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The Aging Stress Response

Haigis, Marcia C., Yankner, Bruce A.·2010·Molecular Cell

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  • Although severe mitochondrial dysfunction is pathogenic, mild respiratory deficiencies may increase lifespan, perhaps due to a hormetic response.

    “although severe mitochondrial dysfunction is pathogenic, mild respiratory deficiencies may increase lifespan, perhaps due to a hormetic response”

    From The Hallmarks of Aging (2013) · cites this paper as Haigis and Yankner, 2010

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Research works printed but not linked: 104

  1. Banks, 2008, SirT1 gain of function increases energy efficiency and prevents diabetes in mice, Cell Metab., 8, 333, 10.1016/j.cmet.2008.08.014 · DOI
  2. Ben-Zvi, 2009, Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging, Proc. Natl. Acad. Sci. USA, 106, 14914, 10.1073/pnas.0902882106 · DOI · Paper page
  3. Bennett, 2005, Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation, Mol. Cell, 17, 351, 10.1016/j.molcel.2004.12.021 · DOI
  4. Bjedov, 2010, Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster, Cell Metab., 11, 35, 10.1016/j.cmet.2009.11.010 · DOI · Paper page
  5. Bonawitz, 2007, Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression, Cell Metab., 5, 265, 10.1016/j.cmet.2007.02.009 · DOI · Paper page
  6. Bonkowski, 2009, Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity, PLoS ONE, 4, e4567, 10.1371/journal.pone.0004567 · DOI
  7. Bordone, 2005, Calorie restriction, SIRT1 and metabolism: understanding longevity, Nat. Rev. Mol. Cell Biol., 6, 298, 10.1038/nrm1616 · DOI
  8. Bordone, 2007, SIRT1 transgenic mice show phenotypes resembling calorie restriction, Aging Cell, 6, 759, 10.1111/j.1474-9726.2007.00335.x · DOI · Paper page
  9. Broadley, 2008, Mitochondrial stress signaling: a pathway unfolds, Trends Cell Biol., 18, 1, 10.1016/j.tcb.2007.11.003 · DOI
  10. Brown, 2007, The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes, Metabolism, 56, 1500, 10.1016/j.metabol.2007.06.016 · DOI
  11. Buchberger, 2010, Protein quality control in the cytosol and the Endoplasmic Reticulum: Brothers in Arms, Mol. Cell, 40, 238, 10.1016/j.molcel.2010.10.001 · DOI · Paper page
  12. Chen, 2007, Longevity determined by developmental arrest genes in Caenorhabditis elegans, Aging Cell, 6, 525, 10.1111/j.1474-9726.2007.00305.x · DOI
  13. Ciccia, 2010, The DNA Damage Response: Making it safe to play with knives, Mol. Cell, 40, 179, 10.1016/j.molcel.2010.09.019 · DOI · Paper page
  14. Cohen, 2006, Opposing activities protect against age-onset proteotoxicity, Science, 313, 1604, 10.1126/science.1124646 · DOI · Paper page
  15. Comfort, 1963, Effect of Delayed and Resumed Growth on the Longevity of a Fish (Lebistes Reticulatus, Peters) in Captivity, Gerontologia, 49, 150, 10.1159/000211216 · DOI
  16. Cuervo, 2010, Protein degradation, aggregation, and misfolding, Mov. Disord., 25, S49, 10.1002/mds.22718 · DOI
  17. Cunningham, 2007, mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex, Nature, 450, 736, 10.1038/nature06322 · DOI · Paper page
  18. Dai, 2010, Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria, Aging Cell, 9, 536, 10.1111/j.1474-9726.2010.00581.x · DOI · Paper page
  19. Dillin, 2002, Rates of behavior and aging specified by mitochondrial function during development, Science, 298, 2398, 10.1126/science.1077780 · DOI · Paper page
  20. Fabrizio, 2010, Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation, PLoS Genet., 6, e1001024, 10.1371/journal.pgen.1001024 · DOI
  21. Frye, 2000, Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins, Biochem. Biophys. Res. Commun., 273, 793, 10.1006/bbrc.2000.3000 · DOI · Paper page
  22. García-Cao, 2002, “Super p53” mice exhibit enhanced DNA damage response, are tumor resistant and age normally, EMBO J., 21, 6225, 10.1093/emboj/cdf595 · DOI · Paper page
  23. Giannakou, 2008, Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response, Aging Cell, 7, 187, 10.1111/j.1474-9726.2007.00362.x · DOI
  24. Greer, 2009, Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans, Aging Cell, 8, 113, 10.1111/j.1474-9726.2009.00459.x · DOI
  25. Guertin, 2007, Defining the role of mTOR in cancer, Cancer Cell, 12, 9, 10.1016/j.ccr.2007.05.008 · DOI · Paper page
  26. Haigis, 2010, Mammalian sirtuins: biological insights and disease relevance, Annu. Rev. Pathol., 5, 253, 10.1146/annurev.pathol.4.110807.092250 · DOI · Paper page
  27. Hansen, 2007, Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans, Aging Cell, 6, 95, 10.1111/j.1474-9726.2006.00267.x · DOI · Paper page
  28. Harman, 1956, Aging: a theory based on free radical and radiation chemistry, J. Gerontol., 11, 298, 10.1093/geronj/11.3.298 · DOI · Paper page
  29. Hartwig, 2009, Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis, Genes Nutr., 4, 59, 10.1007/s12263-009-0113-x · DOI
  30. Hunt, 2006, Bioenergetics of aging and calorie restriction, Ageing Res. Rev., 5, 125, 10.1016/j.arr.2006.03.006 · DOI
  31. Jang, 2009, Overexpression of Mn superoxide dismutase does not increase life span in mice, J. Gerontol. A Biol. Sci. Med. Sci., 64, 1114, 10.1093/gerona/glp100 · DOI
  32. Kahn, 2005, AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism, Cell Metab., 1, 15, 10.1016/j.cmet.2004.12.003 · DOI · Paper page
  33. Kapahi, 2004, Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway, Curr. Biol., 14, 885, 10.1016/j.cub.2004.03.059 · DOI · Paper page
  34. Kelly, 2004, Transcriptional regulatory circuits controlling mitochondrial biogenesis and function, Genes Dev., 18, 357, 10.1101/gad.1177604 · DOI · Paper page
  35. Kenyon, 2010, The genetics of ageing, Nature, 464, 504, 10.1038/nature08980 · DOI · Paper page
  36. Kenyon, 1993, A C. elegans mutant that lives twice as long as wild type, Nature, 366, 461, 10.1038/366461a0 · DOI · Paper page
  37. Kimura, 1997, daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans, Science, 277, 942, 10.1126/science.277.5328.942 · DOI
  38. Komatsu, 2006, Loss of autophagy in the central nervous system causes neurodegeneration in mice, Nature, 441, 880, 10.1038/nature04723 · DOI · Paper page
  39. Kujoth, 2005, Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging, Science, 309, 481, 10.1126/science.1112125 · DOI · Paper page
  40. Kyng, 2005, Gene expression and DNA repair in progeroid syndromes and human aging, Ageing Res. Rev., 4, 579, 10.1016/j.arr.2005.06.008 · DOI · Paper page
  41. Lapointe, 2008, Early mitochondrial dysfunction in long-lived Mclk1+/- mice, J. Biol. Chem., 283, 26217, 10.1074/jbc.M803287200 · DOI
  42. Lapointe, 2010, When a theory of aging ages badly, Cell. Mol. Life Sci., 67, 1, 10.1007/s00018-009-0138-8 · DOI
  43. Le Bacquer, 2007, Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2, J. Clin. Invest., 117, 387, 10.1172/JCI29528 · DOI
  44. Lee, 2009, Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia, J. Neurosci., 29, 8506, 10.1523/JNEUROSCI.0924-09.2009 · DOI
  45. Lee, 1999, Gene expression profile of aging and its retardation by caloric restriction, Science, 285, 1390, 10.1126/science.285.5432.1390 · DOI · Paper page
  46. Lee, 2000, Gene-expression profile of the ageing brain in mice, Nat. Genet., 25, 294, 10.1038/77046 · DOI · Paper page
  47. Lee, 2002, Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts, Proc. Natl. Acad. Sci. USA, 99, 14988, 10.1073/pnas.232308999 · DOI · Paper page
  48. Lee, 2008, A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy, Proc. Natl. Acad. Sci. USA, 105, 3374, 10.1073/pnas.0712145105 · DOI
  49. Lee, 2010, Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations, Cell, 141, 1146, 10.1016/j.cell.2010.05.008 · DOI · Paper page
  50. Long, 2005, Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle, Diabetologia, 48, 2354, 10.1007/s00125-005-1962-5 · DOI
  51. López-Lluch, 2006, Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency, Proc. Natl. Acad. Sci. USA, 103, 1768, 10.1073/pnas.0510452103 · DOI · Paper page
  52. Maier, 2004, Modulation of mammalian life span by the short isoform of p53, Genes Dev., 18, 306, 10.1101/gad.1162404 · DOI · Paper page
  53. Martin, 2005, Genetic modulation of senescent phenotypes in Homo sapiens, Cell, 120, 523, 10.1016/j.cell.2005.01.031 · DOI
  54. Martin, 2009, Sod2 knockdown in the musculature has whole-organism consequences in Drosophila, Free Radic. Biol. Med., 47, 803, 10.1016/j.freeradbiomed.2009.06.021 · DOI
  55. Matsuoka, 2007, ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage, Science, 316, 1160, 10.1126/science.1140321 · DOI · Paper page
  56. Mattagajasingh, 2007, SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase, Proc. Natl. Acad. Sci. USA, 104, 14855, 10.1073/pnas.0704329104 · DOI · Paper page
  57. McCarty, 2004, Chronic activation of AMP-activated kinase as a strategy for slowing aging, Med. Hypotheses, 63, 334, 10.1016/j.mehy.2004.01.043 · DOI
  58. McCay, 1989, The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935, Nutrition, 5, 155
  59. Medvedik, 2007, MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae, PLoS Biol., 5, e261, 10.1371/journal.pbio.0050261 · DOI · Paper page
  60. Moreira, 2008, Nucleic acid oxidation in Alzheimer disease, Free Radic. Biol. Med., 44, 1493, 10.1016/j.freeradbiomed.2008.01.002 · DOI
  61. Morimoto, 2008, Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging, Genes Dev., 22, 1427, 10.1101/gad.1657108 · DOI · Paper page
  62. Morley, 2004, Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones, Mol. Biol. Cell, 15, 657, 10.1091/mbc.E03-07-0532 · DOI
  63. Morley, 2002, The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans, Proc. Natl. Acad. Sci. USA, 99, 10417, 10.1073/pnas.152161099 · DOI
  64. Morris, 1996, A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans, Nature, 382, 536, 10.1038/382536a0 · DOI
  65. Mostoslavsky, 2006, Genomic instability and aging-like phenotype in the absence of mammalian SIRT6, Cell, 124, 315, 10.1016/j.cell.2005.11.044 · DOI · Paper page
  66. Niedernhofer, 2006, A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis, Nature, 444, 1038, 10.1038/nature05456 · DOI · Paper page
  67. Nilsson, 2006, Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice, J. Biol. Chem., 281, 7244, 10.1074/jbc.M510461200 · DOI
  68. Oberdoerffer, 2008, SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging, Cell, 135, 907, 10.1016/j.cell.2008.10.025 · DOI · Paper page
  69. Olsen, 2006, Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments, Biogerontology, 7, 221, 10.1007/s10522-006-9018-x · DOI
  70. Osler, 2008, Adenosine 5′-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle, Endocrinology, 149, 935, 10.1210/en.2007-1441 · DOI
  71. Pan, 2007, Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans, Aging Cell, 6, 111, 10.1111/j.1474-9726.2006.00266.x · DOI
  72. Pawlikowska, 2009, Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity, Aging Cell, 8, 460, 10.1111/j.1474-9726.2009.00493.x · DOI
  73. Pickford, 2008, The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice, J. Clin. Invest., 118, 2190
  74. Powell, 2000, The impact of media composition and petite mutation on the longevity of a polyploid brewing yeast strain, Lett. Appl. Microbiol., 31, 46, 10.1046/j.1472-765x.2000.00766.x · DOI
  75. Qiang, 2007, Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha, Exp. Mol. Med., 39, 535, 10.1038/emm.2007.59 · DOI
  76. Rea, 2007, Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans, PLoS Biol., 5, e259, 10.1371/journal.pbio.0050259 · DOI · Paper page
  77. Richter, 2010, Life on the verge of death: The heat shock response revisited, Mol. Cell, 40, 253, 10.1016/j.molcel.2010.10.006 · DOI
  78. Rogina, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction, Proc. Natl. Acad. Sci. USA, 101, 15998, 10.1073/pnas.0404184101 · DOI · Paper page
  79. Ron, 2007, Signal integration in the endoplasmic reticulum unfolded protein response, Nat. Rev. Mol. Cell Biol., 8, 519, 10.1038/nrm2199 · DOI
  80. Rossi, 2010, Roles of Werner syndrome protein in protection of genome integrity, DNA Repair (Amst.), 9, 331, 10.1016/j.dnarep.2009.12.011 · DOI
  81. Sasaki, 2006, Progressive loss of SIRT1 with cell cycle withdrawal, Aging Cell, 5, 413, 10.1111/j.1474-9726.2006.00235.x · DOI
  82. Schriner, 2005, Extension of murine life span by overexpression of catalase targeted to mitochondria, Science, 308, 1909, 10.1126/science.1106653 · DOI · Paper page
  83. Schwer, 2008, Conserved metabolic regulatory functions of sirtuins, Cell Metab., 7, 104, 10.1016/j.cmet.2007.11.006 · DOI
  84. Sengupta, 2010, Regulation of the mTor complex 1 by nutrients, growth factors and stress, Mol. Cell, 40, 310, 10.1016/j.molcel.2010.09.026 · DOI
  85. Sharp, 2005, Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice, J. Gerontol. A Biol. Sci. Med. Sci., 60, 293, 10.1093/gerona/60.3.293 · DOI · Paper page
  86. Simonsen, 2008, Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila, Autophagy, 4, 176, 10.4161/auto.5269 · DOI · Paper page
  87. Singh, 2009, Autophagy regulates adipose mass and differentiation in mice, J. Clin. Invest., 119, 3329
  88. Sipula, 2006, Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation, Metabolism, 55, 1637, 10.1016/j.metabol.2006.08.002 · DOI
  89. Sohal, 1996, Oxidative stress, caloric restriction, and aging, Science, 273, 59, 10.1126/science.273.5271.59 · DOI
  90. Steffen, 2008, Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4, Cell, 133, 292, 10.1016/j.cell.2008.02.037 · DOI · Paper page
  91. Sun, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies, Mol. Cell. Biol., 19, 216, 10.1128/MCB.19.1.216 · DOI
  92. Tissenbaum, 2001, Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans, Nature, 410, 227, 10.1038/35065638 · DOI · Paper page
  93. Vermulst, 2007, Mitochondrial point mutations do not limit the natural lifespan of mice, Nat. Genet., 39, 540, 10.1038/ng1988 · DOI · Paper page
  94. Vermulst, 2008, DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice, Nat. Genet., 40, 392, 10.1038/ng.95 · DOI · Paper page
  95. Wellen, 2010, Cellular metabolic stress: Considering what happens when cells overeat, Mol. Cell, 40, 323, 10.1016/j.molcel.2010.10.004 · DOI · Paper page
  96. Wenz, 2008, Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype, Cell Metab., 8, 249, 10.1016/j.cmet.2008.07.006 · DOI · Paper page
  97. Wenz, 2009, Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging, Proc. Natl. Acad. Sci. USA, 106, 20405, 10.1073/pnas.0911570106 · DOI · Paper page
  98. Westerheide, 2009, Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1, Science, 323, 1063, 10.1126/science.1165946 · DOI · Paper page
  99. Willcox, 2008, FOXO3A genotype is strongly associated with human longevity, Proc. Natl. Acad. Sci. USA, 105, 13987, 10.1073/pnas.0801030105 · DOI · Paper page
  100. Wong, 2010, Autophagy gone awry in neurodegenerative diseases, Nat. Neurosci., 13, 805, 10.1038/nn.2575 · DOI · Paper page
  101. Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471, 10.1016/j.cell.2006.01.016 · DOI · Paper page
  102. Yu, 2005, Macroautophagy—a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease, J. Cell Biol., 171, 87, 10.1083/jcb.200505082 · DOI · Paper page
  103. Yuan, 2007, SIRT1 regulates the function of the Nijmegen breakage syndrome protein, Mol. Cell, 27, 149, 10.1016/j.molcel.2007.05.029 · DOI
  104. Zhang, 2008, Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function, Nat. Med., 14, 959, 10.1038/nm.1851 · DOI · Paper page

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Metadata

Authors
Haigis, M. C., & Yankner, B. A.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2010-10
Volume
40
Issue
2
Pages
333-344
ISSN
1097-2765
Cited by
488
References
50
Language
en

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