The hypertriglyceridemic waist phenotype versus the National Cholesterol Education Program-Adult Treatment Panel III and International Diabetes Federation clinical criteria to identify high-risk men with an altered cardiometabolic risk profile.
Abstract
The hypertriglyceridemic waist phenotype, the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria, and the International Diabetes Federation (IDF) criteria have been proposed as screening tools to identify subjects with features of the metabolic syndrome and therefore at increased cardiometabolic risk. The aim of the present study was to compare the ability of these 3 clinical approaches to identify individuals at increased cardiometabolic risk as suggested by the presence of deteriorated markers such as hyperinsulinemia, elevated apolipoprotein B levels, small low-density lipoprotein particles, high C-reactive protein concentrations, and low adiponectin levels. For that purpose, physical and cardiometabolic characteristics of a sample of 272 white men recruited for various metabolic investigations were studied. The hypertriglyceridemic waist phenotype was defined as having both a high waist circumference (>or=90 cm) and increased fasting triglyceride levels (>or=2.0 mmol/L). Having at least 3 of the 5 NCEP-ATP III criteria or waist circumference of at least 94 cm plus any 2 of the 4 additional IDF criteria was also used to identify individuals at increased cardiometabolic risk. A large proportion of men with the hypertriglyceridemic waist phenotype also met the NCEP-ATP III (82.7%) or IDF (89.2%) criteria. Men with the hypertriglyceridemic waist phenotype were characterized by alterations in their lipoprotein-lipid profile that included small low-density lipoprotein particles, increased apolipoprotein B and insulin levels, as well as reduced adiponectin concentrations, which were similar to individuals meeting the NCEP-ATP III or the IDF criteria. Moreover, the Framingham risk score of men meeting any of the 3 screening tools criteria was higher and was similar across the 3 approaches (4.2, 3.8, and 3.7, respectively). These results suggest that hypertriglyceridemic waist may be as discriminant as the NCEP-ATP III or the IDF criteria and could be used as an initial screening approach to identify individuals with deteriorated cardiometabolic risk markers.
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Increased waist circumference and plasma triglyceride levels together confer greater CVD risk in these patients.
“Increased waist circumference and plasma triglyceride levels together confer greater CVD risk in these patients (128).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [128]
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- Authors
- Blackburn, P., Lemieux, I., Alméras, N., Bergeron, J., Côté, M., Tremblay, A., Lamarche, B., & Després, J.-P.
- Affiliations
- Université du Québec à Chicoutimi (CA)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Centre hospitalier de l'Université Laval (CA)
- Université Laval (CA)
- Corresponding author
- Després, Jean-Pierre
- ORCID
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 58
- Issue
- 8
- Pages
- 1123-1130
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2090678102
- Cited by
- 67
- References
- 56
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 9 · 2014: 2 · 2013: 8 · 2012: 7
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sanofi
- Université Laval
- Canada Research Chairs
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- hypertriglyceridemic waist phenotype, metabolic syndrome, cardiometabolic risk, NCEP ATP III criteria, IDF criteria, waist circumference, fasting triglycerides, apolipoprotein B, hyperinsulinemia, adiponectin, C-reactive protein, Framingham risk score, cardiovascular risk screening, men
- MeSH terms
- Adult, Apolipoproteins B, C-Reactive Protein, Cardiovascular Diseases, Humans, Cholesterol, LDL, Male, Middle Aged, Phenotype, Risk Factors, Triglycerides, Hypertriglyceridemia, Biomarkers, Body Mass Index, Risk Assessment, Adiponectin, Waist Circumference
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