Cited by 136Ovarian function and disordersAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

Evidence of proatherogenic inflammation in polycystic ovary syndrome

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González, Frank, Rote, Neal S., Minium, Judi, Kirwan, John P.·2009·Metabolism

Abstract

Women with polycystic ovary syndrome (PCOS) have chronic low-level inflammation that can increase the risk of atherogenesis. We measured circulating proatherogenic inflammatory mediators in women with PCOS (8 lean: body mass index, 18-25 kg/m(2); 8 obese: body mass index, 30-40 kg/m(2)) and weight-matched controls (8 lean, 8 obese). Blood samples were obtained fasting and 2 hours after glucose ingestion to measure interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), monocyte chemotactic protein-1 (MCP-1), C-reactive protein (CRP), matrix metalloproteinase-2, plasminogen activator inhibitor-1 (PAI-1), and activated nuclear factor kappaB in mononuclear cells. Truncal fat was determined by dual-energy x-ray absorptiometry. Fasting MCP-1 levels were elevated in lean women with PCOS compared with lean controls (159.9 +/- 14.1 vs 121.2 +/- 5.4 pg/mL, P < .02). Hyperglycemia failed to suppress matrix metalloproteinase-2 in lean women with PCOS compared with lean controls (1.7 +/- 1.2 vs -4.8 +/- 1.6 pg/mL, P < .002). Among women with PCOS, obese individuals exhibited higher fasting sICAM-1 (16.1 +/- 0.8 vs 10.5 +/- 1.0 ng/mL, P < .03) and PAI-1 (6.1 +/- 0.7 vs 3.4 +/- 0.8 ng/mL, P < .03) levels. Trend analysis revealed higher (P < .005) IL-6, sICAM-1, CRP, PAI-1, systolic and diastolic blood pressures, triglycerides, fasting insulin, and homeostasis model assessment of insulin resistance index in women with PCOS compared with weight-matched controls, and the highest levels in the obese regardless of PCOS status. Fasting MCP-1 levels correlated with activated nuclear factor kappaB during hyperglycemia (P < .05) and androstenedione (P < .004). Truncal fat correlated with fasting IL-6 (P < .004), sICAM-1 (P < .006), CRP (P < .0009), and PAI-1 (P < .02). We conclude that both PCOS and obesity contribute to a proatherogenic state; but in women with PCOS, abdominal adiposity and hyperandrogenism may exacerbate the risk of atherosclerosis.

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Crossref · 10.1016/j.metabol.2009.02.022

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Authors
González, F., Rote, N. S., Minium, J., & Kirwan, J. P.
Affiliations
  • Mayo Clinic (US)
  • Case Western Reserve University (US)
  • Cleveland Clinic (US)
Corresponding author
González, Frank
Venue
Metabolism
Publisher
Elsevier BV
Published
2009-07
Volume
58
Issue
7
Pages
954-962
ISSN
0026-0495 (ISSN-L)
OpenAlex
W1968511949
Cited by
135
References
59
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 10 · 2015: 7 · 2014: 13 · 2013: 3 · 2012: 16
FWCI
16.15
Type
journal article
Language
en
Open access
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • University at Buffalo
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-048535, R03HD048535)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
polycystic ovary syndrome, low-grade inflammation, atherogenesis, obesity, truncal fat, interleukin-6, soluble intercellular adhesion molecule-1, MCP-1, C-reactive protein, plasminogen activator inhibitor-1, MMP-2, nuclear factor-kappaB, hyperglycemia, insulin resistance, androstenedione, blood pressure, dyslipidemia, fasting insulin
MeSH terms
Adult, Androgens, C-Reactive Protein, Female, Glucose Tolerance Test, Humans, Obesity, Polycystic Ovary Syndrome, Absorptiometry, Photon, Interleukin-6, NF-kappa B, Plasminogen Activator Inhibitor 1, Intercellular Adhesion Molecule-1, Chemokine CCL2, Matrix Metalloproteinase 2, Electrophoretic Mobility Shift Assay, Atherosclerosis, Young Adult

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