Physical Exercise in Major Depression: Reducing the Mortality Gap While Improving Clinical Outcomes
Open accessAbstract
Major depression shortens life while the effectiveness of frontline treatments remains modest. Exercise has been shown to be effective both in reducing mortality and in treating symptoms of major depression, but it is still underutilized in clinical practice, possibly due to prevalent misperceptions. For instance, a common misperception is that exercise is beneficial for depression mostly because of its positive effects on the body ("from the neck down"), whereas its effectiveness in treating core features of depression ("from the neck up") is underappreciated. Other long-held misperceptions are that patients suffering from depression will not engage in exercise even if physicians prescribe it, and that only vigorous exercise is effective. Lastly, a false assumption is that exercise may be more harmful than beneficial in old age, and therefore should only be recommended to younger patients. This narrative review summarizes relevant literature to address the aforementioned misperceptions and to provide practical recommendations for prescribing exercise to individuals with major depression.
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Stress is not only an indicator of burnout, but can also impact levels of depression, in turn impacting overall functioning and physical health.
“For example, stress is not only an indicator of burnout, but can also impact levels of depression, in turn impacting overall functioning and physical health (Belvederi Murri et al., 2019).”
From A randomised trial of Mindfulness-based Social Work and Self-Care with social workers (2023) · cites this paper as Belvederi Murri et al., 2019
The Introduction states that depression affects individual functioning and physical health. The paper discusses stress-response systems in depression, but it does not say that stress is an indicator of burnout or that stress changes depression levels. (LLM, conf=0.88)
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- Authors
- Belvederi Murri, M., Ekkekakis, P., Magagnoli, M., Zampogna, D., Cattedra, S., Capobianco, L., Serafini, G., Calcagno, P., Zanetidou, S., & Amore, M.
- Affiliations
- University of Genoa (IT)
- Ospedale Policlinico San Martino (IT)
- Venue
- Frontiers in Psychiatry
- Publisher
- Frontiers Media SA
- Published
- 2019-01-10
- Volume
- 9
- Pages
- 762-762
- ISSN
- 1664-0640 (ISSN-L)
- PMC
- PMC6335323
- OpenAlex
- W2910505094
- Cited by
- 163
- References
- 169
- Citations by year
- 2026: 5 · 2025: 20 · 2024: 12 · 2023: 57 · 2022: 29 · 2021: 19 · 2020: 13 · 2019: 6 · 2017: 1
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
- Funders
- Heart and Stroke Foundation of Canada
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, physical activity, exercise prescription, mortality gap, clinical outcomes, elderly exercise, depression treatment
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