 · Cited by 48 · see citing works
Tissue Distribution of S‐(2‐Succino)cysteine (2SC), a Biomarker of Mitochondrial Stress in Obesity and Diabetes
Thomas, S., Storey, K. B., Baynes, J., & Frizzell, N. (2011) · Obesity · doi:10.1038/oby.2011.340 · Cited by 46 · see citing works
High circulating adiponectin levels predict decreased muscle strength among older adults aged 70 years and over: A prospective cohort study
Huang, C. X., Tomata, Y., Kakizaki, M., Sugawara, Y., Hozawa, A., Momma, H., Tsuji, I., & Nagatomi, R. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.03.010 · Cited by 45 · see citing works
Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice
Dankel, S. N., Degerud, E., Borkowski, K., Fjære, E., Midtbø, L. K., Haugen, C., Solsvik, M. H., Lavigne, A. M., Liaset, B., Sagen, J. V., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00188.2013 · Cited by 44 · see citing works
Orally active osteoanabolic agent GTDF binds to adiponectin receptors, with a preference for AdipoR1, induces adiponectin-associated signaling, and improves metabolic health in a rodent model of diabetes
Singh, A. K., Joharapurkar, A. A., Khan, M. P., Mishra, J. S., Singh, N., Yadav, M., Hossain, Z., Khan, K., Kumar, S., Dhanesha, N. A., et al. (2014) · Diabetes · doi:10.2337/db13-1619 · Cited by 43 · see citing works
Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy
Singh, A. K., Shree, S., Chattopadhyay, S., Kumar, S., Gurjar, A., Kushwaha, S., Kumar, H., Trivedi, A. K., Chattopadhyay, N., Maurya, R., et al. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.013 · Cited by 42 · see citing works
Objective Measures of Physical Activity and Cardiometabolic and Endocrine Biomarkers
ALESSA, H. B., CHOMISTEK, A. K., HANKINSON, S. E., BARNETT, J. B., ROOD, J., MATTHEWS, C. E., RIMM, E. B., WILLETT, W. C., HU, F. B., & TOBIAS, D. K. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001287 · Cited by 42 · see citing works
Asymmetric expression of H19 and ADIPOQ in concave/convex paravertebral muscles is associated with severe adolescent idiopathic scoliosis
Jiang, H., Yang, F., Lin, T., Shao, W., Meng, Y., Ma, J., Wang, C., Gao, R., & Zhou, X. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0049-y · Cited by 38 · see citing works
Globular Adiponectin Activates Motility and Regenerative Traits of Muscle Satellite Cells
Fiaschi, T., Giannoni, E., Taddei, M. L., & Chiarugi, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034782 · Cited by 37 · see citing works
Correlation of insulin resistance and motor function in spinal and bulbar muscular atrophy
Nakatsuji, H., Araki, A., Hashizume, A., Hijikata, Y., Yamada, S., Inagaki, T., Suzuki, K., Banno, H., Suga, N., Okada, Y., et al. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8405-3 · Cited by 37 · see citing works
Globular adiponectin as a complete mesoangioblast regulator: Role in proliferation, survival, motility, and skeletal muscle differentiation
Fiaschi, T., Tedesco, F. S., Giannoni, E., Diaz-Manera, J., Parri, M., Cossu, G., & Chiarugi, P. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-04-0310 · Cited by 35 · see citing works
Activation of autophagy by globular adiponectin is required for muscle differentiation
Gamberi, T., Modesti, A., Magherini, F., D’Souza, D. M., Hawke, T. J., & Fiaschi, T. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.01.016 · Cited by 35 · see citing works
Self-citation
Up-Regulation of Adiponectin Expression in Antigravitational Soleus Muscle in Response to Unloading Followed by Reloading, and Functional Overloading in Mice
Goto, A., Ohno, Y., Ikuta, A., Suzuki, M., Ohira, T., Egawa, T., Sugiura, T., Yoshioka, T., Ohira, Y., & Goto, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081929 · Cited by 34 · see citing works
Skeletal muscle secretome in Duchenne muscular dystrophy: A pivotal anti-inflammatory role of adiponectin
Lecompte, S., Abou-Samra, M., Boursereau, R., Noel, L., & Brichard, S. M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2465-5 · Cited by 34 · see citing works
Adiponectin regulates SR Ca2+ cycling following ischemia/reperfusion via sphingosine 1-phosphate-CaMKII signaling in mice
Yan, W., Zhang, F., Zhang, R.-H., Zhang, X., Wang, Y., Zhou, F., Xia, Y., Liu, P., Gao, C., Wang, H., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.05.010 · Cited by 33 · see citing works
Higher Leptin and Adiponectin Concentrations Predict Poorer Performance-based Physical Functioning in Midlife Women: the Michigan Study of Women’s Health Across the Nation
Karvonen-Gutierrez, C. A., Zheng, H. T., Mancuso, P., & Harlow, S. D. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv123 · Cited by 33 · see citing works
Increased plasminogen activator inhibitor-1 activity in offspring of type 2 diabetic patients: lack of association with plasma insulin levels.
Gürlek, A., Bayraktar, M., & Kirazlı, Ş. (2000) · Diabetes Care · doi:10.2337/diacare.23.1.88 · Cited by 32 · see citing works
Relationship of aerobic fitness with cardiovascular risk factors in firefighters
Seyedmehdi, S. M., Attarchi, M., Cherati, A. S., Hajsadeghi, S., Tofighi, R., & Jamaati, H. (2016) · Work · doi:10.3233/wor-162375 · Cited by 29 · see citing works
Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors: ex vivo and in vitro studies
Vetvik, K. K., Sonerud, T., Lindeberg, M. M., Lüders, T., Størkson, R. H., Jónsdóttir, K., Frengen, E., Pietiläinen, K. H., & Bukholm, I. (2014) · Metabolism · doi:10.1016/j.metabol.2014.02.001 · Cited by 28 · see citing works
A novel adipokine C1q/TNF-related protein 3 is expressed in developing skeletal muscle and controls myoblast proliferation and differentiation
Otani, M., Furukawa, S., Wakisaka, S., & Maeda, T. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2531-y · Cited by 27 · see citing works
Activation of adiponectin receptors has negative impact on muscle mass in C2C12 myotubes and fast-type mouse skeletal muscle
Ito, R., Higa, M., Goto, A., Aoshima, M., Ikuta, A., Ohashi, K., Yokoyama, S., Ohno, Y., Egawa, T., Miyata, H., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205645 · Cited by 27 · see citing works
Modulation of Skeletal Muscle Performance and SERCA by Exercise and Adiponectin Gene Therapy in Insulin-Resistant Rat
Safwat, Y., Yassin, N. A., el Din, M. G., & Kassem, L. A. A. (2013) · DNA and Cell Biology · doi:10.1089/dna.2012.1919 · Cited by 26 · see citing works
Potential Therapeutic Action of Adiponectin in Duchenne Muscular Dystrophy
Abou-Samra, M., Boursereau, R., Lecompte, S., Noel, L., & Brichard, S. M. (2017) · The American Journal of Pathology · doi:10.1016/j.ajpath.2017.02.018 · Cited by 24 · see citing works
High-intensity interval training acutely alters plasma adipokine levels in young overweight/obese women
Vardar, S. A., Karaca, A., Güldiken, S., Palabıyık, O., Süt, N., & Demir, A. M. (2017) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2017.1369998 · Cited by 24 · see citing works
Adipokines and Adipocyte Function in Clock Mutant Mice That Retain Melatonin Rhythmicity
Kennaway, D. J., Owens, J. A., Voultsios, A., & Wight, N. (2011) · Obesity · doi:10.1038/oby.2011.276 · Cited by 21 · see citing works
Adiponectin mediates the additive effects of combining daily exercise with caloric restriction for treatment of non-alcoholic fatty liver
Cho, J., Koh, Y., Han, J. M., Kim, D. Y., Kim, T.-K., & Kang, H. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.104 · Cited by 19 · see citing works
Adiponectin is sufficient, but not required, for exercise‐induced increases in the expression of skeletal muscle mitochondrial enzymes
Ritchie, I. R. W., MacDonald, T. L., Wright, D. C., & Dyck, D. J. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.273680 · Cited by 17 · see citing works
Associations of intramyocellular lipid in vastus lateralis and biceps femoris with blood free fatty acid and muscle strength differ between young and elderly adults
Hioki, M., Kanehira, N., Koike, T., Saito, A., Takahashi, H., Shimaoka, K., Sakakibara, H., Oshida, Y., & Akima, H. (2016) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12250 · Cited by 17 · see citing works
Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men
Gastebois, C., Villars, C., Drai, J., Canet‐Soulas, E., Blanc, S., Bergouignan, A., Lefai, É., & Simon, C. (2016) · European Journal of Applied Physiology · doi:10.1007/s00421-016-3466-z · Cited by 17 · see citing works
Skeletal muscle adiponectin induction depends on diet, muscle type/activity, and exercise modality in C57BL/6 mice
Martínez-Huenchullán, S., Maharjan, B. R., Williams, P. F., Tam, C. S., McLennan, S. V., & Twigg, S. M. (2018) · Physiological Reports · doi:10.14814/phy2.13848 · Cited by 17 · see citing works
Intensity-Specific and Modified Effects of Physical Activity on Serum Adiponectin in a Middle-Aged Population
Nishida, Y., Higaki, Y., Taguchi, N., Hara, M., Nakamura, K., Nanri, H., Imaizumi, T., Sakamoto, T., Shimanoe, C., Horita, M., et al. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2018-00255 · Cited by 17 · see citing works
Effect of 2 days of intensive resistance training on appetite‐related hormone and anabolic hormone responses
Goto, K., Shioda, K., & Uchida, S. (2012) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12005 · Cited by 15 · see citing works
Central and peripheral effects of physical exercise without weight reduction in obese and lean mice
de Carvalho, F. P., Moretto, T. L., Benfato, I. D., Barthichoto, M., Ferreira, S. M., Costa-Júnior, J. M., & de Oliveira, C. A. M. (2018) · Bioscience Reports · doi:10.1042/bsr20171033 · Cited by 14 · see citing works
Effects of a 12-week aerobic exercise on markers of hypertension in men
Baghaiee, B., Karimi, P., Ebrahimi, K., Dabagh Nikoo kheslat, S., Sadeghi Zali, M. H., Daneshian Moghaddam, A. M., & Sadaghian, M. (2018) · Journal of Cardiovascular and Thoracic Research · doi:10.15171/jcvtr.2018.26 · Cited by 14 · see citing works
Essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin
Zhang, L., Li, M., Corcoran, M., Zhang, S., & Cooper, G. J. S. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.09.014 · Cited by 13 · see citing works
Adiponectin is not required for exercise training-induced improvements in glucose and insulin tolerance in mice
Ritchie, I. R. W., Wright, D. C., & Dyck, D. J. (2014) · Physiological Reports · doi:10.14814/phy2.12146 · Cited by 6 · see citing works

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Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases
Choi, H. M., Doss, H. M., & Kim, K. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041219 · Cited by 520 · see citing works
Metabolic changes in aging humans: current evidence and therapeutic strategies
Palmer, A. K., & Jensen, M. D. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158451 · Cited by 358 · see citing works
Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis
Livshits, G., & Kalinkovich, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100980 · Cited by 239 · see citing works
Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications
Begum, M., Choubey, M., Tirumalasetty, M. B., Arbee, S., Mohib, M. M., Wahiduzzaman, M., Mamun, M. A., Uddin, M. B., & Mohiuddin, M. S. (2023) · Life · doi:10.3390/life13112213 · Cited by 128 · see citing works
Skeletal muscle adiponectin induction in obesity and exercise
Martínez-Huenchullán, S., Tam, C. S., Ban, L. A., Ehrenfeld-Slater, P., McLennan, S. V., & Twigg, S. M. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154008 · Cited by 117 · see citing works
Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis
Komici, K., Iacono, A. D., Luca, A. D., Perrotta, F., Bencivenga, L., Rengo, G., Rocca, A., & Guerra, G. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.576619 · Cited by 84 · see citing works
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works
Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia
Jang, S. Y., & Choi, K. M. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70000 · Cited by 81 · see citing works
Adiponectin Synthesis, Secretion and Extravasation from Circulation to Interstitial Space
Rosa, S. C. D. S., Liu, M., & Sweeney, G. (2021) · Physiology · doi:10.1152/physiol.00031.2020 · Cited by 79 · see citing works
Muscle in Endocrinology: From Skeletal Muscle Hormone Regulation to Myokine Secretion and Its Implications in Endocrine–Metabolic Diseases
Iglesias, P. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14134490 · Cited by 76 · see citing works
Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors
Aslam, M. A., Ma, E. B., & Huh, J. Y. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155711 · Cited by 74 · see citing works
Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together?
Abou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72 · see citing works
Adiponectin: friend or foe in obesity and inflammation
Luo, L., & Liu, M. (2022) · Medical Review · doi:10.1515/mr-2022-0002 · Cited by 68 · see citing works
Tissue-specific role and associated downstream signaling pathways of adiponectin
Roy, B., & Palaniyandi, S. S. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00587-4 · Cited by 65 · see citing works
Adipose tissue depot differences in adipokines and effects on skeletal and cardiac muscle
Rodrı́guez, A., Becerril, S., Hernández‐Pardos, A. W., & Frühbeck, G. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.04.003 · Cited by 63 · see citing works
Myokines and adipokines in sarcopenia: understanding cross-talk between skeletal muscle and adipose tissue and the role of exercise
Paris, M. T., Bell, K. E., & Mourtzakis, M. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.06.003 · Cited by 62 · see citing works
Adiponectin System (Rescue Hormone): The Missing Link between Metabolic and Cardiovascular Diseases
Aljafary, M. A., & Al-Suhaimi, E. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071430 · Cited by 52 · see citing works
Adiponectin as a Potential Biomarker for Pregnancy Disorders
Pheiffer, C., Dias, S. C., Jack, B. U., Malaza, N., & Adam, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031326 · Cited by 52 · see citing works
Adiponectin in Chronic Kidney Disease
Przybyciński, J., Dziedziejko, V., Puchałowicz, K., Domański, L., & Pawlik, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249375 · Cited by 50 · see citing works
Body Protein Sparing in Hibernators: A Source for Biomedical Innovation
Bertile, F., Habold, C., Maho, Y. L., & Giroud, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.634953 · Cited by 46 · see citing works
Cellular and Molecular Regulation of Exercise—A Neuronal Perspective
Reddy, I., Yadav, Y., & Dey, C. S. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01272-x · Cited by 41 · see citing works
The Pathological Links between Adiposity and the Carpal Tunnel Syndrome
Oțelea, M. R., Nartea, R., Popescu, F. G., Covaleov, A., Mitoiu, B. I., & Nica, A. S. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44060181 · Cited by 39 · see citing works
Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing
Wilhelmsen, A., Tsintzas, K., & Jones, S. W. (2021) · GeroScience · doi:10.1007/s11357-021-00322-4 · Cited by 39 · see citing works
Reactive Oxygen and Nitrogen Species (RONS) and Cytokines—Myokines Involved in Glucose Uptake and Insulin Resistance in Skeletal Muscle
Llanos, P., & Palomero, J. (2022) · Cells · doi:10.3390/cells11244008 · Cited by 37 · see citing works
Aerobic Exercise Alleviates Abnormal Autophagy in Brain Cells of APP/PS1 Mice by Upregulating AdipoR1 Levels
Jian, Y., Yuan, S., Yang, J., Lei, Y., Li, X., & Liu, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179921 · Cited by 36 · see citing works
Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition
Hu, K., Edelen, E. D., Zhuo, W., Khan, A. A., Orbegoso, J., Greenfield, L., Rahi, B., Griffin, M. J., Ilich, J. Z., & Kelly, O. J. (2023) · Metabolites · doi:10.3390/metabo13101056 · Cited by 34 · see citing works
The Role of Adiponectin and ADIPOQ Variation in Metabolic Syndrome: A Narrative Review
Błażejewska, W., Dąbrowska, J., Michałowska, J., & Bogdański, P. (2025) · Genes · doi:10.3390/genes16060699 · Cited by 32 · see citing works
Adiponectin and Asthma: Knowns, Unknowns and Controversies
Oțelea, M. R., Arghir, O. C., Zugravu, C., & Rașcu, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168971 · Cited by 30 · see citing works
ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells
Sung, H. K., Mitchell, P. L., Gross, S. M., Marette, A., & Sweeney, G. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00603.2020 · Cited by 30 · see citing works
Skeletal Muscle Gene Expression in Long-Term Endurance and Resistance Trained Elderly
Bolotta, A., Filardo, G., Abruzzo, P. M., Astolfi, A., Sanctis, P. D., Martino, A. D., Höfer, C., Indio, V., Kern, H., Löfler, S., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113988 · Cited by 29 · see citing works
Another Weapon against Cancer and Metastasis: Physical-Activity-Dependent Effects on Adiposity and Adipokines
Perego, S., Sansoni, V., Ziemann, E., & Lombardi, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042005 · Cited by 28 · see citing works
Peripheral to brain and hippocampus crosstalk induced by exercise mediates cognitive and structural hippocampal adaptations
Blume, G. R., & Royes, L. F. F. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122799 · Cited by 26 · see citing works
Probiotics and muscle health: the impact of Lactobacillus on sarcopenia through the gut-muscle axis
Zhu, J., Peng, F., Yang, H., Luo, J., Zhang, L., Chen, X., Liao, H., Lei, H., Liu, S., Yang, T., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1559119 · Cited by 26 · see citing works
Impact of Physical Activity on Disability Risk in Elderly Patients Hospitalized for Mild Acute Diverticulitis and Diverticular Bleeding Undergone Conservative Management
Rocca, A., Brunese, M. C., Cappuccio, M., Scacchi, A., Martucci, G., Buondonno, A., Perrotta, F. M., Quarto, G., Avella, P., & Amato, B. (2021) · Medicina · doi:10.3390/medicina57040360 · Cited by 24 · see citing works
Mechanisms of Adiponectin Action
Fiaschi, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122894 · Cited by 23 · see citing works
Management of Oxidative Stress: Crosstalk Between Brown/Beige Adipose Tissues and Skeletal Muscles
Pan, R., & Chen, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.712372 · Cited by 22 · see citing works
“Ferrocrinology”—Iron Is an Important Factor Involved in Gluco- and Lipocrinology
Szklarz, M., Gontarz-Nowak, K., Matuszewski, W., & Bandurska-Stankiewicz, E. M. (2022) · Nutrients · doi:10.3390/nu14214693 · Cited by 20 · see citing works
Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin
Quattrocelli, M., Wintzinger, M., Miz, K., Panta, M., Prabakaran, A. D., Barish, G. D., Chandel, N. S., & McNally, E. M. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211906 · Cited by 19 · see citing works
White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle
Ford, H. R., Liu, Q., Fu, X., & Strieder‐Barboza, C. (2023) · Biology · doi:10.3390/biology12101289 · Cited by 19 · see citing works
Influence of adiponectin and inflammatory cytokines in fatty degenerative atrophic muscle
Shinohara, I., Kataoka, T., Mifune, Y., Inui, A., Sakata, R., Nishimoto, H., Yamaura, K., Mukohara, S., Yoshikawa, T., Kato, T., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-05608-x · Cited by 18 · see citing works
Association between APOE Genotype with Body Composition and Cardiovascular Disease Risk Markers Is Modulated by BMI in Healthy Adults: Findings from the BODYCON Study
Ozen, E., Mihaylova, R., Lord, N. J., Lovegrove, J. A., & Jackson, K. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179766 · Cited by 18 · see citing works
Adiponectin Decreases Gastric Smooth Muscle Cell Excitability in Mice
Idrizaj, E., Garella, R., Castellini, G., Francini, F., Ricca, V., Baccari, M. C., & Squecco, R. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01000 · Cited by 18 · see citing works
Different roles of circulating and intramuscular GDF15 as markers of skeletal muscle health
Chiariello, A., Conte, G., Rossetti, L. M., Trofarello, L., Salvioli, S., & Conte, M. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1404047 · Cited by 17 · see citing works
Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2
Liu, X., Yang, Y., Shao, H., Liu, S., Niu, Y., & Fu, L. (2022) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2022.08.001 · Cited by 16 · see citing works
Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study
Ma, L., Xu, Y., Zhang, Y., Ji, T., & Li, Y. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s242397 · Cited by 16 · see citing works
Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression
Chattopadhyay, S., Joharapurkar, A. A., Das, N., Khatoon, S., Kushwaha, S., Gurjar, A. A., Singh, A. K., Shree, S., Ahmed, M. Z., China, S. P., et al. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111525 · Cited by 16 · see citing works
The Developmental Implications of Muscle-Targeted Magnetic Mitohormesis: A Human Health and Longevity Perspective
Franco‐Obregón, A., Tai, Y. K., Wu, K. Y., Iversen, J. N., & Wong, C. J. K. (2023) · Bioengineering · doi:10.3390/bioengineering10080956 · Cited by 16 · see citing works
Changes Induced by Aging and Long-Term Exercise and/or DHA Supplementation in Muscle of Obese Female Mice
Martínez-Gayo, A., Félix‐Soriano, E., Sáinź, N., González‐Muniesa, P., & Moreno-Aliaga, M. J. (2022) · Nutrients · doi:10.3390/nu14204240 · Cited by 15 · see citing works
Targeting Crosstalk of Signaling Pathways among Muscles-Bone-Adipose Tissue: A Promising Therapeutic Approach for Sarcopenia
Sharma, A. R., Chatterjee, S., Lee, Y., & Lee, S. (2023) · Aging and Disease · doi:10.14336/ad.2023.00903 · Cited by 15 · see citing works
The Influence of Body Composition, Lifestyle, and Dietary Components on Adiponectin and Resistin Levels and AR Index in Obese Individuals
Polak-Szczybyło, E., & Tabarkiewicz, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010393 · Cited by 13 · see citing works
The relationship between changes in serum myostatin and adiponectin levels in patients with obesity undergoing a weight loss program
Takao, N., Kurose, S., Miyauchi, T., Onishi, K., Tamanoi, A., Tsuyuguchi, R., Fujii, A., Yoshiuchi, S., Takahashi, K., Tsutsumi, H., et al. (2021) · BMC Endocrine Disorders · doi:10.1186/s12902-021-00808-4 · Cited by 13 · see citing works
Allulose Attenuated Age‐Associated Sarcopenia via Regulating IGF‐1 and Myostatin in Aged Mice
Kim, J., Kwon, E., & Han, Y. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100549 · Cited by 13 · see citing works
Adiponectin overexpression in C2C12 myocytes increases lipid oxidation and myofiber transition
Lopez‐Yus, M., Lopez-Perez, R., García-Sobreviela, M. P., del Moral, R., Lorente‐Cebrián, S., & Arbonés-Mainar, J. M. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00836-7 · Cited by 13 · see citing works
The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion
Su, L., Pan, Y., & Chen, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.924649 · Cited by 12 · see citing works
VLCKD in Combination with Physical Exercise Preserves Skeletal Muscle Mass in Sarcopenic Obesity after Severe COVID-19 Disease: A Case Report
Camajani, E., Feraco, A., Basciani, S., Gnessi, L., Barrea, L., Armani, A., & Caprio, M. (2022) · Healthcare · doi:10.3390/healthcare10030573 · Cited by 11 · see citing works
Unraveling the Molecular Basis of the Dystrophic Process in Limb-Girdle Muscular Dystrophy LGMD-R12 by Differential Gene Expression Profiles in Diseased and Healthy Muscles
Depuydt, C., Goosens, V., Janky, R., D’Hondt, A., Bleecker, J. D., Noppe, N., Derveaux, S., Thal, D. R., & Claeys, K. G. (2022) · Cells · doi:10.3390/cells11091508 · Cited by 11 · see citing works
Promotion of healthy adipose tissue remodeling ameliorates muscle inflammation in a mouse model of sarcopenic obesity
Ge, Y., Li, S., Yao, T., Tang, Y., Wan, Q., Zhang, X., Zhao, J., Zhang, M., Shao, M., Wang, L., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1065617 · Cited by 10 · see citing works
The role of sex in the relationship between fasting adipokines levels, maximal fat oxidation during exercise, and insulin resistance in young adults with excess adiposity
Chávez-Guevara, I. A., Amaro‐Gahete, F. J., Osuna‐Prieto, F. J., Labayen, I., Aguilera, C. M., & Ruiz, J. R. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115757 · Cited by 10 · see citing works
Body composition and dietary patterns in professional and amateur bodybuilders
Makiel, K., Suder, A., Kasza, S., & Kubasiak, K. (2020) · Anthropological Review · doi:10.2478/anre-2020-0016 · Cited by 10 · see citing works
Endoplasmic reticulum stress and muscle dysfunction in congenital lipodystrophies
Campos, J. T. A. D. M., de Medeiros, J. L. D., de Melo, M. E. C., da Silva, M. A., de Sena, M. O., Sarmento, A. S. C., Agnez‐Lima, L. F., Fregonezi, G., & Lima, J. G. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166120 · Cited by 9 · see citing works
Signaling pathways shaping the field of lipidomics
Ahi, E. P., & House, A. H. (2025) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2025.107053 · Cited by 8 · see citing works
Visceral Fat Affects Heart Rate Recovery but Not the Heart Rate Response Post-Single Bout of Vigorous Exercise: A Cross-Sectional Study in Non-Obese and Healthy Participants
Amato, A., Petrigna, L., Sortino, M., & Musumeci, G. (2024) · Sports · doi:10.3390/sports12120323 · Cited by 8 · see citing works
A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function
Degens, H., Swaminathan, A., & Tallis, J. A. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000261 · Cited by 7 · see citing works
FAT AND MUSCLE COMPONENTS OF BODY WEIGHT AND THEIR RELATIONSHIP WITH THE CONCENTRATION OF SERUM ADIPOKINES IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE
Pivtorak, K. V., Fedzhaga, I., Pivtorak, N., Vozniuk, L. A., & Klekоt, O. O. (2022) · Wiadomości Lekarskie · doi:10.36740/wlek202205210 · Cited by 7 · see citing works
Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats
Lee, S. G., Lee, E., Chae, J., Kim, J. S., Lee, H.-S., Lim, Y.-M., So, J.-H., Hahn, D., & Nam, J. (2022) · Nutrients · doi:10.3390/nu14214683 · Cited by 7 · see citing works
Comparative effectiveness of different exercise modality on glycaemic control and lipid profile for prediabetes: systematic review and network meta-analysis
Yan, R., Chen, L., Lin, G., Shi, Y., Huang, W., Mai, Y., Sun, J., & Li, D. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1518871 · Cited by 6 · see citing works
Limitations in metabolic plasticity after traumatic injury are only moderately exacerbated by physical activity restriction
Bruzina, A. S., Raymond‐Pope, C. J., Murray, K. J., Lillquist, T. J., Castelli, K. M., Bijwadia, S. R., Call, J. A., & Greising, S. M. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00006-5 · Cited by 6 · see citing works
Adiponectin promotes myogenic differentiation via a Mef2C-AdipoR1 positive feedback loop
An, Y., Zheng, Y., Gong, Y.-Q., Yu, R., Yang, Z., & Chen, X. (2020) · Gene · doi:10.1016/j.gene.2020.145380 · Cited by 6 · see citing works
Regulation and Role of Adiponectin Secretion in Rat Ovarian Granulosa Cells
Zhou, Y., Zhang, S., Jia, Y., Wang, X., Liu, Y., Zhang, H., Yuan, Z., Han, Y., & Weng, Q. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105155 · Cited by 6 · see citing works
Association of Cardiopulmonary Exercise Capacity and Adipokines in the General Population
Lendeckel, F., Zylla, S., Markus, M. R. P., Ewert, R., Gläser, S., Völzke, H., Albrecht, D., Friedrich, N., Nauck, M. A., Felix, S. B., et al. (2022) · International Journal of Sports Medicine · doi:10.1055/a-1699-2380 · Cited by 6 · see citing works
RELATIONSHIP OF SERUM ADIPONECTIN LEVELS WITH GLYCAEMIC STATUS IN PREGNANT WOMEN
Akhtar, Y., Nawaz, S., Khan, M. S., Habib, S. H., Malik, M. O., & Fatima, S. (2022) · Journal of Ayub Medical College Abbottabad · doi:10.55519/jamc-02-9491 · Cited by 5 · see citing works
Adiponectin resistance parameter as a marker for high normal blood pres-sure and hypertension in patients with metabolic syndrome.
Stojanovic, S., Deljanin-Ilić, M., Ilić, S., Stefanović, M., Petrović, D., Petrović, V., & Stojanović, M. (2020) · PubMed Central · Cited by 5 · see citing works
RETRACTED: Adiponectin protects skeletal muscle from ischaemia–reperfusion injury in mice through miR ‐21/ PI3K /Akt signalling pathway
Zhou, M., Zhang, H., Chen, H., & Qi, B. (2022) · International Wound Journal · doi:10.1111/iwj.14022 · Cited by 5 · see citing works
Retracted
The combined effects of Tabata training and cinnamon supplementation on metabolic changes and body composition in soldiers with overweight or obesity
Rad, R. S., Omidi, H., & Alipour, M. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2564237 · Cited by 4 · see citing works
Adipose dysfunction, lipid dysregulation, and adipokines in sarcopenia: a systematic review and meta-analysis with sex-specific analyses
Vithran, D. T. A., Hassan, M. H. Y., Rahmati, M., Boyer, L., Wehliye, A. A., Xiao, W., & Li, Y. (2026) · Age and Ageing · doi:10.1093/ageing/afag020 · Cited by 4 · see citing works
Inhibition of obesity through alterations of C/EBP- α gene expression by gum Arabic in mice with a high-fat feed diet
Ahmed, A. A., Musa, H. H., Essa, M. E. A., Mollica, A., Zengin, G., Ahmad, H., & Adam, S. Y. (2022) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2022.100231 · Cited by 4 · see citing works
Maternal Supplementation with a Cocoa Extract during Lactation Deeply Modulates Dams’ Metabolism, Increases Adiponectin Circulating Levels and Improves the Inflammatory Profile in Obese Rat Offspring
Mariné-Casadó, R., Domenech-Coca, C., Crescenti, A., Rodriguez, M. A., Bas-Prior, J. M. D., Arola, L., Boqué, N., & Caimari, A. (2022) · Nutrients · doi:10.3390/nu14235134 · Cited by 4 · see citing works
Paraspinal muscle gene expression across different aetiologies in individuals undergoing surgery for lumbar spine pathology
Ordaz, A., Anderson, B. J., Zlomislic, V., Allen, R. T., Garfin, S. R., Schüpbach, R., Farshad, M., Schenk, S., Ward, S. R., & Shahidi, B. (2023) · European Spine Journal · doi:10.1007/s00586-023-07543-5 · Cited by 4 · see citing works
Time Course of Inflammatory and Endocrine Factors Following a Single-Bout of High-Intensity WB-EMS – A Randomized Crossover Study
Teschler, M., Bothur, E., Samel, N., Waranski, M., Walscheid, R., Schmitz, B., & Mooren, F. C. (2025) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2025.2464195 · Cited by 3 · see citing works
Unravelling the Adiponectin Hallmark and Exploring the Therapeutic Potential of Its Receptor Agonists in Cancer Metabolic Reprogramming
Kafeel, S., Palmiero, G., Salzillo, A., Ragone, A., Naviglio, S., & Sapio, L. (2025) · Biomolecules · doi:10.3390/biom15060820 · Cited by 3 · see citing works
Selective Small‐Molecule AdipoR1 Agonist 3‐Hydroxy Pterocarpan Salt (CDRI‐1709S) Ameliorates Skeletal Muscle Atrophy
Moin, M. R., Pal, S., Das, S., Awasthi, P., Talukdar, A., Kumar, A. T. R., Varode, S. S., Nikolas, N., Khatoon, S., Mugale, M. N., et al. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70328 · Cited by 3 · see citing works
Striated Muscle Evaluation Based on Velocity and Amortization Ratio of Mechanical Impulse Propagation in Simulated Microgravity Environment
Nistorescu, A. I., Busnatu, Ș., Dinculescu, A. C., Olteanu, G., Marin, M., Jercălău, C. E., Vizitiu, C., & Papacocea, I. R. (2022) · Biology · doi:10.3390/biology11111677 · Cited by 3 · see citing works
Comparative analysis of paraspinal muscle imbalance between idiopathic scoliosis and congenital scoliosis from the transcriptome aspect
Wang, Z., Zhao, J., Tan, H., Jiao, Y., Chen, X., & Shen, J. (2024) · JOR Spine · doi:10.1002/jsp2.1318 · Cited by 3 · see citing works
Connecting bone metastasis, adipose tissue and adipokines: How does physical activity fit?
Maroni, P., Gomarasca, M., Signo, M., & Lombardi, G. (2024) · Advanced Exercise and Health Science · doi:10.1016/j.aehs.2024.08.001 · Cited by 3 · see citing works
Adiponectin Concentration and Chronic Stroke Individuals, Associations with Body Composition, Physical Activity Levels and Lipid Profile: A Cross-Sectional Explorative Study
García-Salazar, L. F., Ribeiro, J. A. M., Saade-Pacheco, C. R., Mattiello, S. M., Catai, A. M., Garcia-Araújo, A. S., & Russo, T. L. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2021.105993 · Cited by 3 · see citing works
Combination of imeglimin and resistance exercise improves mitochondrial function and glucose metabolism in skeletal muscles
Ishiguro, H., Minato, K., Iwaasa, K., Wu, S., Antao, G., Tsuchida, T., Suwabe, T., Katagiri, T., Suzuki, H., Masuko, M., et al. (2025) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2025.109145 · Cited by 2 · see citing works
Beyond BMI: The musculoskeletal and metabolic consequences of normal weight obesity across the female lifespan
Frost, A., Hirsch, K. R., R, J. A., Gagnon, S., Smith‐Ryan, A. E., Ormsbee, M. J., J, C. A., A, B. P., E, M. J., N, D. R., et al. (2026) · Women s Health · doi:10.1177/17455057261455585 · Cited by 2 · see citing works
Effects of 1,144 km of road cycling performed in 7 days: a cardiometabolic imaging study
Chartrand, D. J., Murphy-Després, A., Lemieux, I., Larose, É., Poirier, P., Després, J., & Alméras, N. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00098.2024 · Cited by 2 · see citing works
Injection of Adipose-Derived Mesenchymal Stem/Stromal Cells Suppresses Muscle Atrophy Markers and Adipogenic Markers in a Rat Fatty Muscle Degeneration Model
Ngeun, S. K., Shimizu, M., & Kaneda, M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080467 · Cited by 2 · see citing works
Circulating Muscle Markers for Sarcopenia in Peritoneal Dialysis
Xu, L., Ng, J. K., Fung, W. W., Chan, G. C., Chow, K., & Szeto, C. (2025) · International Journal of Nephrology · doi:10.1155/ijne/8817404 · Cited by 2 · see citing works
Altered adiponectin regulation in skeletal muscle of patients with chronic kidney disease
Verzola, D., Saio, M., Milanesi, S., Picciotto, D., Frascio, M., Brunori, G., Laudon, A., Porta, E. L., Rumeo, N., Zanetti, V., et al. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae051 · Cited by 2 · see citing works
Empathy, stress and biopsychological homeostasis. Hormonal-loop disorders theoryPreprint
Naumov, D. (2022) · doi:10.31234/osf.io/qyra3 · Cited by 2 · see citing works
Down regulation of the inverse relationship between parathyroid hormone and irisin in male vitamin D-sufficient HIV patients
Karras, S. Ν., Koufakis, T., Dimakopoulos, G., Zisimopoulou, E., Mourampetzis, P., Manthou, E., Karalazou, P., Thisiadou, K., Tsachouridou, Ο., Zebekakis, P. E., et al. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02112-5 · Cited by 1 · see citing works
Role of adiponectin in gestational diabetes mellitus: advances in mechanistic insights and early predictive potential
Chen, Y., He, F., Zhang, L., & Zhang, Z. (2026) · Adipocyte · doi:10.1080/21623945.2026.2705620 · Cited by 1 · see citing works
Obesity, inflammation and muscle weakness
Hasselgren, P.-O. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90960-0.00014-x · Cited by 1 · see citing works
Sarcopenic obesity in patients awaiting liver transplant: Unique challenges for nutritional recommendations
Herscovici, D. M., Cooper, K. M., Colletta, A., Rightmyer, M., Shingina, A., & Feld, L. D. (2024) · World Journal of Transplantation · doi:10.5500/wjt.v14.i2.90202 · Cited by 1 · see citing works
Age-related adiponectin resistance in human skeletal muscle dysfunction: in vivo and in vitro evidence
Surina, S., Scisciola, L., Basilicata, M. G., Pesapane, A., Fontanella, R. A., Balzano, N., Palazzo, A., Zia, A., Tortorella, G., Ulfat, Z., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07959-9 · Cited by 1 · see citing works
Physical activity enhances fecal lactobacilli in rats chronically drinking sweetened cola beverage
Marušáková, M., Dudík, B., Hadová, K., Kmecová, Z., Kráľová, E., Křenek, P., Bilková, A., & Klimas, J. (2022) · Open Life Sciences · doi:10.1515/biol-2022-0070 · Cited by 1 · see citing works
Non-linear associations and threshold effects of BRI, CI, and WHtR with grip strength in U. S. adults aged ≥20 years: a cross-sectional study
Yang, S., Liao, K., Zhou, L., Zhang, S., & Wu, J.-C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1597065 · Cited by 1 · see citing works
Evaluation of adiponectin serum levels and their association with oxidative stress in individuals with type 2 diabetes mellitus in Iraq
Al-Dulaimy, A. H., & Ghafoor, K. F. A. (2024) · Anaesthesia Pain & Intensive Care · doi:10.35975/apic.v28i3.2475 · Cited by 1 · see citing works

Circulating adiponectin and adiponectin receptor expression in skeletal muscle: effects of exercise
Vu, V. P., Riddell, M. C., & Sweeney, G. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.778 · Cited by 63 · see citing works
Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: Associations with metabolic parameters and insulin resistance and regulation by physical training
Blüher, M., Bullen, J. W., Lee, J. H., Kralisch, S., Fasshauer, M., Klöting, N., Niebauer, J., Schön, M. R., Williams, C. J., & Mantzoros, C. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2556 · Cited by 293 · see citing works
Skeletal muscle adiponectin induction in obesity and exercise
Martínez-Huenchullán, S., Tam, C. S., Ban, L. A., Ehrenfeld-Slater, P., McLennan, S. V., & Twigg, S. M. (2019) · Metabolism · doi:10.1016/j.metabol.2019.154008 · Cited by 117 · see citing works
Exercise and Adiponectin
Song, G. (2007) · Xi'an Tiyu Xueyuan xuebao
Effects of Moderate- and High-Intensity Chronic Exercise on the Adiponectin Levels in Slow-Twitch and Fast-Twitch Muscles in Rats
Jiménez‐Maldonado, A., Virgen‐Ortiz, A., Lemus, M., Castro-Rodríguez, E., Cortés, J. C., Muñı́z, J., Montero, S., & Roces, E. (2019) · Medicina · doi:10.3390/medicina55060291 · Cited by 10 · see citing works

Authors: Krause, M. P., Milne, K. J., & Hawke, T. J.
Affiliations: University of Windsor (CA)
McMaster University (CA)
Corresponding author: Krause, Matthew P.
ORCID: Krause, Matthew P.
Milne, Kevin J.
Hawke, Thomas J.
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2019-03-27
Volume: 20
Issue: 7
Pages: 1528
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms20071528
PMC: PMC6480271
OpenAlex: W2924066250
Cited by: 121
References: 121
Citations by year: 2026: 11 · 2025: 15 · 2024: 15 · 2023: 11 · 2022: 32 · 2021: 21 · 2020: 11 · 2019: 5
FWCI: 2.51
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Natural Sciences and Engineering Research Council of Canada (RGPIN-2016-05073)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: adiponectin, skeletal muscle, adipokines, paracrine signaling, muscle regeneration, chronic inflammation, physical activity, insulin sensitivity, obesity, diabetes mellitus, blood glucose regulation, fatty acid oxidation
MeSH terms: Autophagy, Humans, Protein Processing, Post-Translational, Regeneration, Exercise, Muscle, Skeletal, Adiponectin

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Adiponectin—Consideration for its Role in Skeletal Muscle Health

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