The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells
Open accessAbstract
Summary To sustain tumor growth, cancer cells must be able to adapt to fluctuations in energy availability. We have identified a single microRNA that controls glioma cell proliferation, migration, and responsiveness to glucose deprivation. Abundant glucose allows relatively high miR-451 expression, promoting cell growth. In low glucose, miR-451 levels decrease, slowing proliferation but enhancing migration and survival. This allows cells to survive metabolic stress and seek out favorable growth conditions. In glioblastoma patients, elevated miR-451 is associated with shorter survival. The effects of miR-451 are mediated by LKB1, which it represses through targeting its binding partner, CAB39 (MO25α). Overexpression of miR-451 sensitized cells to glucose deprivation, suggesting that its downregulation is necessary for robust activation of LKB1 in response to metabolic stress. Thus, miR-451 is a regulator of the LKB1/AMPK pathway, and this may represent a fundamental mechanism that contributes to cellular adaptation in response to altered energy availability.
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Cited by
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AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
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Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320
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Self-citation
Metadata
- Authors
- Godlewski, J., Nowicki, M. O., Bronisz, A., Nuovo, G., Palatini, J., De Lay, M., Van Brocklyn, J., Ostrowski, M. C., Chiocca, E. A., & Lawler, S. E.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 37
- Issue
- 5
- Pages
- 620-632
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2067122631
- Cited by
- 419
- References
- 53
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Godlewski, J., Nowicki, M. O., Bronisz, A., Nuovo, G., Palatini, J., De Lay, M., Van Brocklyn, J., Ostrowski, M. C., Chiocca, E. A., & Lawler, S. E. (2010). MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.02.018
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