AMPK: Lessons from transgenic and knockout animals
Open accessAbstract
AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine protein kinase, has been proposed to function as a fuel gauge to monitor cellular energy status in response to nutritional environmental variations. AMPK system is a regulator of energy balance that, once activated by low energy status, switches on ATP-producing catabolic pathways (such as fatty acid oxidation and glycolysis), and switches off ATP-consuming anabolic pathways (such as lipogenesis), both by short-term effect on phosphorylation of regulatory proteins and by long-term effect on gene expression. Numerous observations obtained with pharmacological activators and agents that deplete intracellular ATP have been supportive of AMPK playing a role in the control of energy metabolism but none of these studies have provided conclusive evidence. Relatively recent developments in our understanding of precisely how AMPK complexes might operate to control energy metabolism is due in part to the development of transgenic and knockout mouse models. Although there are inevitable caveats with genetic models, some important findings have emerged. In the present review, we discuss recent findings obtained from animal models with inhibition or activation of AMPK signaling pathway.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Double knockout of AMPKα1 and AMPKα2 in mice gives rise to embryonic lethality.
“The α-subunit is essential, and a double knockout (KO) of AMPKα1 and AMPKα2 in mice gives rise to embryonic lethality [24].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
Activation of the AMP-activated Protein Kinase by the Anti-diabetic Drug Metformin in Vivo
Zou, M., Kirkpatrick, S. S., Davis, B. J., Nelson, J. S., Wiles, W. G., Schlattner, U., Neumann, D., Brownlee, M., Freeman, M. B., & Goldman, M. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404421200 · Cited by 471 · see citing works
RetractedRETRACTED: LKB1 and AMPK maintain epithelial cell polarity under energetic stress
Mirouse, V., Swick, L. L., Kazgan, N., Johnston, D. S., & Brenman, J. E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702053 · Cited by 191 · see citing works
RetractedCentral nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works
Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395 · see citing works
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works
Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works
Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,086 · see citing works
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053 · see citing works
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950 · see citing works
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.027 · Cited by 1,619 · see citing works
Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1557 · Cited by 1,396 · see citing works
Hypothalamic mTOR Signaling Regulates Food Intake
Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works
Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232 · see citing works
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation
Kubota, N., Terauchi, Y., Yamauchi, T., Kubota, T., Moroi, M., Matsui, J., Eto, K., Yamashita, T., Kamon, J., Satoh, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200251200 · Cited by 1,213 · see citing works
Disruption of adiponectin causes insulin resistance and neointimal formation
Froguel, P. (2002) · HAL · Cited by 1,126 · see citing works
The LKB1 tumor suppressor negatively regulates mTOR signaling
Shaw, R. J., Bardeesy, N. M., Manning, B. D., Lopez, L. V., Kosmatka, M., DePinho, R. A., & Cantley, L. C. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.007 · Cited by 1,067 · see citing works
Zong, H., Ren, J. M., Young, L. H., Pypaert, M., Mu, J., Birnbaum, M. J., & Shulman, G. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252625599 · Cited by 1,036 · see citing works
Merrill, G. F., Kurth, E. J., Hardie, D. G., & Winder, W. W. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.6.e1107 · Cited by 1,027 · see citing works
Cool, B. L., Zinker, B. A., Chiou, W. J. H., Kifle, L., Cao, N., Perham, M., Dickinson, R., Adler, A. L., Gagné, G. D., Iyengar, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.005 · Cited by 932 · see citing works
Mu, J., Brozinick, J. T., Valladares, O., Bucan, M., & Birnbaum, M. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00251-9 · Cited by 924 · see citing works
Bolster, D. R., Crozier, S. J., Kimball, S. R., & Jefferson, L. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200171200 · Cited by 851 · see citing works
Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake
Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Okamoto, S., Shiuchi, T., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.003 · Cited by 844 · see citing works
AMP‐activated protein kinase phosphorylation of endothelial NO synthase
Chen, Z.-P., Mitchelhill, K. I., Michell, B. J., Stapleton, D., Rodríguez‐Crespo, I., Witters, L. A., Power, D. A., de Montellano, P. R. O., & Kemp, B. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01705-0 · Cited by 835 · see citing works
Greer, E. L., Oskoui, P. R., Banko, M. R., Maniar, J. M., Gygi, M. P., Gygi, S. P., & Brunet, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705325200 · Cited by 820 · see citing works
Greer, E. L., Dowlatshahi, D., Banko, M. R., Villen, J., Hoang, K., Blanchard, D., Gygi, S. P., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.047 · Cited by 801 · see citing works
Winder, W. W., & Hardie, D. G. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.2.e299 · Cited by 799 · see citing works
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake
Andersson-Hall, U. K., Filipsson, K., Abbott, C. R., Woods, A., Smith, K. L., Bloom, S. R., Carling, D., & Small, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300557200 · Cited by 756 · see citing works
Russell, R. R., Li, J., Coven, D. L., Pypaert, M., Zechner, C., Palmeri, M., Giordano, F. J., Mu, J., Birnbaum, M. J., & Young, L. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19297 · Cited by 738 · see citing works
Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
Winder, W. W., Holmes, B. F., Rubink, D. S., Jensen, E. B., Chen, M., & Holloszy, J. O. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.6.2219 · Cited by 709 · see citing works
Adiponectin-mediated modulation of hypertrophic signals in the heart
Shibata, R., Ouchi, N., Ito, M., Kihara, S., Shiojima, I., Pimentel, D. R., Kumada, M., Sato, K., Schiekofer, S., Ohashi, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1137 · Cited by 671 · see citing works
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
Sanders, M. J., Grondin, P., Hegarty, B. D., Snowden, M. A., & Carling, D. (2007) · Biochemical Journal · doi:10.1042/bj20061520 · Cited by 667 · see citing works
Apfeld, J., O'Connor, G., McDonagh, T., DiStefano, P. S., & Curtis, R. (2004) · Genes & Development · doi:10.1101/gad.1255404 · Cited by 643 · see citing works
Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
CHEUNG, P. C. F., SALT, I. P., DAVIES, S. P., HARDIE, D. G., & CARLING, D. (2000) · Biochemical Journal · doi:10.1042/bj3460659 · Cited by 637 · see citing works
Role of AMP-activated protein kinase in mechanism of metformin action
Zhou, G., Myers, R., Li, Y., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113505 · Cited by 635 · see citing works
Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
Bergeron, R., Ren, J. M., Cadman, K. S., Moore, I. K., Perret, P., Pypaert, M., Young, L. H., Semenkovich, C. F., & Shulman, G. I. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1340 · Cited by 561 · see citing works
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
Reznick, R. M., Zong, H., Li, J., Morino, K., Moore, I. K., Yu, H. J., Liu, Z.-X., Dong, J., Mustard, K. J., Hawley, S. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.008 · Cited by 555 · see citing works
Jørgensen, S. B., Viollet, B., Andreelli, F., Frøsig, C., Birk, J. B., Schjerling, P., Vaulont, S., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306205200 · Cited by 553 · see citing works
Self-citationObici, S., Feng, Z., Arduini, A., Conti, R., & Rossetti, L. (2003) · Nature Medicine · doi:10.1038/nm873 · Cited by 548 · see citing works
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
Sakamoto, K., McCarthy, A., Smith, D. P., Green, K. A., Hardie, D. G., Ashworth, A., & Alessi, D. R. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600667 · Cited by 544 · see citing works
Viollet, B., Foretz, M., Guigas, B., Horman, S., Dentin, R., Bertrand, L., Hue, L., & Andréelli, F. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108506 · Cited by 529 · see citing works
Self-citationKim, M., Park, J., NamKoong, C., Jang, P., Ryu, J., Song, H.-S., Yun, J.-Y., Nam‐Goong, I. S., Ha, J., Park, I.-S., et al. (2004) · Nature Medicine · doi:10.1038/nm1061 · Cited by 522 · see citing works
Self-citationAMPK: A Key Sensor of Fuel and Energy Status in Skeletal Muscle
Hardie, D. G., & Sakamoto, K. (2006) · Physiology · doi:10.1152/physiol.00044.2005 · Cited by 519 · see citing works
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
Claret, M., Smith, M. A., Batterham, R. L., Selman, C., Choudhury, A. I., Fryer, L. G. D., Clements, M., Al‐Qassab, H., Heffron, H., Xu, A. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31516 · Cited by 511 · see citing works
Self-citationThe AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity
Viollet, B., Andreelli, F., Jørgensen, S. B., Perrin, C., Geloen, A., Flamez, D., Mu, J., Lenzner, C., Baud, O., Bennoun, M., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16567 · Cited by 499 · see citing works
Self-citationSullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D., & Beri, R. K. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01006-4 · Cited by 488 · see citing works
Suter, M., Riek, U., Tuerk, R. D., Schlattner, U., Wallimann, T., & Neumann, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606357200 · Cited by 479 · see citing works
Hypothalamic sensing of fatty acids
Lam, T. K. T., Schwartz, G. J., & Rossetti, L. (2005) · Nature Neuroscience · doi:10.1038/nn1456 · Cited by 478 · see citing works
Kola, B., Hubina, E., Tucci, S. A., Kirkham, T. C., García, E., Mitchell, S. E., Williams, L. M., Hawley, S. A., Hardie, D. G., Grossman, A. B., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500175200 · Cited by 468 · see citing works
Davis, B. J., Xie, Z., Viollet, B., & Zou, M. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1064 · Cited by 467 · see citing works
Self-citationHorman, S., Browne, G., Krause, U., Patel, J., Vertommen, D., Bertrand, L., Lavoinne, A., Hue, L., Proud, C. G., & Rider, M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01077-1 · Cited by 440 · see citing works
Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase
Göransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G., & Sakamoto, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706536200 · Cited by 433 · see citing works
Self-citationEnergy-dependent regulation of cell structure by AMP-activated protein kinase
Lee, J. H., Koh, H., Kim, M.-J., Kim, Y., Lee, S. Y., Karess, R. E., Lee, S. H., Shong, M., Kim, J., Kim, J., et al. (2007) · Nature · doi:10.1038/nature05828 · Cited by 418 · see citing works
Muoio, D. M., Seefeld, K. J., Witters, L. A., & Coleman, R. (1999) · Biochemical Journal · doi:10.1042/bj3380783 · Cited by 409 · see citing works
AMP-Activated Protein Kinase as a Drug Target
Hardie, D. G. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105304 · Cited by 405 · see citing works
Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle
Vavvas, D., Apazidis, A., Saha, A. K., Gamble, J., Patel, A., Kemp, B. E., Witters, L. A., & Ruderman, N. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13255 · Cited by 395 · see citing works
Foretz, M., Ancellin, N., Andréelli, F., Saintillan, Y., Grondin, P., Kahn, A., Thorens, B., Vaulont, S., & Viollet, B. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1331 · Cited by 389 · see citing works
Self-citationAMPK alterations in cardiac physiology and pathology: enemy or ally?
Dyck, J. R. B., & Lopaschuk, G. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109389 · Cited by 386 · see citing works
Morrow, V. A., Foufelle, F., Connell, J., Petrie, J., Gould, G., & Salt, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212831200 · Cited by 384 · see citing works
Kimura, N., Tokunaga, C., Dalal, S., Richardson, C., Yoshino, K., Hara, K., Kemp, B. E., Witters, L. A., Mimura, O., & Yonezawa, K. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00615.x · Cited by 372 · see citing works
AMP-Activated Protein Kinase in the Heart
Arad, M., Seidman, C. E., & Seidman, J. G. (2007) · Circulation Research · doi:10.1161/01.res.0000258446.23525.37 · Cited by 356 · see citing works
Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle
Terada, S., Goto, M., Kato, M., Kawanaka, K., Shimokawa, T., & Tabata, I. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00881-1 · Cited by 354 · see citing works
Fujii, N., Hayashi, T., Hirshman, M. F., Smith, J. T., Habinowski, S. A., Kaijser, L., Mu, J., Ljungqvist, O., Birnbaum, M. J., Witters, L. A., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3073 · Cited by 351 · see citing works
Sanders, M. J., Ali, Z. S., Hegarty, B. D., Heath, R., Snowden, M. A., & Carling, D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706543200 · Cited by 347 · see citing works
Xie, M., Zhang, D., Dyck, J. R. B., Li, Y., Zhang, H., Morishima, M., Mann, D. L., Taffet, G. E., Baldini, A., Khoury, D. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604708103 · Cited by 344 · see citing works
Xue, B., & Kahn, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113217 · Cited by 338 · see citing works
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke
McCullough, L. D., Zeng, Z., Li, H., Landree, L. E., McFadden, J., & Ronnett, G. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409985200 · Cited by 333 · see citing works
Chan, A. Y. M., Soltys, C.-L. M., Young, M. E., Proud, C. G., & Dyck, J. R. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403528200 · Cited by 331 · see citing works
Cheng, S., Fryer, L., Carling, D., & Shepherd, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300534200 · Cited by 327 · see citing works
Anti-lipolytic Action of AMP-activated Protein Kinase in Rodent Adipocytes
Daval, M., DUPUY, F., Bazin, R., Hainault, I., Viollet, B., Vaulont, S., Hajduch, É., Ferré, P., & Foufelle, F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414222200 · Cited by 325 · see citing works
Self-citationArad, M., Moskowitz, I. P. G., Patel, V. V., Ahmad, F., Pérez‐Atayde, A. R., Sawyer, D. B., Walter, M., Li, G. H., Burgon, P. G., Maguire, C. T., et al. (2003) · Circulation · doi:10.1161/01.cir.0000075270.13497.2b · Cited by 323 · see citing works
Barnes, B. R., Marklund, S., Steiler, T. L., Walter, M., Hjälm, Amarger, V., Mahlapuu, M., Leng, Y., Johansson, C., Galuska, D., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405533200 · Cited by 317 · cited 8× · see citing works
“Recently, the role of AMPK in the regulation of muscle glycogen has been further investigated with AMPKγ3−/− and AMPKα2-KD mice and transgenic mice over-expressing AMPKγ mutants specifically in skeletal muscle (65,76,77).”
InfluentialDentin, R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25256 · Cited by 315 · see citing works
Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, K., Hirshman, M. F., & Goodyear, L. J. (2006) · Diabetes · doi:10.2337/db06-0150 · Cited by 315 · see citing works
Skeletal Muscle Adaptation to Exercise Training
Röckl, K. S. C., Hirshman, M. F., Brandauer, J., FUJII, N. L., Witters, L. A., & Goodyear, L. J. (2007) · Diabetes · doi:10.2337/db07-0255 · Cited by 304 · see citing works
Kim, E.-K., Miller, I., Aja, S., Landree, L. E., Pinn, M., Mcfadden, J., Kuhajda, F., Moran, T., & Ronnett, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402165200 · Cited by 302 · see citing works
Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle
Birk, J. B., & Wojtaszewski, J. F. P. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120972 · Cited by 293 · see citing works
Increased β-Oxidation but No Insulin Resistance or Glucose Intolerance in Mice Lacking Adiponectin
Ma, K., Cabrero, À., Saha, P., Kojima, H., Li, L., Chang, B. H.-J., Paul, A., & Chan, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200362200 · Cited by 284 · see citing works
Treebak, J. T., Glund, S., Deshmukh, A. S., Klein, D. K., Long, Y. C., Jensen, T. E., Jørgensen, S. B., Viollet, B., Andersson, L., Neumann, D., et al. (2006) · Diabetes · doi:10.2337/db06-0175 · Cited by 281 · see citing works
Self-citationBergeron, R., Previs, S. F., Cline, G. W., Perret, P., Russell, R. R., Young, L. H., & Shulman, G. I. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1076 · Cited by 280 · see citing works
Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism
Bjursell, M., Ahnmark, A., Bohlooly‐Y, M., William‐Olsson, L., Rhedin, M., Peng, X., Ploj, K., Gerdin, A.-K., Arnerup, G., Elmgren, A., et al. (2007) · Diabetes · doi:10.2337/db06-1432 · Cited by 277 · see citing works
Warden, S. M., Richardson, C. A., O’Donnell, J. B., Stapleton, D., Kemp, B. E., & Witters, L. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540275 · Cited by 275 · see citing works
Effects of α‐AMPK knockout on exercise‐induced gene activation in mouse skeletal muscle
Jørgensen, S. B., Wojtaszewski, J. F. P., Viollet, B., Andreelli, F., Birk, J. B., Hellsten, Y., Schjerling, P., Vaulont, S., Neufer, P. D., Richter, E. A., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-3144fje · Cited by 274 · see citing works
Self-citationAdenovirus-mediated chronic “hyper-resistinemia” leads to in vivo insulin resistance in normal rats
Satoh, H., Nguyen, M. T., Miles, P. D. G., Imamura, T., Usui, I., & Olefsky, J. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20785 · Cited by 266 · see citing works
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis
Wolfgang, M. J., Kurama, T., Dai, Y., Suwa, A., Asaumi, M., Matsumoto, S.-I., Cha, S. H., Shimokawa, T., & Lane, M. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602205103 · Cited by 250 · see citing works
Buhl, E. S., Jessen, N., Pold, R., Ledet, T., Flyvbjerg, A., Pedersen, S. B., Pedersen, O. B., Schmitz, O., & Lund, S. A. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2199 · Cited by 241 · see citing works
Jørgensen, S. B., Nielsen, J. N., Birk, J. B., Olsen, G. S., Viollet, B., Andreelli, F., Schjerling, P., Vaulont, S., Hardie, D. G., Hansen, B. F., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3074 · Cited by 241 · see citing works
Self-citationRoepstorff, C., Thiele, M., Hillig, T., Pilegaard, H., Richter, E. A., Wojtaszewski, J. F. P., & Kiens, B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108720 · Cited by 238 · see citing works
Andréelli, F., Foretz, M., Knauf, C., Cani, P. D., Perrin, C., Iglesias, M. A., Pillot, B., Bado, A., Tronche, F., Mithieux, G., et al. (2006) · Endocrinology · doi:10.1210/en.2005-0898 · Cited by 238 · see citing works
Self-citationLi, J., Miller, E. J., Ninomiya‐Tsuji, J., Russell, R. R., & Young, L. H. (2005) · Circulation Research · doi:10.1161/01.res.0000187458.77026.10 · Cited by 234 · see citing works
Molecular disruption of hypothalamic nutrient sensing induces obesity
He, W., Lam, T. K. T., Obici, S., & Rossetti, L. (2006) · Nature Neuroscience · doi:10.1038/nn1626 · Cited by 233 · see citing works
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1
Sakamoto, K., Zarrinpashneh, E., Budas, G. R., Pouleur, A., Dutta, A., Prescott, A. R., Vanoverschelde, J., Ashworth, A., Jovanović, A., Alessi, D. R., et al. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00443.2005 · Cited by 221 · see citing works
Curtis, R., O'Connor, G., & DiStefano, P. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00205.x · Cited by 215 · see citing works
Xing, Y., Musi, N., FUJII, N. L., Zou, L., Luptak, I., Hirshman, M. F., Goodyear, L. J., & Tian, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303521200 · Cited by 213 · see citing works
The Effects of AICAR on Adipocyte Differentiation of 3T3-L1 Cells
Habinowski, S. A., & Witters, L. A. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5484 · Cited by 211 · see citing works
Koh, H.-J., Arnolds, D. E., Fujii, N., Tran, T. T., Rogers, M. J., Jessen, N., Li, Y., Liew, C. W., Ho, R. C., Hirshman, M. F., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00979-06 · Cited by 202 · see citing works
Evans, A. M., Mustard, K. J. W., Wyatt, C. N., Peers, C., Dipp, M., Kumar, P., Kinnear, N. P., & Hardie, D. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510040200 · Cited by 187 · see citing works
Aguilar, V. M., Alliouachene, S., Sotiropoulos, A., Sobering, A. K., Athéa, Y., Djouadi, F., Miraux, S., Thiaudière, E., Foretz, M., Viollet, B., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.006 · Cited by 182 · see citing works
Self-citationGuigas, B., Bertrand, L., Taleux, N., Foretz, M., Wiernsperger, N. F., Vertommen, D., Andréelli, F., Viollet, B., & Hue, L. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1178 · Cited by 181 · see citing works
Self-citationFujii, N., Hirshman, M. F., Kane, E. M., Ho, R. C., Peter, L. E., Seifert, M. M., & Goodyear, L. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504208200 · Cited by 177 · see citing works
Jørgensen, S. B., Treebak, J. T., Viollet, B., Schjerling, P., Vaulont, S., Wojtaszewski, J. F. P., & Richter, E. A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00243.2006 · Cited by 176 · see citing works
Self-citationNarbonne, P., & Roy, R. (2006) · Development · doi:10.1242/dev.02232 · Cited by 175 · see citing works
Wojtaszewski, J. F. P., Birk, J. B., Frøsig, C., Holten, M., Pilegaard, H., & Dela, F. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.082669 · Cited by 170 · see citing works
Krause, U., Bertrand, L., & Hue, L. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03074.x · Cited by 169 · see citing works
AMP-Activated Protein Kinase: A Key Stress Signaling Pathway in the Heart
Young, L. H., Li, J., Baron, S. J., & Russell, R. R. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.04.005 · Cited by 166 · see citing works
Villena, J., Viollet, B., Andreelli, F., Kahn, A., Vaulont, S., & Sul, H. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2242 · Cited by 165 · see citing works
Self-citationRamamurthy, S., & Ronnett, G. V. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.110122 · Cited by 164 · see citing works
Frøsig, C., Jørgensen, S. B., Hardie, D. G., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00317.2003 · Cited by 161 · see citing works
Sidhu, J. S., Rajawat, Y. S., Rami, T. G., Gollob, M. H., Wang, Z., Yuan, R., Marian, A. J., DeMayo, F. J., Weilbaecher, D., Taffet, G. E., et al. (2004) · Circulation · doi:10.1161/01.cir.0000151291.32974.d5 · Cited by 145 · see citing works
Bertrand, L., Ginion, A., Beauloye, C., Hebert, A. D., Guigas, B., Hue, L., & Vanoverschelde, J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01269.2005 · Cited by 144 · see citing works
Lee, K., Li, B., Xi, X., Suh, Y., & Martin, R. J. (2004) · Endocrinology · doi:10.1210/en.2004-0968 · Cited by 138 · see citing works
Durante, P. E., Mustard, K. J., Park, S.-H., Winder, W. W., & Hardie, D. G. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00404.2001 · Cited by 137 · see citing works
Sukhodub, A., Jovanović, S., Du, Q., Budas, G. R., Clelland, A. K., Shen, M., Sakamoto, K., Tian, R., & Jovanović, A. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20862 · Cited by 136 · see citing works
Thomson, D. M., & Gordon, S. E. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00811.2004 · Cited by 131 · see citing works
The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing
Tschäpe, J., Hammerschmied, C., Mühlig‐Versen, M., Athenstaedt, K., Daum, G., & Kretzschmar, D. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf636 · Cited by 128 · see citing works
Treebak, J., Birk, J., Rose, A., Kiens, B., Richter, E., & Wojtaszewski, J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00380.2006 · Cited by 123 · see citing works
Activation of AMP kinase α1 subunit induces aortic vasorelaxation in mice
Goirand, F., Solar, M., Athea, Y., Viollet, B., Mateo, P., Fortin, D., Leclerc, J., Hoerter, J., Ventura‐Clapier, R., & Garnier, A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.132589 · Cited by 121 · see citing works
Self-citationHypothalamic resistin induces hepatic insulin resistance
Muse, E. D., Lam, T. K. T., Scherer, P. E., & Rossetti, L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30440 · Cited by 119 · see citing works
Guigas, B., Taleux, N., Foretz, M., Détaille, D., Andréelli, F., Viollet, B., & Hue, L. (2007) · Biochemical Journal · doi:10.1042/bj20070105 · Cited by 117 · see citing works
Self-citationPhysiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells
Hallows, K. R., Kobinger, G., Wilson, J. M., Witters, L. A., & Foskett, J. K. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00227.2002 · Cited by 116 · see citing works
Zhang, L., He, H., & Balschi, J. A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00002.2007 · Cited by 114 · see citing works
The Role of Hypothalamic Malonyl-CoA in Energy Homeostasis
Wolfgang, M. J., & Lane, M. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600016200 · Cited by 114 · see citing works
Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin
Palanivel, R., & Sweeney, G. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.08.011 · Cited by 111 · see citing works
Hue, L., Beauloye, C., Marsin, A.-S., Bertrand, L., Horman, S., & Rider, M. H. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2063 · Cited by 108 · see citing works
Luptak, I., Shen, M., He, H., Hirshman, M. F., Musi, N., Goodyear, L. J., Yan, J., Wakimoto, H., Morita, H., Arad, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30658 · Cited by 108 · see citing works
Central administration of resistin promotes short-term satiety in rats
Tovar, S. A., Nogueiras, R., Tung, L. Y. C., Castañeda, T. R., Vazquez, M. J., Morris, A., Williams, L. M., Dickson, S. L., & Diéguez, C. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01999 · Cited by 104 · see citing works
Thomson, D. M., & Gordon, S. E. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.107490 · Cited by 102 · see citing works
Zarrinpashneh, E., Carjaval, K., Beauloye, C., Ginion, A., Matéo, P., Pouleur, A., Horman, S., Vaulont, S., Hoerter, J. A., Viollet, B., et al. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01032.2005 · Cited by 94 · see citing works
Self-citationSelective suppression of AMP-activated protein kinase in skeletal muscle: update on ‘lazy mice’
Mu, J., Barton, E. R., & Birnbaum, M. J. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310236 · Cited by 93 · cited 1× · see citing works
“In AMPKα2−/−, AMPKγ3−/−, AMPKα2-KD and AMPKα2i mice ex vivo contraction-stimulated glucose uptake is normal (17,65) or only moderately reduced (64,66).”
Metabolic activation of AMP kinase in vascular smooth muscle
Rubin, L. J., Magliola, L., Feng, X., JONES, A. W., & Hale, C. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00075.2004 · Cited by 88 · see citing works
Rencurel, F., Foretz, M., Kaufmann, M., Stroka, D., Looser, R., Leclerc, I., Xavier, G. D. S., Rutter, G. A., Viollet, B., & Meyer, U. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.029421 · Cited by 84 · see citing works
Self-citationDavies, J. K., Wells, D. J., Liu, K., Whitrow, H. R., Daniel, T. D., Grignani, R., Lygate, C. A., Schneider, J. E., Noël, G., Watkins, H. C., et al. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01020.2005 · Cited by 81 · see citing works
5′‐AMP‐activated protein kinase regulates skeletal muscle glycogen content and ergogenics
Barnes, B. R., Glund, S., Long, Y. C., Hjälm, G., Andersson, L., & Zierath, J. R. (2005) · The FASEB Journal · doi:10.1096/fj.04-3221com · Cited by 80 · see citing works
Muoio, D. M., Seefeld, K. J., Witters, L. A., & Coleman, R. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3380783 · Cited by 76 · see citing works
Rossmeisl, M., Barbatelli, G., Flachs, P., Brauner, P., Zingaretti, M. C., Marelli, M., Janovská, P., Horáková, M., Syrový, I., Cinti, S., et al. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2002.02627.x · Cited by 75 · see citing works
Barré, L. K., Richardson, C., Hirshman, M. F., Brozinick, J. T., Fiering, S., Kemp, B. E., Goodyear, L. J., & Witters, L. A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00369.2006 · Cited by 73 · see citing works
Gregor, M., Zeöld, A., Oehler, S., Marobela, K. A., Fuchs, P., Weigel, G., Hardie, D. G., & Wiche, G. (2006) · Journal of Cell Science · doi:10.1242/jcs.02891 · Cited by 72 · see citing works
Dual cardiac contractile effects of the α2-AMPK deletion in low-flow ischemia and reperfusion
Carvajal, K., Zarrinpashneh, E., Szárszoi, O., Joubert, F., Athéa, Y., Matéo, P., Gillet, B., Vaulont, S., Viollet, B., Bigard, X. A., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00683.2006 · Cited by 72 · see citing works
Self-citationKim, M., & Lee, K. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0659-z · Cited by 71 · see citing works
Matejkova, O., Mustard, K. J., Sponarova, J., Flachs, P., Rossmeisl, M., Miksik, I., Thomason-Hughes, M., Grahame Hardie, D., & Kopecky, J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.002 · Cited by 66 · see citing works
AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle
Holmes, B. F., Lang, D. B., Birnbaum, M. J., Mu, J., & Dohm, G. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00080.2004 · Cited by 61 · see citing works
Sambandam, N., Steinmetz, M., Chu, A., Altarejos, J. Y., Dyck, J. R. B., & Lopaschuk, G. D. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04218.x · Cited by 59 · see citing works
Régulation du métabolisme énergétique par l’AMPK
Foretz, M., Taleux, N., Guigas, B., Horman, S., Beauloye, C., Andréelli, F., Bertrand, L., & Viollet, B. (2006) · médecine/sciences · doi:10.1051/medsci/2006224381 · Cited by 57 · see citing works
Self-citationRussell, R. R., Li, J., Coven, D. L., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419297 · Cited by 57 · see citing works
Athéa, Y., Viollet, B., Matéo, P., Rousseau‐Ralliard, D., Novotová, M., Garnier, A., Vaulont, S., Wilding, J. R., Grynberg, A., Veksler, V., et al. (2007) · Diabetes · doi:10.2337/db06-0187 · Cited by 55 · see citing works
Self-citationRaney, M. A., Yee, A. J., Todd, M. K., & Turcotte, L. P. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00301.2004 · Cited by 49 · see citing works
Smith, A. C., Bruce, C. R., & Dyck, D. J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.081687 · Cited by 49 · see citing works
FUJII, N. L., Seifert, M. M., Kane, E. M., Peter, L. E., Ho, R. C., Winstead, S., Hirshman, M. F., & Goodyear, L. J. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.01.040 · Cited by 48 · see citing works
New targets of AMP-activated protein kinase
Hue, L., Beauloye, C., Bertrand, L., Horman, S., Krause, U., Marsin, A.-S., Meisse, D., Vertommen, D., & Rider, M. H. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310213 · Cited by 46 · see citing works
Raney, M. A., & Turcotte, L. P. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00155.2006 · Cited by 44 · see citing works
Yu, H., Hirshman, M. F., FUJII, N. L., Pomerleau, J. M., Peter, L. E., & Goodyear, L. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00073.2006 · Cited by 39 · see citing works
Lack of AMPKα2 enhances pyruvate dehydrogenase activity during exercise
Klein, D. K., Pilegaard, H., Treebak, J. T., Jensen, T. E., Viollet, B., Schjerling, P., & Wojtaszewski, J. F. P. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00382.2007 · Cited by 39 · see citing works
Self-citationBanerjee, S., Ramani, R. N., Saba, S., Rager, J. J., Tian, R., Mathier, M. A., & Ahmad, F. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.067 · Cited by 37 · see citing works
Hue, L. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(02)92063-8 · Cited by 11 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- M. Foretz, N. Taleux, B. Guigas, S. Horman, C. Beauloye, F. Andreelli, L. Bertrand, B. Viollet: Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases. Med Sci 22(4):381-8 (2006)
Cited by
Sorted by citations
The randle cycle revisited: a new head for an old hat.
Hue, L., & Taegtmeyer, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2009 · Cited by 743 · see citing works
Abderrazak, A., Syrovets, T., Couchie, D., Hadri, K. E., Friguet, B., Simmet, T., & Rouis, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.008 · Cited by 737 · see citing works
AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
Wu, N., Zheng, B., Shaywitz, A. J., Dagon, Y., Tower, C., Bellinger, G., Shen, C., Wen, J., Asara, J. M., McGraw, T. E., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.035 · Cited by 665 · see citing works
Hypoxia and mitochondrial oxidative metabolism
Solaini, G., Baracca, A., Lenaz, G., & Sgarbi, G. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.011 · Cited by 608 · see citing works
AMPK in skeletal muscle function and metabolism
Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.-N., Pehmøller, C. K., Shum, M., Marette, A., Mounier, R., Treebak, J. T., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700442r · Cited by 496 · see citing works
Self-citationAMP-activated protein kinase and its downstream transcriptional pathways
Cantó, C., & Auwerx, J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0454-z · Cited by 421 · see citing works
Role of mitochondrial reactive oxygen species in homeostasis regulation
Zhang, B., Pan, C., Feng, C., Yan, C., Yu, Y., Chen, Z., Guo, C., & Wang, X. (2022) · Redox Report · doi:10.1080/13510002.2022.2046423 · Cited by 397 · see citing works
AMPK As a Metabolic Tumor Suppressor: Control of Metabolism and Cell Growth
Luo, Z., Zang, M., & Guo, W. (2010) · Future Oncology · doi:10.2217/fon.09.174 · Cited by 383 · see citing works
<scp>AMP</scp> ‐activated protein kinase: a cellular energy sensor that comes in 12 flavours
Ross, F. A., MacKintosh, C., & Hardie, D. G. (2016) · The FEBS Journal · doi:10.1111/febs.13698 · Cited by 381 · see citing works
Understanding metabolic regulation and its influence on cell physiology
Metallo, C. M., & Vander Heiden, M. G. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.018 · Cited by 367 · see citing works
Kelly, B., Tannahill, G. M., Murphy, M. P., & O'Neill, L. A. J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.662114 · Cited by 334 · see citing works
Wang, S., Zhang, M., Liang, B., Xu, J., Xie, Z., Liu, C., Viollet, B., Yan, D., & Zou, M.-H. (2010) · Circulation Research · doi:10.1161/circresaha.109.212530 · Cited by 296 · see citing works
Srivastava, R. A. K., Pinkosky, S. L., Filippov, S. I., Hanselman, J. C., Cramer, C. T., & Newton, R. S. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r025882 · Cited by 297 · see citing works
Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells
Fisslthaler, B., & Fleming, I. (2009) · Circulation Research · doi:10.1161/circresaha.109.201590 · Cited by 295 · see citing works
AMPK, Mitochondrial Function, and Cardiovascular Disease
Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286 · see citing works
Bergersen, L. H. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.206 · Cited by 255 · see citing works
AMPK: A Contextual Oncogene or Tumor Suppressor?
Liang, J., & Mills, G. B. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3876 · Cited by 254 · see citing works
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation
Gélinas, R., Mailleux, F., Dontaine, J., Bultot, L., Demeulder, B., Ginion, A., Daskalopoulos, E. P., Esfahani, H., Dubois‐Deruy, E., Lauzier, B., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02795-4 · Cited by 254 · see citing works
Self-citationCoral reef survival under accelerating ocean deoxygenation
Hughes, D. J., Alderdice, R., Cooney, C., Kühl, M., Pernice, M., Voolstra, C. R., & Suggett, D. J. (2020) · Nature Climate Change · doi:10.1038/s41558-020-0737-9 · Cited by 238 · see citing works
Mayer, C., & Belsham, D. D. (2009) · Endocrinology · doi:10.1210/en.2009-1122 · Cited by 232 · see citing works
Fontana, R., & Torre, S. D. (2016) · Nutrients · doi:10.3390/nu8020087 · Cited by 218 · see citing works
Kim, S. G., Hoffman, G. R., Poulogiannis, G., Buel, G. R., Jang, Y. J., Lee, K. W., Kim, B.-Y., Erikson, R. L., Cantley, L. C., Choo, A. Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.003 · Cited by 215 · see citing works
Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet
Woods, A., Williams, J., Muckett, P. J., Mayer, F. V., Liljevald, M., Bohlooly‐Y, M., & Carling, D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.011 · Cited by 207 · see citing works
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomesPreprint
Young, N. P., Kamireddy, A., Nostrand, J. L. V., Eichner, L. J., Shokhirev, M. N., Dayn, Y., & Shaw, R. J. (2016) · Genes & Development · doi:10.1101/gad.274142.115 · Cited by 177 · see citing works
Barone, E., Domenico, F. D., Perluigi, M., & Butterfield, D. (2021) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2021.09.006 · Cited by 155 · see citing works
mTOR signaling in tumorigenesis
Xu, K. L., Liu, P., & Wei, W. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.10.007 · Cited by 167 · see citing works
Effects of AMP-Activated Protein Kinase in Cerebral Ischemia
Li, J., & McCullough, L. D. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.255 · Cited by 163 · see citing works
Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium
Xu, L., Kong, L., Wang, J., & Ash, J. D. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802724115 · Cited by 163 · see citing works
Han, Y., Hu, Z., Cui, A., Liu, Z., Ma, F., Xue, Y., Liu, Y., Zhang, F., Zhao, Z., Yu, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08585-4 · Cited by 150 · see citing works
Yang, Q., Xu, J., Ma, Q., Liu, Z., Varadarajan, S., Cao, Y., Wang, L., Zeng, X., Zhou, Y., Zhang, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07132-x · Cited by 143 · see citing works
The role of AMPK in cardiomyocyte health and survival
Bairwa, S. C., Parajuli, N., & Dyck, J. R. B. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.001 · Cited by 141 · see citing works
Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease
Sid, B., Verrax, J., & Calderón, P. B. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.007 · Cited by 137 · see citing works
The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?
Vara‐Ciruelos, D., Russell, F. M., & Hardie, D. G. (2019) · Open Biology · doi:10.1098/rsob.190099 · Cited by 136 · see citing works
Ren, F., Wu, H., Lei, Y., Zhang, H., Liu, R., Zhao, Y., Chen, X., Zeng, D., Tong, A., Chen, L., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-81 · Cited by 136 · see citing works
Compound C/Dorsomorphin: Its Use and Misuse as an AMPK Inhibitor
Dasgupta, B., & Seibel, W. L. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7598-3_12 · Cited by 132 · see citing works
Sanli, T., Linher‐Melville, K., Tsakiridis, T. K., & Singh, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032035 · Cited by 130 · see citing works
ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure
Dijk, W., Heine, M., Vergnes, L., Boon, M. R., Schaart, G., Hesselink, M. K. C., Reue, K., Lichtenbelt, W. D. V. M., Olivecrona, G., Rensen, P. C. N., et al. (2015) · eLife · doi:10.7554/elife.08428 · Cited by 130 · see citing works
Kawakami, T., Hanao, N., Nishiyama, K., Kadota, Y., Inoue, M., Sato, M., & Suzuki, S. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.10.004 · Cited by 123 · see citing works
Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer
Dasgupta, B., & Chhipa, R. R. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.11.007 · Cited by 120 · see citing works
AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation
Daskalopoulos, E. P., Dufeys, C., Bertrand, L., Beauloye, C., & Horman, S. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.01.001 · Cited by 119 · see citing works
AMPK: a therapeutic target of heart failure—not only metabolism regulation
Li, X., Liu, J., Lü, Q., Ren, D., Sun, X., Rousselle, T. V., Tan, Y., & Li, J. (2018) · Bioscience Reports · doi:10.1042/bsr20181767 · Cited by 118 · see citing works
Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
Song, P., & Zou, M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.01.025 · Cited by 119 · see citing works
AMP-activated protein kinase: A target for old drugs against diabetes and cancer
Russo, G. L., Russo, M., & Ungaro, P. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.023 · Cited by 113 · see citing works
Cardiotrophin-1 Is a Key Regulator of Glucose and Lipid Metabolism
Moreno-Aliaga, M. J., Pérez-Echarri, N., Marcos‐Gómeź, B., Larequi, E., Gil-Bea, F. J., Viollet, B., Gimenez-Lopez, I., Martínez, J. A., Prìeto, J., & Bustos, M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.013 · Cited by 113 · see citing works
Self-citationExercise preserves physical fitness during aging through AMPK and mitochondrial dynamics
Campos, J. C., Bozi, L. H. M., Krum, B. N., Bechara, L. R. G., Ferreira, N. D., Arini, G. S., Albuquerque, R. P. E., Traa, A., Ogawa, T., van der Bliek, A. M., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204750120 · Cited by 112 · see citing works
Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators
Miyamoto, T., Rho, E., Sample, V., Akano, H., Magari, M., Ueno, T., Gorshkov, K., Chen, M., Tokumitsu, H., Zhang, J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.057 · Cited by 109 · see citing works
Zhou, S., Lu, W., Liang, C., Ge, Q., Chen, D., Xu, Z., Shi, D., Dai, J. M., Li, J., Ju, H., et al. (2017) · Scientific Reports · doi:10.1038/srep43245 · Cited by 104 · see citing works
Nutrient Sensing and the Oxidative Stress Response
Luo, H., Chiang, H.-H., Louw, M., Susanto, A., & Chen, D. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.02.008 · Cited by 102 · see citing works
AMPK and the Endocrine Control of Metabolism
Townsend, L. K., & Steinberg, G. R. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad012 · Cited by 101 · see citing works
Li, Y.-H., Luo, J., Mosley, Y. C., Hedrick, V., Paul, L. N., Chang, J., Zhang, G., Wang, Y., Banko, M. R., Brunet, A., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.054 · Cited by 99 · see citing works
Wang, P., Zhang, R.-Y., Song, J., Guan, Y., Xu, T., Du, H., Viollet, B., & Miao, C. (2012) · Diabetes · doi:10.2337/db11-1180 · Cited by 95 · see citing works
Self-citationPrantner, D., Perkins, D. J., & Vogel, S. N. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.763268 · Cited by 94 · see citing works
Yamada, E., Pessin, J. E., Kurland, I. J., Schwartz, G. J., & Bastie, C. C. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.12.010 · Cited by 94 · see citing works
Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5
Yan, Y., Tsukamoto, O., Nakano, A., Kato, H., Kioka, H., Ito, N., Higo, S., Yamazaki, S., Shintani, Y., Matsuoka, K., et al. (2015) · Nature Communications · doi:10.1038/ncomms7137 · Cited by 93 · see citing works
AMP-activated Protein Kinase in the Control of Cardiac Metabolism and Remodeling
Horman, S., Beauloye, C., Vanoverschelde, J., & Bertrand, L. (2012) · Current Heart Failure Reports · doi:10.1007/s11897-012-0102-z · Cited by 93 · see citing works
Inhibition of AMP kinase by the protein phosphatase 2a heterotrimer, PP2APpp2r2d
Joseph, B. K., Liu, H.-Y., Francisco, J., Pandya, D., Donigan, M., Gallo-Ebert, C., Giordano, C., Bata, A., & Nickels, J. T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.626259 · Cited by 91 · see citing works
Lombard, D. B., & Zwaans, B. M. M. (2013) · Gerontology · doi:10.1159/000354382 · Cited by 90 · see citing works
Beyond AICA riboside: In search of new specific AMP‐activated protein kinase activators
Guigas, B., Sakamoto, K., Taleux, N., Reyna, S. M., Musi, N., Viollet, B., & Hue, L. (2009) · IUBMB Life · doi:10.1002/iub.135 · Cited by 86 · see citing works
Self-citationSalminen, A., Kaarniranta, K., & Kauppinen, A. (2016) · Biogerontology · doi:10.1007/s10522-016-9655-7 · Cited by 86 · see citing works
The Metabolic Consequences of Hepatic AMP-Kinase Phosphorylation in Rainbow Trout
Polakof, S., Panserat, S., Craig, P. M., Martyres, D. J., Plagnes‐Juan, E., Savari, S., Aris‐Brosou, S., & Moon, T. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020228 · Cited by 82 · see citing works
Metformin-stimulated AMPK-α1 promotes microvascular repair in acute lung injury
Jian, M., ALEXEYEV, M. F., Wolkowicz, P. E., Zmijewski, J. W., & Creighton, J. R. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00173.2013 · Cited by 78 · see citing works
Lee, K. M., Yang, S.-J., Kim, Y. D., Choi, Y. D., Nam, J. H., Choi, C. S., Choi, H.-S., & Park, C.-S. (2013) · Diabetes · doi:10.2337/db12-1030 · Cited by 77 · see citing works
Ibe, J. C. F., Zhou, Q., Chen, T., Tang, H., Yuan, J. X. ‐., Raj, J. U., & Zhou, G. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0446oc · Cited by 76 · see citing works
Molecular mechanisms of tumor suppression by LKB1
Vaahtomeri, K., & Mäkelä, T. P. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.12.034 · Cited by 75 · see citing works
Function of the master energy regulator adenosine monophosphate‐activated protein kinase in stroke
Manwani, B., & McCullough, L. D. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23207 · Cited by 75 · see citing works
Hermida, N., Markl, A., Hamelet, J., Assche, T. V., Vanderper, A., Herijgers, P., van Bilsen, M., Hilfiker‐Kleiner, D., Noppe, G., Beauloye, C., et al. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt070 · Cited by 74 · see citing works
A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer
Khan, A., & Frigo, D. E. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2016.272 · Cited by 72 · see citing works
The Inositol Phosphate System—A Coordinator of Metabolic Adaptability
Tu‐Sekine, B., & Kim, S. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126747 · Cited by 71 · see citing works
Metabolic Rewiring and Communication: An Integrative View of Kidney Proximal Tubule Function
Chrysopoulou, M., & Rinschen, M. M. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042222-024724 · Cited by 70 · see citing works
Enkhjargal, B., Godo, S., Sawada, A., Nergui, S., Saito, H., Noda, K., Satoh, K., & Shimokawa, H. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303735 · Cited by 70 · see citing works
Hypoxia, AMPK activation and uterine artery vasoreactivity
Skeffington, K. L., Higgins, J. S., Mahmoud, A. D., Evans, A. M., Sferruzzi‐Perri, A. N., Fowden, A. L., Yung, H. W., Burton, G. J., Giussani, D. A., & Moore, L. G. (2016) · The Journal of Physiology · doi:10.1113/jp270995 · Cited by 69 · see citing works
Anderson, K. A., Lin, F., Ribar, T. J., Stevens, R. D., Muehlbauer, M. J., Newgard, C. B., & Means, A. R. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1299 · Cited by 69 · see citing works
Jansen, T., Kvandová, M., Daiber, A., Stamm, P., Frenis, K., Schulz, E., Münzel, T., & Kröller-Schön, S. (2020) · Antioxidants · doi:10.3390/antiox9060525 · Cited by 68 · see citing works
The LKB1/AMPK polarity pathway
Mirouse, V., & Billaud, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.12.025 · Cited by 67 · see citing works
Protective effects of AMP‐activated protein kinase in the cardiovascular system
Xu, Q., & Si, L. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01179.x · Cited by 67 · see citing works
Chen, K., Xu, X., Kobayashi, S., Timm, D. J., Jepperson, T. N., & Liang, Q. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.225805 · Cited by 66 · see citing works
AMPK activation regulates neuronal structure in developing hippocampal neurons
Ramamurthy, S., Chang, E., Cao, Y., Zhu, J., & Ronnett, G. V. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.048 · Cited by 65 · see citing works
Wijngaarden, M. A., van der Zon, G. C., van Dijk, K. W., Pijl, H., & Guigas, B. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00008.2013 · Cited by 63 · see citing works
Ginion, A., Auquier, J., Benton, C. R., Mouton, C., Vanoverschelde, J., Hue, L., Horman, S., Beauloye, C., & Bertrand, L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00986.2010 · Cited by 64 · see citing works
Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation
Hasumi, Y., Baba, M., Hasumi, H., Huang, Y. K., Lang, M., Reindorf, R., Oh, H., Sciarretta, S., Nagashima, K., Haines, D. C., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu286 · Cited by 60 · see citing works
Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney
Mahapatra, G., Varughese, A., Ji, Q., Lee, I., Liu, J., Vaishnav, A., Sinkler, C., Kapralov, A. A., Moraes, C. T., Sanderson, T. H., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.744664 · Cited by 61 · see citing works
Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction
Yang, W., Wang, L., Wang, F., & Yuan, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.593005 · Cited by 63 · see citing works
Inata, Y., Kikuchi, S., Samraj, R. S., Hake, P. W., O’Connor, M., Ledford, J. R., O'Connor, J., Lahni, P. M., Wolfe, V., Piraino, G., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700576r · Cited by 63 · see citing works
Fu, X., Zhao, J., Zhu, M. J., Foretz, M., Viollet, B., Dodson, M. V., & Du, . (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01078-13 · Cited by 60 · see citing works
Self-citationEffects of resveratrol in experimental and clinical non-alcoholic fatty liver disease
Heebøll, S. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v6.i4.188 · Cited by 60 · see citing works
AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain
Ramamurthy, S., & Ronnett, G. V. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.2.52 · Cited by 60 · see citing works
Reciprocal regulation of carbon monoxide metabolism and the circadian clock
Klemz, R., Reischl, S., Wallach, T. E., Witte, N., Jürchott, K., Klemz, S., Lang, V., Lorenzen, S., Knauer, M., Heidenreich, S., et al. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3331 · Cited by 59 · see citing works
AMPK Knockdown in Placental Trophoblast Cells Results in Altered Morphology and Function
Carey, E. A. K., Albers, R. E., Doliboa, S. R., Hughes, M., Wyatt, C. N., Natale, D. R. C., & Brown, T. L. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0092 · Cited by 56 · see citing works
Timmermans, A. D., Balteau, M., Gélinas, R., Renguet, E., Ginion, A., de Meester, C., Sakamoto, K., Balligand, J., Bontemps, F., Vanoverschelde, J., et al. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00965.2013 · Cited by 56 · see citing works
Raichur, S., Fitzsimmons, R. L., Myers, S., Pearen, M. A., Lau, P., Eriksson, N. A., Wang, S.-C., & Muscat, G. E. O. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq180 · Cited by 56 · see citing works
Li, X., Li, L., Lei, W., Chua, H. Z., Li, Z., Huang, X., Wang, Q., Li, N., & Zhang, H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111979 · Cited by 54 · see citing works
Morizane, Y., Thanos, A., Takeuchi, K., Murakami, Y., Kayama, M., Trichonas, G., Miller, J. W., Foretz, M., Viollet, B., & Vavvas, D. G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199398 · Cited by 54 · see citing works
Self-citationAMP-activated Protein Kinase Regulates β-Catenin Transcription via Histone Deacetylase 5
Zhao, J., Yue, W., Zhu, M. J., & Du, . (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199372 · Cited by 56 · see citing works
Blockade of GLUT1 by WZB117 resensitizes breast cancer cells to adriamycin
Chen, Q., Meng, Y.-Q., Xu, X.-F., & Gu, J. (2017) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000529 · Cited by 53 · see citing works
AMP-Activated Protein Kinase Regulates the Cell Surface Proteome and Integrin Membrane Traffic
Ross, E., Ata, R., Thavarajah, T., Medvedev, S., Bowden, P., Marshall, J. G., & Antonescu, C. N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128013 · Cited by 52 · see citing works
Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes
Itoh, Y., Sanosaka, M., Fuchino, H., Yahara, Y., Kumagai, A., Takemoto, D., Kagawa, M., Doi, J., Ohta, M., Tsumaki, N., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.640821 · Cited by 52 · see citing works
Adult stem cell deficits drive Slc29a3 disorders in mice
Nair, S. N., Strohecker, A. M., Persaud, A. K., Bissa, B., Muruganandan, S., McElroy, C. A., Pathak, R., Williams, M. M., Raj, R., Kaddoumi, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10925-3 · Cited by 52 · see citing works
AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5
Fu, X., Zhao, J., Liang, J., Zhu, M. J., Foretz, M., Viollet, B., & Du, . (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00124.2013 · Cited by 50 · see citing works
Self-citationPhosphorylation of TET2 by AMPK is indispensable in myogenic differentiation
Zhang, T., Guan, X., Choi, U. L., Dong, Q., Lam, M. M. T., Zeng, J., Xiong, J., Wang, X., Poon, T. C. W., Zhang, H., et al. (2019) · Epigenetics & Chromatin · doi:10.1186/s13072-019-0281-x · Cited by 50 · see citing works
Viollet, B., & Foretz, M. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3 · Cited by 47 · see citing works
Self-citation
- Authors
- Viollet, B.
- Venue
- Frontiers in bioscience
- Publisher
- IMR Press
- Published
- 2009
- Volume
- Volume
- Issue
- 14
- Pages
- 19
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/3229
- PMC
- PMC2666987
- OpenAlex
- W2104083311
- Cited by
- 314
- References
- 157
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 14 · 2023: 7 · 2022: 21 · 2021: 18 · 2020: 20 · 2019: 9 · 2018: 21 · 2017: 15 · 2016: 20 · 2015: 27 · 2014: 22 · 2013: 32 · 2012: 20
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in bioscience (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, cc-by)
- DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
- Funders
- European Commission (LSHMCT-2004-005272)
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation de France
- Fonds Spéciaux de Recherche
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- AMPK, energy metabolism, energy homeostasis, AMPK knockout mice, AMPK signaling, fatty acid oxidation, glycolysis, lipogenesis, ATP depletion, gene expression regulation
- MeSH terms
- Adipose Tissue, Animals, Blood Vessels, Energy Metabolism, Humans, Hypoglycemic Agents, Hypothalamus, Insulin Resistance, Liver, Myocardium, Protein Conformation, Muscle, Skeletal, Models, Animal, Animals, Genetically Modified, AMP-Activated Protein Kinases, Gene Knockout Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
