RETRACTED: Sealing of Chromosomal DNA Nicks during Nucleotide Excision Repair Requires XRCC1 and DNA Ligase IIIα in a Cell-Cycle-Specific Manner
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This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the editors. Molecular Cell has retracted this article following the results of an investigation carried out by Leiden University Medical Center's Committee of Scientific Integrity, which concluded that unacceptable data manipulation by the last author Maria Fousteri led to breaches of scientific integrity, making these results unreliable. Section 2.2, item 2 of the report indicates several duplications in Figure 4 and that, upon inspection of original data, several proteins stained for by western blotting following immunoprecipitation were incorrectly assigned (Figure 4B). The XPA panel in Figure 4A is a mirrored duplication of an image that was published in Figure 5C of Fousteri et al., 2006 (Mol. Cell 23, 471-482, https://doi.org/10.1016/j.molcel.2006.06.029). Additional details can be found in the redacted version of the investigation report (https://www.lumc.nl/cen/att/80813053317221/1263833/report-lumc-committee-scientific-integrity).
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- Authors
- Moser, J., Kool, H., Giakzidis, I., Caldecott, K., Mullenders, L. H. F., & Fousteri, M. I.
- Affiliations
- Leiden University Medical Center (NL)
- University of Sussex (GB)
- Corresponding author
- Mullenders, Leon H.F.
- Fousteri, Maria I.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 27
- Issue
- 2
- Pages
- 311-323
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1989208996
- Cited by
- 261
- References
- 53
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 13 · 2019: 17 · 2018: 16 · 2017: 20 · 2016: 23 · 2015: 16 · 2014: 16 · 2013: 14 · 2012: 26
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
- doi.org
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Sussex Research Online (University of Sussex) (submittedVersion)
- Figshare (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- nucleotide excision repair, XRCC1, cell cycle, DNA damage response, scientific integrity, data manipulation, XPA
- MeSH terms
- DNA Ligase ATP, Poly-ADP-Ribose Binding Proteins, X-ray Repair Cross Complementing Protein 1, Cell Cycle, Cells, Cultured, DNA Polymerase II, DNA Polymerase III, DNA Repair, DNA-Binding Proteins, Humans, Models, Biological, DNA Ligases, Ultraviolet Rays, Down-Regulation, Photobiology, Xenopus Proteins, Multiprotein Complexes, DNA Breaks, Single-Stranded
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