Pathophysiological function of ADAMTS enzymes on molecular mechanism of Alzheimer’s disease

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Proteoglycan degradation by the ADAMTS family of proteinases

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ADAMTS13 is expressed in hepatic stellate cells

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Brain-enriched Hyaluronan Binding (BEHAB)/Brevican Cleavage in a Glioma Cell Line Is Mediated by a Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) Family Member

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Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer’s disease

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Platelet amyloid precursor protein processing: A bio-marker for Alzheimer's disease

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ADAMTS13 turns 3

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Reduced Reelin Expression Accelerates Amyloid-  Plaque Formation and Tau Pathology in Transgenic Alzheimer's Disease Mice

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Adamts9 is widely expressed during mouse embryo development

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ADAMTS expression and function in central nervous system injury and disorders

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ADAMTS proteoglycanases in the physiological and pathological central nervous system.

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Regulated Proteolytic Processing of Reelin through Interplay of Tissue Plasminogen Activator (tPA), ADAMTS-4, ADAMTS-5, and Their Modulators

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The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury

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Expression of lacunin, a large multidomain extracellular matrix protein, accompanies morphogenesis of epithelial monolayers in Manduca sexta

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Adamts5 Deletion Blocks Murine Dermal Repair through CD44-mediated Aggrecan Accumulation and Modulation of Transforming Growth Factor β1 (TGFβ1) Signaling

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ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein

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Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease

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Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension

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A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS‐4) cleaves Reelin in an isoform‐dependent manner

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Alcadein Cleavages by Amyloid β-Precursor Protein (APP) α- and γ-Secretases Generate Small Peptides, p3-Alcs, Indicating Alzheimer Disease-related γ-Secretase Dysfunction

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Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brain

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ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse

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Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter

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The Role of Reelin Signaling in Alzheimer’s Disease

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ADAMTS-13 is produced by glial cells and upregulated after spinal cord injury

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Selective Decline of Synaptic Protein Levels in the Frontal Cortex of Female Mice Deficient in the Extracellular Metalloproteinase ADAMTS1

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Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements

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Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer’s Disease

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New Insights into ADAMTS Metalloproteases in the Central Nervous System

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Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics

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Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s disease

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Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease riskPreprint

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CTSS Modulates Stress-Related Carotid Artery Thrombosis in a Mouse FeCl 3 Model

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Increased dipeptidyl peptidase-4 accelerates chronic stress-related thrombosis in a mouse carotid artery model

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A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients

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Novel Associations Within the Tumor Microenvironment: Fibulins Meet ADAMTSs

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NAD + reverses Alzheimer’s neurological deficits via regulating differential alternative RNA splicing of EVA1C

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Improving reproducibility of differentially expressed genes in single-cell transcriptomic studies of neurodegenerative diseases through meta-analysis

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Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease

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Cell type-specific histone acetylation profiling of Alzheimer’s Disease subjects and integration with geneticsPreprint

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Prediction models of persistent taxane-induced peripheral neuropathy among breast cancer survivors using whole-exome sequencing

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Secretome analysis of oligodendrocytes and precursors reveals their roles as contributors to the extracellular matrix and potential regulators of inflammationPreprint

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Development of Alzheimer’s disease in Down syndrome

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Hypermethylation at CREBBP Is Associated with Cognitive Impairment in a Mexican American Cohort

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A Reproducibility Focused Meta-Analysis Method for Single-Cell Transcriptomic Case-Control Studies Uncovers Robust Differentially Expressed GenesPreprint

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Probing the Interactions of LRP1 Ectodomain-Derived Peptides with Fibrillar Tau Protein and Its Impact on Cellular Internalization

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Mutations in fibulin-1 and collagen IV suppress the short healthspan of mig-17/ADAMTS mutants in Caenorhabditis elegans

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Epigenetic Control of Hyperuricemia and Gout by Gene Writer DNMT1 and RNA Editor ADAR1: Mechanism of Gout and Amyloid Dissolution in Down Syndrome

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Berberine reduce inflammation in RA rats through MCP1/CCR2 pathwayPreprint

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GTsurvival: A Hybrid GCN-Neural Decision Tree Model for Restricted Mean Survival Time Prediction with Complex Censored Data

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Alterations in gene expression and protein levels of extracellular matrix-related molecules in major depressive disorder: Insights from analyses in the hippocampus and prefrontal cortex

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Investigation of extracellular matrix genes associated with Alzheimer’s disease in the hippocampus of experimental diabetic model rats

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Cannabinoid-basierte Therapie in einem Modell für die sporadische Alzheimer-Erkrankung

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Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer’s diseasePreprint

Yu, M., Risacher, S. L., Nho, K. T., Wen, Q., Oblak, A. L., Unverzagt, F. W., Apostolova, L. G., Farlow, M. R., Brosch, J. R., Clark, D. G., et al. (2023) · medRxiv · doi:10.1101/2023.08.12.23294017

Taxane-Induced Peripheral Neuropathy among Early-Stage Breast Cancer Survivors : Prevalence, Risk Factors, Quality of Life and Genetic Prediction Models

Engvall, K. (2024) · Linköping University medical dissertations · doi:10.3384/9789180755146

NAD + - and EVA1-C-dependent reversal of neurological deficits is mediated by differential alternative RNA splicing in tauopathic animal modelsPreprint

Ai, R., Mao, L., Jin, X., Zhang, S., Pan, J., Lagartos-Donate, M. J., Cao, S., Yang, G., Xie, C., Kang, X., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.27.620478

Healthy lifestyles, plasma proteomic profile and long-term risk of dementiaPreprint

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Therapeutic Strategies Targeting Amyloid-β in Alzheimer’s Disease

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Unravelling Synaptic and Metabolic Mechanisms of Cognitive Resilience in Asymptomatic Alzheimer’s Disease Across Two Alzheimer’s Disease Cohorts

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Gene-expression contributions to specific and shared regional vulnerabilities to amyloid, tau, and neurodegeneration in Alzheimer's disease

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New Insights into ADAMTS Metalloproteases in the Central Nervous System

Mohamedi, Y., Fontanil, T., Cobo, T., Cal, S., & Obaya, Á. J. (2020) · Biomolecules · doi:10.3390/biom10030403 · Cited by 39 · see citing works

A Multi-Functional Gene Family From Arthritis to Cancer: A Disintegrin-Like Metalloproteinase with Thrombospondin Type-1 Motif (ADAMTS)

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Adamalysins in biology and disease

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Neurocan is a New Substrate for the ADAMTS12 Metalloprotease: Potential Implications in Neuropathies

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