Cited by 43Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Orally active osteoanabolic agent GTDF binds to adiponectin receptors, with a preference for AdipoR1, induces adiponectin-associated signaling, and improves metabolic health in a rodent model of diabetes

Singh, Abhishek Kumar, Joharapurkar, Amit Arvind, Khan, Mohd. Parvez, Mishra, Jay Sharan, Singh, Nidhi, Yadav, Manisha, Hossain, Zakir, Khan, Kainat +11 more·2014·Diabetes

Abstract

Adiponectin is an adipocytokine that signals through plasma membrane-bound adiponectin receptors 1 and 2 (AdipoR1 and -2). Plasma adiponectin depletion is associated with type 2 diabetes, obesity, and cardiovascular diseases. Adiponectin therapy, however, is yet unavailable owing to its large size, complex multimerization, and functional differences of the multimers. We report discovery and characterization of 6-C-β-D-glucopyranosyl-(2S,3S)-(+)-5,7,3',4'-tetrahydroxydihydroflavonol (GTDF) as an orally active adiponectin mimetic. GTDF interacted with both AdipoRs, with a preference for AdipoR1. It induced adiponectin-associated signaling and enhanced glucose uptake and fatty acid oxidation in vitro, which were augmented or abolished by AdipoR1 overexpression or silencing, respectively. GTDF improved metabolic health, characterized by elevated glucose clearance, β-cell survival, reduced steatohepatitis, browning of white adipose tissue, and improved lipid profile in an AdipoR1-expressing but not an AdipoR1-depleted strain of diabetic mice. The discovery of GTDF as an adiponectin mimetic provides a promising therapeutic tool for the treatment of metabolic diseases.

Integrity signals

Registry

Crossref · 10.2337/db13-1619

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 54 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Singh, A. K., Joharapurkar, A. A., Khan, M. P., Mishra, J. S., Singh, N., Yadav, M., Hossain, Z., Khan, K., Kumar, S., Dhanesha, N. A., Mishra, D. P., Maurya, R., Sharma, S., Jain, M. R., Trivedi, A. K., Godbole, M. M., Gayen, J. R., Chattopadhyay, N., & Sanyal, S.
Affiliations
  • Central Drug Research Institute (IN)
  • Zydus Lifesciences Limited (India) (IN)
  • Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
Venue
Diabetes
Published
2014-09-15
Volume
63
Issue
10
Pages
3530-3544
ISSN
  • 0012-1797 (ISSN-L)
  • 1939-327X
OpenAlex
W2014452447
Cited by
43
References
54
Citations by year
2026: 4 · 2025: 3 · 2024: 3 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2
FWCI
2.02
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
adiponectin receptors, AdipoR1, AdipoR2, type 2 diabetes, glucose uptake, fatty acid oxidation, beta-cell survival, steatohepatitis, white adipose tissue browning, lipid profile, metabolic health, oral bioavailability
MeSH terms
Animals, Diabetes Mellitus, Type 2, Disease Models, Animal, Fatty Acids, Glucose, Insulin, Insulin Resistance, Obesity, Quercetin, Signal Transduction, Muscle, Skeletal, Lipid Metabolism, Mice, Adiponectin, Receptors, Adiponectin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review