The DOI matches its Crossref record; 71 of the 72 references it cites were found in a registry or an index.
Beyond microbial community composition: functional activities of the oral microbiome in health and disease
Open accessAbstract
The oral microbiome plays a relevant role in the health status of the host and is a key element in a variety of oral and non-oral diseases. Despite advances in our knowledge of changes in microbial composition associated with different health conditions the functional aspects of the oral microbiome that lead to dysbiosis remain for the most part unknown. In this review, we discuss the progress made towards understanding the functional role of the oral microbiome in health and disease and how novel technologies are expanding our knowledge on this subject.
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“Yet, individual bacteria do not act in a vacuum, but rather function in interdependent microbial communities whose conglomerate activity can impact oral and systemic health[183,188,189].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [188]
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Citations
Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Microbial complexes in subgingival plaque
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Defining the normal bacterial flora of the oral cavity
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(2000) · Journal of the California Dental Association · doi:10.1080/19424396.2000.12223118 · Cited by 2,484
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Occlusal Caries: Biological Approach for Its Diagnosis and Management
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“Although viruses, fungi and archaea are natural inhabitants of the oral microbiome [22] a description of their role in health and disease goes beyond the scope of this review and in our discussion we will focus exclusively on the role of oral bacteria.”
Defining the healthy “core microbiome” of oral microbial communities
Zaura, E., Keijser, B. J., Huse, S. M., & Crielaard, W. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-259 · Cited by 1,323 · cited 9×
“Changes detected by HOMIM in the subgingival microbiota of patients with refractory periodontitis, in comparison with good responders to treatment, included Bacteroidetes sp., Porphyromonas endodontalis, P. gingivalis, Prevotella spp., T. forsythia, Dialister spp., Selenomonas spp., Catonella morbi, Eubacterium spp.,…”
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Nanozymes: revolutionizing oral health through anti-biofilm strategies
Shubair, M. H., Yin, J., Alsobea, H. A. M., Asaad, W. A., Abdu, S. A., Ashah, A. A., Alburiahi, T. A. H., Zhang, S.-N., Duan, K., Mithu, M. M., et al. (2025) · New discovery. · doi:10.61958/ndwc6091
Metagenomics in the Interplay Among Oral and Gut Dysbiosis
Munzone, M., Marmo, G. M., Polizzi, A., Jovanova, E., Angjelova, A., Lupi, S. M., & Isola, G. (2026) · Metabolites · doi:10.3390/metabo16070502
“…identification of microbial species, shotgun metagenomics enables comprehensive analysis of the collective microbial genome while simultaneously revealing the functional and metabolic potential of microbial communities through the reconstruction of metabolic pathways and gene functions [7,8].”
Wakade, G., Liu, S. C., Diep, N. E., & Daniell, H. (2026) · Molecular Therapy Oncology · doi:10.1016/j.omton.2026.201314
“52 Co-colonization allows them to adhere better to epithelial cells, resist host immune clearance, or evade oxidative stress.”
Bansal, D. K., Katiyar, A., Sharma, K., Shamoo, A., & Mathur, V. P. (2026) · Journal of Indian Society of Pedodontics and Preventive Dentistry · doi:10.4103/jisppd.jisppd_243_26
Metadata
- Authors
- Duran-Pinedo, A. E., & Frias-Lopez, J.
- Affiliations
- The Forsyth Institute (US)
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 17
- Issue
- 7
- Pages
- 505-516
- ISSN
- 1286-4579 (ISSN-L)
- PMC
- PMC4495649
- OpenAlex
- W2079758378
- Cited by
- 187
- References
- 72
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 18 · 2023: 17 · 2022: 19 · 2021: 14 · 2020: 29 · 2019: 12 · 2018: 17 · 2017: 16 · 2016: 17 · 2015: 4
- FWCI
- 24.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Dental and Craniofacial Research of the National Institutes of Health (NIDCR/NIH) (DE021553, DE021127)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Keywords
- oral microbiota, dysbiosis, oral diseases, host-microbe interactions, oral health, metagenomics, metatranscriptomics
- MeSH terms
- Gastrointestinal Microbiome, Dental Caries, Health Status, Humans, Oral Health, Host-Pathogen Interactions, Metagenome
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