The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
The Aging Stress Response
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Although severe mitochondrial dysfunction is pathogenic, mild respiratory deficiencies may increase lifespan, perhaps due to a hormetic response.
“although severe mitochondrial dysfunction is pathogenic, mild respiratory deficiencies may increase lifespan, perhaps due to a hormetic response”
From The Hallmarks of Aging (2013) · cites this paper as Haigis and Yankner, 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491
Hypoxia-inducible factors and the response to hypoxic stress
Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 1×
“A number of studies in model organisms, including yeast, worms, and flies, suggest that the sirtuin Sir2 can extend life span (Kaeberlein et al., 1999; Lin et al., 2000; Rogina and Helfand, 2004; Tissenbaum and Guarente, 2001).”
BackgroundPersistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232
Gene regulation and DNA damage in the ageing human brain
Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874
Self-citationLin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
Hsu, A.-L., Murphy, C. T., & Kenyon, C. (2003) · Science · doi:10.1126/science.1083701 · Cited by 1,513
p53 mutant mice that display early ageing-associated phenotypes
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · cited 1×
“It was originally reported that a mutant p53 allele with enhanced tumor suppressor activity accelerated aging in a variety of different tissues in a mouse model (Tyner et al., 2002).”
BackgroundNeural mechanisms of ageing and cognitive decline
Bishop, N. A., Lu, T., & Yankner, B. A. (2010) · Nature · doi:10.1038/nature08983 · Cited by 1,323
Self-citationSchulz, T. J., Zarse, K., Voigt, A., Urban, N., Birringer, M., & Ristow, M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.08.011 · Cited by 1,209
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · cited 2×
“, 2006) and endothelial nitric oxide synthase (eNOS) (Nisoli et al., 2005).”
BackgroundSpilman, P., Podlutskaya, N., Hart, M. J., Debnath, J., Gorostiza, O., Bredesen, D., Richardson, A., Strong, R., & Galvan, V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009979 · Cited by 1,033
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969
DNA Repair, Genome Stability, and Aging
Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944
Misfolded proteins partition between two distinct quality control compartments
Kaganovich, D., Kopito, R., & Frydman, J. (2008) · Nature · doi:10.1038/nature07195 · Cited by 932
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
Abu-Elheiga, L., Matzuk, M. M., Abo-Hashema, K. A. H., & Wakil, S. J. (2001) · Science · doi:10.1126/science.1056843 · Cited by 903
Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease
Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., de Vries, R., Arias, E., Harris, S., Sulzer, D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2528 · Cited by 885
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
Hansen, M., Chandra, A., Mitic, L. L., Onken, B., Driscoll, M., & Kenyon, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040024 · Cited by 766
Feige, J. N., Lagouge, M., Canto, C., Strehle, A., Houten, S. M., Milne, J. C., Lambert, P. D., Mataki, C., Elliott, P. J., & Auwerx, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.017 · Cited by 719
Functionally significant insulin-like growth factor I receptor mutations in centenarians
Suh, Y., Atzmon, G., Cho, M.-O., Hwang, D., Liu, B., Leahy, D. J., Barzilai, N., & Cohen, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705467105 · Cited by 703
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.
Ishii, N., Fujii, M., Hartman, P. S., Tsuda, M., Yasuda, K., Senoo-Matsuda, N., Yanase, S., Ayusawa, D., & Suzuki, K. (1998) · Nature · doi:10.1038/29331 · Cited by 687 · cited 2×
“…in worms, a mutation of a subunit in complex II of the electron transport chain, succinate dehydrogenase cytochrome b, results in reduced respiration and decreased life span, especially under high-oxygen conditions (Ishii et al., 1998), demonstrating a correlation between ROS and life span.”
BackgroundYankner, B. A., Lu, T., & Loerch, P. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.2.010506.092044 · Cited by 677
Self-citationProgressive disruption of cellular protein folding in models of polyglutamine diseases
Gidalevitz, T., Ben-Zvi, A., Ho, K. H., Brignull, H. R., & Morimoto, R. I. (2006) · Science · doi:10.1126/science.1124514 · Cited by 643
Two neurons mediate diet-restriction-induced longevity in C. elegans
Bishop, N. A., & Guarente, L. (2007) · Nature · doi:10.1038/nature05904 · Cited by 643
Kume, S., Uzu, T., Horiike, K., Chin-Kanasaki, M., Isshiki, K., Araki, S.-I., Sugimoto, T., Haneda, M., Kashiwagi, A., & Koya, D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41376 · Cited by 640
Widespread protein aggregation as an inherent part of aging in C. elegans
David, D. C., Ollikainen, N., Trinidad, J. C., Cary, M. P., Burlingame, A. L., & Kenyon, C. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000450 · Cited by 627
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
Herranz, D., Muñoz-Martin, M., Cañamero, M., Mulero, F., Martinez-Pastor, B., Fernandez-Capetillo, O., & Serrano, M. (2010) · Nature Communications · doi:10.1038/ncomms1001 · Cited by 612
Association of FOXO3A variation with human longevity confirmed in German centenarians
Flachsbart, F., Caliebe, A., Kleindorp, R., Blanché, H., von Eller-Eberstein, H., Nikolaus, S., Schreiber, S., & Nebel, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809594106 · Cited by 572
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
Van Raamsdonk, J. M., & Hekimi, S. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000361 · Cited by 511
Global changes to the ubiquitin system in Huntington's disease
Bennett, E. J., Shaler, T. A., Woodman, B., Ryu, K.-Y., Zaitseva, T. S., Becker, C. H., Bates, G. P., Schulman, H., & Kopito, R. R. (2007) · Nature · doi:10.1038/nature06022 · Cited by 497
Sirtuins as potential targets for metabolic syndrome
Guarente, L. (2006) · Nature · doi:10.1038/nature05486 · Cited by 468
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, B., & Yuan, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600364200 · Cited by 458
Self-citationProteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
De Strooper, B. (2010) · Physiological Reviews · doi:10.1152/physrev.00023.2009 · Cited by 455
SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
Boily, G., Seifert, E. L., Bevilacqua, L., He, X. H., Sabourin, G., Estey, C., Moffat, C., Crawford, S., Saliba, S., Jardine, K., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001759 · Cited by 444
Juhász, G., Érdi, B., Sass, M., & Neufeld, T. P. (2007) · Genes & Development · doi:10.1101/gad.1600707 · Cited by 396
Evolution of the Aging Brain Transcriptome and Synaptic Regulation
Loerch, P. M., Lu, T., Dakin, K. A., Vann, J. M., Isaacs, A., Geula, C., Wang, J., Pan, Y., Gabuzda, D. H., Li, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003329 · Cited by 334
Self-citationRamsey, K. M., Mills, K. F., Satoh, A., & Imai, S. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00355.x · Cited by 321
Malonyl-CoA, a Key Signaling Molecule in Mammalian Cells
Saggerson, D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155434 · Cited by 301
SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
Fan, W., & Luo, J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.006 · Cited by 223
Flagged first, then by citations
Research works printed but not linked: 104
- Banks, 2008, SirT1 gain of function increases energy efficiency and prevents diabetes in mice, Cell Metab., 8, 333, 10.1016/j.cmet.2008.08.014 · DOI
- Ben-Zvi, 2009, Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging, Proc. Natl. Acad. Sci. USA, 106, 14914, 10.1073/pnas.0902882106 · DOI · Paper page
- Bennett, 2005, Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation, Mol. Cell, 17, 351, 10.1016/j.molcel.2004.12.021 · DOI
- Bjedov, 2010, Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster, Cell Metab., 11, 35, 10.1016/j.cmet.2009.11.010 · DOI · Paper page
- Bonawitz, 2007, Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression, Cell Metab., 5, 265, 10.1016/j.cmet.2007.02.009 · DOI · Paper page
- Bonkowski, 2009, Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity, PLoS ONE, 4, e4567, 10.1371/journal.pone.0004567 · DOI
- Bordone, 2005, Calorie restriction, SIRT1 and metabolism: understanding longevity, Nat. Rev. Mol. Cell Biol., 6, 298, 10.1038/nrm1616 · DOI
- Bordone, 2007, SIRT1 transgenic mice show phenotypes resembling calorie restriction, Aging Cell, 6, 759, 10.1111/j.1474-9726.2007.00335.x · DOI · Paper page
- Broadley, 2008, Mitochondrial stress signaling: a pathway unfolds, Trends Cell Biol., 18, 1, 10.1016/j.tcb.2007.11.003 · DOI
- Brown, 2007, The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes, Metabolism, 56, 1500, 10.1016/j.metabol.2007.06.016 · DOI
- Buchberger, 2010, Protein quality control in the cytosol and the Endoplasmic Reticulum: Brothers in Arms, Mol. Cell, 40, 238, 10.1016/j.molcel.2010.10.001 · DOI · Paper page
- Chen, 2007, Longevity determined by developmental arrest genes in Caenorhabditis elegans, Aging Cell, 6, 525, 10.1111/j.1474-9726.2007.00305.x · DOI
- Ciccia, 2010, The DNA Damage Response: Making it safe to play with knives, Mol. Cell, 40, 179, 10.1016/j.molcel.2010.09.019 · DOI · Paper page
- Cohen, 2006, Opposing activities protect against age-onset proteotoxicity, Science, 313, 1604, 10.1126/science.1124646 · DOI · Paper page
- Comfort, 1963, Effect of Delayed and Resumed Growth on the Longevity of a Fish (Lebistes Reticulatus, Peters) in Captivity, Gerontologia, 49, 150, 10.1159/000211216 · DOI
- Cuervo, 2010, Protein degradation, aggregation, and misfolding, Mov. Disord., 25, S49, 10.1002/mds.22718 · DOI
- Cunningham, 2007, mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex, Nature, 450, 736, 10.1038/nature06322 · DOI · Paper page
- Dai, 2010, Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria, Aging Cell, 9, 536, 10.1111/j.1474-9726.2010.00581.x · DOI · Paper page
- Dillin, 2002, Rates of behavior and aging specified by mitochondrial function during development, Science, 298, 2398, 10.1126/science.1077780 · DOI · Paper page
- Fabrizio, 2010, Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation, PLoS Genet., 6, e1001024, 10.1371/journal.pgen.1001024 · DOI
- Frye, 2000, Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins, Biochem. Biophys. Res. Commun., 273, 793, 10.1006/bbrc.2000.3000 · DOI · Paper page
- García-Cao, 2002, “Super p53” mice exhibit enhanced DNA damage response, are tumor resistant and age normally, EMBO J., 21, 6225, 10.1093/emboj/cdf595 · DOI · Paper page
- Giannakou, 2008, Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response, Aging Cell, 7, 187, 10.1111/j.1474-9726.2007.00362.x · DOI
- Greer, 2009, Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans, Aging Cell, 8, 113, 10.1111/j.1474-9726.2009.00459.x · DOI
- Guertin, 2007, Defining the role of mTOR in cancer, Cancer Cell, 12, 9, 10.1016/j.ccr.2007.05.008 · DOI · Paper page
- Haigis, 2010, Mammalian sirtuins: biological insights and disease relevance, Annu. Rev. Pathol., 5, 253, 10.1146/annurev.pathol.4.110807.092250 · DOI · Paper page
- Hansen, 2007, Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans, Aging Cell, 6, 95, 10.1111/j.1474-9726.2006.00267.x · DOI · Paper page
- Harman, 1956, Aging: a theory based on free radical and radiation chemistry, J. Gerontol., 11, 298, 10.1093/geronj/11.3.298 · DOI · Paper page
- Hartwig, 2009, Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis, Genes Nutr., 4, 59, 10.1007/s12263-009-0113-x · DOI
- Hunt, 2006, Bioenergetics of aging and calorie restriction, Ageing Res. Rev., 5, 125, 10.1016/j.arr.2006.03.006 · DOI
- Jang, 2009, Overexpression of Mn superoxide dismutase does not increase life span in mice, J. Gerontol. A Biol. Sci. Med. Sci., 64, 1114, 10.1093/gerona/glp100 · DOI
- Kahn, 2005, AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism, Cell Metab., 1, 15, 10.1016/j.cmet.2004.12.003 · DOI · Paper page
- Kapahi, 2004, Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway, Curr. Biol., 14, 885, 10.1016/j.cub.2004.03.059 · DOI · Paper page
- Kelly, 2004, Transcriptional regulatory circuits controlling mitochondrial biogenesis and function, Genes Dev., 18, 357, 10.1101/gad.1177604 · DOI · Paper page
- Kenyon, 2010, The genetics of ageing, Nature, 464, 504, 10.1038/nature08980 · DOI · Paper page
- Kenyon, 1993, A C. elegans mutant that lives twice as long as wild type, Nature, 366, 461, 10.1038/366461a0 · DOI · Paper page
- Kimura, 1997, daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans, Science, 277, 942, 10.1126/science.277.5328.942 · DOI
- Komatsu, 2006, Loss of autophagy in the central nervous system causes neurodegeneration in mice, Nature, 441, 880, 10.1038/nature04723 · DOI · Paper page
- Kujoth, 2005, Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging, Science, 309, 481, 10.1126/science.1112125 · DOI · Paper page
- Kyng, 2005, Gene expression and DNA repair in progeroid syndromes and human aging, Ageing Res. Rev., 4, 579, 10.1016/j.arr.2005.06.008 · DOI · Paper page
- Lapointe, 2008, Early mitochondrial dysfunction in long-lived Mclk1+/- mice, J. Biol. Chem., 283, 26217, 10.1074/jbc.M803287200 · DOI
- Lapointe, 2010, When a theory of aging ages badly, Cell. Mol. Life Sci., 67, 1, 10.1007/s00018-009-0138-8 · DOI
- Le Bacquer, 2007, Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2, J. Clin. Invest., 117, 387, 10.1172/JCI29528 · DOI
- Lee, 2009, Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia, J. Neurosci., 29, 8506, 10.1523/JNEUROSCI.0924-09.2009 · DOI
- Lee, 1999, Gene expression profile of aging and its retardation by caloric restriction, Science, 285, 1390, 10.1126/science.285.5432.1390 · DOI · Paper page
- Lee, 2000, Gene-expression profile of the ageing brain in mice, Nat. Genet., 25, 294, 10.1038/77046 · DOI · Paper page
- Lee, 2002, Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts, Proc. Natl. Acad. Sci. USA, 99, 14988, 10.1073/pnas.232308999 · DOI · Paper page
- Lee, 2008, A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy, Proc. Natl. Acad. Sci. USA, 105, 3374, 10.1073/pnas.0712145105 · DOI
- Lee, 2010, Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations, Cell, 141, 1146, 10.1016/j.cell.2010.05.008 · DOI · Paper page
- Long, 2005, Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle, Diabetologia, 48, 2354, 10.1007/s00125-005-1962-5 · DOI
- López-Lluch, 2006, Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency, Proc. Natl. Acad. Sci. USA, 103, 1768, 10.1073/pnas.0510452103 · DOI · Paper page
- Maier, 2004, Modulation of mammalian life span by the short isoform of p53, Genes Dev., 18, 306, 10.1101/gad.1162404 · DOI · Paper page
- Martin, 2005, Genetic modulation of senescent phenotypes in Homo sapiens, Cell, 120, 523, 10.1016/j.cell.2005.01.031 · DOI
- Martin, 2009, Sod2 knockdown in the musculature has whole-organism consequences in Drosophila, Free Radic. Biol. Med., 47, 803, 10.1016/j.freeradbiomed.2009.06.021 · DOI
- Matsuoka, 2007, ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage, Science, 316, 1160, 10.1126/science.1140321 · DOI · Paper page
- Mattagajasingh, 2007, SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase, Proc. Natl. Acad. Sci. USA, 104, 14855, 10.1073/pnas.0704329104 · DOI · Paper page
- McCarty, 2004, Chronic activation of AMP-activated kinase as a strategy for slowing aging, Med. Hypotheses, 63, 334, 10.1016/j.mehy.2004.01.043 · DOI
- McCay, 1989, The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935, Nutrition, 5, 155
- Medvedik, 2007, MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae, PLoS Biol., 5, e261, 10.1371/journal.pbio.0050261 · DOI · Paper page
- Moreira, 2008, Nucleic acid oxidation in Alzheimer disease, Free Radic. Biol. Med., 44, 1493, 10.1016/j.freeradbiomed.2008.01.002 · DOI
- Morimoto, 2008, Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging, Genes Dev., 22, 1427, 10.1101/gad.1657108 · DOI · Paper page
- Morley, 2004, Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones, Mol. Biol. Cell, 15, 657, 10.1091/mbc.E03-07-0532 · DOI
- Morley, 2002, The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans, Proc. Natl. Acad. Sci. USA, 99, 10417, 10.1073/pnas.152161099 · DOI
- Morris, 1996, A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans, Nature, 382, 536, 10.1038/382536a0 · DOI
- Mostoslavsky, 2006, Genomic instability and aging-like phenotype in the absence of mammalian SIRT6, Cell, 124, 315, 10.1016/j.cell.2005.11.044 · DOI · Paper page
- Niedernhofer, 2006, A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis, Nature, 444, 1038, 10.1038/nature05456 · DOI · Paper page
- Nilsson, 2006, Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice, J. Biol. Chem., 281, 7244, 10.1074/jbc.M510461200 · DOI
- Oberdoerffer, 2008, SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging, Cell, 135, 907, 10.1016/j.cell.2008.10.025 · DOI · Paper page
- Olsen, 2006, Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments, Biogerontology, 7, 221, 10.1007/s10522-006-9018-x · DOI
- Osler, 2008, Adenosine 5′-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle, Endocrinology, 149, 935, 10.1210/en.2007-1441 · DOI
- Pan, 2007, Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans, Aging Cell, 6, 111, 10.1111/j.1474-9726.2006.00266.x · DOI
- Pawlikowska, 2009, Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity, Aging Cell, 8, 460, 10.1111/j.1474-9726.2009.00493.x · DOI
- Pickford, 2008, The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice, J. Clin. Invest., 118, 2190
- Powell, 2000, The impact of media composition and petite mutation on the longevity of a polyploid brewing yeast strain, Lett. Appl. Microbiol., 31, 46, 10.1046/j.1472-765x.2000.00766.x · DOI
- Qiang, 2007, Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha, Exp. Mol. Med., 39, 535, 10.1038/emm.2007.59 · DOI
- Rea, 2007, Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans, PLoS Biol., 5, e259, 10.1371/journal.pbio.0050259 · DOI · Paper page
- Richter, 2010, Life on the verge of death: The heat shock response revisited, Mol. Cell, 40, 253, 10.1016/j.molcel.2010.10.006 · DOI
- Rogina, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction, Proc. Natl. Acad. Sci. USA, 101, 15998, 10.1073/pnas.0404184101 · DOI · Paper page
- Ron, 2007, Signal integration in the endoplasmic reticulum unfolded protein response, Nat. Rev. Mol. Cell Biol., 8, 519, 10.1038/nrm2199 · DOI
- Rossi, 2010, Roles of Werner syndrome protein in protection of genome integrity, DNA Repair (Amst.), 9, 331, 10.1016/j.dnarep.2009.12.011 · DOI
- Sasaki, 2006, Progressive loss of SIRT1 with cell cycle withdrawal, Aging Cell, 5, 413, 10.1111/j.1474-9726.2006.00235.x · DOI
- Schriner, 2005, Extension of murine life span by overexpression of catalase targeted to mitochondria, Science, 308, 1909, 10.1126/science.1106653 · DOI · Paper page
- Schwer, 2008, Conserved metabolic regulatory functions of sirtuins, Cell Metab., 7, 104, 10.1016/j.cmet.2007.11.006 · DOI
- Sengupta, 2010, Regulation of the mTor complex 1 by nutrients, growth factors and stress, Mol. Cell, 40, 310, 10.1016/j.molcel.2010.09.026 · DOI
- Sharp, 2005, Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice, J. Gerontol. A Biol. Sci. Med. Sci., 60, 293, 10.1093/gerona/60.3.293 · DOI · Paper page
- Simonsen, 2008, Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila, Autophagy, 4, 176, 10.4161/auto.5269 · DOI · Paper page
- Singh, 2009, Autophagy regulates adipose mass and differentiation in mice, J. Clin. Invest., 119, 3329
- Sipula, 2006, Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation, Metabolism, 55, 1637, 10.1016/j.metabol.2006.08.002 · DOI
- Sohal, 1996, Oxidative stress, caloric restriction, and aging, Science, 273, 59, 10.1126/science.273.5271.59 · DOI
- Steffen, 2008, Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4, Cell, 133, 292, 10.1016/j.cell.2008.02.037 · DOI · Paper page
- Sun, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies, Mol. Cell. Biol., 19, 216, 10.1128/MCB.19.1.216 · DOI
- Tissenbaum, 2001, Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans, Nature, 410, 227, 10.1038/35065638 · DOI · Paper page
- Vermulst, 2007, Mitochondrial point mutations do not limit the natural lifespan of mice, Nat. Genet., 39, 540, 10.1038/ng1988 · DOI · Paper page
- Vermulst, 2008, DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice, Nat. Genet., 40, 392, 10.1038/ng.95 · DOI · Paper page
- Wellen, 2010, Cellular metabolic stress: Considering what happens when cells overeat, Mol. Cell, 40, 323, 10.1016/j.molcel.2010.10.004 · DOI · Paper page
- Wenz, 2008, Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype, Cell Metab., 8, 249, 10.1016/j.cmet.2008.07.006 · DOI · Paper page
- Wenz, 2009, Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging, Proc. Natl. Acad. Sci. USA, 106, 20405, 10.1073/pnas.0911570106 · DOI · Paper page
- Westerheide, 2009, Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1, Science, 323, 1063, 10.1126/science.1165946 · DOI · Paper page
- Willcox, 2008, FOXO3A genotype is strongly associated with human longevity, Proc. Natl. Acad. Sci. USA, 105, 13987, 10.1073/pnas.0801030105 · DOI · Paper page
- Wong, 2010, Autophagy gone awry in neurodegenerative diseases, Nat. Neurosci., 13, 805, 10.1038/nn.2575 · DOI · Paper page
- Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471, 10.1016/j.cell.2006.01.016 · DOI · Paper page
- Yu, 2005, Macroautophagy—a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease, J. Cell Biol., 171, 87, 10.1083/jcb.200505082 · DOI · Paper page
- Yuan, 2007, SIRT1 regulates the function of the Nijmegen breakage syndrome protein, Mol. Cell, 27, 149, 10.1016/j.molcel.2007.05.029 · DOI
- Zhang, 2008, Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function, Nat. Med., 14, 959, 10.1038/nm.1851 · DOI · Paper page
Cited by
Sorted by citations
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373
Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.012 · Cited by 850
ROS in Cancer: The Burning Question
Chio, I. I. C., & Tuveson, D. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.004 · Cited by 532
Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock
Rando, T. A., & Chang, H. Y. (2012) · Cell · doi:10.1016/j.cell.2012.01.003 · Cited by 520
Molecular and physiological manifestations and measurement of aging in humans
Khan, S. S., Singer, B. D., & Vaughan, D. E. (2017) · Aging Cell · doi:10.1111/acel.12601 · Cited by 530
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging
Andersson, D. C., Betzenhauser, M. J., Reiken, S., Meli, A. C., Umanskaya, A., Xie, W., Shiomi, T., Zalk, R., Lacampagne, A., & Marks, A. R. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.014 · Cited by 424
Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., & Nishimura, E. K. (2016) · Science · doi:10.1126/science.aad4395 · Cited by 416
Jovaisaite, V., Mouchiroud, L., & Auwerx, J. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.090738 · Cited by 335
Salminen, A., Ojala, J., Kaarniranta, K., Haapasalo, A., Hiltunen, M., & Soininen, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07738.x · Cited by 333
Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice
Kim, K.-A., Jeong, J.-J., Yoo, S.-Y., & Kim, D.-H. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0625-7 · Cited by 196
Transcriptional Signatures of Aging
Stegeman, R., & Weake, V. M. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.06.019 · Cited by 146
Tian, G., Sawashita, J., Kubo, H., Nishio, S.-Y., Hashimoto, S., Suzuki, N., Yoshimura, H., Tsuruoka, M., Wang, Y., Liu, Y., et al. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5406 · Cited by 123
Loss of Metabolic Plasticity Underlies Metformin Toxicity in Aged Caenorhabditis Elegans
Espada, L., Dakhovnik, A., Chaudhari, P., Martirosyan, A., Miek, L., Poliezhaieva, T., Schaub, Y., Nair, A., Döring, N., Rahnis, N., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00307-1 · Cited by 100
Age-Related Oxidative Stress Compromises Endosomal Proteostasis
Cannizzo, E. S., Clement, C. C., Morozova, K., Valdor, R., Kaushik, S., Almeida, L. N., Follo, C., Sahu, R., Cuervo, A. M., Macian, F., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.06.005 · Cited by 95
ATP-dependent chromatin remodelers in ageing and age-related disorders
Swer, P. B., & Sharma, R. (2021) · Biogerontology · doi:10.1007/s10522-020-09899-3 · Cited by 25
Metadata
- Authors
- Haigis, M. C., & Yankner, B. A.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 40
- Issue
- 2
- Pages
- 333-344
- ISSN
- 1097-2765
- PMC
- PMC2987618
- Cited by
- 488
- References
- 50
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review