The DOI matches its Crossref record; 71 of the 72 references it cites were found in a registry or an index.
Beyond microbial community composition: functional activities of the oral microbiome in health and disease
Open accessAbstract
The oral microbiome plays a relevant role in the health status of the host and is a key element in a variety of oral and non-oral diseases. Despite advances in our knowledge of changes in microbial composition associated with different health conditions the functional aspects of the oral microbiome that lead to dysbiosis remain for the most part unknown. In this review, we discuss the progress made towards understanding the functional role of the oral microbiome in health and disease and how novel technologies are expanding our knowledge on this subject.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Yet, individual bacteria do not act in a vacuum, but rather function in interdependent microbial communities whose conglomerate activity can impact oral and systemic health[183,188,189].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [188]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050 · cited 2×
“Using 40 species-specific DNAeDNA hybridization probes, based on whole genomes, to detect oral bacteria in the subgingival plaque, 5 different complexes were identified based on different levels of association with health and severity of periodontitis [25].”
Dewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C. R., Yu, W.-H., Lakshmanan, A., & Wade, W. G. (2010) · Journal of Bacteriology · doi:10.1128/jb.00542-10 · Cited by 3,352
Defining the normal bacterial flora of the oral cavity
Aas, J. A., Paster, B. J., Stokes, L. N., Olsen, I., & Dewhirst, F. E. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5721-5732.2005 · Cited by 3,092 · cited 2×
“[3] Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE.”
Oral Health in America: A Report of the Surgeon General
(2000) · Journal of the California Dental Association · doi:10.1080/19424396.2000.12223118 · Cited by 2,484
Global Burden of Severe Periodontitis in 1990-2010: A Systematic Review and Meta-regression
Kassebaum, N. J., Bernabé, E., Dahiya, M., Bhandari, B., Murray, C. J. L., & Marcenes, W. (2014) · Journal of Dental Research · doi:10.1177/0022034514552491 · Cited by 2,209
Occlusal Caries: Biological Approach for Its Diagnosis and Management
Carvalho, J. C., Dige, I., Mačhiulskienė, V., Qvist, V., Bakhshandeh, A., Parolo, C. C. F., & Maltz, M. (2016) · Caries Research · doi:10.1159/000448662 · Cited by 2,159
Prevalence of Periodontitis in Adults in the United States: 2009 and 2010
Eke, P. I., Dye, B. A., Wei, L., Thornton‐Evans, G. O., & Genco, R. J. (2012) · Journal of Dental Research · doi:10.1177/0022034512457373 · Cited by 1,831
The oral microbiome in health and disease
Wade, W. G. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.11.006 · Cited by 1,347 · cited 1×
“Although viruses, fungi and archaea are natural inhabitants of the oral microbiome [22] a description of their role in health and disease goes beyond the scope of this review and in our discussion we will focus exclusively on the role of oral bacteria.”
Defining the healthy “core microbiome” of oral microbial communities
Zaura, E., Keijser, B. J., Huse, S. M., & Crielaard, W. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-259 · Cited by 1,323 · cited 9×
“Changes detected by HOMIM in the subgingival microbiota of patients with refractory periodontitis, in comparison with good responders to treatment, included Bacteroidetes sp., Porphyromonas endodontalis, P. gingivalis, Prevotella spp., T. forsythia, Dialister spp., Selenomonas spp., Catonella morbi, Eubacterium spp.,…”
Influential
Cited by
Sorted by citations
Abranches, J., Zeng, L., Kajfasz, J. K., Palmer, S. R., Chakraborty, B., Wen, Z. T., Richards, V. P., Brady, L. J., & Lemos, J. A. (2018) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0042-2018 · Cited by 502
“…fi ling with other “ -omics ” technologies (i.e., transcriptomics, proteomics, and metabolomics) is essential for a global understanding of the speci fi c contributions of oral bacteria to health and disease (17), providing a better understanding of how complex communities function and interact (37).”
BackgroundOral Candidiasis: A Disease of Opportunity
Vila, T., Sultan, A. S., Montelongo-Jauregui, D., & Jabra-Rizk, M. A. (2020) · Journal of Fungi · doi:10.3390/jof6010015 · Cited by 537
Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis
Abdulkareem, A. A., Al-Taweel, F. B. H., Al-Sharqi, A. J. B., Gul, S. S., Sha, A. M., & Chapple, I. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2197779 · Cited by 438
“microbial ecology and an emergent dysbiosis of the biofilm [72].”
BackgroundThe Oral Microbiome in Health and Its Implication in Oral and Systemic Diseases
(2016) · Advances in Applied Microbiology · doi:10.1016/bs.aambs.2016.08.002 · Cited by 306
The Evolving Microbiome of Dental Caries
Spatafora, G. A., Li, Y., He, X., Cowan, A. N., & Tanner, A. C. R. (2024) · Microorganisms · doi:10.3390/microorganisms12010121 · Cited by 341
Metadata
- Authors
- Duran-Pinedo, A. E., & Frias-Lopez, J.
- Affiliations
- The Forsyth Institute (US)
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 17
- Issue
- 7
- Pages
- 505-516
- ISSN
- 1286-4579 (ISSN-L)
- PMC
- PMC4495649
- OpenAlex
- W2079758378
- Cited by
- 187
- References
- 72
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 18 · 2023: 17 · 2022: 19 · 2021: 14 · 2020: 29 · 2019: 12 · 2018: 17 · 2017: 16 · 2016: 17 · 2015: 4
- FWCI
- 24.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Dental and Craniofacial Research of the National Institutes of Health (NIDCR/NIH) (DE021553, DE021127)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Keywords
- oral microbiota, dysbiosis, oral diseases, host-microbe interactions, oral health, metagenomics, metatranscriptomics
- MeSH terms
- Gastrointestinal Microbiome, Dental Caries, Health Status, Humans, Oral Health, Host-Pathogen Interactions, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
