The DOI matches its Crossref record; 252 of the 257 references it cites were found in a registry or an index.
Thyroid hormone resistance: Mechanisms and therapeutic development
Abstract
As an essential primary hormone, thyroid hormone (TH) is indispensable for human growth, development and metabolism. Impairment of TH function in several aspects, including TH synthesis, activation, transportation and receptor-dependent transactivation, can eventually lead to thyroid hormone resistance syndrome (RTH). RTH is a rare syndrome that manifests as a reduced target cell response to TH signaling. The majority of RTH cases are related to thyroid hormone receptor β (TRβ) mutations, and only a few RTH cases are associated with thyroid hormone receptor α (TRα) mutations or other causes. Patients with RTH suffer from goiter, mental retardation, short stature and bradycardia or tachycardia. To date, approximately 170 mutated TRβ variants and more than 20 mutated TRα variants at the amino acid level have been reported in RTH patients. In addition to these mutated proteins, some TR isoforms can also reduce TH function by competing with primary TRs for TRE and RXR binding. Fortunately, different treatments for RTH have been explored with structure-activity relationship (SAR) studies and drug design, and among these treatments. With thyromimetic potency but biochemical properties that differ from those of primary TH (T3 and T4), these TH analogs can bypass specific defective transporters or reactive mutant TRs. However, these compounds must be carefully applied to avoid over activating TRα, which is associated with more severe heart impairment. The structural mechanisms of mutation-induced RTH in the TR ligand-binding domain are summarized in this review. Furthermore, strategies to overcome this resistance for therapeutic development are also discussed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the case of THR, there is no therapy that completely corrects the underlying defect, but treatments with thyroid hormone analogs have been investigated to improve symptoms without excessive activation of the a thyroid hormone receptor, which would worsen cardiac prognosis.91”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [91]
In the citing paper
“In the case of THR, there is no therapy that completely corrects the underlying defect, but treatments with thyroid hormone analogs have been investigated to improve symptoms without excessive activation of the a thyroid hormone receptor, which would worsen cardiac prognosis.91”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [91]
Citations
Cites
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,072
Physiological and Molecular Basis of Thyroid Hormone Action
Yen, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1097 · Cited by 2,011
Umesono, K., Murakami, K. K., Thompson, C. C., & Evans, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90020-y · Cited by 1,688
The c-erb-A gene encodes a thyroid hormone receptor
Weinberger, C., Thompson, C. C., Ong, E. S., Lebo, R. V., Gruol, D. J., & Evans, R. M. (1986) · Nature · doi:10.1038/324641a0 · Cited by 1,477
Molecular Aspects of Thyroid Hormone Actions
Cheng, S.-Y., Leonard, J. L., & Davis, P. J. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0007 · Cited by 1,384
The c-erb-A protein is a high-affinity receptor for thyroid hormone
Sap, J., Múñoz, A., Damm, K., Goldberg, Y., Ghysdael, J., Leutz, A., Beug, H., & Vennström, B. (1986) · Nature · doi:10.1038/324635a0 · Cited by 1,314
Regulation of Transcription by a Protein Methyltransferase
Chen, D., Ma, H., Hong, H., Koh, S. S., Huang, S., Schurter, B. T., Aswad, D. W., & Stallcup, M. R. (1999) · Science · doi:10.1126/science.284.5423.2174 · Cited by 1,214
A structural role for hormone in the thyroid hormone receptor
Wagner, R. L., Apriletti, J. W., McGrath, M. E., West, B. L., Baxter, J. D., & Fletterick, R. J. (1995) · Nature · doi:10.1038/378690a0 · Cited by 928
Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter
Friesema, E. C. H., Ganguly, S., Abdalla, A., Fox, J. E. M., Halestrap, A. P., & Visser, T. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300909200 · Cited by 725
Friesema, E. C., Grueters, A., Biebermann, H., Krude, H., von Moers, A., Reeser, M., Barrett, T. G., Mancilla, E. E., Svensson, J., Kester, M. H., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17226-7 · Cited by 709
Structural determinants of nuclear receptor assembly on DNA direct repeats
Rastinejad, F., Perlmann, T., Evans, R. M., & Sigler, P. B. (1995) · Nature · doi:10.1038/375203a0 · Cited by 578
REFETOFF, S., DEWIND, L. T., & DEGROOT, L. J. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-2-279 · Cited by 568
Whole-genome sequencing of quartet families with autism spectrum disorder
Yuen, R. K. C., Thiruvahindrapuram, B., Merico, D., Walker, S., Tammimies, K., Hoang, N., Chrysler, C., Nalpathamkalam, T., Pellecchia, G., Liu, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3792 · Cited by 514
Mutations in SECISBP2 result in abnormal thyroid hormone metabolism
Dumitrescu, A. M., Liao, X.-H., Abdullah, M. S. Y., Lado-Abeal, J., Majed, F. A., Moeller, L. C., Boran, G., Schomburg, L., Weiss, R. E., & Refetoff, S. (2005) · Nature Genetics · doi:10.1038/ng1654 · Cited by 412
Thyroid hormone receptors and resistance to thyroid hormone disorders
Ortiga-Carvalho, T. M., Sidhaye, A. R., & Wondisford, F. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.143 · Cited by 383
A Mutation in the Thyroid Hormone Receptor Alpha Gene
Bochukova, E., Schoenmakers, N., Agostini, M., Schoenmakers, E., Rajanayagam, O., Keogh, J. M., Henning, E., Reinemund, J., Gevers, E., Sarri, M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110296 · Cited by 379
Hurley, D. M., Accili, D., Stratakis, C. A., Karl, M., Vamvakopoulos, N., Rorer, E., Constantine, K., Taylor, S. I., & Chrousos, G. P. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115046 · Cited by 370
Deiodinases and their intricate role in thyroid hormone homeostasis
Luongo, C., Dentice, M., & Salvatore, D. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0218-2 · Cited by 332
Vennström, B., & Bishop, J. M. (1982) · Cell · doi:10.1016/0092-8674(82)90383-x · Cited by 319
Schoenmakers, E., Agostini, M., Mitchell, C., Schoenmakers, N., Papp, L., Rajanayagam, O., Padidela, R., Ceron-Gutierrez, L., Doffinger, R., Prevosto, C., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43653 · Cited by 315
Transcriptional repression by nuclear hormone receptors.
Hu, X., & Lazar, M. (2000) · Trends in endocrinology and metabolism · doi:10.1016/s1043-2760(99)00215-5 · Cited by 297
Central Hypothyroidism: Pathogenic, Diagnostic, and Therapeutic Challenges
Persani, L. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1616 · Cited by 295
Refetoff, S., & Dumitrescu, A. M. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.03.005 · Cited by 294
Paradigms of dynamic control of thyroid hormone signaling
Bianco, A. C., Dumitrescu, A., Gereben, B., Ribeiro, M. O., Fonseca, T. L., Fernandes, G. W., & Bocco, B. M. L. C. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00275 · Cited by 293
Cloning and Characterization of Two Novel Thyroid Hormone Receptor β Isoforms
Williams, G. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.22.8329-8342.2000 · Cited by 290
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor
Chiellini, G., Apriletti, J. W., Yoshihara, H. A. I., Baxter, J. D., Ribeiro, R. C. J., & Scanlan, T. S. (1998) · Chemistry & Biology · doi:10.1016/s1074-5521(98)90168-5 · Cited by 278
Erion, M. D., Cable, E. E., Ito, B. R., Jiang, H., Fujitaki, J. M., Finn, P. D., Zhang, B., Hou, J., Boyer, S. H., van Poelje, P. D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702759104 · Cited by 273
Sakurai, A., Takeda, K., Ain, K., Ceccarelli, P., Nakai, A., Seino, S., Bell, G. I., Refetoff, S., & DeGroot, L. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8977 · Cited by 268
Zechel, C., Shen, X.-Q., Chen, J. Y., Zp, C., Chambon, P., & Gronemeyer, H. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06396.x · Cited by 254
The syndromes of reduced sensitivity to thyroid hormone
Dumitrescu, A. M., & Refetoff, S. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.005 · Cited by 253
The Effect of Thyroid Hormone on Skeletal Integrity
Greenspan, S. L., & Greenspan, F. S. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-9-199905040-00016 · Cited by 249
Parrilla, R., Mixson, A. J., McPherson, J. A., McClaskey, J. H., & Weintraub, B. D. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115542 · Cited by 245
Kelly, M. J., Pietranico-Cole, S., Larigan, J. D., Haynes, N.-E., Reynolds, C. H., Scott, N., Vermeulen, J., Dvorozniak, M., Conde-Knape, K., Huang, K.-S., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm4019299 · Cited by 231
An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction
Peterson, S. J., Cappola, A. R., Castro, M. R., Dayan, C. M., Farwell, A. P., Hennessey, J. V., Kopp, P. A., Ross, D. S., Samuels, M. H., Sawka, A. M., et al. (2018) · Thyroid · doi:10.1089/thy.2017.0681 · Cited by 231
Adams, M., Matthews, C., Collingwood, T. N., Tone, Y., Beck‐Peccoz, P., & Chatterjee, K. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117362 · Cited by 229
Persani, L., Brabant, G., Dattani, M., Bonomi, M., Feldt-Rasmussen, U., Fliers, E., Gruters, A., Maiter, D., Schoenmakers, N., & van Trotsenburg, A. S. P. (2018) · European Thyroid Journal · doi:10.1159/000491388 · Cited by 222
Clinical Phenotype and Mutant TRα1
van Mullem, A. A., van Heerebeek, R., Chrysis, D., Visser, W. E., Medici, M., Andrikoula, M., Tsatsoulis, A. A., Peeters, R. P., & Visser, T. J. (2012) · New England Journal of Medicine · doi:10.1056/nejmc1113940 · Cited by 221
Yoh, S. M., Chatterjee, K., & Privalsky, M. L. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9914 · Cited by 218
Groeneweg, S., van Geest, F. S., Peeters, R. P., Heuer, H., & Visser, W. E. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz008 · Cited by 216
Léger, J., Olivieri, A., Donaldson, M., Torresani, T., Krude, H., van Vliet, G., Polak, M., Butler, G., & on behalf of ESPE-PES-SLEP-JSPE-APEG-APPES-ISPAE, A. T. C. H. C. C. G. (2014) · Hormone Research in Paediatrics · doi:10.1159/000358198 · Cited by 208
Thyroid hormone signaling and the liver
Ritter, M. J., Amano, I., Hollenberg, A. N., et al. (2020) · Hepatology · doi:10.1002/hep.31296 · Cited by 188
Usala, S. J., Tennyson, G. E., Bale, A. E., Lash, R. W., Gesundheit, N., Wondisford, F. E., Accili, D., Hauser, P., & Weintraub, B. D. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114438 · Cited by 183
Ranjan, M., Wong, J., & Shi, Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31447-3 · Cited by 182
Chassande, O., Fraichard, A., Gauthier, K. C., Flamant, F., Legrand, C., Savatier, P., Laudet, V., & Samarut, J. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.9.9972 · Cited by 177
Usala, S. J., Bale, A. E., Gesundheit, N., Weinberger, C., Lash, R. W., Wondisford, F. E., McBride, O. W., & Weintraub, B. D. (1988) · Molecular Endocrinology · doi:10.1210/mend-2-12-1217 · Cited by 169
Fondell, J. D., Guermah, M., Malik, S., & Roeder, R. G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.1959 · Cited by 165
Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature
Flamant, F., Cheng, S.-Y., Hollenberg, A. N., Moeller, L. C., Samarut, J., Wondisford, F. E., Yen, P. M., & Refetoff, S. (2017) · Endocrinology · doi:10.1210/en.2017-00250 · Cited by 165
Nascimento, A. S., Dias, S. M. G., Nunes, F. M., Aparício, R., Ambrosio, A. L. B., Bleicher, L., Figueira, A. C. M., Santos, M. A. M., Neto, M. D. O., Fischer, H., et al. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.05.008 · Cited by 161
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor
Borngraeber, S., Budny, M. J., Chiellini, G., Lima, S. T. D. C., Togashi, M., Webb, P., Baxter, J. D., Scanlan, T. S., & Fletterick, R. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2136689100 · Cited by 161
Detection and treatment of congenital hypothyroidism
Grüters, A., & Krude, H. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.160 · Cited by 160
Liu, Y., Yeh, C., & Lin, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20204986 · Cited by 153
Thyroxine-thyroid hormone receptor interactions
Sandler, B., Webb, P., Apriletti, J. W., Huber, B. R., Togashi, M., Lima, S. T. C., Juric, S., Nilsson, S., Wagner, R., Fletterick, R. J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410124200 · Cited by 152
SUCCESSFUL LABORATORY SCREENING FOR CONGENITAL HYPOTHYROIDISM
Klein, A. H., Agustin, A. V., & Foley, T. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91637-7 · Cited by 151
Collingwood, T. N., Adams, M., Tone, Y., & Chatterjee, K. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.9.7838159 · Cited by 149
Weiss, R. E., Weinberg, M., & Refetoff, S. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116474 · Cited by 147
Collingwood, T. N., Wagner, R. L., Matthews, C. H., Clifton-Bligh, R. J., Gurnell, M., Rajanayagam, O., Agostini, M., Fletterick, R. J., Beck‐Peccoz, P., Reinhardt, W., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.16.4760 · Cited by 146
An Adult Female With Resistance to Thyroid Hormone Mediated by Defective Thyroid Hormone Receptor α
Moran, C., Schoenmakers, N. A., Agostini, M., Schoenmakers, E., Offiah, A. C., Kydd, A. C., Kahaly, G., Mohr-Kahaly, S., Rajanayagam, O., Lyons, G., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2215 · Cited by 144
Thyroid hormone receptor localization in target tissues
Anyetei‐Anum, C. S., Roggero, V. R., & Allison, L. A. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0708 · Cited by 144
Thyroid Receptor Ligands. 1. Agonist Ligands Selective for the Thyroid Receptor β1
Liu, Y., Li, Y.-L., Mellström, K., Mellin, C., Bladh, L.-G., Koehler, K., Garg, N. K., Collazo, A., Litten, C., Husman, B., et al. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm021080f · Cited by 143
Self-citationSanchez, J. G., Rios, M. S., Pérez, C. F., Laakso, M., & Larrad, M. T. M. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470495 · Cited by 143
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
Kojetin, D. J., Matta‐Camacho, E., Hughes, T., Srinivasan, S., Nwachukwu, J. C., Cavett, V. J., Nowak, J., Chalmers, M. J., Marciano, D. P., Kamenecka, T. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9013 · Cited by 141
Groeneweg, S., Peeters, R. P., Moran, C., Stoupa, A., Auriol, F., Tonduti, D., Dica, A., Paone, L., Rozenkova, K., Malikova, J., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30155-x · Cited by 129
Thyroid Hormone Receptor Coactivators and Corepressors
Koenig, R. J. (1998) · Thyroid · doi:10.1089/thy.1998.8.703 · Cited by 128
Moran, C., Agostini, M., Visser, W. E., Schoenmakers, E., Schoenmakers, N., Offiah, A. C., Poole, K., Rajanayagam, O., Lyons, G., Halsall, D., et al. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70111-1 · Cited by 127
Androgen resistance due to mutation of the androgen receptor.
Pinsky, L., Trifiro, M. A., Kaufman, M., Beitel, L. K., Mhatre, A. N., Kazemi‐Esfarjani, P., Sabbaghian, N., Lumbroso, R., Alvarado, C., & Vasiliou, M. (1992) · PubMed · Cited by 127
Usala, S. J., Menke, J. B., Watson, T. L., Wondisford, F. E., Weintraub, B. D., Bérard, J., Bradley, W. E. C., Ono, S. J., Mueller, O. T., & Bercu, B. B. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-3-327 · Cited by 125
Saponaro, F., Sestito, S., Runfola, M., Rapposelli, S., & Chiellini, G. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00331 · Cited by 124
6 Mineralocorticoid resistance
Komesaroff, P. A., Funder, J. W., & Fuller, P. J. (1994) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80256-3 · Cited by 122
Katz, D., & Lazar, M. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36872-3 · Cited by 120
Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells
Chatonnet, F., Guyot, R., Benoît, G., & Flamant, F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210626110 · Cited by 120
Mitchell, C. S., Savage, D. B., Dufour, S., Schoenmakers, N. A., Murgatroyd, P. R., Befroy, D. E., Halsall, D. J., Northcott, S., Raymond‐Barker, P., Curran, S., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38793 · Cited by 118
Goldman, S., McCarren, M., Morkin, E., Ladenson, P. W., Edson, R., Warren, S., Ohm, J., Thai, H., Churby, L., Barnhill, J., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.834424 · Cited by 117
Cosmo, C. D., McLellan, N., Liao, X.-H., Khanna, K. K., Weiss, R. E., Papp, L. V., & Refetoff, S. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0686 · Cited by 116
Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency
Pfäffle, R., & Klammt, J. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.10.014 · Cited by 115
Collingwood, T. N., Rajanayagam, O., Adams, M., Wagner, R., Cavaillès, V., Kalkhoven, E., Matthews, C., Nyström, E. E. L., Stenlof, K., Lindstedt, G., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.248 · Cited by 114
Structural and functional insights into nuclear receptor signaling
Jin, L., & Li, Y. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.08.007 · Cited by 112
Self-citationTransport of Thyroid Hormone in Brain
Wirth, E. K., Schweizer, U., & Köhrle, J. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00098 · Cited by 109
van Mullem, A. A., Chrysis, D., Eythimiadou, A., Chroni, E., Tsatsoulis, A. A., de Rijke, Y. B., Visser, W. E., Visser, T. J., & Peeters, R. P. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1050 · Cited by 109
Selenoprotein-Related Disease in a Young Girl Caused by Nonsense Mutations in the SBP2 Gene
Azevedo, M. F., Barra, G. B., Naves, L. A., Ribeiro Velasco, L. F., Godoy Garcia Castro, P., de Castro, L. C. G., Amato, A. A., Miniard, A., Driscoll, D., Schomburg, L., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2611 · Cited by 106
Thyroid hormone resistance syndrome due to mutations in the thyroid hormone receptor α gene (THRA)
Tylki‐Szymańska, A., Acuña‐Hidalgo, R., Krajewska‐Walasek, M., Lecka-Ambroziak, A., Steehouwer, M., Gilissen, C., Brunner, H. G., Jurecka, A., Różdżyńska‐Świątkowska, A., Hoischen, A., et al. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102936 · Cited by 106
Weiss, R. E., Hayashi, Y., Nagaya, T., Petty, K. J., Murata, Y., TUNCA, H., Seo, H., & Refetoff, S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954015 · Cited by 106
MOLECULAR AND STRUCTURAL BIOLOGY OF THYROID HORMONE RECEPTORS
Apriletti, J. W., Ribeiro, R. C. J., Wagner, R., Feng, W., Webb, P., Kushner, P. J., West, B. L., Nilsson, S. V., Scanlan, T. S., Fletterick, R. J., et al. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02293.x · Cited by 101
Kersseboom, S., Horn, S., Visser, W. E., Chen, J., Friesema, E. C. H., Vaurs‐Barrière, C., Peeters, R. P., Heuer, H., & Visser, T. J. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1135 · Cited by 96
Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis
Schoenmakers, E., Carlson, B. A., Agostini, M., Moran, C., Rajanayagam, O., Bochukova, E. G., Tobe, R., Peat, R. A., Gevers, E. F., Francesco Muntoni, A., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84747 · Cited by 96
Tagami, T., Gu, W.-X., Peairs, P. T., West, B. L., & Jameson, J. L. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.12.0201 · Cited by 94
Giammanco, M., Liegro, C. M. D., Schiera, G., & Liegro, I. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114140 · Cited by 93
Gaining ligand selectivity in thyroid hormone receptors via entropy
Martı́nez, L., Nascimento, A. S., Nunes, F. M., Phillips, K. J., Aparício, R., Dias, S. M. G., Figueira, A. C. M., Lin, J. Z., Nguyen, P. T., Apriletti, J. W., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911024106 · Cited by 84
Horn, S., Kersseboom, S., Mayerl, S. E., Müller, J., Groba, C., Trajkovic‐Arsic, M., Ackermann, T., Visser, T. J., & Heuer, H. (2013) · Endocrinology · doi:10.1210/en.2012-1628 · Cited by 84
Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance
Yao, B., Wei, Y., Zhang, S., Tian, S., Xu, S., Wang, R., Zheng, W., & Li, Y. (2019) · iScience · doi:10.1016/j.isci.2019.10.002 · Cited by 83
Self-citationLi, D., Li, T., Wang, F., Tian, H., & Samuels, H. H. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5782-5792.2002 · Cited by 80
Liu, Y., Heymann, R. S., Moatamed, F., Schultz, J. J., Sobel, D., & Brent, G. A. (2006) · Endocrinology · doi:10.1210/en.2006-0836 · Cited by 79
Takeda, K. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.4.1548332 · Cited by 77
Strømme, P., Groeneweg, S., de Souza, E. C. L., Zevenbergen, C., Torgersbråten, A., Holmgren, A., Gurcan, E., Meima, M. E., Peeters, R. P., Visser, W. E., et al. (2018) · Thyroid · doi:10.1089/thy.2018.0595 · Cited by 77
A Novel Mutation in THRA Gene Associated With an Atypical Phenotype of Resistance to Thyroid Hormone
Espiard, S., Savagner, F., Flamant, F., Vlaeminck-Guillem, V., Guyot, R., Munier, M., d'Herbomez, M., Bourguet, W., Pinto, G., Rose, C., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1120 · Cited by 75
Mixson, A. J., Parrilla, R., Ransom, S. C., Wiggs, E. A., McClaskey, J. H., Hauser, P., & Weintraub, B. D. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400869 · Cited by 75
Pennock, G. D., Raya, T. E., Bahl, J. J., Goldman, S., & Morkin, E. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10319-4 · Cited by 74
Singh, B. K., & Yen, P. M. (2017) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-017-0046-z · Cited by 72
Hashimoto, K., Cohen, R., Yamada, M., Markan, K. R., Monden, T., Satoh, T., Mori, M., & Wondisford, F. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507877200 · Cited by 71
Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha
van Gucht, A. L. M., Moran, C., Meima, M. E., Visser, W. E., Chatterjee, K., Visser, T. J., & Peeters, R. P. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.02.001 · Cited by 71
Visser, W. E., Vrijmoeth, P., Visser, F. E., ARTS, W. F. M., van Toor, H., & Visser, T. J. (2012) · Clinical Endocrinology · doi:10.1111/cen.12023 · Cited by 70
Rut, A. R., Hewlson, Y., Kristjánsson, K., Luisl, B., Hughes, M. R., & O'Riordan, J. L. H. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb01822.x · Cited by 69
Diverse Genotypes and Phenotypes of Three Novel Thyroid Hormone Receptor-α Mutations
Demir, K., van Gucht, A. L. M., Büyükinan, M., Çatlı, G., Ayhan, Y., Baş, V. N., Dündar, B., Özkan, B., Meima, M. E., Visser, W. E., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1404 · Cited by 69
van Gucht, A. L. M., Meima, M. E., Zwaveling-Soonawala, N., Visser, W. E., Fliers, E., Wennink, J. M. B., Henny, C., Visser, T. J., Peeters, R. P., & van Trotsenburg, A. S. P. (2016) · Thyroid · doi:10.1089/thy.2015.0463 · Cited by 67
c- erbA Encodes Multiple Proteins in Chicken Erythroid Cells
Bigler, J., & Eisenman, R. N. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.10.4155 · Cited by 65
Prenatal Diagnosis of Thyroid Hormone Resistance
Asteria, C., Rajanayagam, O., Collingwood, T. N., Persani, L., Romoli, R., Mannavola, D., Zamperini, P., Buzi, F., Ciralli, F., Chatterjee, K., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5479 · Cited by 65
Groeneweg, S., Peeters, R. P., Visser, T. J., & Visser, W. E. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.02.029 · Cited by 65
The diagnosis and management of central hypothyroidism in 2018
Persani, L., Cangiano, B., & Bonomi, M. (2019) · Endocrine Connections · doi:10.1530/ec-18-0515 · Cited by 64
Bigler, J., Hokanson, W., & Eisenman, R. N. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.5.2406 · Cited by 64
Grijota-Martínez, C., Samarut, É., Scanlan, T. S., Morte, B., & Bernal, J. (2011) · Endocrinology · doi:10.1210/en.2010-0813 · Cited by 62
Usala, S. J., Menke, J. B., Watson, T. L., Bérard, J., Bradley, W. E. C., Bale, A. E., Lash, R. W., & Weintraub, B. D. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-1-32 · Cited by 62
Runfola, M., Sestito, S., Bellusci, L., Pietra, V. L., D’Amore, V. M., Kowalik, M. A., Chiellini, G., Gul, S., Perra, A., Columbano, A., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.112006 · Cited by 61
Moran, C., Agostini, M., McGowan, A., Schoenmakers, E., Fairall, L., Lyons, G., Rajanayagam, O., Watson, L., Offiah, A., Barton, J., et al. (2017) · Thyroid® · doi:10.1089/thy.2017.0157 · Cited by 60
Ladenson, P. W., McCarren, M., Morkin, E., Edson, R., Shih, M., Warren, S., BARNHILL, J. G., Churby, L., Thai, H. M., O’Brien, T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1209 · Cited by 57
GORMAN, C. A., JIANG, N.-S., ELLEFSON, R. D., & ELVEBACK, L. R. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-1-1 · Cited by 56
Yamagishi, A., Tomatsu, S., Fukuda, S., Uchiyama, A., Shimozawa, N., Suzuki, Y., Kondo, N., Sukegawa, K., & Orii, T. (1996) · Human Mutation · doi:10.1002/(sici)1098-1004(1996)7:1 · Cited by 53
Behr, M., & Loos, U. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.7.1324420 · Cited by 51
Thyroid Hormone Receptor Variant α2
Yang, Y.-Z., Burgos-Trinidad, M., Wu, Y., & Koenig, R. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.45.28235 · Cited by 49
Wang, C., Lin, K., & Hsu, Y. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00722-4 · Cited by 47
Design and Characterization of a Thyroid Hormone Receptor α (TRα)-Specific Agonist
Ocasio, C. A., & Scanlan, T. S. (2006) · ACS Chemical Biology · doi:10.1021/cb600311v · Cited by 46
Cardiac Dysfunction Caused by Myocardium-Specific Expression of a Mutant Thyroid Hormone Receptor
Pazos-Moura, C. C., Abel, E. D., Boers, M.-E., de Moura, E. G., Hampton, T., Wang, J., Morgan, J. P., & Wondisford, F. E. (2000) · Circulation Research · doi:10.1161/01.res.86.6.700 · Cited by 46
Fozzatti, L., Kim, D. W., Park, J. W., Willingham, M. C., Hollenberg, A. N., & Cheng, S.-Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222334110 · Cited by 45
Onigata, K., & Szinnai, G. (2014) · Endocrine development · doi:10.1159/000363159 · Cited by 45
A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons
Richard, S., Guyot, R., Rey‐Millet, M., Prieux, M., Markossian, S., Aubert, D., & Flamant, F. (2020) · iScience · doi:10.1016/j.isci.2020.100899 · Cited by 45
Wu, S. Y., Cohen, R., Şimşek, E., Şenses, D. A., Yar, N. E., Grasberger, H., Noel, J. A., Refetoff, S., & Weiss, R. E. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2428 · Cited by 44
Elevated Free Thyroxine Levels Detected by a Neonatal Screening System
Tajima, T., Jo, W., Fujikura, K., Fukushi, M., & Fujieda, K. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e3181b1bcbd · Cited by 43
Weiss, R. E., Stein, M. A., Duck, S. C., Chyna, B., Phillips, W., O'Brien, T., Gutermuth, L., & Refetoff, S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.8200958 · Cited by 43
Tariq, A., Wert, Y., Cheriyath, P., & Joshi, R. (2018) · Southern Medical Journal · doi:10.14423/smj.0000000000000823 · Cited by 43
Krieger, T. G., Moran, C., Frangini, A., Visser, W. E., Schoenmakers, E., Muntoni, F., Clark, C. A., Gadian, D. G., Chong, W. K., Kuczynski, A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908762116 · Cited by 43
Inherited defects in thyroid hormone cell-membrane transport and metabolism
Fu, J., & Dumitrescu, A. M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.014 · Cited by 41
Rosen, M. D., & Privalsky, M. L. (2011) · Journal of Thyroid Research · doi:10.4061/2011/361304 · Cited by 41
Thyroid hormone metabolites and analogues
Senese, R., Cioffi, F., Petito, G., Goglia, F., & Lanni, A. (2019) · Endocrine · doi:10.1007/s12020-019-02025-5 · Cited by 41
Chen, Y., & Young, M. A. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0129 · Cited by 39
Adams, M., Nagaya, T., Tone, Y., Jameson, J. L., & Chatterjee, K. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb01444.x · Cited by 39
Extreme Thyroid Hormone Resistance in a Patient with a Novel Truncated TR Mutant
Phillips, S. A., Rotman‐Pikielny, P., Lazar, J., Ando, S., Hauser, P., Skarulis, M. C., Brücker-Davis, F., & Yen, P. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8051 · Cited by 39
Resistance to Thyroid Hormone α–Emerging Definition of a Disorder of Thyroid Hormone Action
Moran, C., & Chatterjee, K. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2317 · Cited by 38
Sasaki, S., Nakamura, H., Tagami, T., Miyoshi, Y., Tanaka, K., & Imura, H. (1992) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(92)90026-3 · Cited by 37
Different causes of Reduced Sensitivity to Thyroid Hormone: Diagnosis and Clinical management
Visser, W. E., van Mullem, A. A., Visser, T. J., & Peeters, R. P. (2013) · Clinical Endocrinology · doi:10.1111/cen.12281 · Cited by 37
Maruo, Y., Mori, A., Morioka, Y., Sawai, C., Mimura, Y., Matui, K., & Takeuchi, Y. (2016) · BMC Endocrine Disorders · doi:10.1186/s12902-015-0081-7 · Cited by 37
Zucchi, R., Rutigliano, G., & Saponaro, F. (2019) · Endocrine · doi:10.1007/s12020-019-02018-4 · Cited by 37
Boothroyd, C. V., Teh, B. T., Hayward, N. K., Hickman, P. E., Ward, G. J., & Cameron, D. P. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)90151-v · Cited by 36
Kalikiri, M. K. R., Mamidala, M. P., Rao, A. N., & Rajesh, V. (2017) · Autism Research · doi:10.1002/aur.1838 · Cited by 36
Predictors of intellectual outcome in a cohort of brazilian children with congenital hypothyroidism
Kreisner, E., Schermann, L. B., Camargo‐Neto, E., & Gross, J. L. (2004) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2004.01974.x · Cited by 35
PHYSIOLOGIC ACTIVITY OF TRIIODO- AND TETRAIODOTHYROACETIC ACID IN HUMAN MYXEDEMA*†
Lerman, J., & Pitt‐Rivers, R. (1956) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-16-11-1470 · Cited by 35
Huber, B. R., Desclozeaux, M., West, B. L., Lima, S. T. D. C., Nguyen, H. T., Baxter, J. D., Ingraham, H. A., & Fletterick, R. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0097 · Cited by 35
Torre, P., Bertoli, M., Giovanni, S. D., Scommegna, S., Conte, C., Novelli, G., & Cianfarani, S. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03347267 · Cited by 34
Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges
Elbers, L. P. B., Kastelein, J. J. P., & Sjouke, B. (2016) · Current Atherosclerosis Reports · doi:10.1007/s11883-016-0564-7 · Cited by 34
Mutational Landscape of Resistance to Thyroid Hormone Beta (RTHβ)
Concolino, P., Costella, A., & Paragliola, R. M. (2019) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-019-00399-w · Cited by 33
UEDA, S., Takamatsu, J., Fukata, S., TANAKA, K., Shimizu, N., Sakata, S., Yamaji, T., Kuma, K., & Ohsawa, N. (1996) · Thyroid · doi:10.1089/thy.1996.6.563 · Cited by 32
Cellular mechanism of action of thyroid hormones
Liegro, I. D., Savettieri, G., & Cestelli, A. (1987) · Differentiation · doi:10.1111/j.1432-0436.1987.tb00165.x · Cited by 32
Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain
Bárez‐López, S., Hartley, M. D., Grijota-Martínez, C., Scanlan, T. S., & Guadaño‐Ferraz, A. (2018) · Thyroid · doi:10.1089/thy.2018.0008 · Cited by 32
Resistance to Thyroid Hormone in a Patient with Coexisting Graves' Disease
Sivakumar, T., & Chaidarun, S. (2010) · Thyroid · doi:10.1089/thy.2009.0175 · Cited by 31
Two Resistance to Thyroid Hormone Mutants with Impaired Hormone Binding
Huber, B. R., Sandler, B., West, B. L., Lima, S. T. D. C., Nguyen, H. T., Apriletti, J. W., Baxter, J. D., & Fletterick, R. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0095 · Cited by 30
Ishii, S., Yamada, M., Satoh, T., Monden, T., Hashimoto, K., Shibusawa, N., Onigata, K., Morikawa, A., & Mori, M. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0067 · Cited by 30
Frank‐Raue, K., Lorenz, A., Haag, C. D., Höppner, W., Boll, H., Knorr, D., Hentze, S., & Raue, F. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500819 · Cited by 30
Wejaphikul, K., Groeneweg, S., Hilhorst‐Hofstee, Y., Chatterjee, K., Peeters, R. P., Meima, M. E., & Visser, W. E. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02794 · Cited by 30
A histone deacetylase inhibitor improves hypothyroidism caused by a TR 1 mutant
Kim, D., Park, J. W., Willingham, M. C., & Cheng, S.-Y. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt660 · Cited by 29
Tissue thyroid hormones and thyronamines
Accorroni, A., Saponaro, F., & Zucchi, R. (2016) · Heart Failure Reviews · doi:10.1007/s10741-016-9553-8 · Cited by 29
Burman, K. D., Djuh, Y.-Y., Nicholson, D. E., Rhooms, P., Wartofsky, L., Fein, H. G., Usala, S. J., Hao, E., Bradley, W. E. C., Bérard, J., et al. (1992) · Journal of Endocrinological Investigation · doi:10.1007/bf03344927 · Cited by 28
Two Novel Cases of Resistance to Thyroid Hormone Due to THRA Mutation
le Maire, A., Bouhours‐Nouet, N., Soamalala, J., Mirebeau‐Prunier, D., Paloni, M., Guée, L., Héron, D., Mignot, C., Illouz, F., Joubert, F., et al. (2020) · Thyroid · doi:10.1089/thy.2019.0602 · Cited by 27
Nakajima, Y., Yamada, M., Horiguchi, K., Satoh, T., Hashimoto, K., Tokuhiro, E., Onigata, K., & Mori, M. (2010) · Thyroid · doi:10.1089/thy.2009.0389 · Cited by 26
Hughes, D. J., Hill, A. J. M., Maçek, M., Redmond, A. O. B., Nevin, N. C., & Graham, C. A. (1996) · Human Mutation · doi:10.1002/(sici)1098-1004(1996)8:4 · Cited by 26
Taniyama, M., Ishikawa, N., Momotani, N., Ito, K., & Ban, Y. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01033.x · Cited by 26
Thyroid hormone resistance from newborns to adults: a Spanish experience
Spanish Group for the Study of RTH, Vela, A., Pérez-Nanclares, G., Ríos, I., Rica, I., Portillo, N., & Castaño, L. A. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-1007-4 · Cited by 26
Treatment of congenital thyroid dysfunction: Achievements and challenges
Krude, H., Kühnen, P., & Biebermann, H. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.04.004 · Cited by 25
Cheng, S.-Y., Ransom, S. C., McPhie, P., Bhat, M. K., Mixson, A. J., & Weintraub, B. D. (1994) · Biochemistry · doi:10.1021/bi00180a028 · Cited by 25
Tsukaguchi, H., Yoshimasa, Y., Fujimoto, K., Ishii, H., Yamamoto, T., Yoshimasa, T., Yagura, T., & Takamatsu, J. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530608 · Cited by 25
New Case of Thyroid Hormone Resistance α Caused by a Mutation of THRA/TRα1
Sun, H., Wu, H., Xie, R., Wang, F., Chen, T., Chen, X., Wang, X., Flamant, F., & Chen, L. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00011 · Cited by 25
Schwartz, I. D., & Bercu, B. B. (1992) · Thyroid · doi:10.1089/thy.1992.2.15 · Cited by 24
Weiss, R. E., Chyna, B., Duell, P. B., Hayashi, Y., Sunthornthepvarakul, T., & Refetoff, S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.5.8175986 · Cited by 23
Casas, F., Busson, M., Grandemange, S., Seyer, P., Carazo, Á., Pessemesse, L., Wrutniak‐Cabello, C., & Cabello, G. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0074 · Cited by 23
A Case of Resistance to Thyroid Hormone with Thyroid Cancer
Kim, H. K., Kim, D., Yoo, E., Lee, J. I., Jang, H. W., Tan, A. H. K., Hur, K. Y., Kim, J. H., Kim, K., Chung, J. H., et al. (2010) · Journal of Korean Medical Science · doi:10.3346/jkms.2010.25.9.1368 · Cited by 23
Development of support matrices for affinity chromatography of thyroid hormone receptors.
Latham, K. R., Apriletti, J. W., Eberhardt, N. L., & Baxter, J. D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43237-1 · Cited by 22
Furlanetto, T. W., Kopp, P. A., Peccin, S., Gu, W.-X., & Jameson, J. L. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3088 · Cited by 21
Kvistad, P. H., Løvås, K., Boman, H., & Myking, O. L. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500425 · Cited by 21
Lado‐Abeal, J., Dumitrescu, A. M., Liao, X.-H., Cohen, R., Pohlenz, J., Weiss, R. E., Lebrethon, M.-C., Verloès, A., & Refetoff, S. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1488 · Cited by 21
Sriphrapradang, C., Srichomkwun, P., Refetoff, S., & Mamanasiri, S. (2016) · Thyroid · doi:10.1089/thy.2016.0450 · Cited by 21
Identification of a novel human thyroid hormone receptor β isoform as a transcriptional modulator
Tagami, T., Yamamoto, H., Moriyama, K., Sawai, K., Usui, T., Shimatsu, A., & Naruse, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.038 · Cited by 20
Recent Advances in the Development of Agonists Selective for β1-Type Thyroid Hormone Receptor
Malm, J., Grover, G. J., & Färnegårdh, M. (2006) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955707779317885 · Cited by 20
Rivolta, C. M., Olcese, M. C., Belforte, F. S., Chiesa, A. E., Gruñeiro‐Papendieck, L., Iorcansky, S., Herzovich, V., CASSORLA, F. G., Gauna, A., González‐Sarmiento, R., et al. (2009) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2009.02.002 · Cited by 20
Resistance to Thyroid Hormone Accompanied by Graves' Disease
Shiwa, T., Oki, K., Awaya, T., Nakanishi, S., & Yamane, K. (2011) · Internal Medicine · doi:10.2169/internalmedicine.50.4904 · Cited by 19
Sarkissian, G., Dace, A., Mesmacque, A., Bony-Trifunovic, H., Malezet‐Desmoulins, C., Torrésani, J., & Margotat, A. (1999) · Thyroid · doi:10.1089/thy.1999.9.165 · Cited by 19
Korkmaz, Ö., Özen, S., Özdemir, T. R., Gökşen, D., & Darcan, Ş. (2019) · HORMONES · doi:10.1007/s42000-019-00094-9 · Cited by 18
Alternative routes of levothyroxine administration for hypothyroidism
Ritter, M. J., Gupta, S., & Hennessey, J. V. (2020) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000558 · Cited by 18
Miyoshi, Y., Nakamura, H., Sasaki, S., Tagami, T., Misaki, T., Konishi, J., & Nakao, K. (1995) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03636-l · Cited by 17
Amor, A. J., Halperín, I., Alfayate, R., Borrás, V. M., Escribano, A., González, C., Gutierrez, A. M., Maurí, M., Pérez, P., Pico, A. M., et al. (2014) · HORMONES · doi:10.1007/bf03401322 · Cited by 17
Thyroid Hormone Action: The p43 Mitochondrial Pathway
Wrutniak‐Cabello, C., Casas, F., & Cabello, G. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7902-8_14 · Cited by 17
Bigler, J., Hokanson, W., & Eisenman, R. N. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.5.2406-2417.1992 · Cited by 17
Resistance to thyroid hormone due to a novel mutation of thyroid hormone receptor beta gene
Lee, J. H., & Kim, E. Y. (2014) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2014.19.4.229 · Cited by 16
Margotat, A., Sarkissian, G., Malezet‐Desmoulins, C., Peyrol, N., Vlaeminck‐Guillem, V., Wémeau, J.-L., & Torrésani, J. (2001) · PubMed · Cited by 16
Groenhout, E. G., & Dorin, R. I. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90149-x · Cited by 15
Cardoso, L. F., de Paula, F. J. A., & Maciel, L. M. Z. (2014) · Bone · doi:10.1016/j.bone.2014.07.017 · Cited by 15
Işık, E., Beck‐Peccoz, P., Campi, I., Özön, A., Alikaşifoğlu, A., Gonc, N. E., & Kandemir, N. (2013) · The Turkish Journal of Pediatrics · doi:10.24953/turkjpediatr.2013.1506 · Cited by 15
Alopecia: Association with Resistance to Thyroid Hormones
Güran, T., Bircan, R., Turan, S., & Bereket, A. (2009) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2009.22.11.1075 · Cited by 13
Hughes, D. J., Wallace, A. J., Taylor, J., Tassabehji, M., McMahon, R., Hill, A. J. M., Nevin, N. C., & Graham, C. A. (1996) · Human Mutation · doi:10.1002/(sici)1098-1004(1996)8:3 · Cited by 13
Pohlenz, J., MANDERS, L., Sadow, P. M., KANSAL, P. C., Refetoff, S., & Weiss, R. E. (1999) · Thyroid · doi:10.1089/thy.1999.9.1195 · Cited by 13
Sato, H., Koike, Y., Honma, M., Yagame, M., & Ito, K. (2007) · Endocrine Journal · doi:10.1507/endocrj.k07-014 · Cited by 13
Weiss, R. E., TUNCA, H., Gerstein, H. C., & Refetoff, S. (1996) · Thyroid · doi:10.1089/thy.1996.6.311 · Cited by 13
Siervi, A. D., C�diz, D. E. W., Parera, V. E., Batlle, A. M. D. C., & Rossetti, M. V. (2000) · Human Mutation · doi:10.1002/1098-1004(200010)16:4 · Cited by 12
Paone, L., Fleisch, A. F., Feldman, H. A., Brown, R. S., & Wassner, A. J. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.04.022 · Cited by 12
Choi, J., Cho, J. H., Kim, J. H., Yoo, E.-G., Kim, G.-H., & Yoo, H. (2018) · Hormone Research in Paediatrics · doi:10.1159/000493468 · Cited by 12
Research works printed but not linked: 12
- Abdi, 2019, Antithyroid drugs, Iran, J. Pharm. Res., 18, 1
- Behr, 1997, Deoxyribonucleic acid binding and transcriptional silencing by a truncated c-erbA beta 1 thyroid hormone receptor identified in a severely retarded patient with resistance to thyroid hormone, J. Clin. Endocrinol. Metab., 82, 1081
- Bellarbi, 2017, Resistance to thyroid hormones: a NOVEL MUTATION OF THE THYROID HORMONE RECEPTOR beta GENE IN AN ALGERIAN FAMILY, Acta Endocrinol., 13, 502
- Canadas, 2011, Resistance to thyroid hormone associated with a novel mutation of the thyroid beta receptor gene in a four-year-old female, Int. J. Pediatr. Endocrinol., 3
- Clifton-Bligh, 1998, A novel TR beta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation, Mol. Endocrinol., 12, 609
- Guo, 2016, Thyroid hormone resistance syndrome caused by heterozygous A317T mutation in thyroid hormone receptor beta gene: report of one Chinese pedigree and review of the literature, Medicine (Baltim.), 95
- Menzaghi, 1998, T426I a new mutation in the thyroid hormone receptor beta gene in a sporadic patient with resistance to thyroid hormone and dysmorphism. Mutations in brief no. 192, Online, Hum Mutat., 12, 289
- Neamtu, 2016, A new TRbeta mutation in resistance to thyroid hormone syndrome, Hormones (Basel), 15, 534, 10.14310/horm.2002.1700 · DOI
- Rivolta, 2004, A novel 1297-1304delGCCTGCCA mutation in the exon 10 of the thyroid hormone receptor beta gene causes resistance to thyroid hormone, Mol. Diagn., 8, 163
- Schoenmakers, 2010, Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans, J. Clin. Invest., 120, 4220, 10.1172/JCI43653 · DOI · Paper page
- Yagi, 1997, Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3'-triiodothyroinine binding affinity, J. Clin. Endocrinol. Metab., 82, 1608
- Yu, 2018, Pituitary resistance to thyroid hormone caused by a novel mutation (H435A) in the thyroid hormone receptor beta: a case report, Medicine (Baltim.), 97
Cited by
Sorted by citations
Kowalska, D., Sosnowska, A., Buławska, N., Stepnik, M., Behnisch, P., Behnisch, P., & Puzyn, T. (2023) · Molecules · doi:10.3390/molecules28020479 · Cited by 56
Lv, F., Cai, X., Li, Y., Zhang, X., Zhou, X., Han, X., & Ji, L. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13441 · Cited by 35
Self-citationAbdel-Rasol, M. A., & El-Sayed, W. M. (2025) · European journal of medical research · doi:10.1186/s40001-025-03073-6 · Cited by 30
Thyroid hormone receptor beta: Relevance in human health and diseases
Rehman, G., Kumari, N., Bano, F., & Tyagi, R. K. (2023) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2023.100144 · Cited by 31
Structural Insights Into Thyroid Hormone Receptors
Tambones, I., & le Maire, A. (2024) · Endocrinology · doi:10.1210/endocr/bqae154 · Cited by 15
Metadata
- Authors
- Yao, B., Yang, C., Pan, C., & Li, Y.
- Affiliations
- Xiamen University (CN)
- Corresponding author
- Yang, Chunyan
- Li, Yong
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2022-08
- Volume
- 553
- Pages
- 111679
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W4283168004
- Semantic Scholar
- 1b55c5412d9ac36b45f4511fb0cfbea61939b35e
- Cited by
- 26
- References
- 257
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 6 · 2023: 9
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- thyroid hormone resistance, thyroid hormone receptor beta, thyroid hormone receptor alpha, structure-activity relationship, drug design, goiter, bradycardia, short stature, intellectual disability
- MeSH terms
- Humans, Mutation, Receptors, Thyroid Hormone, Thyroid Hormones, Triiodothyronine, Thyroid Hormone Resistance Syndrome, Thyroid Hormone Receptors alpha, Thyroid Hormone Receptors beta
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
