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Genome-wide Kinase-Chromatin Interactions Reveal the Regulatory Network of ERK Signaling in Human Embryonic Stem Cells

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SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway

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STAT3 Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts

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NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability

Parplys, A. C., Zhao, W., Sharma, N., Groesser, T., Liang, F., Maranon, D. G., Leung, S. G., Grundt, K., Dray, E. V., Idate, R., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv859 · Cited by 62 · see citing works

A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7

Wang, W., Angulo‐Ibáñez, M., Lyu, J., Kurra, Y., Tong, Z., Wu, B., Zhang, L., Sharma, V., Zhou, J., Lin, H., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b12083 · Cited by 62 · see citing works

Identification of a novel SIRT7 inhibitor as anticancer drug candidate

Kim, J. H., Kim, D., Cho, S. J., Jung, K.-Y., Kim, J., Lee, J. M., Jung, H. J., & Kim, K. R. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.11.120 · Cited by 60 · see citing works

Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells

Singh, S., Kumar, P., Thakur, S., Kiran, S., Sen, B., Sharma, S., Rao, V. V., Poongothai, A., & Ramakrishna, G. (2015) · Tumor Biology · doi:10.1007/s13277-015-3300-y · Cited by 59 · see citing works

Histone deficiency and accelerated replication stress in T cell aging

Kim, C., Jin, J., Ye, Z., Jadhav, R. R., Gustafson, C. E., Hu, B., Cao, W., Tian, L., Weyand, C. M., & Goronzy, J. J. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143632 · Cited by 47 · see citing works

SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders

Kaiser, A., Schmidt, M., Huber, O., Frietsch, J. J., Scholl, S., Heidel, F. H., Hochhaus, A., Müller, J. P., & Ernst, T. (2020) · Leukemia · doi:10.1038/s41375-020-0803-3 · Cited by 46 · see citing works

NUCKS Is a Positive Transcriptional Regulator of Insulin Signaling

Qiu, B., Shi, X., Wong, E. T., Lim, J., Bezzi, M., Low, D., Zhou, Q., Akıncılar, S. C., Lakshmanan, M., Swa, H. L. F., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.030 · Cited by 45 · see citing works

Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomics

Wiśniewski, J. R., Zougman, A., Krüger, S., Ziolkowski, P. P., Pudełko, M., Bębenek, M., & Mann, M. (2008) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.22104 · Cited by 44 · see citing works

SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis

Liu, Z., Qian, M., Tang, X., Hu, W., Sun, S., Guo, L., Zhang, S., Meng, F., Cao, X., Sun, J. L., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0136-6 · Cited by 43 · see citing works

Age-Related Changes in Sirtuin 7 Expression in Calorie-Restricted and Refed Rats

Wrońska, A., Ławniczak, A., Wierzbicki, P., & Kmieć, Z. (2015) · Gerontology · doi:10.1159/000441603 · Cited by 40 · see citing works

SIRT7 activates p53 by enhancing PCAF-mediated MDM2 degradation to arrest the cell cycle

Lu, Y.-F., Xu, X.-P., Lu, X.-P., Zhu, Q., Liu, G., Bao, Y.-T., Wen, H., Li, Y.-L., Gu, W., & Zhu, W.-G. (2020) · Oncogene · doi:10.1038/s41388-020-1305-5 · Cited by 40 · see citing works

Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver

Bozukova, M., Nikopoulou, C., Kleinenkuhnen, N., Grbavac, D., Goetsch, K., & Tessarz, P. (2022) · Molecular Systems Biology · doi:10.15252/msb.202211002 · Cited by 39 · see citing works

STAT1 mediates cellular senescence induced by angiotensin II and H2O2 in human glomerular mesangial cells

Jiao, S., Meng, F., Zhang, J. C., Yang, X. W., Zheng, X., & Wang, L. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1197-3 · Cited by 34 · see citing works

Increased Histone Acetylation and Decreased Expression of Specific Histone Deacetylases in Ultraviolet-Irradiated and Intrinsically Aged Human Skin In Vivo

Lee, Y., Shin, M. H., Kim, M. K., Kim, Y. K., Shin, H. S., Lee, D. H., & Chung, J. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042032 · Cited by 34 · see citing works

SIRT7 Facilitates CENP-A Nucleosome Assembly and Suppresses Intestinal Tumorigenesis

Liu, X., Li, C., Li, Q., Chang, H.-C., & Tang, Y. (2020) · iScience · doi:10.1016/j.isci.2020.101461 · Cited by 32 · see citing works

NUCKS1 promotes RAD54 activity in homologous recombination DNA repair

Maranon, D. G., Sharma, N., Huang, Y., Selemenakis, P., Wang, M., Altina, N. H., Zhao, W., & Wiese, C. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201911049 · Cited by 30 · see citing works

SIRT7 promotes chromosome synapsis during prophase I of female meiosis

Vázquez, B. N., Blengini, C. S., Hernandez, Y., Serrano, L., & Schindler, K. (2019) · Chromosoma · doi:10.1007/s00412-019-00713-9 · Cited by 29 · see citing works

Resveratrol rescues cutaneous radiation-induced DNA damage via a novel AMPK/SIRT7/HMGB1 regulatory axis

Jin, Y., Liu, X., Liang, X., Liu, J., Liu, J., Han, Z., Lu, Q., Wang, K., Meng, B., Zhang, C., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05281-y · Cited by 29 · see citing works

Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4

Karim, M. F., Yoshizawa, T., Sobuz, S. U., Sato, Y., & Yamagata, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.057 · Cited by 28 · see citing works

Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn

Poon, M.-W., Jiang, D., Qin, P., Zhang, Y., Qiu, B., Chanda, S. K., Tergaonkar, V., Li, Q., Wong, I. Y., Yu, Z., et al. (2017) · Scientific Reports · doi:10.1038/srep41224 · Cited by 27 · see citing works

SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development

Korogi, W., Yoshizawa, T., Karim, M. F., Tanoue, H., Yugami, M., Sobuz, S. U., Hinoi, E., Sato, Y., Oike, Y., Mizuta, H., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.129 · Cited by 24 · see citing works

SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability

Yu, M., Shi, X., Ren, M., Liu, L., Qi, H., Zhang, C., Zou, J., Qiu, X., Zhu, W., Zhang, Y. E., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114122 · Cited by 20 · see citing works

E3 ligase adaptor FBXO7 contributes to ubiquitination and proteasomal degradation of SIRT7 and promotes cell death in response to hydrogen peroxide

Lee, S. H., Lee, Y. J., Jung, S., & Chung, K. C. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.102909 · Cited by 12 · see citing works

Hypothalamic NUCKS regulates peripheral glucose homoeostasis

Qiu, B., Shi, X., Zhou, Q., Chen, H. S., Lim, J., Han, W., & Tergaonkar, V. (2015) · Biochemical Journal · doi:10.1042/bj20150450 · Cited by 11 · see citing works

Identification of kinases phosphorylating 13 sites in the nuclear, DNA-binding protein NUCKS

Grundt, K., Thiede, B., & Østvold, A. C. (2016) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2016.12.009 · Cited by 10 · see citing works

Signaling pathways that control mRNA translation initiation in macrophages

Tabatabaei, N., Hou, S., Kim, K.-W., & Tahmasebi, S. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109700 · Cited by 10 · see citing works

Differential Detergent Lysis of Cellular Fractions for ImmunoprecipitationPreprint

DeCaprio, J. A., & Kohl, T. O. (2020) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot098582 · Cited by 7 · see citing works

Phosphoproteomic analysis reveals the mechanisms of human umbilical cord mesenchymal stem cell-derived exosomes attenuate renal aging

Yu, W., Xu, J., Qiao, H., Liu, D., Sun, Y., Yan, R., Zhang, C., Yu, N., Song, Y., Ling, M., et al. (2024) · Journal of Proteomics · doi:10.1016/j.jprot.2024.105335 · Cited by 11 · see citing works

Rehmannioside D ameliorates hepatocyte apoptosis and liver fibrosis by suppressing Sirt7/p53 axis

Liang, Y., Cheng, T.-Y., Pu, J.-Y., Chen, G., Liu, W., Mu, Y., Zhang, H., Chen, J., & Liu, P. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120863 · Cited by 8 · see citing works

TRIP12 promotes HIV-1 replication and latency reactivation by stabilizing Tat via USP7-mediated deubiquitination

Shi, H., Quan, P., Hou, Y., Wang, H., Wang, Y., Wang, H., & Zhang, W. (2026) · Journal of Virology · doi:10.1128/jvi.00396-26 · Cited by 3 · see citing works

A Double-Edged Role for SIRT7 in Cancer: Can Anti-Cancer Immunity Tip the Balance?

Tarighi, S., Ning, Z., Gámez-García, A., Vaquero, A., Braun, T. W., & Ianni, A. (2025) · Pharmaceuticals · doi:10.3390/ph18121878 · Cited by 2 · see citing works

The Sirtuin Network: Linking NAD + Metabolism, Mitochondrial Function, and Metabolic Homoeostasis

Szczęsny-Małysiak, E., Schiavoni, V., Rotondo, R., Zeppa, S. D., Vignini, A., Moriconi, E., Cecati, M., Armani, A., Gorini, S., Campagna, R., et al. (2026) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.70201 · Cited by 2 · see citing works

Apelin‐12 Attenuates LPS‐Induced Cellular Senescence in Human Dental Pulp Cells via SIRT6‐Mediated Pathways: Implications for Gingivitis Management

Zhang, L., Luo, D., & Bai, L. (2025) · Molecular Oral Microbiology · doi:10.1111/omi.70012 · Cited by 1 · see citing works

SIRT7 safeguards ERα proteostasis via deacetylation-dependent degradation of unliganded and misfolded receptors

Cao, M., Zhang, J., Liu, H., Fan, R., Wu, F., Meng, Y., Li, T., Wu, Y., & Tang, X. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111173 · Cited by 1 · see citing works

Emerging roles of SIRT7 in metabolic homeostasis and related disorders

Yu, S., Rabiu, L., Zhu, W., & Tian, Y. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168343 · Cited by 1 · see citing works

SF3A2 deacetylation at lysin 10 mitigates myocardial pathological remodeling by reprogramming cardiomyocyte metabolismPreprint

Guo, R., Zhang, Z., Zhang, H., Yang, Y. J., Qiao, M., Zhang, J., Wang, Y., Chen, J., Li, J., Wu, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.26.696635

Research Progress of the Sirtuins Family in Intervertebral Disc Degeneration

赵, 泽. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.162526

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Jiang, J., Wang, Y., Qin, Y., Chen, L., Xu, X., Fan, G., Jing, D., Wei, M., Yu, X., Xu, J., et al. (2026) · Advanced Science · doi:10.1002/advs.202519824

The role of HECT-type E3 ubiquitin ligases in inflammation

Wang, Z., Wang, P., Xie, H., You, Z., Liu, X., Cao, F., & Yao, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1810360

Single-cell eQTL-based Mendelian randomization identifies immune cell subtype-specific regulators of epigenetic aging and prioritizes candidate therapeutic targets

Zhang, C., & Zhang, J. (2026) · Biogerontology · doi:10.1007/s10522-026-10453-w

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Meng, N., Zhou, J., Guo, X., Hong, T., Li, X., Wei, X., Zhang, C., Zhang, X., Liu, S., Zhang, Y., et al. (2026) · Advanced Science · doi:10.1002/advs.77642

Role of sirtuin 7 (SIRT7) in hepatic physiology and pathophysiology: mechanism, prospective and therapeutic potential

Chen, W., Yang, D., Liu, H., Tong, S., Liang, G., Zhang, J., Yang, J., & Li, Z. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118519

Chromatin and Nuclear Signaling

Angulo‐Ibáñez, M., & Chua, K. F. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00010-1

Chromatin Regulation and Genome Maintenance by Mammalian SIRT6 and SIRT7

Chua, K. F. (2020) · The FASEB Journal · doi:10.1096/fasebj.2020.34.s1.00152

Oxidative stress impairs the Nur77‐Sirt1 axis resulting in a decline in organism homeostasis during aging

Yu, Y., Song, X., Ma, G., Zheng, L., Wang, X., Chen, F., Liu, T., Tian, H., Xu, Y., Li, D., et al. (2023) · Aging Cell · doi:10.1111/acel.13812 · Cited by 31 · see citing works

Chromatin Regulation and Genome Maintenance by Mammalian SIRT7

Cho, J. (2020) · Innovation in Aging · doi:10.1093/geroni/igaa057.2653

Comparative interactomes of SIRT 6 and SIRT 7: Implication of functional links to aging

Lee, N., Kim, D., Kim, E., Park, S. J., Kwon, J., Shin, J., Park, S., Moon, Y. H., Wang, H.-J., Gho, Y. S., et al. (2014) · PROTEOMICS · doi:10.1002/pmic.201400001 · Cited by 85 · see citing works