Cited by 204Oral microbiology and periodontitis researchGut microbiota and healthDental Research and COVID-19

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Beyond microbial community composition: functional activities of the oral microbiome in health and disease

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Duran-Pinedo, Ana E., Frias-Lopez, Jorge·2015·Microbes and Infection

DOI 10.1016/j.micinf.2015.03.014PMC PMC4495649

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Abstract

The oral microbiome plays a relevant role in the health status of the host and is a key element in a variety of oral and non-oral diseases. Despite advances in our knowledge of changes in microbial composition associated with different health conditions the functional aspects of the oral microbiome that lead to dysbiosis remain for the most part unknown. In this review, we discuss the progress made towards understanding the functional role of the oral microbiome in health and disease and how novel technologies are expanding our knowledge on this subject.

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“Under normal conditions, the oral microbiota communities are balanced to maintain oral health (Duran-Pinedo and Frias-Lopez 2015).”
Shifts in the bacterial community of saliva give insights on the relationship between obesity and oral microbiota in adolescents
de Andrade, P. A. M., Giovani, P. A., Araujo, D. S., de Souza, A. J., Pedroni-Pereira, A., Kantovitz, K. R., Andreote, F. D., Castelo, P. M., & Nociti, F. H. (2020) · Archives of Microbiology · doi:10.1007/s00203-020-01817-y · Cited by 33
The Microbiome and Its Implications in Cancer Immunotherapy
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Distinct Regulatory Role of Carbon Catabolite Protein A (CcpA) in Oral Streptococcal spxB Expression
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Oral Microbiome Profiling in Smokers with and without Head and Neck Cancer Reveals Variations Between Health and Disease
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“Among them, Porphyromonas is closely associated with the occurrence and development of periodontitis, and is also a driving factor for developing digestive tract tumors, including colorectal cancer and pancreatic cancer (Duran-Pinedo and Frias-Lopez 2015).”
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Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome
Sedghi, L., Byron, C., Jennings, R., Chlipala, G. E., Green, S. J., & Silo-Suh, L. (2019) · Dentistry Journal · doi:10.3390/dj7020058 · Cited by 25
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Background
Advances, practice, and clinical perspectives in high‐throughput sequencing
Park, S., Saito-Adachi, M., Komiyama, Y., & Nakai, K. (2015) · Oral Diseases · doi:10.1111/odi.12403 · Cited by 26
“In particular, the applications of HTS have been used to characterize the human oral microbiome, one of the most diverse microbial communities that is increasingly important for studying human oral cancers and pathogens (Xu and Gunsolley, 2014; Duran-Pinedo and Frias-Lopez, 2015).”
Background
Biology of Oral Streptococci
Abranches, J., Zeng, L., Kajfasz, J. K., Palmer, S. R., Chakraborty, B., Wen, Z. T., Richards, V. P., Brady, L. J., & Lemos, J. A. C. (2019) · ASM Press eBooks · doi:10.1128/9781683670131.ch26 · Cited by 28
Integrated analysis of the salivary microbiome and metabolome in chronic and aggressive periodontitis: A pilot study
Wei, Y., Shi, M. Q., Nie, Y., Wang, C., Sun, F., Jiang, W., Hu, W., & Wu, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.959416 · Cited by 25
“Moreover, it is now clear that some important factors that connect microbiota to periodontitis are microbial metabolites (Lu et al., 2013; Duran-Pinedo and Frias-Lopez, 2015).”
Background
The interaction between gut microbiome and bone health
Inchingolo, F., Inchingolo, A. M., Piras, F., Ferrante, L., Mancini, A., Palermo, A., Inchingolo, A. D., & Dipalma, G. (2024) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000863 · Cited by 32
In silico evaluation and selection of the best 16S rRNA gene primers for use in next-generation sequencing to detect oral bacteria and archaea
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Human dental stem cells suppress PMN activity after infection with the periodontopathogens Prevotella intermedia and Tannerella forsythia
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Oral microbiome and oral cancer – The probable nexus
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“The microbial community can be characterized by its composition (Metagenome), by the analysis of transcripts (Metatranscriptome), by the analysis of proteins (Metaproteome) or by the analysis of the final products resulting from the collective action of the community (Metabolomics).[46]”
BackgroundMethod
Chlamydia pneumoniae is present in the dental plaque of periodontitis patients and stimulates an inflammatory response in gingival epithelial cells
Almeida-da-Silva, C. L. C., Alpagot, T., Zhu, Y., Lee, S. S., Roberts, B. P., Hung, S.-C., Tang, N., & Ojcius, D. M. (2019) · Microbial Cell · doi:10.15698/mic2019.04.674 · Cited by 22
“Considering that periodontitis is a polymicrobial disease caused by complex interactions between distinct pathogens [37, 38, 51], it is possible that other microbial agents present in the dental plaques of periodontitis patients could be the cause of disease, and C.”
Background
Do Oral Pathogens Inhabit the Eye and Play a Role in Ocular Diseases?
Arjunan, P., & Swaminathan, R. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102938 · Cited by 24
“A perturbed balance in the oral microbiome conglomerate culminates in a variety of chronic systemic disorders, including cardiovascular disease, stroke, preterm birth, diabetes, and pneumonia [55].”
Background
Diversity of the gut, vaginal and oral microbiome among pregnant women in South Africa with and without pre-eclampsia
Geldenhuys, J., Redelinghuys, M. J., Lombaard, H. A., Ehlers, M. M., Cowan, D. A., & Kock, M. M. (2022) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2022.810673 · Cited by 22
Identifying oral microbiome alterations in adult betel quid chewing population of Delhi, India
Bahuguna, M., Hooda, S., Mohan, L., Gupta, R. K., & Diwan, P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0278221 · Cited by 20
“The oral cavity is made up of diverse structures and tissues, including cheeks, gingiva, gingival sulcus, lips, teeth, tongue and palate, providing different habitats, nutrients, and growth conditions [3] for microbes.”
Background
Anthropogenic impact on airborne bacteria of the Tibetan Plateau
Zhang, Z., Qi, J., Liu, Y., Ji, M., Wang, W., Wu, W., Liu, K., & Huang, Z. (2023) · Environment International · doi:10.1016/j.envint.2023.108370 · Cited by 18
Oral Health Interventions Using Chlorhexidine—Effects on the Prevalence of Oral Opportunistic Pathogens in Stroke Survivors: A Randomized Clinical Trial
Malik, N. A., Razak, F. B. A., Yatim, S. M., Lam, O., Jin, L., Li, L. S. W., & McGrath, C. P. J. (2017) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2017.08.002 · Cited by 18
Oral Microbiome and Gingival Gene Expression of Inflammatory Biomolecules With Aging and Periodontitis
Ebersole, J., Nagarajan, R., Kirakodu, S., & Gonzalez, O. A. (2021) · Frontiers in Oral Health · doi:10.3389/froh.2021.725115 · Cited by 15
Preliminary functional analysis of the subgingival microbiota of cats with periodontitis and feline chronic gingivostomatitis
Rodrigues, M. X., Fiani, N., Bicalho, R. C., & Peralta, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-86466-x · Cited by 17
Functional signatures of ex-vivo dental caries onset
Moussa, D. G., Sharma, A. K., Mansour, T. A., Witthuhn, B. A., Perdigão, J., Rudney, J. D., Aparicio, C., & Gomez, A. M. (2022) · Journal of Oral Microbiology · doi:10.1080/20002297.2022.2123624 · Cited by 17
Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention
Diwan, P., Nirwan, M., Bahuguna, M., Kumari, S. P., Wahlang, J., & Gupta, R. K. (2023) · Pathogens · doi:10.3390/pathogens12080996 · Cited by 20
The Bidirectional Relationship Between Cardiovascular Medications and Oral and Gut Microbiome Health: A Comprehensive Review
Dharmarathne, G., Kazi, S., King, S., & Jayasinghe, T. N. (2024) · Microorganisms · doi:10.3390/microorganisms12112246 · Cited by 19
Eye on the Enigmatic Link: Dysbiotic Oral Pathogens in Ocular Diseases; The Flip Side
Arjunan, P. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1845330 · Cited by 16
“Studies have emphasized that perturbed balance in the oral microbiome culminate in a variety of chronic systemic disorders, including cardiovascular disease, stroke, preterm birth, diabetes and pneumonia [21].”
Background
Probiotics During the Therapeutic Management of Periodontitis
Furlaneto, F. A. C., Ishikawa, K., Messora, M. R., & Mayer, M. P. A. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-96881-6_19 · Cited by 20
Probiotics, Prebiotics, Synbiotics, Postbiotics, and Bioactive Agents in Modulating Harmful Oral Biofilms
Ghamari, M., Sabzi, S., Rajabi, E., Khodadadi, G., Navidifar, T., Sadeghi, Z., & Bostanghadiri, N. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10636-w · Cited by 17
Impact of high altitude on composition and functional profiling of oral microbiome in Indian male population
Kumari, M., Bhushan, B., Eslavath, M. R., Srivastava, A. K., Meena, R. C., Varshney, R. K., & Ganju, L. (2023) · Scientific Reports · doi:10.1038/s41598-023-30963-8 · Cited by 14
Oral bacteriophages: metagenomic clues to interpret microbiomes
Banar, M., Rokaya, D., Azizian, R., Khurshid, Z., & Banakar, M. (2024) · PeerJ · doi:10.7717/peerj.16947 · Cited by 14
Insight Into the Effects of Nisin and Cecropin on the Oral Microbial Community of Rats by High-Throughput Sequencing
Wu, L., Li, F., Ran, L., Gao, Y., Xie, P., Yang, J., Ke, F., Liu, L., Wang, Q., & Gao, X. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01082 · Cited by 14
Epigenetic Mechanisms in Microbial Members of the Human Microbiota: Current Knowledge and Perspectives
Cureau, N., Aljahdali, N. H., Vo, N., & Carbonero, F. G. (2016) · Epigenomics · doi:10.2217/epi-2016-0057 · Cited by 13
Impact of 16S rRNA Gene Redundancy and Primer Pair Selection on the Quantification and Classification of Oral Microbiota in Next-Generation Sequencing
Regueira‐Iglesias, A., Vázquez-González, L., Balsa‐Castro, C., Blanco‐Pintos, T., Vila-Blanco, N., Carreira, M. J., & Tomás, I. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04398-22 · Cited by 13
“However, this limited approach does not reflect the complexity of the oral microbiota, where around 700 species have been identified (15, 16).”
Background
Polymicrobial Biofilms: Fundamentals, diseases, and treatments - A review
Espinosa-Duque, A., de Concepción, U., Palencia, S. L., García, A., Palencia, M., & del Valle, U. (2020) · Journal of Science with Technological Applications · doi:10.34294/j.jsta.20.8.54 · Cited by 14
“…multiple structures of teeth and tissues such as tongue, gums and palate, causing a rapid growth of microorganisms that are resistant to environmental stressors (Bjarnsholt, 2013; Duran-Pinedo and Frias-Lopez, 2015; Filoche et al. , 2010; Jakubovics and Kolenbrander, 2010; Willems et al. , 2016).”
The Function of the Oral Microbiome in Health and Disease
Frias‐Lopez, J., & Duran-Pinedo, A. E. (2020) · Springer eBooks · doi:10.1007/978-3-030-42990-4_10 · Cited by 12
A Survey of Bacterial Microcompartment Distribution in the Human Microbiome
Asija, K., Sutter, M., & Kerfeld, C. A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.669024 · Cited by 12
Therapeutic Modulation of the Microbiome in Oncology: Current Trends and Future Directions
Saraswat, I., & Goel, A. (2024) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010353600241109132441 · Cited by 12
The Oral Microbiota: A Literature Review for Updating Professionals in Dentistry. Part I
Barboza‐Solís, C., & Acuña-Amador, L. (2019) · Odovtos - International Journal of Dental Sciences · doi:10.15517/ijds.2020.39178 · Cited by 11
“As previously mentioned, oral bacteria communities are described as organized into biofilms (13,21,27).”
Influential
A comparison of the alterations of oral microbiome with fixed orthodontic therapy and clear aligners: a systematic review
Lucchese, A., Marcolina, M., Mancini, N., Ferrarese, R., Acconciaioco, S., Gherlone, E. F., Bonini, C., Manuelli, M., & Polimeni, A. (2025) · Journal of Oral Microbiology · doi:10.1080/20002297.2024.2372751 · Cited by 10
“Oral microbiome plays a fundamental role in maintaining the homeostasis of the oral cavity and of systemic health too [2,3].”
Ex vivo oral biofilm model for rapid screening of antimicrobial agents including natural cranberry polyphenols
Adami, G. R., Li, W., Green, S. J., Kim, E. M., & Wu, C. D. (2025) · Scientific Reports · doi:10.1038/s41598-025-87382-0 · Cited by 11
Antiplanktonic and Antibiofilm Activity of Rheum palmatum Against Streptococcus oralis and Porphyromonas gingivalis
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Effect of experimental gingivitis induction and erythritol on the salivary metabolome and functional biochemistry of systemically healthy young adults
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“The oral cavity is a specialized ecological niche with thousands of microbial species, and the site of complex interactions between oral microbiota, salivary components, and host immune factors (Duran-Pinedo and Frias-Lopez 2015).”
Background

Authors: Duran-Pinedo, A. E., & Frias-Lopez, J.
Affiliations: The Forsyth Institute (US)
ORCID: Duran-Pinedo, Ana E.
Frias-Lopez, Jorge
Venue: Microbes and Infection
Publisher: Elsevier BV
Published: 2015-07
Volume: 17
Issue: 7
Pages: 505-516
ISSN: 1286-4579 (ISSN-L)
DOI: 10.1016/j.micinf.2015.03.014
PMC: PMC4495649
OpenAlex: W2079758378
Cited by: 187
References: 72
Citations by year: 2026: 7 · 2025: 17 · 2024: 18 · 2023: 17 · 2022: 19 · 2021: 14 · 2020: 29 · 2019: 12 · 2018: 17 · 2017: 16 · 2016: 17 · 2015: 4
FWCI: 24.36
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3072 d)
Locations: Microbes and Infection (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Dental and Craniofacial Research of the National Institutes of Health (NIDCR/NIH) (DE021553, DE021127)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
Keywords: oral microbiota, dysbiosis, oral diseases, host-microbe interactions, oral health, metagenomics, metatranscriptomics
MeSH terms: Gastrointestinal Microbiome, Dental Caries, Health Status, Humans, Oral Health, Host-Pathogen Interactions, Metagenome

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Beyond microbial community composition: functional activities of the oral microbiome in health and disease

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