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Cited by 53Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingNeurotransmitter Receptor Influence on Behavior

Muscarinic acetylcholine receptor stimulation induces expression of the activity-regulated cytoskeleton-associated gene (ARC)

Teber, Iskender, Köhling, Rüdiger, Speckmann, Erwin-Josef, Barnekow, Angelika, Kremerskothen, Joachim·2004·Molecular Brain Research
DOI 10.1016/j.molbrainres.2003.11.017
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Abstract

Muscarinic acetylcholine receptors (mAChR) are involved in learning and memory but their molecular function in these processes is not fully understood. In this study, the signal transduction pathway coupling mAChR activation to induction of the activity-regulated cytoskeleton-associated gene (ARC) was examined. ARC was first identified as an effector immediate early gene induced by neuronal activity and ARC protein is thought to play a role in synaptic plasticity. In rats, intraperitoneal injection of pilocarpine, a potent agonist of mAChR, led to increased ARC expression in the brain. In human SH-SY5Y neuroblastoma cells mAChR stimulation with carbachol caused a rapid and robust induction of ARC expression. This effect was inhibited by atropine, a nonselective muscarinic receptor antagonist as well as by M1/M3 subtype-specific antagonists. Analysis of mAChR downstream effectors revealed that protein kinase C (PKC) and tyrosine kinases of the src family are key molecules in the signal cascade leading to ARC expression. Our data suggest, for the first time, that a correlation exists among mAChR-controlled signal cascades, the induction of the effector immediate early gene ARC and synaptic plasticity.

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  • The effects of cholinergic manipulation are consistent with a role of acetylcholine in synaptic consolidation, e.g., by promoting activity of plasticity-related immediate early genes and maintenance of LTP in cortico-striatal networks.

    “The effects are consistent with a role of acetylcholine in synaptic consolidation, e.g., by promoting activity of plasticity-related immediate early genes (475, 615, 1182) and maintenance of LTP in cortico-striatal networks (742).”

    From About Sleep's Role in Memory (2013) · cites this paper as [1182]

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Authors
Teber, I., Köhling, R., Speckmann, E.-J., Barnekow, A., & Kremerskothen, J.
Affiliations
University of Münster (DE)
Corresponding author
Kremerskothen, Joachim
ORCID
Köhling, Rüdiger
Venue
Molecular Brain Research
Publisher
Elsevier BV
Published
2004-02
Volume
121
Issue
1-2
Pages
131-136
ISSN
0169-328X (ISSN-L)
DOI
10.1016/j.molbrainres.2003.11.017
OpenAlex
W1996117707
Cited by
53
References
24
Citations by year
2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 3
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
muscarinic receptors, Arc, immediate early gene expression, synaptic plasticity, pilocarpine, carbachol, atropine, protein kinase C, Src family kinases, signal transduction, learning and memory, SH-SY5Y cells
MeSH terms
Animals, Brain, Cytoskeletal Proteins, Drug Interactions, Enzyme Inhibitors, Gene Expression Regulation, Humans, Male, Nerve Tissue Proteins, Neuroblastoma, Pilocarpine, Receptors, Muscarinic, RNA, Messenger, Time Factors, Blotting, Northern, Signal Transduction, Rats, Wistar, Immediate-Early Proteins, Cholinergic Agents, Muscarinic Agonists, Intercellular Signaling Peptides and Proteins, Cell Line, Tumor, Rats, Cysteine-Rich Protein 61

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