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Beyond microbial community composition: functional activities of the oral microbiome in health and disease
Open accessAbstract
The oral microbiome plays a relevant role in the health status of the host and is a key element in a variety of oral and non-oral diseases. Despite advances in our knowledge of changes in microbial composition associated with different health conditions the functional aspects of the oral microbiome that lead to dysbiosis remain for the most part unknown. In this review, we discuss the progress made towards understanding the functional role of the oral microbiome in health and disease and how novel technologies are expanding our knowledge on this subject.
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“Yet, individual bacteria do not act in a vacuum, but rather function in interdependent microbial communities whose conglomerate activity can impact oral and systemic health[183,188,189].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [188]
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Huang, S.-C., Burne, R. A., & Chen, Y. M. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00755-14 · Cited by 33 · cited 1×
“For example, Streptococcus salivarius, one of the major alkali producers in the mouth, expresses urease gene under acidic pH and excess of carbohydrates [10].”
BACTERIAL FLORA OF DENTAL PLAQUE
Hardie, J. M., & Bowden, G. H. (1975) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a071266 · Cited by 28 · cited 1×
“As the biofilm matured more Gram-negative filamentous organisms were found, such as Fusobacterium spp [24].”
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Abranches, J., Zeng, L., Kajfasz, J. K., Palmer, S. R., Chakraborty, B., Wen, Z. T., Richards, V. P., Brady, L. J., & Lemos, J. A. (2018) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0042-2018 · Cited by 502
“…fi ling with other “ -omics ” technologies (i.e., transcriptomics, proteomics, and metabolomics) is essential for a global understanding of the speci fi c contributions of oral bacteria to health and disease (17), providing a better understanding of how complex communities function and interact (37).”
BackgroundOral Candidiasis: A Disease of Opportunity
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Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis
Abdulkareem, A. A., Al-Taweel, F. B. H., Al-Sharqi, A. J. B., Gul, S. S., Sha, A. M., & Chapple, I. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2197779 · Cited by 438
“microbial ecology and an emergent dysbiosis of the biofilm [72].”
BackgroundThe Oral Microbiome in Health and Its Implication in Oral and Systemic Diseases
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The Evolving Microbiome of Dental Caries
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Metadata
- Authors
- Duran-Pinedo, A. E., & Frias-Lopez, J.
- Affiliations
- The Forsyth Institute (US)
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 17
- Issue
- 7
- Pages
- 505-516
- ISSN
- 1286-4579 (ISSN-L)
- PMC
- PMC4495649
- OpenAlex
- W2079758378
- Cited by
- 187
- References
- 72
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 18 · 2023: 17 · 2022: 19 · 2021: 14 · 2020: 29 · 2019: 12 · 2018: 17 · 2017: 16 · 2016: 17 · 2015: 4
- FWCI
- 24.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Dental and Craniofacial Research of the National Institutes of Health (NIDCR/NIH) (DE021553, DE021127)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Keywords
- oral microbiota, dysbiosis, oral diseases, host-microbe interactions, oral health, metagenomics, metatranscriptomics
- MeSH terms
- Gastrointestinal Microbiome, Dental Caries, Health Status, Humans, Oral Health, Host-Pathogen Interactions, Metagenome
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