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The role of leptin in regulating bone metabolism

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Upadhyay, Jagriti, Farr, Olivia M., Mantzoros, Christos S.·2015·Metabolism
DOI 10.1016/j.metabol.2014.10.021
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Abstract

Leptin was initially best known for its role in energy homeostasis and regulation of energy expenditure. In the past few years we have realized that leptin also plays a major role in neuroendocrine regulation and bone metabolism. Here, we review the literature on indirect and direct pathways through which leptin acts to influence bone metabolism and discuss bone abnormalities related to leptin deficiency in both animal and human studies. The clinical utility of leptin in leptin deficient individuals and its potential to improve metabolic bone disease are also discussed. We are beginning to understand the critical role leptin plays in bone metabolism; future randomized studies are needed to fully assess the potential and risk – benefit of leptin's use in metabolic bone disease particularly in leptin deficient individuals.

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Metadata

Authors
Upadhyay, J., Farr, O. M., & Mantzoros, C. S.
Venue
Metabolism
Publisher
Elsevier BV
Published
2015-01
Volume
64
Issue
1
Pages
105-113
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2014.10.021
OpenAlex
W1965172675
Cited by
268
References
29
FWCI
4.75
Type
journal article
Language
en
Open access
green
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Funders
  • Department of Veterans Affairs Fellowship
  • Office of Academic Affiliations
  • NICHD (5T32HD052961)

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