Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease
Abstract
ADAMTS-1 is a disintegrin and metalloproteinase with thrombospondin 1 (TSP1)-like motifs with ubiquitous though variable expression. Natural substrates of this protease are proteoglycans as aggrecan and versican and null mutant mice propose a role for growth, fertility, organ structure and function. As the gene for this protein is encoded on chromosome 21 and maybe overexpressed due to the gene dosage hypothesis based upon the presence of a third chromosome in trisomy 21, we decided to study expression in Down syndrome (DS) brain and used brains of patients with Alzheimer's (AD) and Pick's disease (PD) as controls. Frontal cortex of controls, DS, AD and PD were homogenized and extracted proteins were used for immunoblotting using antibodies against ADAMTS-1 and ADAMTS-5. ADAMTS-1-immunoreactivity was manifold increased in brain with DS and neurodegeneration, whereas ADAMTS-5 levels were comparable. Overexpression of this metalloproteinase maybe specifically involved in proteoglycan degradation and handling in brain of patients with neurodegenerative disease which in turn may lead to or reflect pathological lesions in DS, AD and PD brain. The manifold overexpression of ADAMTS-1 may be used as marker protein for neurodegeneration.
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ADAMTS1 is elevated in Down's syndrome with neurodegeneration and Alzheimer's disease, and it is a potential neuroprotective or neuroinflammatory gene.
“ADAMTS1 is elevated in Down’s syndrome with neurodegeneration and Alzheimer’s disease86, and it is a potential neuroprotective gene87–89 or a neuroinflammatory gene important to microglial response90.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [86]
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- Authors
- Miguel, R. F., Pollak, A., & Lubec, G.
- Affiliations
- Medical University of Vienna (AT)
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 133
- Issue
- 1
- Pages
- 1-5
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W2059581260
- Cited by
- 64
- References
- 26
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 11 · 2019: 6 · 2018: 3 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Keywords
- ADAMTS1, ADAMTS5, Down syndrome, Alzheimer's disease, Pick's disease, neurodegeneration, proteoglycan degradation, aggrecan, versican, frontal cortex
- MeSH terms
- ADAMTS1 Protein, ADAMTS5 Protein, Aged, Alzheimer Disease, Down Syndrome, Frontal Lobe, Gene Expression Regulation, Humans, Immunohistochemistry, Male, Metalloendopeptidases, Middle Aged, Postmortem Changes, Blotting, Western, Disintegrins, Pick Disease of the Brain, ADAM Proteins
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