Orally active osteoanabolic agent GTDF binds to adiponectin receptors, with a preference for AdipoR1, induces adiponectin-associated signaling, and improves metabolic health in a rodent model of diabetes
Abstract
Adiponectin is an adipocytokine that signals through plasma membrane-bound adiponectin receptors 1 and 2 (AdipoR1 and -2). Plasma adiponectin depletion is associated with type 2 diabetes, obesity, and cardiovascular diseases. Adiponectin therapy, however, is yet unavailable owing to its large size, complex multimerization, and functional differences of the multimers. We report discovery and characterization of 6-C-β-D-glucopyranosyl-(2S,3S)-(+)-5,7,3',4'-tetrahydroxydihydroflavonol (GTDF) as an orally active adiponectin mimetic. GTDF interacted with both AdipoRs, with a preference for AdipoR1. It induced adiponectin-associated signaling and enhanced glucose uptake and fatty acid oxidation in vitro, which were augmented or abolished by AdipoR1 overexpression or silencing, respectively. GTDF improved metabolic health, characterized by elevated glucose clearance, β-cell survival, reduced steatohepatitis, browning of white adipose tissue, and improved lipid profile in an AdipoR1-expressing but not an AdipoR1-depleted strain of diabetic mice. The discovery of GTDF as an adiponectin mimetic provides a promising therapeutic tool for the treatment of metabolic diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GTDF attenuated diabetic phenotype and complications in obese db/db mice through an AdipoR1-dependent mechanism.
“which was shown to attenuate the diabetic phenotype and its complications in obese db/db mice, through an AdipoR1-dependent mechanism [135].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [135]
Cites
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541 · see citing works
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238 · see citing works
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176 · see citing works
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133 · see citing works
Adiponectin and Adiponectin Receptors
Kadowaki, T., & Yamauchi, T. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0005 · Cited by 2,634 · see citing works
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,239 · see citing works
Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 1,987 · see citing works
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation
Kubota, N., Terauchi, Y., Yamauchi, T., Kubota, T., Moroi, M., Matsui, J., Eto, K., Yamashita, T., Kamon, J., Satoh, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200251200 · Cited by 1,213 · see citing works
Disruption of adiponectin causes insulin resistance and neointimal formation
Froguel, P. (2002) · HAL · Cited by 1,126 · see citing works
Adiponectin Levels and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis
Li, S., Shin, H. J., Ding, E. L., & van Dam, R. M. (2009) · JAMA · doi:10.1001/jama.2009.976 · Cited by 991 · see citing works
Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1
Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., et al. (2010) · Nature · doi:10.1038/nature08991 · Cited by 971 · see citing works
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209033200 · Cited by 911 · see citing works
Fatty acids, obesity, and insulin resistance: Time for a reevaluation
Karpe, F., Dickmann, J. R., & Frayn, K. N. (2011) · Diabetes · doi:10.2337/db11-0425 · Cited by 896 · see citing works
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
Holland, W. L., Miller, R. A., Wang, Z. V., Sun, K., Barth, B. M., Bui, H. H., Davis, K. E., Bikman, B. T., Halberg, N., Rutkowski, J. M., et al. (2011) · Nature Medicine · doi:10.1038/nm.2277 · Cited by 892 · see citing works
T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
Hug, C., Wang, J., Ahmad, N. S., Bogan, J. S., Tsao, T., & Lodish, H. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403382101 · Cited by 861 · see citing works
Adiponectin acts in the brain to decrease body weight
Qi, Y., Takahashi, N., Hileman, S. M., Patel, H. R., Berg, A. H., Pajvani, U. B., Scherer, P. E., & Ahima, R. S. (2004) · Nature Medicine · doi:10.1038/nm1029 · Cited by 809 · see citing works
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature · doi:10.1038/nature12656 · Cited by 757 · see citing works
Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex
Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P., & Spiegelman, B. M. (2009) · Nature · doi:10.1038/nature08262 · Cited by 703 · see citing works
Shapiro, L. S., & Scherer, P. E. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70133-2 · Cited by 652 · see citing works
Tsuchida, A., Yamauchi, T., Ito, Y., Hada, Y., Maki, T., Takekawa, S., Kamon, J., Kobayashi, M., Suzuki, R., Hara, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402367200 · Cited by 550 · see citing works
Yoon, M. J., Lee, G. Y., Chung, J.-J., Ahn, Y. H., Hong, S. H., & Kim, J. B. (2006) · Diabetes · doi:10.2337/db05-1322 · Cited by 546 · see citing works
Role of Disulfide Bonds in Acrp30/Adiponectin Structure and Signaling Specificity
Tsao, T., Tomás, E., Murrey, H. E., Hug, C., Lee, D. H., Ruderman, N. B., Heuser, J. E., & Lodish, H. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309469200 · Cited by 473 · see citing works
Tsao, T., Murrey, H. E., Hug, C., Lee, D. H., & Lodish, H. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200312200 · Cited by 352 · see citing works
Jeong, S.-M., Kang, M.-J., Choi, H., Kim, J., & Kim, J.-I. (2012) · Nutrition Research and Practice · doi:10.4162/nrp.2012.6.3.201 · Cited by 266 · see citing works
Shklyaev, S., Aslanidi, G., Tennant, M., Prima, V., Kohlbrenner, E., Kroutov, V., Campbell‐Thompson, M., Crawford, J. M., Shek, E. W., Scarpace, P. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2333912100 · Cited by 244 · see citing works
Clinical review: Adiponectin biology and its role in inflammation and critical illness
Robinson, K., Prins, J. B., & Venkatesh, B. (2011) · Critical Care · doi:10.1186/cc10021 · Cited by 238 · see citing works
Wijesekara, N., Krishnamurthy, M., Bhattacharjee, A., Suhail, A., Sweeney, G., & Wheeler, M. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085084 · Cited by 229 · see citing works
Wang, C., Mao, X., Wang, L., Liu, M., Wetzel, M. D., Guan, K.-L., Dong, L. Q., & Liu, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700098200 · Cited by 210 · see citing works
Quercetin's Influence on Exercise Performance and Muscle Mitochondrial Biogenesis
NIEMAN, D. C., WILLIAMS, A. S., SHANELY, R. A., JIN, F., MCANULTY, S. R., TRIPLETT, N. T., AUSTIN, M. D., & HENSON, D. A. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181b18fa3 · Cited by 194 · see citing works
Tonra, J. R., Ono, M., Liu, X., Garcia, K., Jackson, C., Yancopoulos, G. D., Wiegand, S. J., & Wong, V. (1999) · Diabetes · doi:10.2337/diabetes.48.3.588 · Cited by 186 · see citing works
Bates, S. H., Kulkarni, R. N., Seifert, M., & Myers, M. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.02.001 · Cited by 173 · see citing works
A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db / db mice
Chen, D., Liao, J., Li, N., Zhou, C., Liu, Q., Wang, G., Zhang, R., Zhang, S., Lin, L., Chen, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610173104 · Cited by 171 · see citing works
Bauche, I. B., Ait-El-Mkadem, S., Pottier, A.-M., Sènou, M., Many, M., Rezsöhazy, R., Pénicaud, L., Maeda, N., Funahashi, T., & Brichard, S. M. (2007) · Endocrinology · doi:10.1210/en.2006-0838 · Cited by 143 · see citing works
Sharan, K., Mishra, J. S., Swarnkar, G., Siddiqui, J. A., Khan, K., Kumari, R., Rawat, P., Maurya, R., Sanyal, S., & Chattopadhyay, N. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.434 · Cited by 109 · see citing works
Self-citationWilden, P. A., Backer, J., Kahn, C. R., Cahill, D. A., Schroeder, G. J., & White, M. F. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.9.3358 · Cited by 107 · see citing works
Sleeman, M. W., Garcia, K., Liu, R., Murray, J. D., Malinova, L., Moncrieffe, M., Yancopoulos, G. D., & Wiegand, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2335926100 · Cited by 98 · see citing works
Early Hepatic Insulin Resistance Precedes the Onset of Diabetes in Obese C57BLKS-db/db Mice
Davis, R. C., Castellani, L. W., Hosseini, M., Ben-Zeev, O., Mao, H. Z., Weinstein, M. M., Jung, D. Y., Jun, J. Y., Kim, J. K., Lusis, A. J., et al. (2010) · Diabetes · doi:10.2337/db09-0878 · Cited by 65 · see citing works
Sun, Y., Zang, Z., Zhong, L., Wu, M., Su, Q., Gao, X., Zan, W., Lin, D., Zhao, Y., & Zhang, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063354 · Cited by 60 · see citing works
Anti-osteoporotic constituents from Indian medicinal plants
Kumar, M., Rawat, P., Dixit, P., Mishra, D. P., Gautam, A. K., Pandey, R., Singh, D. R., Chattopadhyay, N., & Maurya, R. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.03.014 · Cited by 60 · see citing works
Self-citationRNA-Binding Protein PTB and MicroRNA-221 Coregulate AdipoR1 Translation and Adiponectin Signaling
Lustig, Y., Barhod, E., Ashwal-Fluss, R., Gordin, R., Shomron, N., Umansky, K. B., Hemi, R., Karasik, A., & Kanety, H. (2013) · Diabetes · doi:10.2337/db13-1032 · Cited by 56 · see citing works
Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors
Neumeier, M., Weigert, J., Schäffler, A., Weiß, T. S., Kirchner, S., Laberer, S., Schölmerich, J., & Buechler, C. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.06.187 · Cited by 46 · see citing works
Siddiqui, J. A., Sharan, K., Swarnkar, G., Rawat, P., Kumar, M., Manickavasagam, L., Maurya, R., Pierroz, D. D., & Chattopadhyay, N. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181e84e67 · Cited by 43 · see citing works
Self-citationSiddiqui, J. A., Swarnkar, G., Sharan, K., Chakravarti, B., Gautam, A. K., Rawat, P., Kumar, M. N. V. R., Gupta, V., Manickavasagam, L., Dwivedi, A. K., et al. (2011) · Osteoporosis International · doi:10.1007/s00198-010-1519-4 · Cited by 42 · see citing works
Self-citationDwivedi, S. K. D., Singh, N., Kumari, R., Mishra, J. S., Tripathi, S., Banerjee, P., Shah, P., Kukshal, V., Tyagi, A. M., Gaikwad, A. N., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0512 · Cited by 36 · see citing works
Self-citationKim, J. H., Lee, J. O., Lee, S., Moon, J. W., You, G. Y., Kim, S. J., Park, S.-H., Park, J., Lim, S. Y., Suh, P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.149328 · Cited by 36 · see citing works
Khan, M. P., Mishra, J. S., Sharan, K., Yadav, M., Singh, A. K., Srivastava, A., Kumar, S., Bhaduaria, S., Maurya, R., Sanyal, S., et al. (2013) · Phytomedicine · doi:10.1016/j.phymed.2013.07.007 · Cited by 32 · see citing works
Self-citationSharan, K., Swarnkar, G., Siddiqui, J. A., Kumar, A., Rawat, P., Kumar, M., Nagar, G. K., Manickavasagam, L., Singh, S. P., Mishra, G., et al. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181d2ce7f · Cited by 26 · see citing works
Self-citationAshwal-Fluss, R., Hemi, R., Tirosh, A., Gordin, R., Yissachar, E., Cohen-Dayag, A., Rosenberg, A. Z., Karasik, A., Blüher, M., & Kanety, H. (2011) · Diabetes · doi:10.2337/db09-0532 · Cited by 13 · see citing works
125 I-Labeled Quercetin as a Novel DNA-Targeted Radiotracer
Hosseinimehr, S. J., Tolmachev, V., & Stenerlöw, B. (2011) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2010.0951 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 54 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Adiponectin—Consideration for its Role in Skeletal Muscle Health
Krause, M. P., Milne, K. J., & Hawke, T. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071528 · Cited by 121 · see citing works
Long acting GLP-1 analog liraglutide ameliorates skeletal muscle atrophy in rodents
Gurjar, A. A., Kushwaha, S., Chattopadhyay, S., Das, N., Pal, S., China, S. P., Kumar, H., Trivedi, A. K., Guha, R., Chattopadhyay, N., et al. (2020) · Metabolism · doi:10.1016/j.metabol.2019.154044 · Cited by 79 · see citing works
Self-citationAhmad, A., Ali, T., Kim, M. W., Khan, A., Jo, M. H., Rehman, S. U., Khan, M. S., Abid, N. B., Khan, M., Ullah, R., et al. (2019) · Metabolism · doi:10.1016/j.metabol.2018.10.004 · Cited by 76 · see citing works
Self-citationAbou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72 · see citing works
Khan, M. P., Singh, A. K., Joharapurkar, A. A., Yadav, M., Shree, S., Kumar, H., Gurjar, A. A., Mishra, J. S., Tiwari, M. C., Nagar, G. K., et al. (2015) · Diabetes · doi:10.2337/db14-1611 · Cited by 72 · see citing works
Self-citationLiu, Y., Vu, V., & Sweeney, G. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00842 · Cited by 69 · see citing works
Adiponectin and Adiponectin Receptors in Atherosclerosis
Gianopoulos, I., Mantzoros, C. S., & Daskalopoulou, S. S. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae021 · Cited by 71 · see citing works
Rafeh, R. W., Viveiros, A., Oudit, G. Y., & EL‐Yazbi, A. F. (2020) · Clinical Science · doi:10.1042/cs20190227 · Cited by 63 · see citing works
Potential Adiponectin Receptor Response Modifier Therapeutics
Otvos, L. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00539 · Cited by 60 · see citing works
Adiponectin signaling and its role in bone metabolism
Pal China, S., Sanyal, S., & Chattopadhyay, N. (2018) · Cytokine · doi:10.1016/j.cyto.2018.06.012 · Cited by 53 · see citing works
Self-citationGlobular adiponectin reverses osteo-sarcopenia and altered body composition in ovariectomized rats
China, S. P., Pal, S., Chattopadhyay, S., Porwal, K., Kushwaha, S., Bhattacharyya, S., Mittal, M., Gurjar, A. A., Barbhuyan, T. K., Singh, A. K., et al. (2017) · Bone · doi:10.1016/j.bone.2017.08.005 · Cited by 53 · see citing works
Self-citationSharma, A., Mah, M., Ritchie, R. H., & Blasio, M. J. D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108008 · Cited by 50 · see citing works
Targeting Adiponectin in Breast Cancer
Nehme, R., Diab‐Assaf, M., Decombat, C., Delort, L., & Caldefie‐Chezet, F. (2022) · Biomedicines · doi:10.3390/biomedicines10112958 · Cited by 46 · see citing works
AdipoRon and Other Adiponectin Receptor Agonists as Potential Candidates in Cancer Treatments
Nigro, E., Daniele, A., Salzillo, A., Ragone, A., Naviglio, S., & Sapio, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115569 · Cited by 46 · see citing works
Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy
Singh, A. K., Shree, S., Chattopadhyay, S., Kumar, S., Gurjar, A., Kushwaha, S., Kumar, H., Trivedi, A. K., Chattopadhyay, N., Maurya, R., et al. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.013 · Cited by 42 · see citing works
Self-citationThe role of adiponectin in periodontitis: Current state and future prospects
Wang, Z., Chen, Z., Fang, F., & Qiu, W. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111358 · Cited by 35 · see citing works
Pal, S., Singh, M., Porwal, K., Rajak, S., Das, N., Rajput, S., Trivedi, A. K., Maurya, R., Sinha, R. A., Siddiqi, M. I., et al. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174634 · Cited by 28 · see citing works
Self-citationPal, S., Porwal, K., Rajak, S., Sinha, R. A., & Chattopadhyay, N. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110207 · Cited by 27 · see citing works
Self-citationValicherla, G. R., Gupta, A. P., Hossain, Z., Riyazuddin, M., Syed, A. A., Husain, A., Lahiri, S., Dave, K. M., & Gayen, J. R. (2019) · Peptides · doi:10.1016/j.peptides.2019.170147 · Cited by 21 · see citing works
Self-citationPal, S., Sharma, S., Porwal, K., Riyazuddin, M., Kulkarni, C., Chattopadhyay, S., Sanyal, S., Gayen, J. R., & Chattopadhyay, N. (2022) · Calcified Tissue International · doi:10.1007/s00223-022-00979-9 · Cited by 19 · see citing works
Self-citationDiscovery of a transdermally deliverable pentapeptide for activating AdipoR1 to promote hair growth
Ohn, J., Been, K. W., Kim, J. Y., Kim, E. J., Park, T., Yoon, H., Ji, J. S., Okada‐Iwabu, M., Iwabu, M., Yamauchi, T., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202013790 · Cited by 19 · see citing works
Wang, Y., Wang, X., Guo, Y., Bian, Y., Bai, R., Liang, B., & Xiao, C. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4321 · Cited by 17 · see citing works
Chattopadhyay, S., Joharapurkar, A. A., Das, N., Khatoon, S., Kushwaha, S., Gurjar, A. A., Singh, A. K., Shree, S., Ahmed, M. Z., China, S. P., et al. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111525 · Cited by 16 · see citing works
Self-citationYadav, M., Singh, A. K., Kumar, H., Rao, G., Chakravarti, B., Gurjar, A. A., Dogra, S., Kushwaha, S., Vishwakarma, A. L., Yadav, P. N., et al. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.05.011 · Cited by 16 · see citing works
Self-citationRajput, S., Kulkarni, C., Sharma, S., Tomar, M. S., Khatoon, S., Gupta, A., Sanyal, S., Shrivastava, A., Ghosh, J. K., & Chattopadhyay, N. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01509-x · Cited by 15 · see citing works
Self-citationKhan, M. P., Singh, A. K., Singh, A. K., Shrivastava, P., Tiwari, M. C., Nagar, G. K., Bora, H. K., Parameswaran, V., Sanyal, S., Bellare, J., et al. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2719 · Cited by 15 · see citing works
Self-citationRetractedShree, S., Singh, A. K., Saxena, R., Kumar, H., Agarwal, A., Sharma, V. K., Srivastava, K., Srivastava, K. K., Sanyal, S., & Ramachandran, R. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2177-2 · Cited by 15 · see citing works
Self-citationDiscovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I
Sun, G., You, Y., Li, H., Cheng, Y., Qian, M. D., Zhou, X., Yuan, H., Xu, Q., Dai, L. X., Wang, P., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112466 · Cited by 14 · see citing works
Mohri, S., Takahashi, H., Sakai, M., Waki, N., Takahashi, S., Aizawa, K., Suganuma, H., Ara, T., Sugawara, T., Shibata, D., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267248 · Cited by 12 · see citing works
Liu, S., Liu, H., Liu, Y., Zhang, J., Liu, Z., Zheng, Z., & Luo, E. (2022) · Cell Proliferation · doi:10.1111/cpr.13370 · Cited by 10 · see citing works
Guo, H., Ou, H., Yu, J., Rosa, J. M., Formolo, D. A., Cheng, T., Yau, S., & Tsang, H. W. H. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-00943 · Cited by 10 · see citing works
Bengal, E., & Aviram, S. (2025) · Cells · doi:10.3390/cells14161277 · Cited by 10 · see citing works
Glycemic index of ten commercially Indonesian rice cultivars
Kusmiyati, F., Lukiwati, D. R., Kristanto, B. A., & Herwibawa, B. (2019) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/250/1/012028 · Cited by 9 · see citing works
Khatoon, S., Das, N., Chattopadhyay, S., Joharapurkar, A. A., Singh, A., Patel, V. J., Nirwan, A., Kumar, A., Mugale, M. N., Mishra, D. P., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176800 · Cited by 8 · see citing works
Self-citationBariatric surgery—what the ophthalmologist needs to know
Hari, T., & Elsherbiny, S. (2021) · Eye · doi:10.1038/s41433-021-01811-8 · Cited by 7 · see citing works
Isovitexin, a natural adiponectin agonist, prevents glucocorticoid-induced osteosarcopenia
Kulkarni, C., Kumar, S., Khatoon, S., Sadhukhan, S., Washimkar, K. R., Kumar, A., Sharma, S., Rajput, S., Porwal, K., Mugale, M. N., et al. (2025) · Endocrine · doi:10.1007/s12020-025-04251-6 · Cited by 6 · see citing works
Self-citationAdiponectin and aging: Mechanistic insights, clinical paradox, and therapeutic horizons
McGregor, E. R., Osterbauer, K. J., Gustafson, G. E., Clark, J. P., Rhoads, T. W., & Anderson, R. M. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103059 · Cited by 6 · see citing works
Adiponectin and Adiponectin Signaling
Hadley, J. T., Ryu, J., & Dong, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819801-8.00013-2 · Cited by 5 · see citing works
Pathak, M. P., Das, A., Patowary, P., & Chattopadhyay, P. (2020) · Biochimie · doi:10.1016/j.biochi.2020.05.008 · Cited by 4 · see citing works
Adiponectin and central nervous system disorders: Regulatory mechanisms and therapeutic potential
Li, M., Wu, M., Gao, H., Xue, X., Xiao, W., & Zhu, L. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108260 · Cited by 2 · see citing works
C. elegans PAQR-2 ‒ A Regulator of Membrane Homeostasis
Svensk, E. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Khan, M. P., Crowe, E., Letson, J., Baroi, S., Czernik, P. J., & Lecka‐Czernik, B. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.02.722443
Self-citationDas, S., Awasthi, P., Moin, M. R., Pal, S., Talukdar, A., Kumar, A., Nikolas, N., Varode, S. S., Khatoon, S., Das, N., et al. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70364
Self-citation
- Authors
- Singh, A. K., Joharapurkar, A. A., Khan, M. P., Mishra, J. S., Singh, N., Yadav, M., Hossain, Z., Khan, K., Kumar, S., Dhanesha, N. A., Mishra, D. P., Maurya, R., Sharma, S., Jain, M. R., Trivedi, A. K., Godbole, M. M., Gayen, J. R., Chattopadhyay, N., & Sanyal, S.
- Affiliations
- Central Drug Research Institute (IN)
- Zydus Lifesciences Limited (India) (IN)
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
- ORCID
- Singh, Abhishek Kumar
- Joharapurkar, Amit Arvind
- Khan, Mohd. Parvez
- Mishra, Jay Sharan
- Singh, Nidhi
- Hossain, Zakir
- Kumar, Sudhir
- Dhanesha, Nirav Anilkumar
- Mishra, Devendra Pratap
- Maurya, Rakesh
- Sharma, Sharad
- Jain, Mukul Rameshchandra
- Trivedi, Arun Kumar
- Godbole, Madan Madhav
- Gayen, Jiaur Rahaman
- Chattopadhyay, Naibedya
- Sanyal, Sabyasachi
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2014-09-15
- Volume
- 63
- Issue
- 10
- Pages
- 3530-3544
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- OpenAlex
- W2014452447
- Cited by
- 43
- References
- 54
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adiponectin receptors, AdipoR1, AdipoR2, type 2 diabetes, glucose uptake, fatty acid oxidation, beta-cell survival, steatohepatitis, white adipose tissue browning, lipid profile, metabolic health, oral bioavailability
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Disease Models, Animal, Fatty Acids, Glucose, Insulin, Insulin Resistance, Obesity, Quercetin, Signal Transduction, Muscle, Skeletal, Lipid Metabolism, Mice, Adiponectin, Receptors, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review