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Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

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Targeted protein degradation: expanding the toolbox

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Advancing targeted protein degradation for cancer therapy

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Structural basis of Keap1 interactions with Nrf2

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The integrated landscape of driver genomic alterations in glioblastoma

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The cullin protein family

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Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

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Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants

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Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

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Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif

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Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

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Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases

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The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

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A mutually assured destruction mechanism attenuates light signaling in Arabidopsis

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Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO

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Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants

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Cullin-RING Ubiquitin Ligase Regulatory Circuits: A Quarter Century Beyond the F-Box Hypothesis

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Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

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Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

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Nrf2: a dark horse in Alzheimer's disease treatment

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Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

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A proximity-tagging system to identify membrane protein–protein interactions

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Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

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Structural assembly of cullin-RING ubiquitin ligase complexes

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Comprehensive assessment of cancer missense mutation clustering in protein structures

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SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression

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Structural regulation of cullin-RING ubiquitin ligase complexes

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Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles

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Structural basis of NPR1 in activating plant immunity

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Mechanism and evolution of cytosolic Hedgehog signal transduction

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Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer

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Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors

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SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer

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Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

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MATH/BTB CRL3 Receptors Target the Homeodomain-Leucine Zipper ATHB6 to Modulate Abscisic Acid Signaling

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Evidence for Molecular Differences in Prostate Cancer between African American and Caucasian Men

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SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts

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NEDD8 and ubiquitin ligation by cullin-RING E3 ligases

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Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation

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Quantifying Ubiquitin Signaling

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Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy

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Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics

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TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

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Adaptor Protein Self-Assembly Drives the Control of a Cullin-RING Ubiquitin Ligase

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Emerging Role of Ubiquitination in the Regulation of PD-1/PD-L1 in Cancer Immunotherapy

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Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory

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Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility

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Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells

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KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders

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Sequence-based drug design as a concept in computational drug design

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Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

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Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor

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Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator

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SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein

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Prostate Cancer-associated SPOP mutations enhance cancer cell survival and docetaxel resistance by upregulating Caprin1-dependent stress granule assembly

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The emerging role of SPOP protein in tumorigenesis and cancer therapy

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DAXX in cancer: phenomena, processes, mechanisms and regulation

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Sleep Fragmentation and Motor Restlessness in a Drosophila Model of Restless Legs Syndrome

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The Critical Role of the Pathologist in Determining Eligibility for Active Surveillance as a Management Option in Patients With Prostate Cancer: Consensus Statement With Recommendations Supported by the College of American Pathologists, International Society of Urological Pathology, Association of Directors of Anatomic and Surgical Pathology, the New Zealand Society of Pathologists, and the Prostate Cancer Foundation

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LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases

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Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCFFBXL17 in NRF2 Activation via BACH1 Repressor Turnover

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Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex

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The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses

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The role of natural products in revealing NRF2 function

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BPM-CUL3 E3 ligase modulates thermotolerance by facilitating negative regulatory domain-mediated degradation of DREB2A in Arabidopsis

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Survey of the 2009 commercial optical biosensor literature

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Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins

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CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers

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UUCD: a family-based database of ubiquitin and ubiquitin-like conjugation

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ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer

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Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2

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The diverse roles of SPOP in prostate cancer and kidney cancer

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Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the Kelch domain substrate-recognition surface and enhance RAS-MAPK signaling

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Aberrant phase separation and cancer

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Time-resolved Global and Chromatin Proteomics during Herpes Simplex Virus Type 1 (HSV-1) Infection

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Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy

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