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SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
Open accessAbstract
SIRT1, a NAD(+)-dependent histone deacetylase, plays crucial roles in multiple biological processes including gene transcription, cellular metabolism, stress response, and tumorigenesis. Xeroderma pigmentosum group A (XPA) is a core nucleotide excision repair (NER) factor essential for NER process. Here we show that SIRT1 plays an important role in the regulation of NER pathway. Downregulation of SIRT1 significantly sensitizes cells to UV irradiation. SIRT1 interacts with XPA, and the interaction is enhanced after UV irradiation. XPA can be acetylated at lysines 63 and 67. SIRT1 deacetylates XPA both in vitro and in cells. Importantly, SIRT1-mediated deacetylation of XPA is required for optimal NER pathway since XPA-deficient cells complemented with XPA-K6367Q, which mimics hyperacetylated XPA, display significantly higher UV sensitivity compared with the XPA cells complemented with wild-type XPA. Furthermore, SIRT1-mediated XPA deacetylation enhances its interaction with RPA32. Our results demonstrate that SIRT1 regulates NER pathway through modulation of XPA acetylation status.
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“They observed that the reduced level of NAD+ downregulated SIRT1, a NAD+- dependent deacetylase involved in regulating mitochondrial homeostasis and XPA repair activity 91–93.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [91]
In the citing paper
“It previously was reported that the DNA damage checkpoint protein kinase ATR was involved in the regulation of the UV-induced XPA nuclear import23.”
From UV-Induced Nuclear Import of XPA Is Mediated by Importin-α4 in An ATR-Dependent Manner (2013) · cites this paper as [23]
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Metadata
- Authors
- Fan, W., & Luo, J.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Luo, Jianyuan
- ORCID
- Luo, Jianyuan
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 39
- Issue
- 2
- Pages
- 247-258
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2137855486
- Cited by
- 223
- References
- 37
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 4 · 2023: 7 · 2022: 11 · 2021: 15 · 2020: 23 · 2019: 14 · 2018: 12 · 2017: 15 · 2016: 10 · 2015: 18 · 2014: 19 · 2013: 24 · 2012: 17
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG026534)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- SIRT1, XPA, nucleotide excision repair, UV-induced DNA repair, histone deacetylase, protein acetylation, lysine acetylation, UV sensitivity, RPA32, protein-protein interaction, NAD+-dependent deacetylation
- MeSH terms
- Acetylation, DNA Repair, Genetic Complementation Test, HeLa Cells, Humans, Protein Processing, Post-Translational, Ultraviolet Rays, Mutation, Missense, Replication Protein A, Xeroderma Pigmentosum Group A Protein, Sirtuin 1
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