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Cited by 17Hormonal and reproductive studiesBariatric Surgery and OutcomesSperm and Testicular Function

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Metabolism of testosterone during weight loss in men with obesity

Van de Velde, Frederique, Deventer, Koen, Van Gansbeke, Wim, Van Eenoo, Peter, Van Renterghem, Pieter, Fiers, Tom, Reyns, Tim, Kaufman, Jean Marc, Van Nieuwenhove, Yves, Lapauw, Bruno·2021·The Journal of Steroid Biochemistry and Molecular Biology
DOI 10.1016/j.jsbmb.2021.105851
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Abstract

Objective Men with obesity often have low total and, with increasing adiposity, also low free testosterone (T) levels, which can partially restore during weight loss. Although this is partly explained by lower sex hormone binding globulin (SHBG) production and hypothalamic-pituitary downregulation, it is still not unravelled whether changes in androgen metabolism contribute to this phenomenon. Therefore, early changes in urinary excretion of T and its metabolites, during weight loss, in men with obesity are investigated. Design Longitudinal study. Methods Fourteen men with obesity (age 52(45-60)years, BMI 42.6(41.8-44.8)kg/m²) underwent gastric bypass surgery (GBS). Before surgery and 3 weeks, 6 weeks, 6 months and 1 year thereafter, 24 h urine and fasting serum samples were collected. Serum T and estradiol (E 2 ) levels were analyzed using LC-MS/MS and urinary metabolites of T with GC-MS/MS. Results Already three weeks after GBS, serum SHBG and total T levels increased and remained increased as compared to baseline (all,p 2 levels were unchanged, serum E 2 /T ratio decreased (p 2 /T, estrone/T, 3α-androstanediol/T and androsterone/T ratios decreased after GBS (p Conclusions Restoration of circulating T levels during weight loss in this population is not only brought about by normalization of circulating SHBG levels, but increased production of and alterations in T metabolism also contribute. More specifically, relative decreases in aromatization and lower 5α-reductase activi…

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Metadata

Authors
Van de Velde, F., Deventer, K., Van Gansbeke, W., Van Eenoo, P., Van Renterghem, P., Fiers, T., Reyns, T., Kaufman, J. M., Van Nieuwenhove, Y., & Lapauw, B.
Affiliations
  • Ghent University (BE)
  • Ghent University Hospital (BE)
ORCID
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
2021-05
Volume
209
Pages
105851
ISSN
0960-0760 (ISSN-L)
DOI
10.1016/j.jsbmb.2021.105851
OpenAlex
W3132324715
Cited by
17
References
52
Citations by year
2026: 2 · 2025: 7 · 2024: 1 · 2023: 3 · 2022: 4
FWCI
1.49
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders
Fund for Scientific Research
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
testosterone metabolism, obesity, weight loss, gastric bypass, sex hormone-binding globulin, estradiol, aromatization, 5α-reductase, androsterone, estrone, free testosterone, androgen metabolism, men
MeSH terms
Humans, Hydroxysteroid Dehydrogenases, Longitudinal Studies, Male, Middle Aged, Obesity, Prospective Studies, Sex Hormone-Binding Globulin, Testosterone, Weight Loss

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