Transcriptional Activators Are Dispensable for Transcription in the Absence of Spt6-Mediated Chromatin Reassembly of Promoter Regions

Adkins, Melissa W.; Tyler, Jessica K.

doi:10.1016/j.molcel.2005.12.010

Cited by 163Genomics and Chromatin DynamicsNuclear Structure and FunctionFungal and yeast genetics research

Transcriptional Activators Are Dispensable for Transcription in the Absence of Spt6-Mediated Chromatin Reassembly of Promoter Regions

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Adkins, Melissa W., Tyler, Jessica K.·2006·Molecular Cell

DOI 10.1016/j.molcel.2005.12.010

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Abstract

The packaging of the eukaryotic genome into chromatin is likely to have a profound influence on transcription from the underlying genes. We have previously shown that the disassembly of promoter nucleosomes is obligatory for activation of the yeast PHO5 and PHO8 genes. Here, we show that the PHO5 promoter nucleosomes are reassembled concomitant with transcriptional repression and displacement of the TATA binding protein and RNA polymerase II (RNA Pol II). We identify the histone H3-H4 chaperone Spt6 as the factor that mediates nucleosome reassembly onto the PHO5, PHO8, ADH2, ADY2, and SUC2 promoters during transcriptional repression. Furthermore, promoter nucleosome reassembly is essential for transcriptional repression. In the absence of Spt6-mediated nucleosome reassembly, the activators Pho4 and Pho2 are displaced from the PHO5 promoter in repressing conditions, yet transcription is sustained. As such, these studies demonstrate that activators are not required for transcription in the absence of competing chromatin reassembly.

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Spt6 physically interacts with histone H3 and can facilitate nucleosome reassembly.
“Another factor reported to increase RNA Pol II speed is the transcription elongation factor Spt6, which physically interacts with histone H3 (Bortvin & Winston, 1996; Winkler et al, 2000) and can facilitate nucleosome reassembly (Adkins & Tyler, 2006).”
From RNA polymerase II speed: a key player in controlling and adapting transcriptome composition (2021) · cites this paper as Adkins & Tyler, 2006

Crystal structure of the nucleosome core particle at 2.8 Å resolution
Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466 · see citing works
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
Longtine, M. S., Mckenzie, A., DeMarini, D. J., Shah, N. G., Wach, A., Brachat, A., Philippsen, P., & Pringle, J. R. (1998) · Yeast · doi:10.1002/(sici)1097-0061(199807)14:10 · Cited by 5,367 · see citing works
Methods in Yeast Genetics
Jacob, H. (1988) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(88)80052-7 · Cited by 4,911 · see citing works
Functional organization of the yeast proteome by systematic analysis of protein complexes
Gavin, A., Böesche, M., Krause, R., Grandi, P., Marzioch, M., Bauer, A., Schultz, J., Rick, J. M., Michon, A., Cruciat, C., et al. (2002) · Nature · doi:10.1038/415141a · Cited by 4,729 · see citing works
Dissecting the regulatory circuitry of a eukaryotic genome
Holstege, F. C. P., Jennings, E. G., Wyrick, J. J., Lee, T. I., Hengartner, C. J., Green, M. R., Golub, T. R., Lander, E. S., & Young, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81641-4 · Cited by 1,670 · see citing works
Histones and histone modifications
Peterson, C. L., & Laniel, M.-A. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.007 · Cited by 1,313 · see citing works
FACT Facilitates Transcription-Dependent Nucleosome Alteration
Belotserkovskaya, R., Oh, S., Bondarenko, V. A., Orphanides, G., Studitsky, V. M., & Reinberg, D. (2003) · Science · doi:10.1126/science.1085703 · Cited by 869 · see citing works
Ssn6-Tup1 is a general repressor of transcription in yeast
Keleher, C. A., Redd, M. J., Schultz, J., Carlson, M., & Johnson, A. D. (1992) · Cell · doi:10.1016/0092-8674(92)90146-4 · Cited by 666 · see citing works
Transcription Elongation Factors Repress Transcription Initiation from Cryptic Sites
Kaplan, C. D., Laprade, L., & Winston, F. (2003) · Science · doi:10.1126/science.1087374 · Cited by 590 · see citing works
RNA Polymerase II Elongation Factors of Saccharomyces cerevisiae: a Targeted Proteomics Approach
Krogan, N. J., Kim, M., Ahn, S., Zhong, G., Kobor, M. S., Cagney, G., Emili, A., Shilatifard, A., Buratowski, S., & Greenblatt, J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.20.6979-6992.2002 · Cited by 497 · see citing works
A transcription reinitiation intermediate that is stabilized by activator
Yudkovsky, N., Ranish, J. A., & Hahn, S. (2000) · Nature · doi:10.1038/35041603 · Cited by 421 · see citing works
Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein.
Treitel, M. A., & Carlson, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3132 · Cited by 403 · see citing works
Evidence for Eviction and Rapid Deposition of Histones upon Transcriptional Elongation by RNA Polymerase II
Schwabish, M. A., & Struhl, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10111-10117.2004 · Cited by 399 · see citing works
Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast
Wyrick, J. J., Holstege, F. C. P., Jennings, E. G., Causton, H. C., Shore, D., Grunstein, M. R., Lander, E. S., & Young, R. A. (1999) · Nature · doi:10.1038/46567 · Cited by 394 · see citing works
Histones Are First Hyperacetylated and Then Lose Contact with the Activated PHO5 Promoter
Reinke, H., & Hörz, W. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00186-2 · Cited by 394 · see citing works
Evidence That Spt6p Controls Chromatin Structure by a Direct Interaction with Histones
Bortvin, A., & Winston, F. (1996) · Science · doi:10.1126/science.272.5267.1473 · Cited by 354 · see citing works
Regulation of Chromatin Remodeling by Inositol Polyphosphates
Steger, D. J., Haswell, E. S., Miller, A. L., Wente, S. R., & O'Shea, E. K. (2003) · Science · doi:10.1126/science.1078062 · Cited by 352 · see citing works
p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiationPreprint
Kraus, W. L., & Kadonaga, J. T. (1998) · Genes & Development · doi:10.1101/gad.12.3.331 · Cited by 334 · see citing works
Regulation of PHO4 Nuclear Localization by the PHO80-PHO85 Cyclin-CDK Complex
O’Neill, E., Kaffman, A., Jolly, E. R., & O’Shea, E. K. (1996) · Science · doi:10.1126/science.271.5246.209 · Cited by 330 · see citing works
Chromatin Disassembly Mediated by the Histone Chaperone Asf1 Is Essential for Transcriptional Activation of the Yeast PHO5 and PHO8 Genes
Adkins, M. W., Howar, S. R., & Tyler, J. K. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.016 · Cited by 294 · see citing works
Self-citation
Histone variants meet their match
Sarma, K., & Reinberg, D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1567 · Cited by 292 · see citing works
Tracking FACT and the RNA Polymerase II Elongation Complex Through Chromatin in Vivo
Saunders, A., Werner, J. K., Andrulis, E. D., Nakayama, T. W., Hirose, S., Reinberg, D., & Lis, J. T. (2003) · Science · doi:10.1126/science.1085712 · Cited by 289 · see citing works
Dimeric ligands define a role for transcriptional activation domains in reinitiation
Ho, S. N., Biggar, S. R., Spencer, D. M., Schreiber, S. L., & Crabtree, G. R. (1996) · Nature · doi:10.1038/382822a0 · Cited by 261 · see citing works
Removal of Promoter Nucleosomes by Disassembly Rather Than Sliding In Vivo
Boeger, H., Griesenbeck, J., Strattan, J. S., & Kornberg, R. D. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.013 · Cited by 258 · see citing works
Depletion of histone H4 and nucleosomes activates the PHO5 gene in Saccharomyces cerevisiae.
Han, M., Kim, U. J., Kayne, P. S., & Grunstein, M. R. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03061.x · Cited by 221 · see citing works
NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro.Preprint
Pazin, M. J., Sheridan, P. L., Cannon, K. S., Cao, Z. D., Keck, J., Kadonaga, J. T., & Jones, K. A. (1996) · Genes & Development · doi:10.1101/gad.10.1.37 · Cited by 186 · see citing works
SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae.
Swanson, M. S., & Winston, F. (1992) · Genetics · doi:10.1093/genetics/132.2.325 · Cited by 177 · see citing works
Chromatin remodeling complexes: strength in diversity, precision through specialization
Cairns, B. R. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.01.003 · Cited by 174 · see citing works
Analysis of the role of the transcription factor ATF in the assembly of a functional preinitiation complex
Hai, T., Horikoshi, M., Roeder, R. G., & Green, M. R. (1988) · Cell · doi:10.1016/0092-8674(88)90119-5 · Cited by 170 · see citing works
IDENTIFICATION OF NEW GENES INVOLVED IN THE REGULATION OF YEAST ALCOHOL DEHYDROGENASE II
Denis, C. L. (1984) · Genetics · doi:10.1093/genetics/108.4.833 · Cited by 169 · see citing works
Nucleosome disruption at the yeast PHO5 promoter upon PHO5 induction occurs in the absence of DNA replication
Schmid, A., Fascher, K.-D., & Hörz, W. (1992) · Cell · doi:10.1016/0092-8674(92)90560-y · Cited by 157 · see citing works
A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter.
Venter, U., Svaren, J. P., Schmitz, J., Schmid, A., & Hörz, W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06811.x · Cited by 132 · see citing works
The RNA polymerase II transcription cycle: cycling through chromatin
Svejstrup, J. Q. (2003) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2003.10.012 · Cited by 99 · see citing works
Chromatin Remodeling during Saccharomyces cerevisiae ADH2 Gene Activation
Verdone, L., Camilloni, G., Mauro, E. D., & Caserta, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.1978 · Cited by 97 · see citing works
Multiple Mechanistically Distinct Functions of SAGA at the PHO5 Promoter
Barbarić, S., Reinke, H., & Hürz, W. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.10.3468-3476.2003 · Cited by 95 · see citing works
Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation
Nourani, A., Utley, R. T., Allard, S., & Côté, J. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600230 · Cited by 93 · see citing works
Polyphosphate Loss Promotes SNF/SWI- and Gcn5-Dependent Mitotic Induction of PHO5
Neef, D. W., & Kladde, M. P. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.11.3788-3797.2003 · Cited by 88 · see citing works
Effects of Sin− versions of histone H4 on yeast chromatin structure and function
Wechser, M. A., Kladde, M. P., Alfieri, J. A., & Peterson, C. L. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.2086 · Cited by 79 · see citing works
Interplay of yeast global transcriptional regulators Ssn6p–Tup1p and Swi–Snf and their effect on chromatin structure
Gavin, I. M., & Simpson, R. T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6263 · Cited by 78 · see citing works
Identification and Characterization of Elf1, a Conserved Transcription Elongation Factor in Saccharomyces cerevisiae
Prather, D. M., Krogan, N. J., Emili, A., Greenblatt, J., & Winston, F. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10122-10135.2005 · Cited by 78 · see citing works
The Homeodomain Protein Pho2 and the Basic-Helix-Loop-Helix Protein Pho4 Bind DNA Cooperatively at the Yeast PHO5 Promoter
Barbarić, S., Münsterkötter, M., Svaren, J. P., & Hörz, W. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.22.4479 · Cited by 74 · see citing works
Heat Shock Factor Increases the Reinitiation Rate from Potentiated Chromatin Templates
Sandaltzopoulos, R., & Becker, P. B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.361 · Cited by 66 · see citing works
Activation of the weakly regulated PHO8 promoter inS.cerevisiae:chromatin transition and binding sites for the positive regulatory protein PHO4
Barbarić, S., Fascher, K.-D., & Hoörz, W. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.5.1031 · Cited by 50 · see citing works
Post-translational Regulation of Adr1 Activity Is Mediated by Its DNA Binding Domain
Sloan, J. S., Dombek, K. M., & Young, E. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37575 · Cited by 39 · see citing works
Interplay between nucleosomes and transcription factors at the yeastPHO5promoter
Svaren, J. P., & Hörz, W. (1995) · Seminars in Cell Biology · doi:10.1006/scel.1995.0025 · Cited by 27 · see citing works
Common Chromatin Architecture, Common Chromatin Remodeling, and Common Transcription Kinetics of Adr1-Dependent Genes in Saccharomyces cerevisiae
Agricola, E., Verdone, L., Xella, B., Mauro, E. D., & Caserta, M. (2004) · Biochemistry · doi:10.1021/bi049577+ · Cited by 20 · see citing works
Functional analysis of the signal‐sequence processing site of yeast acid phosphatase
Monod, M., Haguenauer‐Tsapis, R., Koenig-Rauseo, I., & Hinnen, A. (1989) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1989.tb14820.x · Cited by 17 · see citing works

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1 of the 48 references couldn’t be matched to a known paper.

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Segal, E., & Widom, J. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.06.002 · Cited by 381 · see citing works
Histone chaperones: an escort network regulating histone traffic
de Koning, L., Corpet, A., Haber, J. E., & Almouzni, G. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1318 · Cited by 365 · see citing works
Inducible gene expression: diverse regulatory mechanisms
Weake, V. M., & Workman, J. L. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2781 · Cited by 365 · see citing works
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Talbert, P. B., & Henikoff, S. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.148 · Cited by 347 · see citing works
Nucleolin: a multiFACeTed protein
Mongélard, F., & Bouvet, P. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.11.010 · Cited by 344 · see citing works
Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast agingPreprint
Hu, Z., Chen, K., Xia, Z., Chavez-Tomar, M., Pal, S., Seol, J.-H., Chen, C., Li, W., & Tyler, J. K. (2014) · Genes & Development · doi:10.1101/gad.233221.113 · Cited by 330 · see citing works
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Venkatesh, S., Smolle, M. M., Li, H., Gogol, M., Saint, M., Kumar, S. A., Natarajan, K., & Workman, J. L. (2012) · Nature · doi:10.1038/nature11326 · Cited by 319 · see citing works
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Rando, O. J., & Winston, F. (2012) · Genetics · doi:10.1534/genetics.111.132266 · Cited by 269 · see citing works
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Yoh, S. M., Cho, H. K., Pickle, L., Evans, R. M., & Jones, K. A. (2007) · Genes & Development · doi:10.1101/gad.1503107 · Cited by 257 · see citing works
Nucleolin is a histone chaperone with FACT‐like activity and assists remodeling of nucleosomes
Angelov, D., Bondarenko, V. A., Almagro, S., Menoni, H., Mongélard, F., Hans, F., Mietton, F., Studitsky, V. M., Hamiche, A., Dimitrov, S. I., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601046 · Cited by 256 · see citing works
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Bai, L., & Morozov, A. V. (2010) · Trends in Genetics · doi:10.1016/j.tig.2010.08.003 · Cited by 247 · see citing works
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Yoh, S. M., Lucas, J., & Jones, K. A. (2008) · Genes & Development · doi:10.1101/gad.1720008 · Cited by 238 · see citing works
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Lam, F. H., Steger, D. J., & O’Shea, E. K. (2008) · Nature · doi:10.1038/nature06867 · Cited by 237 · see citing works
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Histone chaperones: 30 years from isolation to elucidation of the mechanisms of nucleosome assembly and disassembly
Eitoku, M., Sato, L., Senda, T., & Horikoshi, M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7305-6 · Cited by 207 · see citing works
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“Another factor reported to increase RNA Pol II speed is the transcription elongation factor Spt6, which physically interacts with histone H3 (Bortvin & Winston, 1996; Winkler et al , 2000) and can facilitate nucleosome reassembly (Adkins & Tyler, 2006).”
Continuous Histone H2B and Transcription-Dependent Histone H3 Exchange in Yeast Cells outside of Replication
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McDonald, S., Close, D. W., Hua, X., Formosa, T., & Hill, C. P. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.014 · Cited by 78 · see citing works
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Zhang, L., Fletcher, A. G. L., Cheung, V., Winston, F., & Stargell, L. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01733-07 · Cited by 78 · see citing works
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Ivanovska, I., Jacques, P., Rando, O. J., Robert, F., & Winston, F. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01068-10 · Cited by 76 · see citing works
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Sdano, M. A., Fulcher, J. M., Palani, S., Chandrasekharan, M. B., Parnell, T. J., Whitby, F. G., Formosa, T., & Hill, C. P. (2017) · eLife · doi:10.7554/elife.28723 · Cited by 74 · see citing works
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Doris, S. M., Chuang, J., Viktorovskaya, O., Murawska, M., Spatt, D., Churchman, L. S., & Winston, F. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.09.005 · Cited by 70 · see citing works
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Ransom, M., Williams, S. K., Dechassa, M. L., Das, C., Linger, J. G., Adkins, M. W., Liu, C., Bartholomew, B., & Tyler, J. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019562 · Cited by 68 · see citing works
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Diebold, M.-L., Koch, M., Loeliger, E., Cura, V., Winston, F., Cavarelli, J., & Romier, C. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.272 · Cited by 67 · see citing works
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Kim, J.-W., Jang, S., Kim, C.-H., An, J., Kang, E.-J., & Choi, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.278465 · Cited by 65 · see citing works
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Erkina, T. Y., Zou, Y., Freeling, S., Vorobyev, V. I., & Erkine, A. M. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1130 · Cited by 64 · see citing works
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Hadwiger, L. A. (2008) · Phytopathology · doi:10.1094/phyto-98-4-0372 · Cited by 61 · see citing works
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Korber, P., & Barbarić, S. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku784 · Cited by 61 · see citing works
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Morse, R. H. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21493 · Cited by 60 · see citing works
Emerging Views on the CTD Code
Zhang, D. W., Rodríguez‐Molina, J. B., Tietjen, J. R., Nemec, C. M., & Ansari, A. Z. (2012) · Genetics Research International · doi:10.1155/2012/347214 · Cited by 58 · see citing works
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Epigenetic and replacement roles of histone variant H3.3 in reproduction and development
Orsi, G. A., Couble, P., & Loppin, B. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082653go · Cited by 56 · see citing works
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Munemasa, Y., Suzuki, T., Aizawa, K., Miyamoto, S., Imai, Y., Matsumura, T., Horikoshi, M., & Nagai, R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01396-07 · Cited by 56 · see citing works
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Erkina, T. Y., Tschetter, P. A., & Erkine, A. M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01069-07 · Cited by 53 · see citing works
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Zaugg, J. B., & Luscombe, N. M. (2011) · Genome Research · doi:10.1101/gr.124099.111 · Cited by 52 · see citing works
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Johnson, S. J., Close, D. W., Robinson, H. H., Vallet-Gély, I., Dove, S. L., & Hill, C. P. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.01.096 · Cited by 50 · see citing works
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Dengl, S., Mayer, A., Sun, M., & Cramer, P. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.04.016 · Cited by 48 · see citing works
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Wang, S., Zhou, B. O., & Zhou, J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05017-11 · Cited by 45 · see citing works
Clothing up DNA for all seasons: Histone chaperones and nucleosome assembly pathways
Rocha, W., & Verreault, A. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.03.006 · Cited by 45 · see citing works
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Duina, A. A. (2011) · Genetics Research International · doi:10.4061/2011/625210 · Cited by 45 · see citing works
Chromatin disassembly and reassembly during DNA repair
Linger, J. G., & Tyler, J. K. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.05.039 · Cited by 44 · see citing works
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Klein, D. C., & Hainer, S. J. (2019) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2019.11.002 · Cited by 39 · see citing works
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He, Q., Battistella, L., & Morse, R. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708266200 · Cited by 28 · see citing works
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Reim, N. I., Chuang, J., Jain, D. S., Alver, B. H., Park, P. J., & Winston, F. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa745 · Cited by 26 · see citing works
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Groth, A. (2009) · Biochemistry and Cell Biology · doi:10.1139/o08-102 · Cited by 24 · see citing works
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Pujari, V., Radebaugh, C. A., Chodaparambil, J. V., Muthurajan, U. M., Almeida, A. R., Fischbeck, J. A., Luger, K., & Stargell, L. A. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.09.040 · Cited by 23 · see citing works
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Burugula, B. B., Jerónimo, C., Pathak, R., Jones, J. W., Robert, F., & Govind, C. K. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00695-14 · Cited by 22 · see citing works
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Li, S., Almeida, A. R., Radebaugh, C. A., Zhang, L., Chen, X., Huang, L., Thurston, A. K., Kalashnikova, A. A., Hansen, J. C., Luger, K., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1305 · Cited by 21 · see citing works
The use of chemical genomics to detect functional systems affecting the non-host disease resistance of pea to Fusarium solani f. sp. phaseoli
Hartney, S. L., Carson, J., & Hadwiger, L. A. (2006) · Plant Science · doi:10.1016/j.plantsci.2006.07.014 · Cited by 20 · see citing works

Interplay between nucleosomes and transcription factors at the yeastPHO5promoter
Svaren, J. P., & Hörz, W. (1995) · Seminars in Cell Biology · doi:10.1006/scel.1995.0025 · Cited by 27 · see citing works
Chromatin Disassembly from the PHO5 Promoter Is Essential for the Recruitment of the General Transcription Machinery and Coactivators
Adkins, M. W., Williams, S. K., Linger, J. G., & Tyler, J. K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00981-07 · Cited by 87 · see citing works
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Adkins, M. W., Howar, S. R., & Tyler, J. K. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.016 · Cited by 294 · see citing works
Self-citation
Structural and Functional Requirements for the Chromatin Transition at the PHO5 Promoter in Saccharomyces cerevisiae upon PHO5 Activation
Fascher, K.-D., Schmitz, J., & Hörz, W. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1317 · Cited by 119 · see citing works
FACT and the Proteasome Promote Promoter Chromatin Disassembly and Transcriptional Initiation
Ransom, M., Williams, S. K., Dechassa, M. L., Das, C., Linger, J. G., Adkins, M. W., Liu, C., Bartholomew, B., & Tyler, J. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019562 · Cited by 68 · see citing works
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Authors: Adkins, M. W., & Tyler, J. K.
Affiliations: University of Colorado Health (US)
Corresponding author: Tyler, Jessica K.
ORCID: Tyler, Jessica K.
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2006-02
Volume: 21
Issue: 3
Pages: 405-416
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2005.12.010
OpenAlex: W2059504699
Cited by: 162
References: 48
Citations by year: 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 6 · 2013: 8 · 2012: 15
FWCI: 8.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2759 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (R01GM064475)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Spt6, nucleosome reassembly, promoter nucleosomes, transcriptional repression, transcriptional activator, Pho4, PHO2, PHO5, ADH2, SUC2, TATA-binding protein, RNA polymerase II, chromatin, Saccharomyces cerevisiae
MeSH terms: Acid Phosphatase, Chromatin, Nuclear Proteins, Nucleosomes, Promoter Regions, Genetic, Repressor Proteins, Saccharomyces cerevisiae, Transcription, Genetic, Trans-Activators, Gene Expression Regulation, Fungal, Open Reading Frames, Saccharomyces cerevisiae Proteins, Transcriptional Elongation Factors, Histone Chaperones

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Transcriptional Activators Are Dispensable for Transcription in the Absence of Spt6-Mediated Chromatin Reassembly of Promoter Regions

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